SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2qjf'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1GMK_C_DVAC8_0
(GRAMICIDIN A)		 2qjf BIFUNCTIONAL
3'-PHOSPHOADENOSINE
5'-PHOSPHOSULFATE
SYNTHETASE 1
(Homo
sapiens) 		3 / 4 VAL A 387
TRP A 274
TRP A 389
 None
 1.40A 1gmkC-2qjfA:
undetectable
1gmkD-2qjfA:
undetectable		 1gmkC-2qjfA:
5.19
1gmkD-2qjfA:
5.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1L7X_A_CFFA864_1
(GLYCOGEN
PHOSPHORYLASE, LIVER
FORM)		 2qjf BIFUNCTIONAL
3'-PHOSPHOADENOSINE
5'-PHOSPHOSULFATE
SYNTHETASE 1
(Homo
sapiens) 		3 / 3 TRP A 457
HIS A 363
LYS A 367
 None
 1.08A 1l7xA-2qjfA:
0.0		 1l7xA-2qjfA:
20.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QEU_A_ACTA142_0
(PUTATIVE
CARBOXYMUCONOLACTONE
DECARBOXYLASE)		 2qjf BIFUNCTIONAL
3'-PHOSPHOADENOSINE
5'-PHOSPHOSULFATE
SYNTHETASE 1
(Homo
sapiens) 		4 / 5 GLU A 342
PRO A 341
ILE A 377
GLY A 378
 None
 0.97A 2qeuA-2qjfA:
undetectable
2qeuC-2qjfA:
undetectable		 2qeuA-2qjfA:
17.75
2qeuC-2qjfA:
17.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3A25_A_SAMA279_0
(UNCHARACTERIZED
PROTEIN PH0793)		 2qjf BIFUNCTIONAL
3'-PHOSPHOADENOSINE
5'-PHOSPHOSULFATE
SYNTHETASE 1
(Homo
sapiens) 		5 / 12 SER A 305
ASN A 303
GLY A 542
ASP A 523
PHE A 418
 None
None
None
None
ADX  A 100 (-4.3A)
 1.35A 3a25A-2qjfA:
undetectable		 3a25A-2qjfA:
21.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3AF0_A_PAUA314_0
(PANTOTHENATE KINASE)		 2qjf BIFUNCTIONAL
3'-PHOSPHOADENOSINE
5'-PHOSPHOSULFATE
SYNTHETASE 1
(Homo
sapiens) 		4 / 8 VAL A 262
LEU A 454
GLY A 456
TYR A 497
 None
 0.94A 3af0A-2qjfA:
undetectable		 3af0A-2qjfA:
21.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LCV_B_SAMB301_0
(SISOMICIN-GENTAMICIN
RESISTANCE METHYLASE
SGM)		 2qjf BIFUNCTIONAL
3'-PHOSPHOADENOSINE
5'-PHOSPHOSULFATE
SYNTHETASE 1
(Homo
sapiens) 		5 / 12 TYR A 330
ALA A 336
ASP A 385
LEU A 384
LEU A 338
 None
 1.38A 3lcvB-2qjfA:
undetectable		 3lcvB-2qjfA:
22.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3WG7_P_CHDP306_0
(CYTOCHROME C OXIDASE
SUBUNIT 3
CYTOCHROME C OXIDASE
SUBUNIT 7A1,
MITOCHONDRIAL)		 2qjf BIFUNCTIONAL
3'-PHOSPHOADENOSINE
5'-PHOSPHOSULFATE
SYNTHETASE 1
(Homo
sapiens) 		4 / 6 ARG A 319
LEU A 320
PHE A 326
LEU A 257
 None
 1.04A 3wg7P-2qjfA:
undetectable
3wg7W-2qjfA:
undetectable		 3wg7P-2qjfA:
20.15
3wg7W-2qjfA:
9.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4L6V_A_PQNA2001_1
(PHOTOSYSTEM I P700
CHLOROPHYLL A
APOPROTEIN A1
FUSION PROTEIN OF
PHOTOSYSTEM I
SUBUNIT III AND
SUBUNIT IX)		 2qjf BIFUNCTIONAL
3'-PHOSPHOADENOSINE
5'-PHOSPHOSULFATE
SYNTHETASE 1
(Homo
sapiens) 		5 / 9 PHE A 281
ALA A 271
LEU A 270
GLY A 280
ALA A 498
 None
 1.19A 4l6va-2qjfA:
undetectable
4l6vf-2qjfA:
undetectable		 4l6va-2qjfA:
18.59
4l6vf-2qjfA:
18.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XE3_A_CL6A502_1
(CYTOCHROME P-450)		 2qjf BIFUNCTIONAL
3'-PHOSPHOADENOSINE
5'-PHOSPHOSULFATE
SYNTHETASE 1
(Homo
sapiens) 		4 / 5 LEU A 291
ALA A 353
VAL A 369
ILE A 366
 None
 0.94A 4xe3A-2qjfA:
undetectable		 4xe3A-2qjfA:
21.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XE3_B_CL6B502_1
(CYTOCHROME P-450)		 2qjf BIFUNCTIONAL
3'-PHOSPHOADENOSINE
5'-PHOSPHOSULFATE
SYNTHETASE 1
(Homo
sapiens) 		4 / 5 LEU A 291
ALA A 353
VAL A 369
ILE A 366
 None
 0.88A 4xe3B-2qjfA:
undetectable		 4xe3B-2qjfA:
21.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HPU_A_IPHA101_0
(INSULIN, CHAIN A
INSULIN, CHAIN B)		 2qjf BIFUNCTIONAL
3'-PHOSPHOADENOSINE
5'-PHOSPHOSULFATE
SYNTHETASE 1
(Homo
sapiens) 		4 / 4 CYH A 507
LEU A 552
LEU A 546
ALA A 549
 None
 0.64A 5hpuA-2qjfA:
undetectable
5hpuB-2qjfA:
undetectable		 5hpuA-2qjfA:
4.71
5hpuB-2qjfA:
6.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5XXI_A_LSNA501_2
(CYTOCHROME P450 2C9)		 2qjf BIFUNCTIONAL
3'-PHOSPHOADENOSINE
5'-PHOSPHOSULFATE
SYNTHETASE 1
(Homo
sapiens) 		4 / 4 PHE A 326
LEU A 270
LEU A 310
VAL A 383
 None
 1.32A 5xxiA-2qjfA:
undetectable		 5xxiA-2qjfA:
21.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6HU9_E_PCFE202_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE 5A,
MITOCHONDRIAL
CYTOCHROME C OXIDASE
SUBUNIT 1)		 2qjf BIFUNCTIONAL
3'-PHOSPHOADENOSINE
5'-PHOSPHOSULFATE
SYNTHETASE 1
(Homo
sapiens) 		4 / 8 GLN A 419
ALA A 513
VAL A 512
ARG A 510
 ADX  A 100 (-3.6A)
None
None
None
 1.04A 6hu9a-2qjfA:
undetectable
6hu9e-2qjfA:
undetectable		 6hu9a-2qjfA:
19.60
6hu9e-2qjfA:
16.26