SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2qgy'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ERR_A_CCSA381_0
(ESTROGEN RECEPTOR)		 2qgy ENOLASE FROM THE
ENVIRONMENTAL GENOME
SHOTGUN SEQUENCING
OF THE SARGASSO SEA
(-) 		4 / 5 HIS A 300
GLU A 326
ALA A 309
SER A 304
 None
 1.40A 1errA-2qgyA:
undetectable
1errB-2qgyA:
undetectable		 1errA-2qgyA:
21.30
1errB-2qgyA:
21.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HK4_A_T44A1008_1
(SERUM ALBUMIN)		 2qgy ENOLASE FROM THE
ENVIRONMENTAL GENOME
SHOTGUN SEQUENCING
OF THE SARGASSO SEA
(-) 		5 / 10 ALA A 267
LYS A 239
GLU A 250
ASN A 271
VAL A 246
 None
None
MG  A 701 (-2.4A)
None
None
 1.47A 1hk4A-2qgyA:
0.1		 1hk4A-2qgyA:
18.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HK5_A_T44A1008_1
(SERUM ALBUMIN)		 2qgy ENOLASE FROM THE
ENVIRONMENTAL GENOME
SHOTGUN SEQUENCING
OF THE SARGASSO SEA
(-) 		5 / 10 ALA A 267
LYS A 239
GLU A 250
ASN A 271
VAL A 246
 None
None
MG  A 701 (-2.4A)
None
None
 1.49A 1hk5A-2qgyA:
0.0		 1hk5A-2qgyA:
18.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1KYV_D_RBFD504_1
(6,7-DIMETHYL-8-RIBIT
YLLUMAZINE SYNTHASE)		 2qgy ENOLASE FROM THE
ENVIRONMENTAL GENOME
SHOTGUN SEQUENCING
OF THE SARGASSO SEA
(-) 		5 / 12 ILE A  80
LEU A 110
GLY A 279
SER A 104
ILE A 106
 None
 1.16A 1kyvC-2qgyA:
undetectable
1kyvD-2qgyA:
undetectable		 1kyvC-2qgyA:
17.07
1kyvD-2qgyA:
17.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1KYV_E_RBFE505_1
(6,7-DIMETHYL-8-RIBIT
YLLUMAZINE SYNTHASE)		 2qgy ENOLASE FROM THE
ENVIRONMENTAL GENOME
SHOTGUN SEQUENCING
OF THE SARGASSO SEA
(-) 		5 / 12 ILE A  80
LEU A 110
GLY A 279
SER A 104
ILE A 106
 None
 1.16A 1kyvD-2qgyA:
undetectable
1kyvE-2qgyA:
undetectable		 1kyvD-2qgyA:
17.07
1kyvE-2qgyA:
17.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1XMU_A_ROFA101_0
(CAMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE 4B)		 2qgy ENOLASE FROM THE
ENVIRONMENTAL GENOME
SHOTGUN SEQUENCING
OF THE SARGASSO SEA
(-) 		5 / 12 ASP A 206
PRO A 202
ILE A 238
PHE A 242
MET A 244
 None
 1.32A 1xmuA-2qgyA:
undetectable		 1xmuA-2qgyA:
22.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1XMU_B_ROFB102_0
(CAMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE 4B)		 2qgy ENOLASE FROM THE
ENVIRONMENTAL GENOME
SHOTGUN SEQUENCING
OF THE SARGASSO SEA
(-) 		5 / 12 ASP A 206
PRO A 202
ILE A 238
PHE A 242
MET A 244
 None
 1.31A 1xmuB-2qgyA:
undetectable		 1xmuB-2qgyA:
22.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1YA4_B_CTXB2_1
(CES1 PROTEIN)		 2qgy ENOLASE FROM THE
