SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2qjc'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HPV_B_478B200_1
(HIV-1 PROTEASE)		 2qjc DIADENOSINE
TETRAPHOSPHATASE,
PUTATIVE
(Trypanosoma
brucei) 		5 / 9 LEU A  14
GLY A  19
VAL A 137
ILE A  22
ILE A 132
 None
 0.88A 1hpvA-2qjcA:
undetectable		 1hpvA-2qjcA:
20.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1OE1_A_CUA502_0
(DISSIMILATORY
COPPER-CONTAINING
NITRITE REDUCTASE)		 2qjc DIADENOSINE
TETRAPHOSPHATASE,
PUTATIVE
(Trypanosoma
brucei) 		3 / 3 ASP A  55
HIS A  82
HIS A  28
 MN  A 401 (-3.0A)
PO4  A 500 (-4.1A)
MN  A 400 (-3.6A)
 0.67A 1oe1A-2qjcA:
undetectable		 1oe1A-2qjcA:
23.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1OE3_A_CUA502_0
(DISSIMILATORY
COPPER-CONTAINING
NITRITE REDUCTASE)		 2qjc DIADENOSINE
TETRAPHOSPHATASE,
PUTATIVE
(Trypanosoma
brucei) 		3 / 3 ASP A  55
HIS A  82
HIS A  28
 MN  A 401 (-3.0A)
PO4  A 500 (-4.1A)
MN  A 400 (-3.6A)
 0.66A 1oe3A-2qjcA:
undetectable		 1oe3A-2qjcA:
23.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1WSV_A_THHA3001_0
(AMINOMETHYLTRANSFERA
SE)		 2qjc DIADENOSINE
TETRAPHOSPHATASE,
PUTATIVE
(Trypanosoma
brucei) 		5 / 12 THR A  49
LEU A  50
ILE A  22
VAL A 235
LEU A  34
 None
 1.22A 1wsvA-2qjcA:
undetectable		 1wsvA-2qjcA:
24.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1WSV_B_THHB4001_0
(AMINOMETHYLTRANSFERA
SE)		 2qjc DIADENOSINE
TETRAPHOSPHATASE,
PUTATIVE
(Trypanosoma
brucei) 		5 / 12 THR A  49
LEU A  50
ILE A  22
VAL A 235
LEU A  34
 None
 1.23A 1wsvB-2qjcA:
undetectable		 1wsvB-2qjcA:
24.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XXG_A_CUA1338_0
(DISSIMILATORY
COPPER-CONTAINING
NITRITE REDUCTASE)		 2qjc DIADENOSINE
TETRAPHOSPHATASE,
PUTATIVE
(Trypanosoma
brucei) 		3 / 3 ASP A  55
HIS A  82
HIS A  28
 MN  A 401 (-3.0A)
PO4  A 500 (-4.1A)
MN  A 400 (-3.6A)
 0.68A 2xxgA-2qjcA:
undetectable		 2xxgA-2qjcA:
23.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XXG_C_CUC1339_0
(DISSIMILATORY
COPPER-CONTAINING
NITRITE REDUCTASE)		 2qjc DIADENOSINE
TETRAPHOSPHATASE,
PUTATIVE
(Trypanosoma
brucei) 		3 / 3 ASP A  55
HIS A  82
HIS A  28
 MN  A 401 (-3.0A)
PO4  A 500 (-4.1A)
MN  A 400 (-3.6A)
 0.69A 2xxgC-2qjcA:
undetectable		 2xxgC-2qjcA:
23.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BVB_B_017B401_2
(PROTEASE
(RETROPEPSIN))		 2qjc DIADENOSINE
TETRAPHOSPHATASE,
PUTATIVE
(Trypanosoma
brucei) 		5 / 12 LEU A  14
GLY A  19
VAL A 137
ILE A  22
ILE A 132
 None
 0.88A 3bvbB-2qjcA:
undetectable		 3bvbB-2qjcA:
20.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3DLC_A_SAMA220_0
(PUTATIVE
S-ADENOSYL-L-METHION
INE-DEPENDENT
METHYLTRANSFERASE)		 2qjc DIADENOSINE
TETRAPHOSPHATASE,
PUTATIVE
(Trypanosoma
brucei) 		5 / 12 TYR A 227
GLY A  29
GLY A  60
PHE A  64
VAL A  67
 None
 1.20A 3dlcA-2qjcA:
undetectable		 3dlcA-2qjcA:
22.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3IV6_C_SAMC301_0
(PUTATIVE
ZN-DEPENDENT ALCOHOL
DEHYDROGENASE)		 2qjc DIADENOSINE
