SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2qi9'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1AQ7_B_AG2B4_1
(TRYPSIN
AERUGINOSIN 98-B)		 2qi9 VITAMIN B12 IMPORT
SYSTEM PERMEASE
PROTEIN BTUC
(Escherichia
coli) 		5 / 8 SER A  94
SER A 246
VAL A 243
GLY A 254
GLY A  89
 None
 1.36A 1aq7A-2qi9A:
undetectable		 1aq7A-2qi9A:
19.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1D0V_A_NIOA991_1
(NICOTINATE
MONONUCLEOTIDE:5,6-D
IMETHYLBENZIMIDAZOLE
PHOSPHORIBOSYLTRANSF
ERASE)		 2qi9 VITAMIN B12 IMPORT
SYSTEM PERMEASE
PROTEIN BTUC
(Escherichia
coli) 		4 / 8 THR A 129
GLY A 240
GLY A  92
GLY A  96
 None
 0.76A 1d0vA-2qi9A:
undetectable		 1d0vA-2qi9A:
26.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1JHQ_A_NIOA991_1
(NICOTINATE
MONONUCLEOTIDE:5,6-D
IMETHYLBENZIMIDAZOLE
PHOSPHORIBOSYLTRANSF
ERASE)		 2qi9 VITAMIN B12 IMPORT
SYSTEM PERMEASE
PROTEIN BTUC
(Escherichia
coli) 		4 / 8 THR A 129
GLY A 240
GLY A  92
GLY A  96
 None
 0.75A 1jhqA-2qi9A:
undetectable		 1jhqA-2qi9A:
25.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1JHV_A_NIOA991_1
(NICOTINATE
MONONUCLEOTIDE:5,6-D
IMETHYLBENZIMIDAZOLE
PHOSPHORIBOSYLTRANSF
ERASE)		 2qi9 VITAMIN B12 IMPORT
SYSTEM PERMEASE
PROTEIN BTUC
(Escherichia
coli) 		4 / 8 THR A 129
GLY A 240
GLY A  92
GLY A  96
 None
 0.76A 1jhvA-2qi9A:
undetectable		 1jhvA-2qi9A:
25.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1SGU_B_MK1B2632_1
(POL POLYPROTEIN)		 2qi9 VITAMIN B12 IMPORT
SYSTEM PERMEASE
PROTEIN BTUC
(Escherichia
coli) 		5 / 8 ALA A 148
ILE A 128
GLY A  92
GLY A 153
ILE A 154
 None
 1.05A 1sguA-2qi9A:
undetectable		 1sguA-2qi9A:
18.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1TNL_A_TPAA900_1
(TRYPSIN)		 2qi9 VITAMIN B12 IMPORT
SYSTEM PERMEASE
PROTEIN BTUC
(Escherichia
coli) 		5 / 6 SER A  94
SER A 246
VAL A 243
GLY A 254
GLY A  89
 None
 1.35A 1tnlA-2qi9A:
undetectable		 1tnlA-2qi9A:
20.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2FXD_A_DR7A102_1
(POL PROTEIN)		 2qi9 VITAMIN B12 IMPORT
SYSTEM PERMEASE
PROTEIN BTUC
(Escherichia
coli) 		5 / 11 LEU A  70
GLY A 251
ALA A 250
ILE A 122
VAL A  66
 None
 0.97A 2fxdA-2qi9A:
undetectable		 2fxdA-2qi9A:
18.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2VIN_A_505A1247_1
(UROKINASE-TYPE
PLASMINOGEN
ACTIVATOR CHAIN B)		 2qi9 VITAMIN B12 IMPORT
SYSTEM PERMEASE
PROTEIN BTUC
(Escherichia
coli) 		5 / 8 SER A  94
SER A 246
VAL A 243
GLY A 254
GLY A  89
 None
 1.37A 2vinA-2qi9A:
undetectable		 2vinA-2qi9A:
22.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2X1L_B_ADNB601_1
(METHIONYL-TRNA
SYNTHETASE)		 2qi9 VITAMIN B12 IMPORT
SYSTEM PERMEASE
PROTEIN BTUC
(Escherichia
coli) 		5 / 12 ALA A 286
ALA A 284
GLY A 278
ILE A 256
LEU A 269
 None
 1.00A 2x1lB-2qi9A:
3.2		 2x1lB-2qi9A:
20.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BSZ_E_RTLE177_0
(PLASMA
RETINOL-BINDING
PROTEIN)		 2qi9 VITAMIN B12 IMPORT
SYSTEM PERMEASE
PROTEIN BTUC
(Escherichia
coli) 		5 / 11 ALA A 248
VAL A 105
LEU A 175
GLN A 174
GLN A 190
 None
 1.26A 3bszE-2qi9A:
undetectable		 3bszE-2qi9A:
17.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3GGU_B_017B201_1
(PROTEASE)		 2qi9 VITAMIN B12 IMPORT
SYSTEM PERMEASE
PROTEIN BTUC
(Escherichia
coli) 		5 / 12 LEU A  70
GLY A 251
ALA A 250
ILE A 122
VAL A  66
 None
 1.15A 3gguA-2qi9A:
undetectable		 3gguA-2qi9A:
14.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3GYQ_A_SAMA270_0
(RRNA
(ADENOSINE-2'-O-)-ME
THYLTRANSFERASE)		 2qi9 VITAMIN B12 IMPORT
SYSTEM PERMEASE
PROTEIN BTUC
(Escherichia
coli) 		5 / 12 LEU A 264
ALA A  75
GLY A 283
MET A 211
LEU A 276
 None
 1.27A 3gyqA-2qi9A:
undetectable
3gyqB-2qi9A:
undetectable		 3gyqA-2qi9A:
25.56
3gyqB-2qi9A:
25.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3H52_A_486A3_1
(GLUCOCORTICOID
RECEPTOR)		 2qi9 VITAMIN B12 IMPORT
SYSTEM PERMEASE
PROTEIN BTUC
(Escherichia
coli) 		5 / 12 GLY A 244
VAL A 247
MET A  77
LEU A  91
ILE A 128
 None
 1.35A 3h52A-2qi9A:
undetectable		 3h52A-2qi9A:
24.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3L8L_D_DVAD6_0
(GRAMICIDIN D)		 2qi9 VITAMIN B12 IMPORT
SYSTEM PERMEASE
PROTEIN BTUC
(Escherichia
coli) 		3 / 3 TRP A 241
ALA A  69
VAL A 200
 None
 0.90A 3l8lC-2qi9A:
undetectable
3l8lD-2qi9A:
undetectable		 3l8lC-2qi9A:
7.27
3l8lD-2qi9A:
7.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3Q1E_C_T44C128_1
(5-HYDROXYISOURATE
HYDROLASE)		 2qi9 VITAMIN B12 IMPORT
SYSTEM PERMEASE
PROTEIN BTUC
(Escherichia
coli) 		4 / 6 LEU A  64
LEU A 288
LEU A  19
LEU A  22
 None
 0.99A 3q1eA-2qi9A:
undetectable
3q1eC-2qi9A:
undetectable		 3q1eA-2qi9A:
16.26
3q1eC-2qi9A:
16.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3RXF_A_4APA9_1
(CATIONIC TRYPSIN)		 2qi9 VITAMIN B12 IMPORT
SYSTEM PERMEASE
PROTEIN BTUC
(Escherichia
coli) 		5 / 6 SER A  94
SER A 246
VAL A 243
GLY A 254
GLY A  89
 None
 1.34A 3rxfA-2qi9A:
undetectable		 3rxfA-2qi9A:
19.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SUD_B_SUEB1201_1
(NS3 PROTEASE, NS4A
PROTEIN)		 2qi9 VITAMIN B12 IMPORT