ENVIRONMENTAL GENOME
SHOTGUN SEQUENCING
OF THE SARGASSO SEA
(-) 		5 / 12 PHE A  99
GLY A 278
GLY A 279
LEU A 280
LEU A  68
 None
 1.16A 1ya4B-2qgyA:
undetectable		 1ya4B-2qgyA:
19.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2NNI_A_MTKA501_2
(CYTOCHROME P450 2C8)		 2qgy ENOLASE FROM THE
ENVIRONMENTAL GENOME
SHOTGUN SEQUENCING
OF THE SARGASSO SEA
(-) 		4 / 8 ILE A 283
ILE A 284
ILE A  80
ILE A 274
 None
 0.70A 2nniA-2qgyA:
undetectable		 2nniA-2qgyA:
24.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OTF_A_2TNA201_1
(PHOSPHOLIPASE A2
VRV-PL-VIIIA)		 2qgy ENOLASE FROM THE
ENVIRONMENTAL GENOME
SHOTGUN SEQUENCING
OF THE SARGASSO SEA
(-) 		4 / 5 LEU A 126
ILE A  80
SER A 114
GLY A 115
 None
 1.01A 2otfA-2qgyA:
undetectable		 2otfA-2qgyA:
15.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QMM_B_SAMB301_0
(UPF0217 PROTEIN
AF_1056)		 2qgy ENOLASE FROM THE
ENVIRONMENTAL GENOME
SHOTGUN SEQUENCING
OF THE SARGASSO SEA
(-) 		5 / 11 SER A  88
LEU A 110
ILE A 106
SER A  79
LEU A  78
 None
 1.01A 2qmmA-2qgyA:
undetectable
2qmmB-2qgyA:
undetectable		 2qmmA-2qgyA:
20.56
2qmmB-2qgyA:
20.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XYT_D_TC9D1206_2
(SOLUBLE
ACETYLCHOLINE
RECEPTOR)		 2qgy ENOLASE FROM THE
ENVIRONMENTAL GENOME
SHOTGUN SEQUENCING
OF THE SARGASSO SEA
(-) 		4 / 8 ARG A  57
ILE A  61
ASP A 273
SER A 308
 None
 1.12A 2xytE-2qgyA:
undetectable		 2xytE-2qgyA:
18.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XYT_G_TC9G1206_2
(SOLUBLE
ACETYLCHOLINE
RECEPTOR)		 2qgy ENOLASE FROM THE
ENVIRONMENTAL GENOME
SHOTGUN SEQUENCING
OF THE SARGASSO SEA
(-) 		4 / 8 ARG A  57
ILE A  61
ASP A 273
SER A 308
 None
 1.06A 2xytH-2qgyA:
undetectable		 2xytH-2qgyA:
18.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZUJ_A_CAMA422_0
(CAMPHOR
5-MONOOXYGENASE)		 2qgy ENOLASE FROM THE
ENVIRONMENTAL GENOME
SHOTGUN SEQUENCING
OF THE SARGASSO SEA
(-) 		4 / 8 THR A 148
LEU A 152
VAL A 185
LEU A 172
 None
 0.83A 2zujA-2qgyA:
undetectable		 2zujA-2qgyA:
22.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3IA4_A_MTXA164_1
(DIHYDROFOLATE
REDUCTASE)		 2qgy ENOLASE FROM THE
ENVIRONMENTAL GENOME
SHOTGUN SEQUENCING
OF THE SARGASSO SEA
(-) 		5 / 12 GLU A 107
SER A 287
ILE A 286
ARG A 259
LEU A 255
 None
 1.39A 3ia4A-2qgyA:
undetectable		 3ia4A-2qgyA:
15.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3JZ0_B_CLYB900_1
(LINCOSAMIDE
NUCLEOTIDYLTRANSFERA
SE)		 2qgy ENOLASE FROM THE
ENVIRONMENTAL GENOME
SHOTGUN SEQUENCING
OF THE SARGASSO SEA
(-) 		4 / 8 TYR A 331
