SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2qhx'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1E7W_A_MTXA301_1
(PTERIDINE REDUCTASE)		 2qhx PTERIDINE REDUCTASE
1
(Leishmania
major) 		10 / 12 ARG A  17
SER A 111
PHE A 113
PRO A 115
ASP A 181
LEU A 188
TYR A 191
TYR A 194
LEU A 226
LEU A 229
 NAP  A1300 ( 3.7A)
FE1  A1301 ( 2.8A)
FE1  A1301 (-3.4A)
None
NAP  A1300 ( 3.6A)
FE1  A1301 (-4.5A)
None
FE1  A1301 ( 4.5A)
FE1  A1301 ( 4.9A)
None
 0.23A 1e7wA-2qhxA:
45.3		 1e7wA-2qhxA:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1E7W_B_MTXB301_1
(PTERIDINE REDUCTASE)		 2qhx PTERIDINE REDUCTASE
1
(Leishmania
major) 		9 / 11 ARG A  17
SER A 111
PHE A 113
PRO A 115
ASP A 181
LEU A 188
TYR A 191
TYR A 194
LEU A 226
 NAP  A1300 ( 3.7A)
FE1  A1301 ( 2.8A)
FE1  A1301 (-3.4A)
None
NAP  A1300 ( 3.6A)
FE1  A1301 (-4.5A)
None
FE1  A1301 ( 4.5A)
FE1  A1301 ( 4.9A)
 0.21A 1e7wB-2qhxA:
44.6		 1e7wB-2qhxA:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1E7W_B_MTXB301_1
(PTERIDINE REDUCTASE)		 2qhx PTERIDINE REDUCTASE
1
(Leishmania
major) 		8 / 11 ARG A  17
SER A 111
PHE A 113
PRO A 115
LEU A 188
TYR A 191
LEU A 226
HIS A 241
 NAP  A1300 ( 3.7A)
FE1  A1301 ( 2.8A)
FE1  A1301 (-3.4A)
None
FE1  A1301 (-4.5A)
None
FE1  A1301 ( 4.9A)
FE1  A1301 (-4.2A)
 0.68A 1e7wB-2qhxA:
44.6		 1e7wB-2qhxA:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1E7W_B_MTXB301_1
(PTERIDINE REDUCTASE)		 2qhx PTERIDINE REDUCTASE
1
(Leishmania
major) 		6 / 11 SER A 111
PHE A 113
PRO A 115
TYR A 191
LEU A 229
HIS A 241
 FE1  A1301 ( 2.8A)
FE1  A1301 (-3.4A)
None
None
None
FE1  A1301 (-4.2A)
 1.28A 1e7wB-2qhxA:
44.6		 1e7wB-2qhxA:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1E7W_B_MTXB301_1
(PTERIDINE REDUCTASE)		 2qhx PTERIDINE REDUCTASE
1
(Leishmania
major) 		6 / 11 SER A 111
PHE A 113
PRO A 115
TYR A 191
TYR A 194
LEU A 229
 FE1  A1301 ( 2.8A)
FE1  A1301 (-3.4A)
None
None
FE1  A1301 ( 4.5A)
None
 0.95A 1e7wB-2qhxA:
44.6		 1e7wB-2qhxA:
100.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1JHV_A_NIOA991_1
(NICOTINATE
MONONUCLEOTIDE:5,6-D
IMETHYLBENZIMIDAZOLE
PHOSPHORIBOSYLTRANSF
ERASE)		 2qhx PTERIDINE REDUCTASE
1
(Leishmania
major) 		4 / 8 GLY A 221
GLY A 199
LEU A 201
GLY A 203
 None
 0.73A 1jhvA-2qhxA:
2.9		 1jhvA-2qhxA:
23.70
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1MXF_A_MTXA1278_1
(PTERIDINE REDUCTASE
2)		 2qhx PTERIDINE REDUCTASE
1
(Leishmania
major) 		5 / 10 ARG A  17
SER A 111
ASP A 181
LEU A 188
TYR A 194
 NAP  A1300 ( 3.7A)
FE1  A1301 ( 2.8A)
NAP  A1300 ( 3.6A)
FE1  A1301 (-4.5A)
FE1  A1301 ( 4.5A)
 0.30A 1mxfA-2qhxA:
40.2		 1mxfA-2qhxA:
43.77
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1MXF_A_MTXA1278_1
(PTERIDINE REDUCTASE
2)		 2qhx PTERIDINE REDUCTASE
1
(Leishmania
major) 		5 / 10 ARG A  17
SER A 111
ASP A 181
TYR A 194
LEU A 226
 NAP  A1300 ( 3.7A)
FE1  A1301 ( 2.8A)
NAP  A1300 ( 3.6A)
FE1  A1301 ( 4.5A)
FE1  A1301 ( 4.9A)
 0.66A 1mxfA-2qhxA:
40.2		 1mxfA-2qhxA:
43.77
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1MXF_B_MTXB2278_1
(PTERIDINE REDUCTASE
2)		 2qhx PTERIDINE REDUCTASE
1
(Leishmania
major) 		5 / 11 ARG A  17
SER A 111
ASP A 181
LEU A 188
TYR A 194
 NAP  A1300 ( 3.7A)
FE1  A1301 ( 2.8A)
NAP  A1300 ( 3.6A)
FE1  A1301 (-4.5A)
FE1  A1301 ( 4.5A)
 0.28A 1mxfB-2qhxA:
40.4		 1mxfB-2qhxA:
43.77
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1MXF_B_MTXB2278_1
