SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2qi2'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1M8E_B_H4BB903_1
(INDUCIBLE NITRIC
OXIDE SYNTHASE)		 2qi2 CELL DIVISION
PROTEIN PELOTA
RELATED PROTEIN
(Thermoplasma
acidophilum) 		3 / 3 ARG A 293
ILE A  70
TRP A  24
 None
 0.85A 1m8eB-2qi2A:
undetectable		 1m8eB-2qi2A:
22.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1NV8_A_SAMA300_0
(HEMK PROTEIN)		 2qi2 CELL DIVISION
PROTEIN PELOTA
RELATED PROTEIN
(Thermoplasma
acidophilum) 		5 / 12 GLY A 217
THR A 134
VAL A 136
ASN A 214
ALA A 205
 None
 1.00A 1nv8A-2qi2A:
undetectable		 1nv8A-2qi2A:
24.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1QOM_A_H4BA902_1
(NITRIC OXIDE
SYNTHASE)		 2qi2 CELL DIVISION
PROTEIN PELOTA
RELATED PROTEIN
(Thermoplasma
acidophilum) 		3 / 3 ARG A 293
ILE A  70
TRP A  24
 None
 1.04A 1qomA-2qi2A:
undetectable		 1qomA-2qi2A:
23.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2WB9_A_CYSA301_0
(GLUTATHIONE
TRANSFERASE SIGMA
CLASS)		 2qi2 CELL DIVISION
PROTEIN PELOTA
RELATED PROTEIN
(Thermoplasma
acidophilum) 		4 / 5 GLY A 162
ARG A 163
TYR A 172
TYR A 177
 None
 1.36A 2wb9A-2qi2A:
0.4		 2wb9A-2qi2A:
18.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3E68_A_H4BA902_1
(NITRIC OXIDE
SYNTHASE, INDUCIBLE)		 2qi2 CELL DIVISION
PROTEIN PELOTA
RELATED PROTEIN
(Thermoplasma
acidophilum) 		3 / 3 ARG A 293
ILE A  70
TRP A  24
 None
 0.87A 3e68A-2qi2A:
undetectable		 3e68A-2qi2A:
22.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3E6T_B_H4BB902_1
(NITRIC OXIDE
SYNTHASE, INDUCIBLE)		 2qi2 CELL DIVISION
PROTEIN PELOTA
RELATED PROTEIN
(Thermoplasma
acidophilum) 		3 / 3 ARG A 293
ILE A  70
TRP A  24
 None
 0.88A 3e6tB-2qi2A:
undetectable		 3e6tB-2qi2A:
22.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3E7I_B_H4BB2902_1
(NITRIC OXIDE
SYNTHASE, INDUCIBLE)		 2qi2 CELL DIVISION
PROTEIN PELOTA
RELATED PROTEIN
(Thermoplasma
acidophilum) 		3 / 3 ARG A 293
ILE A  70
TRP A  24
 None
 0.95A 3e7iB-2qi2A:
undetectable		 3e7iB-2qi2A:
22.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3G9E_A_RO7A1_1
(PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR GAMMA)		 2qi2 CELL DIVISION
PROTEIN PELOTA
RELATED PROTEIN
(Thermoplasma
acidophilum) 		5 / 12 SER A  31
HIS A 117
LEU A  26
VAL A 101
ILE A  99
 None
 1.20A 3g9eA-2qi2A:
undetectable		 3g9eA-2qi2A:
22.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3HRD_B_NIOB5661_1
(NICOTINATE
DEHYDROGENASE LARGE
MOLYBDOPTERIN
SUBUNIT
NICOTINATE
DEHYDROGENASE MEDIUM
MOLYBDOPTERIN
SUBUNIT)		 2qi2 CELL DIVISION
PROTEIN PELOTA
RELATED PROTEIN
(Thermoplasma
acidophilum) 		4 / 8 ALA A 331
PHE A 257
LEU A 282
ALA A 260
 None
 0.89A 3hrdA-2qi2A:
undetectable
3hrdB-2qi2A:
undetectable		 3hrdA-2qi2A:
21.19
3hrdB-2qi2A:
23.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4AC9_C_DXCC1479_0
(MJ0495-LIKE PROTEIN)		 2qi2 CELL DIVISION
PROTEIN PELOTA
RELATED PROTEIN
(Thermoplasma
acidophilum) 		4 / 5 THR A 134
ILE A 148
GLU A 245
PHE A 232
 None
 1.23A 4ac9C-2qi2A:
undetectable		 4ac9C-2qi2A:
21.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ACA_C_DXCC1479_0
(TRANSLATION
ELONGATION FACTOR
SELB)		 2qi2 CELL DIVISION
PROTEIN PELOTA
RELATED PROTEIN
(Thermoplasma
acidophilum) 		4 / 5 THR A 134
ILE A 148
GLU A 245
PHE A 232
 None
 1.23A 4acaC-2qi2A:
undetectable		 4acaC-2qi2A:
21.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ACB_C_DXCC1479_0
(TRANSLATION
ELONGATION FACTOR
SELB)		 2qi2 CELL DIVISION
PROTEIN PELOTA
RELATED PROTEIN
(Thermoplasma
acidophilum) 		4 / 5 THR A 134
ILE A 148
GLU A 245
PHE A 232
 None
 1.19A 4acbC-2qi2A:
undetectable		 4acbC-2qi2A:
21.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DT8_B_ADNB401_1
(APH(2'')-ID)		 2qi2 CELL DIVISION
PROTEIN PELOTA
RELATED PROTEIN
(Thermoplasma
acidophilum) 		5 / 10 GLY A 329
ILE A 286
ILE A 311
LEU A 301
ILE A 313
 None
 1.10A 4dt8B-2qi2A:
undetectable		 4dt8B-2qi2A:
23.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4F93_B_SANB3004_1
(U5 SMALL NUCLEAR
RIBONUCLEOPROTEIN
200 KDA HELICASE)		 2qi2 CELL DIVISION
PROTEIN PELOTA
RELATED PROTEIN
(Thermoplasma
acidophilum) 		4 / 8 GLU A 290
ASN A 318
GLN A 322
GLY A 321
 None
 0.57A 4f93B-2qi2A:
undetectable		 4f93B-2qi2A:
12.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5L1F_A_6ZPA902_1
(GLUTAMATE RECEPTOR 2)		 2qi2 CELL DIVISION
PROTEIN PELOTA
RELATED PROTEIN
(Thermoplasma
acidophilum) 		4 / 8 ASP A 126
TYR A  25
SER A 243
ASN A 244
 None
 1.14A 5l1fA-2qi2A:
undetectable
5l1fB-2qi2A:
undetectable		 5l1fA-2qi2A:
17.52
5l1fB-2qi2A:
17.52