SYSTEM PERMEASE
PROTEIN BTUC
(Escherichia
coli) 		5 / 12 GLY A  67
ILE A 263
GLY A 257
ALA A  71
SER A 267
 None
 1.12A 3sudB-2qi9A:
undetectable		 3sudB-2qi9A:
21.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4RTM_A_SAMA301_0
(DNA ADENINE
METHYLASE)		 2qi9 VITAMIN B12 IMPORT
SYSTEM PERMEASE
PROTEIN BTUC
(Escherichia
coli) 		5 / 12 GLY A 251
GLY A  98
ALA A  97
ILE A 164
SER A 167
 None
 0.80A 4rtmA-2qi9A:
undetectable		 4rtmA-2qi9A:
19.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KIR_B_RCXB601_2
(PROSTAGLANDIN G/H
SYNTHASE 2)		 2qi9 VITAMIN B12 IMPORT
SYSTEM PERMEASE
PROTEIN BTUC
(Escherichia
coli) 		4 / 4 LEU A 287
ARG A 295
ILE A 305
PHE A 183
 None
 0.91A 5kirB-2qi9A:
0.0		 5kirB-2qi9A:
18.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5OY0_1_PQN1842_1
(PHOTOSYSTEM I P700
CHLOROPHYLL A
APOPROTEIN A1
PHOTOSYSTEM I
REACTION CENTER
SUBUNIT IX)		 2qi9 VITAMIN B12 IMPORT
SYSTEM PERMEASE
PROTEIN BTUC
(Escherichia
coli) 		5 / 10 PHE A 183
ALA A 294
GLY A 182
ILE A 263
LEU A 264
 None
 1.21A 5oy01-2qi9A:
undetectable
5oy07-2qi9A:
undetectable		 5oy01-2qi9A:
11.56
5oy07-2qi9A:
8.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5TE8_C_08JC602_1
(CYTOCHROME P450 3A4)		 2qi9 VITAMIN B12 IMPORT
SYSTEM PERMEASE
PROTEIN BTUC
(Escherichia
coli) 		4 / 7 SER A 205
ALA A 280
ILE A 260
LEU A 264
 None
 0.97A 5te8C-2qi9A:
undetectable		 5te8C-2qi9A:
20.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UIH_A_8CVA201_1
(DIHYDROFOLATE
REDUCTASE)		 2qi9 VITAMIN B12 IMPORT
SYSTEM PERMEASE
PROTEIN BTUC
(Escherichia
coli) 		4 / 8 ILE A 256
ALA A  68
LEU A 288
ILE A 253
 None
 0.85A 5uihA-2qi9A:
undetectable		 5uihA-2qi9A:
12.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VW5_A_NCAA403_0
(FERREDOXIN--NADP
REDUCTASE)		 2qi9 VITAMIN B12 IMPORT
SYSTEM PERMEASE
PROTEIN BTUC
(Escherichia
coli) 		4 / 8 GLY A 124
GLY A 100
LEU A 101
ALA A 104
 None
 0.63A 5vw5A-2qi9A:
undetectable		 5vw5A-2qi9A:
21.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DH3_A_017A101_0
(PROTEASE)		 2qi9 VITAMIN B12 IMPORT
SYSTEM PERMEASE
PROTEIN BTUC
(Escherichia
coli) 		5 / 12 GLY A  98
ALA A  97
VAL A 243
GLY A  92
ILE A 253
 None
 0.79A 6dh3A-2qi9A:
undetectable		 6dh3A-2qi9A:
13.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6I5Z_D_SAMD401_0
(O-METHYLTRANSFERASE
1)		 2qi9 VITAMIN B12 IMPORT
SYSTEM PERMEASE
PROTEIN BTUC
(Escherichia
coli) 		5 / 11 SER A 205
GLY A  67
GLY A 283
LEU A 288
ASP A 291
 None
 1.25A 6i5zD-2qi9A:
undetectable		 6i5zD-2qi9A:
21.04