SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2qiw'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
11GS_A_EAAA211_1
(GLUTATHIONE
S-TRANSFERASE)		 2qiw PEP PHOSPHONOMUTASE
(Corynebacterium
glutamicum) 		4 / 7 VAL A  86
ILE A 132
TYR A 131
GLY A  89
 None
 0.94A 11gsA-2qiwA:
undetectable		 11gsA-2qiwA:
22.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1IBG_H_OBNH1_1
(IGG2B-KAPPA 40-50
FAB (HEAVY CHAIN))		 2qiw PEP PHOSPHONOMUTASE
(Corynebacterium
glutamicum) 		4 / 6 HIS A  15
LEU A  21
PHE A  11
VAL A 147
 None
GOL  A 258 (-4.6A)
None
None
 1.17A 1ibgH-2qiwA:
undetectable		 1ibgH-2qiwA:
21.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MMK_A_H4BA1427_1
(PHENYLALANINE-4-HYDR
OXYLASE)		 2qiw PEP PHOSPHONOMUTASE
(Corynebacterium
glutamicum) 		5 / 12 VAL A  26
LEU A  23
LEU A  43
SER A  41
PHE A  40
 None
None
None
GOL  A 258 (-3.7A)
None
 1.15A 1mmkA-2qiwA:
undetectable		 1mmkA-2qiwA:
21.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2HKK_A_ALEA300_1
(CARBONIC ANHYDRASE 2)		 2qiw PEP PHOSPHONOMUTASE
(Corynebacterium
glutamicum) 		4 / 6 ASN A 110
ASN A 149
ILE A 173
THR A 209
 SO4  A 255 (-3.8A)
None
None
GOL  A 264 ( 3.9A)
 1.13A 2hkkA-2qiwA:
undetectable		 2hkkA-2qiwA:
21.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2NXE_B_SAMB303_1
(RIBOSOMAL PROTEIN
L11
METHYLTRANSFERASE)		 2qiw PEP PHOSPHONOMUTASE
(Corynebacterium
glutamicum) 		3 / 3 THR A  44
ASP A  58
SER A  56
 SO4  A 255 ( 4.1A)
UNL  A 256 (-4.3A)
None
 0.86A 2nxeB-2qiwA:
undetectable		 2nxeB-2qiwA:
24.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2VUF_A_FUAA2002_1
(SERUM ALBUMIN)		 2qiw PEP PHOSPHONOMUTASE
(Corynebacterium
glutamicum) 		4 / 9 ILE A 208
ALA A 192
VAL A 195
GLU A 196
 None
 0.71A 2vufA-2qiwA:
undetectable		 2vufA-2qiwA:
19.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3B9M_A_SALA1200_1
(SERUM ALBUMIN)		 2qiw PEP PHOSPHONOMUTASE
(Corynebacterium
glutamicum) 		4 / 5 ILE A 208
HIS A 216
TYR A 185
GLY A 188
 None
None
SO4  A 255 ( 4.3A)
None
 1.26A 3b9mA-2qiwA:
undetectable		 3b9mA-2qiwA:
19.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3CYX_A_ROCA201_4
(HIV-1 PROTEASE)		 2qiw PEP PHOSPHONOMUTASE
(Corynebacterium
glutamicum) 		4 / 4 LEU A 102
ASP A  85
VAL A  71
THR A  75
 None
 1.31A 3cyxB-2qiwA:
undetectable		 3cyxB-2qiwA:
16.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LBD_A_9CRA424_1
(RETINOIC ACID
RECEPTOR GAMMA)		 2qiw PEP PHOSPHONOMUTASE
(Corynebacterium
glutamicum) 		5 / 12 ALA A 106
MET A   1
SER A  76
GLY A 143
ALA A 139
 None
None
None
GOL  A 261 (-3.9A)
None
 1.48A 3lbdA-2qiwA:
undetectable		 3lbdA-2qiwA:
19.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3N8Y_B_DIFB585_1
(PROSTAGLANDIN G/H
