SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2qik'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1DHF_A_FOLA187_0
(DIHYDROFOLATE
REDUCTASE)		 2qik UPF0131 PROTEIN YKQA
(Bacillus
subtilis) 		5 / 12 PHE A 143
ILE A 194
PRO A 195
LEU A 202
TYR A 259
 None
 1.04A 1dhfA-2qikA:
undetectable		 1dhfA-2qikA:
19.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1DRF_A_FOLA187_0
(DIHYDROFOLATE
REDUCTASE)		 2qik UPF0131 PROTEIN YKQA
(Bacillus
subtilis) 		5 / 12 PHE A 143
ILE A 194
PRO A 195
LEU A 202
TYR A 259
 None
 0.90A 1drfA-2qikA:
undetectable		 1drfA-2qikA:
19.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2W3B_A_FOLA401_0
(DIHYDROFOLATE
REDUCTASE)		 2qik UPF0131 PROTEIN YKQA
(Bacillus
subtilis) 		5 / 12 PHE A 143
ILE A 194
PRO A 195
LEU A 202
TYR A 259
 None
 0.96A 2w3bA-2qikA:
undetectable		 2w3bA-2qikA:
20.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2W3B_B_FOLB401_0
(DIHYDROFOLATE
REDUCTASE)		 2qik UPF0131 PROTEIN YKQA
(Bacillus
subtilis) 		5 / 12 PHE A 143
ILE A 194
PRO A 195
LEU A 202
TYR A 259
 None
 0.99A 2w3bB-2qikA:
undetectable		 2w3bB-2qikA:
20.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2W3M_A_FOLA1188_0
(DIHYDROFOLATE
REDUCTASE)		 2qik UPF0131 PROTEIN YKQA
(Bacillus
subtilis) 		5 / 12 PHE A 143
ILE A 194
PRO A 195
LEU A 202
TYR A 259
 None
 1.00A 2w3mA-2qikA:
undetectable		 2w3mA-2qikA:
20.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3GWX_A_EPAA1_2
(PROTEIN (PEROXISOME
PROLIFERATOR
ACTIVATED RECEPTOR
(PPAR-DELTA)))		 2qik UPF0131 PROTEIN YKQA
(Bacillus
subtilis) 		5 / 12 THR A 165
THR A 187
THR A 186
ILE A 252
MET A 138
 None
 1.33A 3gwxA-2qikA:
undetectable		 3gwxA-2qikA:
21.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ID5_B_SAMB301_0
(FIBRILLARIN-LIKE
RRNA/TRNA
2'-O-METHYLTRANSFERA
SE)		 2qik UPF0131 PROTEIN YKQA
(Bacillus
subtilis) 		5 / 11 GLY A 255
GLU A 257
ASP A 139
ILE A 252
GLN A 249
 None
 1.19A 3id5B-2qikA:
undetectable		 3id5B-2qikA:
22.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ID5_F_SAMF301_0
(FIBRILLARIN-LIKE
RRNA/TRNA
2'-O-METHYLTRANSFERA
SE)		 2qik UPF0131 PROTEIN YKQA
(Bacillus
subtilis) 		5 / 11 GLY A 255
GLU A 257
ASP A 139
ILE A 252
GLN A 249
 None
 1.19A 3id5F-2qikA:
undetectable		 3id5F-2qikA:
22.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LK0_D_Z80D92_1
(PROTEIN S100-B)		 2qik UPF0131 PROTEIN YKQA
(Bacillus
subtilis) 		3 / 3 HIS A  18
PHE A  75
PHE A  76
 None
 0.73A 3lk0D-2qikA:
undetectable		 3lk0D-2qikA:
16.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3V81_A_NVPA901_1
(HIV-1 REVERSE
TRANSCRIPTASE P66
SUBUNIT)		 2qik UPF0131 PROTEIN YKQA
(Bacillus
subtilis) 		4 / 8 LEU A   5
VAL A  86
TYR A   8
LEU A  11
 None
 1.09A 3v81A-2qikA:
undetectable		 3v81A-2qikA:
19.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FQS_A_LYAA302_1
(THYMIDYLATE SYNTHASE)		 2qik UPF0131 PROTEIN YKQA
(Bacillus
subtilis) 		5 / 12 HIS A 226
LEU A 191
GLY A 157
TYR A 192
ALA A 133
 None
None
None
None
CIT  A 301 (-3.9A)
 1.06A 4fqsA-2qikA:
undetectable		 4fqsA-2qikA:
23.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FQS_B_LYAB302_1
(THYMIDYLATE SYNTHASE)		 2qik UPF0131 PROTEIN YKQA
(Bacillus
subtilis) 		5 / 12 HIS A 226
LEU A 191
GLY A 157
TYR A 192
ALA A 133
 None
None
None
None
CIT  A 301 (-3.9A)
 1.07A 4fqsB-2qikA:
undetectable		 4fqsB-2qikA:
23.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KFJ_B_FOLB202_0
(DIHYDROFOLATE
REDUCTASE)		 2qik UPF0131 PROTEIN YKQA
(Bacillus
subtilis) 		5 / 12 PHE A 143
ILE A 194
PRO A 195
LEU A 202
TYR A 259
 None
 0.96A 4kfjB-2qikA:
undetectable		 4kfjB-2qikA:
19.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4M6K_A_FOLA201_0
(DIHYDROFOLATE
REDUCTASE)		 2qik UPF0131 PROTEIN YKQA
(Bacillus
subtilis) 		5 / 12 PHE A 143
ILE A 194
PRO A 195
LEU A 202
TYR A 259
 None
 0.93A 4m6kA-2qikA:
undetectable		 4m6kA-2qikA:
20.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4PUO_C_NVPC901_1
(HIV-1 REVERSE
TRANSCRIPTASE, P66
SUBUNIT)		 2qik UPF0131 PROTEIN YKQA
(Bacillus
subtilis) 		4 / 8 LEU A   5
VAL A  86
TYR A   8
LEU A  11
 None
 1.04A 4puoC-2qikA:
undetectable		 4puoC-2qikA:
19.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4RJD_B_TFPB204_1
(CALMODULIN)		 2qik UPF0131 PROTEIN YKQA
(Bacillus
subtilis) 		4 / 8 LEU A  11
GLY A   9
GLU A  15
ALA A  40
 None
 0.90A 4rjdA-2qikA:
undetectable
4rjdB-2qikA:
undetectable		 4rjdA-2qikA:
15.81
4rjdB-2qikA:
15.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4TWD_C_377C401_1
(CYS-LOOP
LIGAND-GATED ION
CHANNEL)		 2qik UPF0131 PROTEIN YKQA
(Bacillus
subtilis) 		4 / 6 ASN A 273
GLU A 241
LEU A 268
PHE A 168
 None
 1.23A 4twdB-2qikA:
undetectable
4twdC-2qikA:
undetectable		 4twdB-2qikA:
19.88
4twdC-2qikA:
19.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4TWD_E_377E401_1
(CYS-LOOP
LIGAND-GATED ION
CHANNEL)		 2qik UPF0131 PROTEIN YKQA
(Bacillus
subtilis) 		4 / 6 ASN A 273
GLU A 241
LEU A 268
PHE A 168
 None
 1.13A 4twdD-2qikA:
undetectable
4twdE-2qikA:
undetectable		 4twdD-2qikA:
19.88
4twdE-2qikA:
19.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4TWD_J_377J401_1
(CYS-LOOP
LIGAND-GATED ION
CHANNEL)		 2qik UPF0131 PROTEIN YKQA
(Bacillus
subtilis) 		4 / 6 ASN A 273
GLU A 241
LEU A 268
PHE A 168
 None
 1.18A 4twdI-2qikA:
undetectable
4twdJ-2qikA:
undetectable		 4twdI-2qikA:
19.88
4twdJ-2qikA:
19.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HWK_A_BEZA301_0
(GLUTATHIONE-SPECIFIC
GAMMA-GLUTAMYLCYCLOT
RANSFERASE)		 2qik UPF0131 PROTEIN YKQA
(Bacillus
subtilis) 		5 / 10 TYR A   8
GLY A   9
LEU A  11
TYR A  79
TYR A  98
 None
 0.71A 5hwkA-2qikA:
10.6		 5hwkA-2qikA:
22.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HWK_B_BEZB301_0
(GLUTATHIONE-SPECIFIC
GAMMA-GLUTAMYLCYCLOT
RANSFERASE)		 2qik UPF0131 PROTEIN YKQA
(Bacillus
subtilis) 		5 / 10 TYR A   8
GLY A   9
LEU A  11
TYR A  79
TYR A  98
 None
 0.72A 5hwkB-2qikA:
10.7		 5hwkB-2qikA:
22.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IGY_A_ERYA403_1
(MACROLIDE
2'-PHOSPHOTRANSFERAS
E II)		 2qik UPF0131 PROTEIN YKQA
(Bacillus
subtilis) 		4 / 6 TYR A 259
ASP A 149
ILE A 194
TYR A 131
 None
 1.39A 5igyA-2qikA:
undetectable		 5igyA-2qikA:
22.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5TUD_A_ERMA2001_2
(5-HYDROXYTRYPTAMINE
RECEPTOR 2B,SOLUBLE
CYTOCHROME B562
CHIMERA)		 2qik UPF0131 PROTEIN YKQA
(Bacillus
subtilis) 		4 / 7 LEU A 234
VAL A 208
GLN A 237
GLU A 239
 None
 1.09A 5tudA-2qikA:
undetectable		 5tudA-2qikA:
21.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6B0L_B_TA1B502_1
(TUBULIN BETA CHAIN)		 2qik UPF0131 PROTEIN YKQA
(Bacillus
subtilis) 		5 / 12 VAL A 148
ASP A 149
LEU A 231
LEU A 199
THR A 232
 None
 0.97A 6b0lB-2qikA:
undetectable		 6b0lB-2qikA:
15.47