(PTERIDINE REDUCTASE
2)		 2qhx PTERIDINE REDUCTASE
1
(Leishmania
major) 		5 / 11 ARG A  17
SER A 111
ASP A 181
TYR A 194
LEU A 226
 NAP  A1300 ( 3.7A)
FE1  A1301 ( 2.8A)
NAP  A1300 ( 3.6A)
FE1  A1301 ( 4.5A)
FE1  A1301 ( 4.9A)
 0.61A 1mxfB-2qhxA:
40.4		 1mxfB-2qhxA:
43.77
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1MXF_C_MTXC3278_1
(PTERIDINE REDUCTASE
2)		 2qhx PTERIDINE REDUCTASE
1
(Leishmania
major) 		5 / 11 ARG A  17
SER A 111
ASP A 181
LEU A 188
TYR A 194
 NAP  A1300 ( 3.7A)
FE1  A1301 ( 2.8A)
NAP  A1300 ( 3.6A)
FE1  A1301 (-4.5A)
FE1  A1301 ( 4.5A)
 0.33A 1mxfC-2qhxA:
40.6		 1mxfC-2qhxA:
43.77
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1MXF_C_MTXC3278_1
(PTERIDINE REDUCTASE
2)		 2qhx PTERIDINE REDUCTASE
1
(Leishmania
major) 		5 / 11 ARG A  17
SER A 111
ASP A 181
TYR A 194
LEU A 226
 NAP  A1300 ( 3.7A)
FE1  A1301 ( 2.8A)
NAP  A1300 ( 3.6A)
FE1  A1301 ( 4.5A)
FE1  A1301 ( 4.9A)
 0.65A 1mxfC-2qhxA:
40.6		 1mxfC-2qhxA:
43.77
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1MXF_D_MTXD4278_1
(PTERIDINE REDUCTASE
2)		 2qhx PTERIDINE REDUCTASE
1
(Leishmania
major) 		5 / 11 ARG A  17
SER A 111
ASP A 181
LEU A 188
TYR A 194
 NAP  A1300 ( 3.7A)
FE1  A1301 ( 2.8A)
NAP  A1300 ( 3.6A)
FE1  A1301 (-4.5A)
FE1  A1301 ( 4.5A)
 0.29A 1mxfD-2qhxA:
40.6		 1mxfD-2qhxA:
43.77
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1MXF_D_MTXD4278_1
(PTERIDINE REDUCTASE
2)		 2qhx PTERIDINE REDUCTASE
1
(Leishmania
major) 		5 / 11 ARG A  17
SER A 111
ASP A 181
TYR A 194
LEU A 226
 NAP  A1300 ( 3.7A)
FE1  A1301 ( 2.8A)
NAP  A1300 ( 3.6A)
FE1  A1301 ( 4.5A)
FE1  A1301 ( 4.9A)
 0.63A 1mxfD-2qhxA:
40.6		 1mxfD-2qhxA:
43.77
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1P33_A_MTXA351_1
(PTERIDINE REDUCTASE
1)		 2qhx PTERIDINE REDUCTASE
1
(Leishmania
major) 		9 / 12 ARG A  17
SER A 111
PHE A 113
ASP A 181
LEU A 188
TYR A 191
TYR A 194
LEU A 226
LEU A 229
 NAP  A1300 ( 3.7A)
FE1  A1301 ( 2.8A)
FE1  A1301 (-3.4A)
NAP  A1300 ( 3.6A)
FE1  A1301 (-4.5A)
None
FE1  A1301 ( 4.5A)
FE1  A1301 ( 4.9A)
None
 0.46A 1p33A-2qhxA:
44.4		 1p33A-2qhxA:
71.04
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1P33_B_MTXB352_1
(PTERIDINE REDUCTASE
1)		 2qhx PTERIDINE REDUCTASE
1
(Leishmania
major) 		9 / 12 ARG A  17
SER A 111
PHE A 113
ASP A 181
LEU A 188
TYR A 191
TYR A 194
LEU A 226
LEU A 229
 NAP  A1300 ( 3.7A)
FE1  A1301 ( 2.8A)
FE1  A1301 (-3.4A)
NAP  A1300 ( 3.6A)
FE1  A1301 (-4.5A)
None
FE1  A1301 ( 4.5A)
FE1  A1301 ( 4.9A)
None
 0.43A 1p33B-2qhxA:
44.2		 1p33B-2qhxA:
71.04
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1P33_C_MTXC353_1
(PTERIDINE REDUCTASE
1)		 2qhx PTERIDINE REDUCTASE
1
(Leishmania
major) 		9 / 12 ARG A  17
SER A 111
PHE A 113
ASP A 181
LEU A 188
TYR A 191
TYR A 194
LEU A 226
LEU A 229
 NAP  A1300 ( 3.7A)
FE1  A1301 ( 2.8A)
FE1  A1301 (-3.4A)
NAP  A1300 ( 3.6A)
FE1  A1301 (-4.5A)
None
FE1  A1301 ( 4.5A)
FE1  A1301 ( 4.9A)
None
 0.46A 1p33C-2qhxA:
44.3		 1p33C-2qhxA:
71.04
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1P33_C_MTXC353_1
(PTERIDINE REDUCTASE
1)		 2qhx PTERIDINE REDUCTASE
1
(Leishmania
major) 		6 / 12 SER A 111
PHE A 113
LEU A 188
TYR A 191
TYR A 194
LEU A 229
 FE1  A1301 ( 2.8A)
FE1  A1301 (-3.4A)
FE1  A1301 (-4.5A)
None
FE1  A1301 ( 4.5A)
None
 0.89A 1p33C-2qhxA:
44.3		 1p33C-2qhxA:
71.04