TETRAPHOSPHATASE,
PUTATIVE
(Trypanosoma
brucei) 		5 / 12 ARG A 207
GLY A 220
ILE A 241
ARG A 224
LEU A 210
 None
 1.25A 3iv6C-2qjcA:
undetectable		 3iv6C-2qjcA:
22.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NDU_D_ROCD100_1
(PROTEASE)		 2qjc DIADENOSINE
TETRAPHOSPHATASE,
PUTATIVE
(Trypanosoma
brucei) 		5 / 12 LEU A  14
GLY A  19
VAL A 137
ILE A  22
ILE A 132
 None
 0.91A 3nduC-2qjcA:
undetectable		 3nduC-2qjcA:
20.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NUJ_B_478B401_2
(PROTEASE)		 2qjc DIADENOSINE
TETRAPHOSPHATASE,
PUTATIVE
(Trypanosoma
brucei) 		5 / 9 LEU A  14
GLY A  19
VAL A 137
ILE A  22
ILE A 132
 None
 0.93A 3nujB-2qjcA:
undetectable		 3nujB-2qjcA:
18.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3RAE_F_LFXF101_1
(DNA TOPOISOMERASE 4
SUBUNIT A
DNA TOPOISOMERASE 4
SUBUNIT B)		 2qjc DIADENOSINE
TETRAPHOSPHATASE,
PUTATIVE
(Trypanosoma
brucei) 		3 / 4 SER A 114
GLY A  29
GLU A  35
 None
 0.50A 3raeA-2qjcA:
undetectable
3raeC-2qjcA:
undetectable		 3raeA-2qjcA:
19.56
3raeC-2qjcA:
21.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4AC9_C_DXCC1476_0
(MJ0495-LIKE PROTEIN)		 2qjc DIADENOSINE
TETRAPHOSPHATASE,
PUTATIVE
(Trypanosoma
brucei) 		4 / 5 ILE A  23
ALA A 233
HIS A 135
ARG A  20
 None
 1.21A 4ac9B-2qjcA:
undetectable
4ac9C-2qjcA:
undetectable		 4ac9B-2qjcA:
21.07
4ac9C-2qjcA:
21.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ACA_C_DXCC1476_0
(TRANSLATION
ELONGATION FACTOR
SELB)		 2qjc DIADENOSINE
TETRAPHOSPHATASE,
PUTATIVE
(Trypanosoma
brucei) 		4 / 5 ILE A  23
ALA A 233
HIS A 135
ARG A  20
 None
 1.23A 4acaB-2qjcA:
undetectable
4acaC-2qjcA:
undetectable		 4acaB-2qjcA:
21.07
4acaC-2qjcA:
21.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4JUO_F_LFXF101_1
(DNA TOPOISOMERASE 4
SUBUNIT A
DNA TOPOISOMERASE 4
SUBUNIT B
E-SITE DNA)		 2qjc DIADENOSINE
TETRAPHOSPHATASE,
PUTATIVE
(Trypanosoma
brucei) 		3 / 4 SER A 114
GLY A  29
GLU A  35
 None
 0.49A 4juoA-2qjcA:
undetectable
4juoC-2qjcA:
undetectable		 4juoA-2qjcA:
19.56
4juoC-2qjcA:
16.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4K4Y_A_ACTA502_0
(RNA-DEPENDENT RNA
POLYMERASE)		 2qjc DIADENOSINE
TETRAPHOSPHATASE,
PUTATIVE
(Trypanosoma
brucei) 		4 / 5 LYS A 188
LEU A 164
GLU A 166
LEU A 177
 None
 1.03A 4k4yA-2qjcA:
undetectable		 4k4yA-2qjcA:
20.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4K4Y_E_ACTE503_0
(RNA-DEPENDENT RNA
POLYMERASE)		 2qjc DIADENOSINE
TETRAPHOSPHATASE,
PUTATIVE
(Trypanosoma
brucei) 		4 / 4 LYS A 188
LEU A 164
GLU A 166
LEU A 177
 None
 1.05A 4k4yE-2qjcA:
undetectable		 4k4yE-2qjcA:
20.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4K4Y_I_ACTI503_0
(RNA-DEPENDENT RNA
POLYMERASE)		 2qjc DIADENOSINE
TETRAPHOSPHATASE,
PUTATIVE
(Trypanosoma
brucei) 		4 / 5 LYS A 188
LEU A 164
GLU A 166
LEU A 177
 None
 1.03A 4k4yI-2qjcA:
undetectable		 4k4yI-2qjcA:
20.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4M2R_A_BZ1A302_2
(CARBONIC ANHYDRASE 2)		 2qjc DIADENOSINE
