SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2qgn'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1I7Q_A_BEZA1501_0
(ANTHRANILATE
SYNTHASE)		 2qgn TRNA
DELTA(2)-ISOPENTENYL
PYROPHOSPHATE
TRANSFERASE
(Bacillus
halodurans) 		5 / 11 ILE A 221
GLU A 223
LEU A 263
GLY A  46
GLU A 218
 None
 1.32A 1i7qA-2qgnA:
undetectable		 1i7qA-2qgnA:
21.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1OG5_A_SWFA502_1
(CYTOCHROME P450 2C9)		 2qgn TRNA
DELTA(2)-ISOPENTENYL
PYROPHOSPHATE
TRANSFERASE
(Bacillus
halodurans) 		5 / 12 LEU A  80
ALA A  81
LEU A  62
THR A 101
LEU A 103
 None
 1.19A 1og5A-2qgnA:
undetectable		 1og5A-2qgnA:
21.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BXQ_A_IMNA2001_1
(SERUM ALBUMIN)		 2qgn TRNA
DELTA(2)-ISOPENTENYL
PYROPHOSPHATE
TRANSFERASE
(Bacillus
halodurans) 		6 / 10 ALA A 107
PHE A  77
ALA A  81
LEU A  84
LEU A  62
LEU A 114
 None
 1.47A 2bxqA-2qgnA:
undetectable		 2bxqA-2qgnA:
19.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2X9G_A_LYAA1270_2
(PTERIDINE REDUCTASE)		 2qgn TRNA
DELTA(2)-ISOPENTENYL
PYROPHOSPHATE
TRANSFERASE
(Bacillus
halodurans) 		3 / 3 MET A  37
VAL A  31
GLU A  54
 None
 0.91A 2x9gA-2qgnA:
4.9		 2x9gA-2qgnA:
20.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4CUT_A_TYLA2971_1
(BROMODOMAIN ADJACENT
TO ZINC FINGER
DOMAIN PROTEIN 2B)		 2qgn TRNA
DELTA(2)-ISOPENTENYL
PYROPHOSPHATE
TRANSFERASE
(Bacillus
halodurans) 		4 / 4 VAL A 284
VAL A   9
ASN A 106
ILE A 109
 None
 1.24A 4cutA-2qgnA:
0.0		 4cutA-2qgnA:
17.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4OLT_A_GCSA303_1
(CHITOSANASE)		 2qgn TRNA
DELTA(2)-ISOPENTENYL
PYROPHOSPHATE
TRANSFERASE
(Bacillus
halodurans) 		4 / 6 ARG A  91
GLY A  29
VAL A  58
HIS A  61
 None
 1.07A 4oltA-2qgnA:
undetectable		 4oltA-2qgnA:
20.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4OLT_B_GCSB303_1
(CHITOSANASE)		 2qgn TRNA
DELTA(2)-ISOPENTENYL
PYROPHOSPHATE
TRANSFERASE
(Bacillus
halodurans) 		4 / 6 ARG A  91
GLY A  29
VAL A  58
HIS A  61
 None
 1.04A 4oltB-2qgnA:
undetectable		 4oltB-2qgnA:
20.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QTU_D_SAMD301_0
(PUTATIVE
METHYLTRANSFERASE
BUD23)		 2qgn TRNA
DELTA(2)-ISOPENTENYL
PYROPHOSPHATE
TRANSFERASE
(Bacillus
halodurans) 		5 / 12 GLY A 242
GLY A  46
SER A 237
ALA A 240
ARG A 273
 None
 1.12A 4qtuD-2qgnA:
undetectable		 4qtuD-2qgnA:
22.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QWP_B_GCSB307_1
(CHITOSANASE)		 2qgn TRNA
DELTA(2)-ISOPENTENYL
PYROPHOSPHATE
TRANSFERASE
(Bacillus
halodurans) 		4 / 7 ARG A  91
GLY A  29
VAL A  58
HIS A  61
 None
 0.96A 4qwpB-2qgnA:
undetectable		 4qwpB-2qgnA:
20.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IK1_A_CAMA503_0
(CAMPHOR
5-MONOOXYGENASE)		 2qgn TRNA
DELTA(2)-ISOPENTENYL
PYROPHOSPHATE
TRANSFERASE
(Bacillus
halodurans) 		5 / 7 PHE A 287
GLY A 307
VAL A   6
ILE A 195
VAL A 193
 None
 1.33A 5ik1A-2qgnA:
0.6		 5ik1A-2qgnA:
21.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5O96_H_SAMH501_0
(RIBOSOMAL RNA SMALL
SUBUNIT
METHYLTRANSFERASE E)		 2qgn TRNA
DELTA(2)-ISOPENTENYL
PYROPHOSPHATE
TRANSFERASE
(Bacillus
halodurans) 		6 / 10 LEU A  62
GLY A  34
GLY A 100
LEU A  80
VAL A  74
ALA A  81
 None
 1.49A 5o96G-2qgnA:
undetectable
5o96H-2qgnA:
undetectable		 5o96G-2qgnA:
19.02
5o96H-2qgnA:
19.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UAN_B_REAB503_1
(RETINOIC ACID
RECEPTOR BETA)		 2qgn TRNA
DELTA(2)-ISOPENTENYL
PYROPHOSPHATE
TRANSFERASE
(Bacillus
halodurans) 		5 / 12 ALA A  24
ILE A 301
ILE A 298
LEU A 197
VAL A  98
 None
 1.40A 5uanB-2qgnA:
undetectable		 5uanB-2qgnA:
20.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6GNA_A_ACTA307_0
(THIOREDOXIN
REDUCTASE)		 2qgn TRNA
DELTA(2)-ISOPENTENYL
PYROPHOSPHATE
TRANSFERASE
(Bacillus
halodurans) 		3 / 3 ARG A 269
LYS A 272
TYR A 205
 None
 1.14A 6gnaA-2qgnA:
1.6		 6gnaA-2qgnA:
22.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6GNB_A_ACTA307_0
(THIOREDOXIN
REDUCTASE)		 2qgn TRNA
DELTA(2)-ISOPENTENYL
PYROPHOSPHATE
TRANSFERASE
(Bacillus
halodurans) 		3 / 3 ARG A 269
LYS A 272
TYR A 205
 None
 1.14A 6gnbA-2qgnA:
1.6		 6gnbA-2qgnA:
22.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6HU9_E_PCFE202_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE 5A,
MITOCHONDRIAL
CYTOCHROME C OXIDASE
SUBUNIT 1)		 2qgn TRNA
DELTA(2)-ISOPENTENYL
PYROPHOSPHATE
TRANSFERASE
(Bacillus
halodurans) 		4 / 8 ILE A 305
ALA A  24
VAL A  21
ARG A  26
 None
 1.06A 6hu9a-2qgnA:
undetectable
6hu9e-2qgnA:
undetectable		 6hu9a-2qgnA:
19.66
6hu9e-2qgnA:
16.56