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1P33_D_MTXD354_1
(PTERIDINE REDUCTASE
1)		 2qhx PTERIDINE REDUCTASE
1
(Leishmania
major) 		9 / 12 ARG A  17
SER A 111
PHE A 113
PRO A 115
ASP A 181
LEU A 188
TYR A 191
TYR A 194
LEU A 229
 NAP  A1300 ( 3.7A)
FE1  A1301 ( 2.8A)
FE1  A1301 (-3.4A)
None
NAP  A1300 ( 3.6A)
FE1  A1301 (-4.5A)
None
FE1  A1301 ( 4.5A)
None
 0.41A 1p33D-2qhxA:
43.9		 1p33D-2qhxA:
71.04
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1P33_D_MTXD354_1
(PTERIDINE REDUCTASE
1)		 2qhx PTERIDINE REDUCTASE
1
(Leishmania
major) 		5 / 12 SER A 111
PHE A 113
PRO A 115
TYR A 191
LEU A 226
 FE1  A1301 ( 2.8A)
FE1  A1301 (-3.4A)
None
None
FE1  A1301 ( 4.9A)
 1.01A 1p33D-2qhxA:
43.9		 1p33D-2qhxA:
71.04
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2BFM_A_TOPA1290_1
(PTERIDINE REDUCTASE
1)		 2qhx PTERIDINE REDUCTASE
1
(Leishmania
major) 		8 / 9 PHE A 113
ASP A 181
LEU A 188
TYR A 194
LEU A 226
LEU A 229
HIS A 241
TYR A 283
 FE1  A1301 (-3.4A)
NAP  A1300 ( 3.6A)
FE1  A1301 (-4.5A)
FE1  A1301 ( 4.5A)
FE1  A1301 ( 4.9A)
None
FE1  A1301 (-4.2A)
None
 0.40A 2bfmA-2qhxA:
45.8
2bfmD-2qhxA:
44.9		 2bfmA-2qhxA:
87.80
2bfmD-2qhxA:
87.80
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2BFM_A_TOPA1290_1
(PTERIDINE REDUCTASE
1)		 2qhx PTERIDINE REDUCTASE
1
(Leishmania
major) 		5 / 9 PHE A 113
LEU A 188
TYR A 194
LEU A 226
HIS A 241
 FE1  A1301 (-3.4A)
FE1  A1301 (-4.5A)
FE1  A1301 ( 4.5A)
FE1  A1301 ( 4.9A)
FE1  A1301 (-4.2A)
 1.34A 2bfmA-2qhxA:
45.8
2bfmD-2qhxA:
44.9		 2bfmA-2qhxA:
87.80
2bfmD-2qhxA:
87.80
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2BFM_B_TOPB1290_1
(PTERIDINE REDUCTASE
1)		 2qhx PTERIDINE REDUCTASE
1
(Leishmania
major) 		8 / 9 PHE A 113
ASP A 181
LEU A 188
TYR A 191
TYR A 194
LEU A 226
LEU A 229
HIS A 241
 FE1  A1301 (-3.4A)
NAP  A1300 ( 3.6A)
FE1  A1301 (-4.5A)
None
FE1  A1301 ( 4.5A)
FE1  A1301 ( 4.9A)
None
FE1  A1301 (-4.2A)
 0.42A 2bfmB-2qhxA:
45.7
2bfmC-2qhxA:
44.7		 2bfmB-2qhxA:
87.80
2bfmC-2qhxA:
87.80
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2BFM_B_TOPB1290_1
(PTERIDINE REDUCTASE
1)		 2qhx PTERIDINE REDUCTASE
1
(Leishmania
major) 		6 / 9 PHE A 113
LEU A 188
TYR A 191
TYR A 194
LEU A 226
HIS A 241
 FE1  A1301 (-3.4A)
FE1  A1301 (-4.5A)
None
FE1  A1301 ( 4.5A)
FE1  A1301 ( 4.9A)
FE1  A1301 (-4.2A)
 1.34A 2bfmB-2qhxA:
45.7
2bfmC-2qhxA:
44.7		 2bfmB-2qhxA:
87.80
2bfmC-2qhxA:
87.80
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2BFP_A_H4BA1290_1
(PTERIDINE REDUCTASE
1)		 2qhx PTERIDINE REDUCTASE
1
(Leishmania
major) 		8 / 8 ARG A  17
SER A 111
PHE A 113
ASP A 181
LEU A 188
TYR A 194
LEU A 226
LEU A 229
 NAP  A1300 ( 3.7A)
FE1  A1301 ( 2.8A)
FE1  A1301 (-3.4A)
NAP  A1300 ( 3.6A)
FE1  A1301 (-4.5A)
FE1  A1301 ( 4.5A)
FE1  A1301 ( 4.9A)
None
 0.27A 2bfpA-2qhxA:
46.4		 2bfpA-2qhxA:
87.80
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2BFP_A_H4BA1290_1
(PTERIDINE REDUCTASE
1)		 2qhx PTERIDINE REDUCTASE
1
(Leishmania
major) 		4 / 8 SER A 111
PHE A 113
TYR A 194
LEU A 226
 FE1  A1301 ( 2.8A)
FE1  A1301 (-3.4A)
FE1  A1301 ( 4.5A)
FE1  A1301 ( 4.9A)
 0.76A 2bfpA-2qhxA:
46.4		 2bfpA-2qhxA:
87.80
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2BFP_B_H4BB1290_1
(PTERIDINE REDUCTASE
1)		 2qhx PTERIDINE REDUCTASE
1
(Leishmania
major) 		8 / 8 ARG A  17
SER A 111
PHE A 113
ASP A 181
LEU A 188
TYR A 194
LEU A 226
LEU A 229
 NAP  A1300 ( 3.7A)
