SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2qj6'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HTT_C_HISC450_0
(HISTIDYL-TRNA
SYNTHETASE)		 2qj6 TOXIN A
(Clostridioides
difficile) 		5 / 12 THR A 256
ARG A 271
LEU A 273
TYR A 250
TYR A 268
 THR  A 256 ( 0.8A)
ARG  A 271 ( 0.6A)
LEU  A 273 ( 0.5A)
TYR  A 250 ( 1.3A)
TYR  A 268 ( 1.3A)
 1.28A 1httC-2qj6A:
undetectable		 1httC-2qj6A:
20.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HTT_D_HISD450_0
(HISTIDYL-TRNA
SYNTHETASE)		 2qj6 TOXIN A
(Clostridioides
difficile) 		5 / 12 THR A 256
ARG A 271
LEU A 273
TYR A 250
TYR A 268
 THR  A 256 ( 0.8A)
ARG  A 271 ( 0.6A)
LEU  A 273 ( 0.5A)
TYR  A 250 ( 1.3A)
TYR  A 268 ( 1.3A)
 1.28A 1httD-2qj6A:
undetectable		 1httD-2qj6A:
20.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ELZ_A_CHDA150_0
(ILEAL BILE
ACID-BINDING PROTEIN)		 2qj6 TOXIN A
(Clostridioides
difficile) 		5 / 12 PHE A 315
MET A 303
THR A 290
VAL A 289
ILE A 317
 PHE  A 315 ( 1.3A)
MET  A 303 ( 0.0A)
THR  A 290 ( 0.8A)
VAL  A 289 ( 0.6A)
ILE  A 317 ( 0.6A)
 1.40A 3elzA-2qj6A:
undetectable		 3elzA-2qj6A:
18.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ZVM_A_DM2A303_1
(RIBOSYLDIHYDRONICOTI
NAMIDE DEHYDROGENASE
[QUINONE])		 2qj6 TOXIN A
(Clostridioides
difficile) 		5 / 12 GLY A 108
THR A 107
PHE A 138
ILE A 133
PHE A 140
 GLY  A 108 ( 0.0A)
THR  A 107 ( 0.8A)
PHE  A 138 ( 1.3A)
ILE  A 133 ( 0.7A)
PHE  A 140 ( 1.3A)
 1.09A 4zvmA-2qj6A:
undetectable
4zvmB-2qj6A:
undetectable		 4zvmA-2qj6A:
21.45
4zvmB-2qj6A:
21.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5H3A_A_D16A401_1
(ORF70)		 2qj6 TOXIN A
(Clostridioides
difficile) 		4 / 7 PHE A 138
ILE A 133
GLY A 129
PHE A 140
 PHE  A 138 ( 1.3A)
ILE  A 133 ( 0.7A)
GLY  A 129 ( 0.0A)
PHE  A 140 ( 1.3A)
 0.87A 5h3aA-2qj6A:
undetectable		 5h3aA-2qj6A:
18.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5K4P_A_SORA611_0
(PROBABLE
PHOSPHATIDYLETHANOLA
MINE TRANSFERASE
MCR-1)		 2qj6 TOXIN A
(Clostridioides
difficile) 		4 / 6 GLY A 129
THR A 128
TYR A 139
GLY A 144
 GLY  A 129 ( 0.0A)
THR  A 128 ( 0.8A)
TYR  A 139 ( 1.3A)
GLY  A 144 ( 0.0A)
 0.91A 5k4pA-2qj6A:
undetectable		 5k4pA-2qj6A:
22.77