SYNTHASE 1)		 2qiw PEP PHOSPHONOMUTASE
(Corynebacterium
glutamicum) 		5 / 12 VAL A  26
ILE A 101
GLY A 105
ALA A 106
LEU A  43
 None
 1.08A 3n8yB-2qiwA:
undetectable		 3n8yB-2qiwA:
16.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3S3M_A_DLUA398_1
(PFV INTEGRASE)		 2qiw PEP PHOSPHONOMUTASE
(Corynebacterium
glutamicum) 		4 / 8 ASP A  58
GLY A  59
PRO A  49
GLN A 239
 UNL  A 256 (-4.3A)
None
None
None
 0.98A 3s3mA-2qiwA:
2.2		 3s3mA-2qiwA:
17.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UAW_A_ADNA236_1
(PURINE NUCLEOSIDE
PHOSPHORYLASE
DEOD-TYPE)		 2qiw PEP PHOSPHONOMUTASE
(Corynebacterium
glutamicum) 		5 / 11 THR A 152
GLY A 150
VAL A 111
GLU A 112
ILE A 148
 None
 0.93A 3uawA-2qiwA:
undetectable		 3uawA-2qiwA:
24.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UAY_A_ADNA236_1
(PURINE NUCLEOSIDE
PHOSPHORYLASE
DEOD-TYPE)		 2qiw PEP PHOSPHONOMUTASE
(Corynebacterium
glutamicum) 		5 / 10 THR A 152
GLY A 150
VAL A 111
GLU A 112
ILE A 148
 None
 0.94A 3uayA-2qiwA:
undetectable		 3uayA-2qiwA:
24.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3WXO_A_NIZA802_1
(CATALASE-PEROXIDASE)		 2qiw PEP PHOSPHONOMUTASE
(Corynebacterium
glutamicum) 		5 / 8 LEU A  97
ILE A 109
ASN A 149
GLY A 150
ILE A 132
 None
 1.32A 3wxoA-2qiwA:
undetectable		 3wxoA-2qiwA:
18.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ZOA_A_ACRA1587_2
(TREHALOSE
SYNTHASE/AMYLASE
TRES)		 2qiw PEP PHOSPHONOMUTASE
(Corynebacterium
glutamicum) 		3 / 3 ARG A 172
PHE A 162
PRO A 165
 None
 0.70A 3zoaB-2qiwA:
5.9		 3zoaB-2qiwA:
20.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ESK_A_1YNA701_1
(LANOSTEROL 14-ALPHA
DEMETHYLASE)		 2qiw PEP PHOSPHONOMUTASE
(Corynebacterium
glutamicum) 		5 / 12 GLY A 228
LEU A  23
ILE A  45
PHE A  11
GLY A 108
 GOL  A 259 (-3.6A)
None
None
None
None
 1.13A 5eskA-2qiwA:
undetectable		 5eskA-2qiwA:
20.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5FSA_B_X2NB590_1
(CYP51 VARIANT1)		 2qiw PEP PHOSPHONOMUTASE
(Corynebacterium
glutamicum) 		5 / 12 GLY A 228
LEU A  23
PHE A  11
ILE A 101
GLY A 108
 GOL  A 259 (-3.6A)
None
None
None
None
 1.04A 5fsaB-2qiwA:
undetectable		 5fsaB-2qiwA:
19.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IH0_A_ERYA404_0
(MACROLIDE
2'-PHOSPHOTRANSFERAS
E II)		 2qiw PEP PHOSPHONOMUTASE
(Corynebacterium
glutamicum) 		5 / 12 ILE A 173
GLY A 150
GLU A 196
ALA A 154
ILE A 208
 None
 1.25A 5ih0A-2qiwA:
undetectable		 5ih0A-2qiwA:
21.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5YN6_A_SAMA401_0
(NSP16 PROTEIN)		 2qiw PEP PHOSPHONOMUTASE
(Corynebacterium
glutamicum) 		5 / 12 PRO A 236
GLY A 235
ASP A  66
ASP A  85
PHE A  64
 UNL  A 256 ( 4.1A)
SO4  A 255 (-3.1A)
None
None
None
 1.34A 5yn6A-2qiwA:
undetectable		 5yn6A-2qiwA:
21.21