FE1  A1301 ( 2.8A)
FE1  A1301 (-3.4A)
NAP  A1300 ( 3.6A)
FE1  A1301 (-4.5A)
FE1  A1301 ( 4.5A)
FE1  A1301 ( 4.9A)
None
 0.34A 2bfpB-2qhxA:
46.4		 2bfpB-2qhxA:
87.80
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2BFP_B_H4BB1290_1
(PTERIDINE REDUCTASE
1)		 2qhx PTERIDINE REDUCTASE
1
(Leishmania
major) 		5 / 8 SER A 111
PHE A 113
LEU A 188
TYR A 194
LEU A 226
 FE1  A1301 ( 2.8A)
FE1  A1301 (-3.4A)
FE1  A1301 (-4.5A)
FE1  A1301 ( 4.5A)
FE1  A1301 ( 4.9A)
 0.80A 2bfpB-2qhxA:
46.4		 2bfpB-2qhxA:
87.80
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2BFP_C_H4BC1290_1
(PTERIDINE REDUCTASE
1)		 2qhx PTERIDINE REDUCTASE
1
(Leishmania
major) 		8 / 8 ARG A  17
SER A 111
PHE A 113
ASP A 181
LEU A 188
TYR A 194
LEU A 226
LEU A 229
 NAP  A1300 ( 3.7A)
FE1  A1301 ( 2.8A)
FE1  A1301 (-3.4A)
NAP  A1300 ( 3.6A)
FE1  A1301 (-4.5A)
FE1  A1301 ( 4.5A)
FE1  A1301 ( 4.9A)
None
 0.23A 2bfpC-2qhxA:
45.6		 2bfpC-2qhxA:
87.80
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2BFP_D_H4BD1290_1
(PTERIDINE REDUCTASE
1)		 2qhx PTERIDINE REDUCTASE
1
(Leishmania
major) 		8 / 8 ARG A  17
SER A 111
PHE A 113
ASP A 181
LEU A 188
TYR A 194
LEU A 226
LEU A 229
 NAP  A1300 ( 3.7A)
FE1  A1301 ( 2.8A)
FE1  A1301 (-3.4A)
NAP  A1300 ( 3.6A)
FE1  A1301 (-4.5A)
FE1  A1301 ( 4.5A)
FE1  A1301 ( 4.9A)
None
 0.26A 2bfpD-2qhxA:
45.6		 2bfpD-2qhxA:
87.80
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2C7V_A_MTXA1272_1
(PTERIDINE REDUCTASE)		 2qhx PTERIDINE REDUCTASE
1
(Leishmania
major) 		5 / 9 ARG A  17
SER A 111
PHE A 113
PRO A 115
TYR A 194
 NAP  A1300 ( 3.7A)
FE1  A1301 ( 2.8A)
FE1  A1301 (-3.4A)
None
FE1  A1301 ( 4.5A)
 0.22A 2c7vA-2qhxA:
41.2		 2c7vA-2qhxA:
42.99
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2C7V_B_MTXB1272_1
(PTERIDINE REDUCTASE)		 2qhx PTERIDINE REDUCTASE
1
(Leishmania
major) 		7 / 12 ARG A  17
SER A 111
PHE A 113
PRO A 115
ASP A 181
TYR A 194
LEU A 229
 NAP  A1300 ( 3.7A)
FE1  A1301 ( 2.8A)
FE1  A1301 (-3.4A)
None
NAP  A1300 ( 3.6A)
FE1  A1301 ( 4.5A)
None
 0.45A 2c7vB-2qhxA:
41.3		 2c7vB-2qhxA:
42.99
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2C7V_B_MTXB1272_1
(PTERIDINE REDUCTASE)		 2qhx PTERIDINE REDUCTASE
1
(Leishmania
major) 		5 / 12 SER A 111
PHE A 113
PRO A 115
TYR A 194
LEU A 226
 FE1  A1301 ( 2.8A)
FE1  A1301 (-3.4A)
None
FE1  A1301 ( 4.5A)
FE1  A1301 ( 4.9A)
 1.03A 2c7vB-2qhxA:
41.3		 2c7vB-2qhxA:
42.99
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2C7V_C_MTXC1272_1
(PTERIDINE REDUCTASE)		 2qhx PTERIDINE REDUCTASE
1
(Leishmania
major) 		7 / 12 ARG A  17
SER A 111
PHE A 113
PRO A 115
ASP A 181
TYR A 194
LEU A 229
 NAP  A1300 ( 3.7A)
FE1  A1301 ( 2.8A)
FE1  A1301 (-3.4A)
None
NAP  A1300 ( 3.6A)
FE1  A1301 ( 4.5A)
None
 0.46A 2c7vC-2qhxA:
41.3		 2c7vC-2qhxA:
42.99
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2C7V_C_MTXC1272_1
(PTERIDINE REDUCTASE)		 2qhx PTERIDINE REDUCTASE
1
(Leishmania
major) 		5 / 12 SER A 111
PHE A 113
PRO A 115
TYR A 194
LEU A 226
 FE1  A1301 ( 2.8A)
FE1  A1301 (-3.4A)
None
FE1  A1301 ( 4.5A)
FE1  A1301 ( 4.9A)
 1.05A 2c7vC-2qhxA:
41.3		 2c7vC-2qhxA:
42.99
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2C7V_D_MTXD1272_1
(PTERIDINE REDUCTASE)		 2qhx PTERIDINE REDUCTASE
1
(Leishmania
major) 		6 / 10 ARG A  17
SER A 111
PHE A 113
PRO A 115
ASP A 181
TYR A 194
 NAP  A1300 ( 3.7A)
FE1  A1301 ( 2.8A)
FE1  A1301 (-3.4A)
None