GLU A 326
PHE A  34
ILE A  36
 None
 1.03A 3jz0B-2qgyA:
undetectable		 3jz0B-2qgyA:
22.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SNF_A_ACTA110_0
(PROTEIN P-30)		 2qgy ENOLASE FROM THE
ENVIRONMENTAL GENOME
SHOTGUN SEQUENCING
OF THE SARGASSO SEA
(-) 		4 / 5 ILE A  87
THR A 103
SER A 100
PHE A  99
 None
 1.03A 3snfA-2qgyA:
undetectable		 3snfA-2qgyA:
15.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4AC9_B_DXCB1473_0
(MJ0495-LIKE PROTEIN)		 2qgy ENOLASE FROM THE
ENVIRONMENTAL GENOME
SHOTGUN SEQUENCING
OF THE SARGASSO SEA
(-) 		5 / 11 ILE A 283
ASP A 282
GLY A 254
PHE A 258
GLY A 249
 None
 1.02A 4ac9B-2qgyA:
2.3
4ac9C-2qgyA:
2.2		 4ac9B-2qgyA:
23.23
4ac9C-2qgyA:
23.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4E47_A_SAMA401_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
SETD7)		 2qgy ENOLASE FROM THE
ENVIRONMENTAL GENOME
SHOTGUN SEQUENCING
OF THE SARGASSO SEA
(-) 		5 / 11 ILE A  39
ALA A 109
GLY A  49
GLU A  50
GLY A 278
 None
 1.16A 4e47A-2qgyA:
undetectable		 4e47A-2qgyA:
20.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4E47_B_SAMB800_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
SETD7)		 2qgy ENOLASE FROM THE
ENVIRONMENTAL GENOME
SHOTGUN SEQUENCING
OF THE SARGASSO SEA
(-) 		5 / 11 ILE A  39
ALA A 109
GLY A  49
GLU A  50
GLY A 278
 None
 1.18A 4e47B-2qgyA:
undetectable		 4e47B-2qgyA:
20.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4E47_C_SAMC800_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
SETD7)		 2qgy ENOLASE FROM THE
ENVIRONMENTAL GENOME
SHOTGUN SEQUENCING
OF THE SARGASSO SEA
(-) 		5 / 11 ILE A  39
ALA A 109
GLY A  49
GLU A  50
GLY A 278
 None
 1.15A 4e47C-2qgyA:
undetectable		 4e47C-2qgyA:
20.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4E47_C_SAMC800_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
SETD7)		 2qgy ENOLASE FROM THE
ENVIRONMENTAL GENOME
SHOTGUN SEQUENCING
OF THE SARGASSO SEA
(-) 		5 / 11 ILE A  39
ALA A 109
GLY A  49
GLU A  50
GLY A 279
 None
 1.22A 4e47C-2qgyA:
undetectable		 4e47C-2qgyA:
20.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4IAQ_A_2GMA2001_2
(CHIMERA PROTEIN OF
HUMAN
5-HYDROXYTRYPTAMINE
RECEPTOR 1B AND E.
COLI SOLUBLE
CYTOCHROME B562)		 2qgy ENOLASE FROM THE
ENVIRONMENTAL GENOME
SHOTGUN SEQUENCING
OF THE SARGASSO SEA
(-) 		4 / 6 ILE A  36
THR A  19
VAL A 361
SER A 304
 None
 1.11A 4iaqA-2qgyA:
undetectable		 4iaqA-2qgyA:
22.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4IAR_A_ERMA2001_2
(CHIMERA PROTEIN OF
HUMAN
5-HYDROXYTRYPTAMINE
RECEPTOR 1B AND E.