TETRAPHOSPHATASE,
PUTATIVE
(Trypanosoma
brucei) 		4 / 4 HIS A 204
GLU A 155
HIS A 128
LEU A 123
 MN  A 401 ( 3.3A)
None
None
None
 1.42A 4m2rA-2qjcA:
undetectable		 4m2rA-2qjcA:
20.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4NKX_D_STRD601_1
(STEROID
17-ALPHA-HYDROXYLASE
/17,20 LYASE)		 2qjc DIADENOSINE
TETRAPHOSPHATASE,
PUTATIVE
(Trypanosoma
brucei) 		5 / 12 LEU A 126
ALA A  52
ALA A  75
ILE A  27
VAL A  67
 None
 1.09A 4nkxD-2qjcA:
undetectable		 4nkxD-2qjcA:
20.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4PUO_C_NVPC901_1
(HIV-1 REVERSE
TRANSCRIPTASE, P66
SUBUNIT)		 2qjc DIADENOSINE
TETRAPHOSPHATASE,
PUTATIVE
(Trypanosoma
brucei) 		4 / 8 LEU A  34
VAL A  41
VAL A 244
LEU A  50
 None
 1.00A 4puoC-2qjcA:
undetectable		 4puoC-2qjcA:
18.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4PWD_A_NVPA901_1
(HIV-1 REVERSE
TRANSCRIPTASE, P66
SUBUNIT)		 2qjc DIADENOSINE
TETRAPHOSPHATASE,
PUTATIVE
(Trypanosoma
brucei) 		4 / 8 LEU A  34
VAL A  41
VAL A 244
LEU A  50
 None
 1.01A 4pwdA-2qjcA:
undetectable		 4pwdA-2qjcA:
18.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4RVJ_B_478B101_2
(HIV-1 PROTEASE)		 2qjc DIADENOSINE
TETRAPHOSPHATASE,
PUTATIVE
(Trypanosoma
brucei) 		5 / 9 LEU A  14
GLY A  19
VAL A 137
ILE A  22
ILE A 132
 None
 0.82A 4rvjB-2qjcA:
undetectable		 4rvjB-2qjcA:
19.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4RVJ_D_478D101_2
(HIV-1 PROTEASE)		 2qjc DIADENOSINE
TETRAPHOSPHATASE,
PUTATIVE
(Trypanosoma
brucei) 		5 / 9 LEU A  14
GLY A  19
VAL A 137
ILE A  22
ILE A 132
 None
 0.83A 4rvjD-2qjcA:
undetectable		 4rvjD-2qjcA:
19.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ZN7_A_DESA601_1
(ESTROGEN RECEPTOR)		 2qjc DIADENOSINE
TETRAPHOSPHATASE,
PUTATIVE
(Trypanosoma
brucei) 		5 / 12 ALA A 233
LEU A 231
LEU A  37
LEU A  38
LEU A 221
 None
 1.17A 4zn7A-2qjcA:
undetectable		 4zn7A-2qjcA:
20.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5XXI_A_LSNA501_2
(CYTOCHROME P450 2C9)		 2qjc DIADENOSINE
TETRAPHOSPHATASE,
PUTATIVE
(Trypanosoma
brucei) 		4 / 4 PHE A  43
LEU A  56
LEU A  69
VAL A  24
 None
 1.08A 5xxiA-2qjcA:
undetectable		 5xxiA-2qjcA:
21.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6CE2_B_SVRB202_1
()		 2qjc DIADENOSINE
TETRAPHOSPHATASE,
PUTATIVE
(Trypanosoma
brucei) 		4 / 8 LEU A 111
LEU A 108
LEU A  56
GLY A  54
 None
 0.82A 6ce2A-2qjcA:
undetectable		 6ce2A-2qjcA:
18.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6CLX_A_SAMA401_0
(O-METHYLTRANSFERASE)		 2qjc DIADENOSINE
TETRAPHOSPHATASE,
PUTATIVE
(Trypanosoma
brucei) 		5 / 12 ASP A  26
ALA A 140
GLY A 220
GLY A 203
VAL A 200
 MN  A 400 (-3.3A)
None
None
None
None
 1.31A 6clxA-2qjcA:
undetectable		 6clxA-2qjcA:
25.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DH3_A_017A101_0
(PROTEASE)		 2qjc DIADENOSINE
TETRAPHOSPHATASE,
PUTATIVE
(Trypanosoma
brucei) 		5 / 12 LEU A  14
VAL A 137
ILE A  22
ILE A 130
ILE A 132
 None
 0.91A 6dh3A-2qjcA:
undetectable		 6dh3A-2qjcA:
18.60