NAP  A1300 ( 3.6A)
FE1  A1301 ( 4.5A)
 0.26A 2c7vD-2qhxA:
40.8		 2c7vD-2qhxA:
42.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2DDW_B_PXLB1005_1
(PYRIDOXINE KINASE)		 2qhx PTERIDINE REDUCTASE
1
(Leishmania
major) 		4 / 7 THR A 165
PRO A 166
HIS A 169
GLY A 101
 None
 0.70A 2ddwB-2qhxA:
5.5		 2ddwB-2qhxA:
21.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2I91_A_ACTA601_0
(60 KDA SS-A/RO
RIBONUCLEOPROTEIN)		 2qhx PTERIDINE REDUCTASE
1
(Leishmania
major) 		4 / 7 TYR A 114
SER A 146
SER A 112
SER A  67
 None
NAP  A1300 ( 4.3A)
NAP  A1300 (-4.1A)
None
 0.98A 2i91A-2qhxA:
4.3		 2i91A-2qhxA:
19.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2I91_B_ACTB602_0
(60 KDA SS-A/RO
RIBONUCLEOPROTEIN)		 2qhx PTERIDINE REDUCTASE
1
(Leishmania
major) 		4 / 7 TYR A 114
SER A 146
SER A 112
SER A  67
 None
NAP  A1300 ( 4.3A)
NAP  A1300 (-4.1A)
None
 0.99A 2i91B-2qhxA:
undetectable		 2i91B-2qhxA:
19.71
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2X9G_A_LYAA1270_1
(PTERIDINE REDUCTASE)		 2qhx PTERIDINE REDUCTASE
1
(Leishmania
major) 		7 / 12 ARG A  17
SER A 111
PHE A 113
PRO A 115
ASP A 181
TYR A 194
LEU A 229
 NAP  A1300 ( 3.7A)
FE1  A1301 ( 2.8A)
FE1  A1301 (-3.4A)
None
NAP  A1300 ( 3.6A)
FE1  A1301 ( 4.5A)
None
 0.49A 2x9gA-2qhxA:
41.0		 2x9gA-2qhxA:
49.09
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2X9G_A_LYAA1270_1
(PTERIDINE REDUCTASE)		 2qhx PTERIDINE REDUCTASE
1
(Leishmania
major) 		5 / 12 SER A 111
PHE A 113
PRO A 115
TYR A 194
LEU A 226
 FE1  A1301 ( 2.8A)
FE1  A1301 (-3.4A)
None
FE1  A1301 ( 4.5A)
FE1  A1301 ( 4.9A)
 1.03A 2x9gA-2qhxA:
41.0		 2x9gA-2qhxA:
49.09
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2X9G_B_LYAB1270_1
(PTERIDINE REDUCTASE)		 2qhx PTERIDINE REDUCTASE
1
(Leishmania
major) 		7 / 12 ARG A  17
SER A 111
PHE A 113
PRO A 115
ASP A 181
TYR A 194
LEU A 229
 NAP  A1300 ( 3.7A)
FE1  A1301 ( 2.8A)
FE1  A1301 (-3.4A)
None
NAP  A1300 ( 3.6A)
FE1  A1301 ( 4.5A)
None
 0.45A 2x9gB-2qhxA:
41.0		 2x9gB-2qhxA:
49.09
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2X9G_B_LYAB1270_1
(PTERIDINE REDUCTASE)		 2qhx PTERIDINE REDUCTASE
1
(Leishmania
major) 		5 / 12 SER A 111
PHE A 113
PRO A 115
TYR A 194
LEU A 226
 FE1  A1301 ( 2.8A)
FE1  A1301 (-3.4A)
None
FE1  A1301 ( 4.5A)
FE1  A1301 ( 4.9A)
 0.98A 2x9gB-2qhxA:
41.0		 2x9gB-2qhxA:
49.09
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2X9G_C_LYAC1270_1
(PTERIDINE REDUCTASE)		 2qhx PTERIDINE REDUCTASE
1
(Leishmania
major) 		7 / 12 ARG A  17
SER A 111
PHE A 113
PRO A 115
ASP A 181
TYR A 194
LEU A 229
 NAP  A1300 ( 3.7A)
FE1  A1301 ( 2.8A)
FE1  A1301 (-3.4A)
None
NAP  A1300 ( 3.6A)
FE1  A1301 ( 4.5A)
None
 0.43A 2x9gC-2qhxA:
41.2		 2x9gC-2qhxA:
49.09
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2X9G_C_LYAC1270_1
(PTERIDINE REDUCTASE)		 2qhx PTERIDINE REDUCTASE
1
(Leishmania
major) 		5 / 12 SER A 111
PHE A 113
PRO A 115
TYR A 194
LEU A 226
 FE1  A1301 ( 2.8A)
FE1  A1301 (-3.4A)
None
FE1  A1301 ( 4.5A)
FE1  A1301 ( 4.9A)
 0.99A 2x9gC-2qhxA:
41.2		 2x9gC-2qhxA:
49.09
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2X9G_D_LYAD1270_1
(PTERIDINE REDUCTASE)		 2qhx PTERIDINE REDUCTASE
1
(Leishmania
major) 		7 / 12 ARG A  17
SER A 111
PHE A 113
PRO A 115
ASP A 181
TYR A 194
LEU A 229
 NAP  A1300 ( 3.7A)
FE1  A1301 ( 2.8A)
FE1  A1301 (-3.4A)
None
NAP  A1300 ( 3.6A)
FE1  A1301 ( 4.5A)
None