COLI SOLUBLE
CYTOCHROME B562)		 2qgy ENOLASE FROM THE
ENVIRONMENTAL GENOME
SHOTGUN SEQUENCING
OF THE SARGASSO SEA
(-) 		4 / 7 ILE A  36
THR A  19
VAL A 361
SER A 304
 None
 1.16A 4iarA-2qgyA:
undetectable		 4iarA-2qgyA:
22.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4JDS_A_SAMA401_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
SETD7)		 2qgy ENOLASE FROM THE
ENVIRONMENTAL GENOME
SHOTGUN SEQUENCING
OF THE SARGASSO SEA
(-) 		5 / 11 ILE A  39
ALA A 109
GLY A  49
GLU A  50
GLY A 278
 None
 1.19A 4jdsA-2qgyA:
undetectable		 4jdsA-2qgyA:
20.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4JDS_B_SAMB401_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
SETD7)		 2qgy ENOLASE FROM THE
ENVIRONMENTAL GENOME
SHOTGUN SEQUENCING
OF THE SARGASSO SEA
(-) 		5 / 11 ILE A  39
ALA A 109
GLY A  49
GLU A  50
GLY A 278
 None
 1.16A 4jdsB-2qgyA:
undetectable		 4jdsB-2qgyA:
20.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4JLG_A_SAMA401_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
SETD7)		 2qgy ENOLASE FROM THE
ENVIRONMENTAL GENOME
SHOTGUN SEQUENCING
OF THE SARGASSO SEA
(-) 		5 / 12 ILE A  39
ALA A 109
GLY A  49
GLU A  50
GLY A 278
 None
 1.15A 4jlgA-2qgyA:
undetectable		 4jlgA-2qgyA:
20.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4JLG_A_SAMA401_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
SETD7)		 2qgy ENOLASE FROM THE
ENVIRONMENTAL GENOME
SHOTGUN SEQUENCING
OF THE SARGASSO SEA
(-) 		5 / 12 ILE A  39
ALA A 109
GLY A  49
GLU A  50
GLY A 279
 None
 1.22A 4jlgA-2qgyA:
undetectable		 4jlgA-2qgyA:
20.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4O8F_B_BRLB501_2
(PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR GAMMA)		 2qgy ENOLASE FROM THE
ENVIRONMENTAL GENOME
SHOTGUN SEQUENCING
OF THE SARGASSO SEA
(-) 		4 / 6 ILE A 108
GLY A 279
ILE A 274
LEU A 358
 None
 0.73A 4o8fB-2qgyA:
undetectable		 4o8fB-2qgyA:
21.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Q5M_A_ROCA1101_1
(PROTEASE)		 2qgy ENOLASE FROM THE
ENVIRONMENTAL GENOME
SHOTGUN SEQUENCING
OF THE SARGASSO SEA
(-) 		5 / 12 ASN A 293
ILE A 262
VAL A 247
VAL A 315
ILE A 274
 None
 1.01A 4q5mA-2qgyA:
undetectable		 4q5mA-2qgyA:
19.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Q5M_A_ROCA1101_1
(PROTEASE)		 2qgy ENOLASE FROM THE
ENVIRONMENTAL GENOME
SHOTGUN SEQUENCING
OF THE SARGASSO SEA
(-) 		5 / 12 GLY A 294
ASN A 265
ILE A 286
VAL A 247
ILE A 283
 None
 1.02A 4q5mA-2qgyA:
undetectable		 4q5mA-2qgyA:
19.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4R20_A_AERA602_1
(CYTOCHROME P450
FAMILY 17
POLYPEPTIDE 2)		 2qgy ENOLASE FROM THE
ENVIRONMENTAL GENOME
SHOTGUN SEQUENCING
OF THE SARGASSO SEA
(-) 		4 / 8 ASN A 353
ILE A 352
GLY A 359
SER A 304
 None
 0.84A 4r20A-2qgyA:
undetectable		 4r20A-2qgyA:
21.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5AYF_A_SAMA401_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
SETD7)		 2qgy ENOLASE FROM THE
ENVIRONMENTAL GENOME
SHOTGUN SEQUENCING
OF THE SARGASSO SEA
(-) 		5 / 11 ILE A  39
ALA A 109
GLY A  49
GLU A  50
GLY A 278
 None
