SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2qib'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1WRL_D_TFPD207_1
(TROPONIN C, SLOW
SKELETAL AND CARDIAC
MUSCLES)		 2qib TETR-FAMILY
TRANSCRIPTIONAL
REGULATOR
(Streptomyces
coelicolor) 		4 / 8 LEU A 208
PHE A 186
MET A 190
SER A 193
 None
P6G  A 703 (-4.1A)
None
None
 1.02A 1wrlC-2qibA:
undetectable
1wrlD-2qibA:
undetectable		 1wrlC-2qibA:
17.14
1wrlD-2qibA:
17.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1WRL_F_TFPF211_1
(TROPONIN C, SLOW
SKELETAL AND CARDIAC
MUSCLES)		 2qib TETR-FAMILY
TRANSCRIPTIONAL
REGULATOR
(Streptomyces
coelicolor) 		4 / 7 LEU A 137
PHE A 186
MET A 190
SER A 193
 None
P6G  A 703 (-4.1A)
None
None
 0.86A 1wrlE-2qibA:
undetectable
1wrlF-2qibA:
undetectable		 1wrlE-2qibA:
17.14
1wrlF-2qibA:
17.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2VMY_A_FFOA505_1
(SERINE
HYDROXYMETHYLTRANSFE
RASE)		 2qib TETR-FAMILY
TRANSCRIPTIONAL
REGULATOR
(Streptomyces
coelicolor) 		5 / 12 LEU A 109
VAL A 116
SER A  69
ALA A  68
SER A  30
 None
None
P6G  A 701 ( 4.3A)
P6G  A 701 ( 3.9A)
None
 1.27A 2vmyB-2qibA:
undetectable		 2vmyB-2qibA:
22.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3F8W_B_ADNB301_1
(PURINE-NUCLEOSIDE
PHOSPHORYLASE)		 2qib TETR-FAMILY
TRANSCRIPTIONAL
REGULATOR
(Streptomyces
coelicolor) 		5 / 12 GLY A 117
VAL A 116
GLY A 112
ASN A 122
VAL A 125
 None
None
None
None
P6G  A 701 ( 4.0A)
 1.34A 3f8wB-2qibA:
undetectable		 3f8wB-2qibA:
21.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4L9Q_B_9TPB601_1
(SERUM ALBUMIN)		 2qib TETR-FAMILY
TRANSCRIPTIONAL
REGULATOR
(Streptomyces
coelicolor) 		5 / 12 LEU A  88
ALA A 191
ILE A 157
LEU A 140
LEU A 137
 P6G  A 703 (-4.0A)
None
P6G  A 701 ( 4.8A)
None
None
 1.14A 4l9qB-2qibA:
4.4		 4l9qB-2qibA:
16.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6FOS_A_PQNA2001_1
(PHOTOSYSTEM I P700
CHLOROPHYLL A
APOPROTEIN A1)		 2qib TETR-FAMILY
TRANSCRIPTIONAL
REGULATOR
(Streptomyces
coelicolor) 		4 / 6 MET A 110
GLY A 105
ALA A  68
LEU A  65
 P6G  A 701 ( 4.3A)
P6G  A 701 ( 4.1A)
P6G  A 701 ( 3.9A)
P6G  A 701 (-4.4A)
 0.96A 6fosA-2qibA:
2.2		 6fosA-2qibA:
14.22