 0.43A 2x9gD-2qhxA:
40.8		 2x9gD-2qhxA:
49.09
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2X9G_D_LYAD1270_1
(PTERIDINE REDUCTASE)		 2qhx PTERIDINE REDUCTASE
1
(Leishmania
major) 		5 / 12 SER A 111
PHE A 113
PRO A 115
TYR A 194
LEU A 226
 FE1  A1301 ( 2.8A)
FE1  A1301 (-3.4A)
None
FE1  A1301 ( 4.5A)
FE1  A1301 ( 4.9A)
 1.01A 2x9gD-2qhxA:
40.8		 2x9gD-2qhxA:
49.09
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2X9V_A_TMQA1270_1
(PTERIDINE REDUCTASE)		 2qhx PTERIDINE REDUCTASE
1
(Leishmania
major) 		6 / 11 ARG A  17
SER A 111
PHE A 113
ASP A 181
TYR A 194
LEU A 229
 NAP  A1300 ( 3.7A)
FE1  A1301 ( 2.8A)
FE1  A1301 (-3.4A)
NAP  A1300 ( 3.6A)
FE1  A1301 ( 4.5A)
None
 0.53A 2x9vA-2qhxA:
41.2		 2x9vA-2qhxA:
49.09
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2X9V_B_TMQB1270_1
(PTERIDINE REDUCTASE)		 2qhx PTERIDINE REDUCTASE
1
(Leishmania
major) 		6 / 9 ARG A  17
SER A 111
PHE A 113
ASP A 181
TYR A 194
LEU A 229
 NAP  A1300 ( 3.7A)
FE1  A1301 ( 2.8A)
FE1  A1301 (-3.4A)
NAP  A1300 ( 3.6A)
FE1  A1301 ( 4.5A)
None
 0.44A 2x9vB-2qhxA:
41.7		 2x9vB-2qhxA:
49.09
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2X9V_C_TMQC1270_1
(PTERIDINE REDUCTASE)		 2qhx PTERIDINE REDUCTASE
1
(Leishmania
major) 		6 / 10 ARG A  17
SER A 111
PHE A 113
ASP A 181
TYR A 194
LEU A 229
 NAP  A1300 ( 3.7A)
FE1  A1301 ( 2.8A)
FE1  A1301 (-3.4A)
NAP  A1300 ( 3.6A)
FE1  A1301 ( 4.5A)
None
 0.29A 2x9vC-2qhxA:
41.4		 2x9vC-2qhxA:
49.09
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2X9V_D_TMQD1270_1
(PTERIDINE REDUCTASE)		 2qhx PTERIDINE REDUCTASE
1
(Leishmania
major) 		5 / 9 SER A 111
PHE A 113
ASP A 181
TYR A 194
LEU A 229
 FE1  A1301 ( 2.8A)
FE1  A1301 (-3.4A)
NAP  A1300 ( 3.6A)
FE1  A1301 ( 4.5A)
None
 0.35A 2x9vD-2qhxA:
41.3		 2x9vD-2qhxA:
49.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3AX9_A_SALA1341_1
(XANTHINE
DEHYDROGENASE/OXIDAS
E)		 2qhx PTERIDINE REDUCTASE
1
(Leishmania
major) 		4 / 8 LEU A  51
SER A  48
THR A  61
ALA A  14
 None
 1.00A 3ax9A-2qhxA:
undetectable		 3ax9A-2qhxA:
12.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3AX9_B_SALB1340_1
(XANTHINE
DEHYDROGENASE/OXIDAS
E)		 2qhx PTERIDINE REDUCTASE
1
(Leishmania
major) 		4 / 8 LEU A  51
SER A  48
THR A  61
ALA A  14
 None
 0.99A 3ax9B-2qhxA:
undetectable		 3ax9B-2qhxA:
12.80
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3BMC_A_FOLA270_0
(PTERIDINE REDUCTASE)		 2qhx PTERIDINE REDUCTASE
1
(Leishmania
major) 		5 / 11 ARG A  17
SER A 111
PHE A 113
PRO A 115
TYR A 194
 NAP  A1300 ( 3.7A)
FE1  A1301 ( 2.8A)
FE1  A1301 (-3.4A)
None
FE1  A1301 ( 4.5A)
 0.31A 3bmcA-2qhxA:
40.7		 3bmcA-2qhxA:
49.09
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3BMC_B_FOLB270_0
(PTERIDINE REDUCTASE)		 2qhx PTERIDINE REDUCTASE
1
(Leishmania
major) 		5 / 11 ARG A  17
SER A 111
PHE A 113
PRO A 115
TYR A 194
 NAP  A1300 ( 3.7A)
FE1  A1301 ( 2.8A)
FE1  A1301 (-3.4A)
None
FE1  A1301 ( 4.5A)
 0.33A 3bmcB-2qhxA:
40.5		 3bmcB-2qhxA:
49.09
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3BMC_C_FOLC270_0
(PTERIDINE REDUCTASE)		 2qhx PTERIDINE REDUCTASE
1
(Leishmania
major) 		6 / 12 ARG A  17
SER A 111
PHE A 113
PRO A 115
TYR A 194
LEU A 229
 NAP  A1300 ( 3.7A)
FE1  A1301 ( 2.8A)
FE1  A1301 (-3.4A)
None
FE1  A1301 ( 4.5A)
None
 0.63A 3bmcC-2qhxA:
40.5		 3bmcC-2qhxA:
49.09
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3BMC_D_FOLD270_0