 1.14A 5ayfA-2qgyA:
undetectable		 5ayfA-2qgyA:
19.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HIE_C_P06C801_2
(SERINE/THREONINE-PRO
TEIN KINASE B-RAF)		 2qgy ENOLASE FROM THE
ENVIRONMENTAL GENOME
SHOTGUN SEQUENCING
OF THE SARGASSO SEA
(-) 		4 / 7 ILE A 284
VAL A 247
ILE A 295
CYH A 316
 None
 0.87A 5hieC-2qgyA:
undetectable		 5hieC-2qgyA:
22.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IGZ_A_SPRA404_2
(MACROLIDE
2'-PHOSPHOTRANSFERAS
E II)		 2qgy ENOLASE FROM THE
ENVIRONMENTAL GENOME
SHOTGUN SEQUENCING
OF THE SARGASSO SEA
(-) 		5 / 9 LEU A  11
ILE A   8
ILE A  65
GLU A  67
PHE A  69
 None
 1.29A 5igzA-2qgyA:
undetectable		 5igzA-2qgyA:
21.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5MUR_E_PFLE406_1
(PROTON-GATED ION
CHANNEL)		 2qgy ENOLASE FROM THE
ENVIRONMENTAL GENOME
SHOTGUN SEQUENCING
OF THE SARGASSO SEA
(-) 		5 / 10 ILE A  64
ILE A  61
THR A 103
ILE A 106
ILE A  37
 None
 1.01A 5murE-2qgyA:
undetectable		 5murE-2qgyA:
14.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UUN_A_ACTA309_0
(GLUTATHIONE
S-TRANSFERASE-LIKE
PROTEIN)		 2qgy ENOLASE FROM THE
ENVIRONMENTAL GENOME
SHOTGUN SEQUENCING
OF THE SARGASSO SEA
(-) 		4 / 4 LEU A 280
GLY A 279
SER A 104
SER A 275
 None
 1.27A 5uunA-2qgyA:
undetectable		 5uunA-2qgyA:
20.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UUN_B_ACTB306_0
(GLUTATHIONE
S-TRANSFERASE-LIKE
PROTEIN)		 2qgy ENOLASE FROM THE
ENVIRONMENTAL GENOME
SHOTGUN SEQUENCING
OF THE SARGASSO SEA
(-) 		4 / 4 LEU A 280
GLY A 279
SER A 104
SER A 275
 None
 1.27A 5uunB-2qgyA:
undetectable		 5uunB-2qgyA:
20.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6BAA_E_GBME2001_2
(ATP-BINDING CASSETTE
SUB-FAMILY C MEMBER
8)		 2qgy ENOLASE FROM THE
ENVIRONMENTAL GENOME
SHOTGUN SEQUENCING
OF THE SARGASSO SEA
(-) 		3 / 3 LEU A 367
THR A  31
ASN A  21
 None
 0.72A 6baaE-2qgyA:
0.5		 6baaE-2qgyA:
13.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6BAA_F_GBMF2001_2
(ATP-BINDING CASSETTE
SUB-FAMILY C MEMBER
8)		 2qgy ENOLASE FROM THE
ENVIRONMENTAL GENOME
SHOTGUN SEQUENCING
OF THE SARGASSO SEA
(-) 		3 / 3 LEU A 367
THR A  31
ASN A  21
 None
 0.72A 6baaF-2qgyA:
0.5		 6baaF-2qgyA:
13.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6BAA_G_GBMG2001_2
(ATP-BINDING CASSETTE
SUB-FAMILY C MEMBER
8)		 2qgy ENOLASE FROM THE
ENVIRONMENTAL GENOME
SHOTGUN SEQUENCING
OF THE SARGASSO SEA
(-) 		3 / 3 LEU A 367
THR A  31
ASN A  21
 None
 0.73A 6baaG-2qgyA:
0.0		 6baaG-2qgyA:
13.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6BAA_H_GBMH2001_2
(ATP-BINDING CASSETTE
SUB-FAMILY C MEMBER
8)		 2qgy ENOLASE FROM THE
ENVIRONMENTAL GENOME
SHOTGUN SEQUENCING
OF THE SARGASSO SEA
(-) 		3 / 3 LEU A 367
THR A  31
ASN A  21
 None
 0.73A 6baaH-2qgyA:
0.5		 6baaH-2qgyA:
13.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6GSD_A_STRA401_0
(PROGESTERONE
5-BETA-REDUCTASE)		 2qgy ENOLASE FROM THE
ENVIRONMENTAL GENOME
SHOTGUN SEQUENCING
OF THE SARGASSO SEA
(-) 		5 / 12 VAL A 189
PHE A 158
ILE A 155
TRP A 222
ILE A 168
 None
 1.43A 6gsdA-2qgyA:
undetectable		 6gsdA-2qgyA:
13.49