SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2qio'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XKW_A_P1BA1478_2
(PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR GAMMA)		 2qio ENOYL-(ACYL-CARRIER-
PROTEIN) REDUCTASE
(Bacillus
anthracis) 		4 / 7 LEU A 233
ILE A 188
ALA A 215
ILE A 211
 None
 0.81A 2xkwA-2qioA:
undetectable		 2xkwA-2qioA:
22.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Y7W_B_SALB1300_1
(LYSR-TYPE REGULATORY
PROTEIN)		 2qio ENOYL-(ACYL-CARRIER-
PROTEIN) REDUCTASE
(Bacillus
anthracis) 		5 / 10 ILE A  87
GLY A  89
GLY A 139
THR A 137
ILE A 183
 None
 1.37A 2y7wB-2qioA:
undetectable		 2y7wB-2qioA:
21.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4AFT_D_QMRD301_1
(SOLUBLE
ACETYLCHOLINE
RECEPTOR)		 2qio ENOYL-(ACYL-CARRIER-
PROTEIN) REDUCTASE
(Bacillus
anthracis) 		4 / 8 VAL A  11
CYH A  76
VAL A  90
ILE A  36
 None
 1.09A 4aftD-2qioA:
undetectable
4aftE-2qioA:
undetectable		 4aftD-2qioA:
22.76
4aftE-2qioA:
22.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LB2_A_DM5A601_1
(SERUM ALBUMIN)		 2qio ENOYL-(ACYL-CARRIER-
PROTEIN) REDUCTASE
(Bacillus
anthracis) 		4 / 7 LEU A  61
VAL A  62
PRO A  64
GLU A  83
 None
 1.12A 4lb2A-2qioA:
undetectable		 4lb2A-2qioA:
19.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4O1Z_A_MXMA807_1
(PROSTAGLANDIN G/H
SYNTHASE 1)		 2qio ENOYL-(ACYL-CARRIER-
PROTEIN) REDUCTASE
(Bacillus
anthracis) 		5 / 12 ILE A  20
GLY A  23
SER A  27
LEU A  28
LEU A   4
 NAD  A 501 (-3.9A)
None
None
None
None
 0.90A 4o1zA-2qioA:
undetectable		 4o1zA-2qioA:
17.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EEU_G_TRPG101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 2qio ENOYL-(ACYL-CARRIER-
PROTEIN) REDUCTASE
(Bacillus
anthracis) 		5 / 10 THR A  86
GLY A 139
HIS A  88
ALA A 132
ILE A 183
 None
 1.28A 5eeuG-2qioA:
undetectable
5eeuH-2qioA:
undetectable		 5eeuG-2qioA:
16.14
5eeuH-2qioA:
16.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EEV_G_TRPG101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 2qio ENOYL-(ACYL-CARRIER-
PROTEIN) REDUCTASE
(Bacillus
anthracis) 		5 / 10 THR A  86
GLY A 139
HIS A  88
ALA A 132
ILE A 183
 None
 1.29A 5eevG-2qioA:
undetectable
5eevH-2qioA:
undetectable		 5eevG-2qioA:
16.14
5eevH-2qioA:
16.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EEW_G_TRPG101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 2qio ENOYL-(ACYL-CARRIER-
PROTEIN) REDUCTASE
(Bacillus
anthracis) 		5 / 10 THR A  86
GLY A 139
HIS A  88
ALA A 132
ILE A 183
 None
 1.29A 5eewG-2qioA:
undetectable
5eewH-2qioA:
undetectable		 5eewG-2qioA:
16.14
5eewH-2qioA:
16.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EEX_G_TRPG101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 2qio ENOYL-(ACYL-CARRIER-
PROTEIN) REDUCTASE
(Bacillus
anthracis) 		5 / 10 THR A  86
GLY A 139
HIS A  88
ALA A 132
ILE A 183
 None
 1.29A 5eexG-2qioA:
undetectable
5eexH-2qioA:
undetectable		 5eexG-2qioA:
16.14
5eexH-2qioA:
16.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EEY_G_TRPG101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 2qio ENOYL-(ACYL-CARRIER-
PROTEIN) REDUCTASE
(Bacillus
anthracis) 		5 / 10 THR A  86
GLY A 139
HIS A  88
ALA A 132
ILE A 183
 None
 1.29A 5eeyG-2qioA:
undetectable
5eeyH-2qioA:
undetectable		 5eeyG-2qioA:
16.14
5eeyH-2qioA:
16.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EEZ_G_TRPG101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 2qio ENOYL-(ACYL-CARRIER-
PROTEIN) REDUCTASE
(Bacillus
anthracis) 		5 / 10 THR A  86
GLY A 139
HIS A  88
ALA A 132
ILE A 183
 None
 1.29A 5eezG-2qioA:
undetectable
5eezH-2qioA:
undetectable		 5eezG-2qioA:
16.14
5eezH-2qioA:
16.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EF0_G_TRPG101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 2qio ENOYL-(ACYL-CARRIER-
PROTEIN) REDUCTASE
(Bacillus
anthracis) 		5 / 10 THR A  86
GLY A 139
HIS A  88
ALA A 132
ILE A 183
 None
 1.29A 5ef0G-2qioA:
undetectable
5ef0H-2qioA:
undetectable		 5ef0G-2qioA:
16.14
5ef0H-2qioA:
16.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EF1_G_TRPG101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 2qio ENOYL-(ACYL-CARRIER-
PROTEIN) REDUCTASE
(Bacillus
anthracis) 		5 / 10 THR A  86
GLY A 139
HIS A  88
ALA A 132
ILE A 183
 None
 1.29A 5ef1G-2qioA:
undetectable
5ef1H-2qioA:
undetectable		 5ef1G-2qioA:
16.14
5ef1H-2qioA:
16.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EF2_G_TRPG101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 2qio ENOYL-(ACYL-CARRIER-
PROTEIN) REDUCTASE
(Bacillus
anthracis) 		5 / 10 THR A  86
GLY A 139
HIS A  88
ALA A 132
ILE A 183
 None
 1.29A 5ef2G-2qioA:
undetectable
5ef2H-2qioA:
undetectable		 5ef2G-2qioA:
16.14
5ef2H-2qioA:
16.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EF3_G_TRPG101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 2qio ENOYL-(ACYL-CARRIER-
PROTEIN) REDUCTASE
(Bacillus
anthracis) 		5 / 10 THR A  86
GLY A 139
HIS A  88
ALA A 132
ILE A 183
 None
 1.29A 5ef3G-2qioA:
undetectable
5ef3H-2qioA:
undetectable		 5ef3G-2qioA:
16.14
5ef3H-2qioA:
16.14