(PTERIDINE REDUCTASE)		 2qhx PTERIDINE REDUCTASE
1
(Leishmania
major) 		5 / 12 ARG A  17
SER A 111
PHE A 113
PRO A 115
TYR A 194
 NAP  A1300 ( 3.7A)
FE1  A1301 ( 2.8A)
FE1  A1301 (-3.4A)
None
FE1  A1301 ( 4.5A)
 0.33A 3bmcD-2qhxA:
40.7		 3bmcD-2qhxA:
49.09
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3JQ7_A_DX2A271_1
(PTERIDINE REDUCTASE
1)		 2qhx PTERIDINE REDUCTASE
1
(Leishmania
major) 		6 / 10 ARG A  17
SER A 111
PHE A 113
ASP A 181
TYR A 194
LEU A 229
 NAP  A1300 ( 3.7A)
FE1  A1301 ( 2.8A)
FE1  A1301 (-3.4A)
NAP  A1300 ( 3.6A)
FE1  A1301 ( 4.5A)
None
 0.49A 3jq7A-2qhxA:
41.2		 3jq7A-2qhxA:
49.09
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3JQ7_B_DX2B271_1
(PTERIDINE REDUCTASE
1)		 2qhx PTERIDINE REDUCTASE
1
(Leishmania
major) 		6 / 8 ARG A  17
SER A 111
PHE A 113
ASP A 181
TYR A 194
LEU A 229
 NAP  A1300 ( 3.7A)
FE1  A1301 ( 2.8A)
FE1  A1301 (-3.4A)
NAP  A1300 ( 3.6A)
FE1  A1301 ( 4.5A)
None
 0.42A 3jq7B-2qhxA:
41.2		 3jq7B-2qhxA:
49.09
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3JQ7_C_DX2C270_1
(PTERIDINE REDUCTASE
1)		 2qhx PTERIDINE REDUCTASE
1
(Leishmania
major) 		6 / 8 ARG A  17
SER A 111
PHE A 113
ASP A 181
TYR A 194
LEU A 229
 NAP  A1300 ( 3.7A)
FE1  A1301 ( 2.8A)
FE1  A1301 (-3.4A)
NAP  A1300 ( 3.6A)
FE1  A1301 ( 4.5A)
None
 0.52A 3jq7C-2qhxA:
40.1		 3jq7C-2qhxA:
49.09
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3JQ7_D_DX2D270_1
(PTERIDINE REDUCTASE
1)		 2qhx PTERIDINE REDUCTASE
1
(Leishmania
major) 		6 / 9 ARG A  17
SER A 111
PHE A 113
ASP A 181
TYR A 194
LEU A 229
 NAP  A1300 ( 3.7A)
FE1  A1301 ( 2.8A)
FE1  A1301 (-3.4A)
NAP  A1300 ( 3.6A)
FE1  A1301 ( 4.5A)
None
 0.48A 3jq7D-2qhxA:
41.2		 3jq7D-2qhxA:
49.09
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3JQA_A_DX4A270_0
(PTERIDINE REDUCTASE
1)		 2qhx PTERIDINE REDUCTASE
1
(Leishmania
major) 		5 / 6 ARG A  17
SER A 111
PHE A 113
ASP A 181
TYR A 194
 NAP  A1300 ( 3.7A)
FE1  A1301 ( 2.8A)
FE1  A1301 (-3.4A)
NAP  A1300 ( 3.6A)
FE1  A1301 ( 4.5A)
 0.18A 3jqaA-2qhxA:
40.8		 3jqaA-2qhxA:
49.09
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3JQA_B_DX4B270_0
(PTERIDINE REDUCTASE
1)		 2qhx PTERIDINE REDUCTASE
1
(Leishmania
major) 		5 / 6 ARG A  17
SER A 111
PHE A 113
ASP A 181
TYR A 194
 NAP  A1300 ( 3.7A)
FE1  A1301 ( 2.8A)
FE1  A1301 (-3.4A)
NAP  A1300 ( 3.6A)
FE1  A1301 ( 4.5A)
 0.16A 3jqaB-2qhxA:
40.7		 3jqaB-2qhxA:
49.09
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3JQA_C_DX4C270_0
(PTERIDINE REDUCTASE
1)		 2qhx PTERIDINE REDUCTASE
1
(Leishmania
major) 		5 / 6 ARG A  17
SER A 111
PHE A 113
ASP A 181
TYR A 194
 NAP  A1300 ( 3.7A)
FE1  A1301 ( 2.8A)
FE1  A1301 (-3.4A)
NAP  A1300 ( 3.6A)
FE1  A1301 ( 4.5A)
 0.19A 3jqaC-2qhxA:
40.6		 3jqaC-2qhxA:
49.09
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3JQA_D_DX4D270_0
(PTERIDINE REDUCTASE
1)		 2qhx PTERIDINE REDUCTASE
1
(Leishmania
major) 		5 / 6 ARG A  17
SER A 111
PHE A 113
ASP A 181
TYR A 194
 NAP  A1300 ( 3.7A)
FE1  A1301 ( 2.8A)
FE1  A1301 (-3.4A)
NAP  A1300 ( 3.6A)
FE1  A1301 ( 4.5A)
 0.21A 3jqaD-2qhxA:
40.8		 3jqaD-2qhxA:
49.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3MBH_A_PXLA400_1
(PUTATIVE
PHOSPHOMETHYLPYRIMID
INE KINASE)		 2qhx PTERIDINE REDUCTASE
1
(Leishmania
major) 		5 / 11 ASP A 142
SER A 112
LEU A 143
VAL A  69
ASP A  65
 NAP  A1300 (-3.7A)
NAP  A1300 (-4.1A)
None
None
NAP  A1300 (-4.6A)
 1.35A 3mbhA-2qhxA:
6.1		 3mbhA-2qhxA:
22.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3MBH_F_PXLF400_1
(PUTATIVE
PHOSPHOMETHYLPYRIMID
INE KINASE)		 2qhx PTERIDINE REDUCTASE
1
(Leishmania
major) 		5 / 11 ASP A 142
SER A 112
LEU A 143
VAL A  69
ASP A  65
 NAP  A1300 (-3.7A)
NAP  A1300 (-4.1A)
None
None
NAP  A1300 (-4.6A)
 1.35A 3mbhF-2qhxA:
6.2		 3mbhF-2qhxA:
22.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3U9H_B_NCAB1164_0
(TANKYRASE-2)		 2qhx PTERIDINE REDUCTASE
1
(Leishmania
major) 		5 / 8 HIS A  36
GLY A  13
ALA A  44
LYS A  16
GLU A  43
 NAP  A1300 (-4.7A)
NAP  A1300 ( 3.9A)
None
NAP  A1300 ( 4.5A)
None
 1.45A 3u9hB-2qhxA:
undetectable		 3u9hB-2qhxA:
22.73
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5JDC_A_6JPA302_1
(PTERIDINE REDUCTASE)		 2qhx PTERIDINE REDUCTASE
1
(Leishmania
major) 		7 / 10 ARG A  17
SER A 111
PHE A 113
ASP A 181
MET A 183
TYR A 194
LEU A 229
 NAP  A1300 ( 3.7A)
FE1  A1301 ( 2.8A)
FE1  A1301 (-3.4A)
NAP  A1300 ( 3.6A)
None
FE1  A1301 ( 4.5A)
None
 0.56A 5jdcA-2qhxA:
40.8
5jdcD-2qhxA:
40.9		 5jdcA-2qhxA:
49.09
5jdcD-2qhxA:
49.09
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5JDC_B_6JPB302_1
(PTERIDINE REDUCTASE)		 2qhx PTERIDINE REDUCTASE
1
(Leishmania
major) 		7 / 9 ARG A  17
SER A 111
PHE A 113
ASP A 181
MET A 183
TYR A 194
LEU A 229
 NAP  A1300 ( 3.7A)
FE1  A1301 ( 2.8A)
FE1  A1301 (-3.4A)
NAP  A1300 ( 3.6A)
None
FE1  A1301 ( 4.5A)
None
 0.54A 5jdcB-2qhxA:
41.0		 5jdcB-2qhxA:
49.09
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5JDC_C_6JPC302_1
(PTERIDINE REDUCTASE)		 2qhx PTERIDINE REDUCTASE
1
(Leishmania
major) 		7 / 10 ARG A  17
SER A 111
PHE A 113
ASP A 181
MET A 183
TYR A 194
LEU A 229
 NAP  A1300 ( 3.7A)
FE1  A1301 ( 2.8A)
FE1  A1301 (-3.4A)
NAP  A1300 ( 3.6A)
None
FE1  A1301 ( 4.5A)
None
 0.57A 5jdcB-2qhxA:
41.0
5jdcC-2qhxA:
39.6		 5jdcB-2qhxA:
49.09
5jdcC-2qhxA:
49.09
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5JDC_D_6JPD302_1
(PTERIDINE REDUCTASE)		 2qhx PTERIDINE REDUCTASE
1
(Leishmania
major) 		7 / 11 ARG A  17
SER A 111
PHE A 113
ASP A 181
MET A 183
TYR A 194
LEU A 229
 NAP  A1300 ( 3.7A)
FE1  A1301 ( 2.8A)
FE1  A1301 (-3.4A)
NAP  A1300 ( 3.6A)
None
FE1  A1301 ( 4.5A)
None
 0.57A 5jdcA-2qhxA:
40.8
5jdcD-2qhxA:
40.9		 5jdcA-2qhxA:
49.09
5jdcD-2qhxA:
49.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5NZY_A_CE3A1103_1
(DNA CROSS-LINK
REPAIR 1A PROTEIN)		 2qhx PTERIDINE REDUCTASE
1
(Leishmania
major) 		4 / 8 THR A   5
PRO A   7
TYR A  31
VAL A 105
 None
 0.96A 5nzyA-2qhxA:
undetectable		 5nzyA-2qhxA:
20.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5TL8_A_X2NA502_2
(PROTEIN CYP51)		 2qhx PTERIDINE REDUCTASE
1
(Leishmania
major) 		4 / 6 PRO A 151
LEU A 154
PHE A 153
LEU A 204
 None
 1.16A 5tl8A-2qhxA:
undetectable		 5tl8A-2qhxA:
21.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6B0C_D_TA1D502_1
(TUBULIN BETA CHAIN)		 2qhx PTERIDINE REDUCTASE
1
(Leishmania
major) 		6 / 12 LEU A  10
HIS A  36
ALA A 110
SER A 112
LEU A 154
LEU A  85
 None
NAP  A1300 (-4.7A)
NAP  A1300 (-3.7A)
NAP  A1300 (-4.1A)
None
None
 1.48A 6b0cD-2qhxA:
7.7		 6b0cD-2qhxA:
13.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6FDY_U_DB8U302_1
(-)		 2qhx PTERIDINE REDUCTASE
1
(Leishmania
major) 		5 / 9 MET A 179
VAL A 107
SER A 266
LEU A 264
ILE A 177
 None
 1.40A 6fdyU-2qhxA:
undetectable		 6fdyU-2qhxA:
22.79