SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2qjo'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1FK9_A_EFZA999_1
(HIV-1 RT, A-CHAIN)		 2qjo BIFUNCTIONAL NMN
ADENYLYLTRANSFERASE/
NUDIX HYDROLASE
(Synechocystis
sp.
PCC
6803) 		5 / 10 LEU A  27
VAL A  35
VAL A 107
TYR A  10
GLY A   8
 None
None
None
NAD  A 601 (-4.6A)
None
 1.07A 1fk9A-2qjoA:
undetectable		 1fk9A-2qjoA:
21.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1FKO_A_EFZA999_1
(HIV-1 RT, A-CHAIN)		 2qjo BIFUNCTIONAL NMN
ADENYLYLTRANSFERASE/
NUDIX HYDROLASE
(Synechocystis
sp.
PCC
6803) 		5 / 10 LEU A  27
VAL A  35
VAL A 107
TYR A  10
GLY A   8
 None
None
None
NAD  A 601 (-4.6A)
None
 1.09A 1fkoA-2qjoA:
undetectable		 1fkoA-2qjoA:
21.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1IKV_A_EFZA2000_1
(POL POLYPROTEIN)		 2qjo BIFUNCTIONAL NMN
ADENYLYLTRANSFERASE/
NUDIX HYDROLASE
(Synechocystis
sp.
PCC
6803) 		5 / 9 LEU A  27
VAL A  35
VAL A 107
TYR A  10
GLY A   8
 None
None
None
NAD  A 601 (-4.6A)
None
 1.15A 1ikvA-2qjoA:
undetectable		 1ikvA-2qjoA:
19.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1IKW_A_EFZA2000_1
(POL POLYPROTEIN)		 2qjo BIFUNCTIONAL NMN
ADENYLYLTRANSFERASE/
NUDIX HYDROLASE
(Synechocystis
sp.
PCC
6803) 		5 / 10 LEU A  27
VAL A  35
VAL A 107
TYR A  10
GLY A   8
 None
None
None
NAD  A 601 (-4.6A)
None
 1.11A 1ikwA-2qjoA:
undetectable		 1ikwA-2qjoA:
19.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1IOL_A_ESTA400_1
(ESTROGENIC 17-BETA
HYDROXYSTEROID
DEHYDROGENASE)		 2qjo BIFUNCTIONAL NMN
ADENYLYLTRANSFERASE/
NUDIX HYDROLASE
(Synechocystis
sp.
PCC
6803) 		5 / 11 GLY A 110
LEU A 109
TYR A 128
GLY A 132
GLU A  30
 NAD  A 601 ( 3.7A)
None
None
None
None
 1.40A 1iolA-2qjoA:
4.8		 1iolA-2qjoA:
22.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1LW0_A_NVPA999_1
(HIV-1 REVERSE
TRANSCRIPTASE)		 2qjo BIFUNCTIONAL NMN
ADENYLYLTRANSFERASE/
NUDIX HYDROLASE
(Synechocystis
sp.
PCC
6803) 		5 / 10 LEU A  27
VAL A  35
VAL A 107
TYR A  10
GLY A   8
 None
None
None
NAD  A 601 (-4.6A)
None
 1.17A 1lw0A-2qjoA:
undetectable		 1lw0A-2qjoA:
20.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1XVA_A_SAMA293_0
(GLYCINE
N-METHYLTRANSFERASE)		 2qjo BIFUNCTIONAL NMN
ADENYLYLTRANSFERASE/
NUDIX HYDROLASE
(Synechocystis
sp.
PCC
6803) 		5 / 12 THR A  24
VAL A  35
GLY A 132
TYR A 119
TYR A 128
 None
None
None
NAD  A 601 (-4.2A)
None
 1.41A 1xvaA-2qjoA:
3.5		 1xvaA-2qjoA:
23.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2HA4_B_ACHB603_0
(ACETYLCHOLINESTERASE)		 2qjo BIFUNCTIONAL NMN
ADENYLYLTRANSFERASE/
NUDIX HYDROLASE
(Synechocystis
sp.
PCC
6803) 		4 / 7 TYR A 119
GLU A 130
HIS A 111
GLY A 132
 NAD  A 601 (-4.2A)
None
NAD  A 601 (-4.3A)
None
 1.26A 2ha4B-2qjoA:
undetectable		 2ha4B-2qjoA:
21.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XKW_B_P1BB1475_2
(PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR GAMMA)		 2qjo BIFUNCTIONAL NMN
ADENYLYLTRANSFERASE/
NUDIX HYDROLASE
(Synechocystis
sp.
PCC
6803) 		4 / 6 LEU A 317
ILE A 332
ILE A 266
LEU A 292
 None
 0.97A 2xkwB-2qjoA:
undetectable		 2xkwB-2qjoA:
23.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3G1U_B_ADNB438_1
(ADENOSYLHOMOCYSTEINA
SE)		 2qjo BIFUNCTIONAL NMN
ADENYLYLTRANSFERASE/
NUDIX HYDROLASE
(Synechocystis
sp.
PCC
6803) 		5 / 12 HIS A 328
GLN A 330
ASP A 205
THR A 203
PHE A 272
 APR  A 501 (-4.0A)
None
APR  A 501 (-2.8A)
APR  A 501 (-3.6A)
None
 1.34A 3g1uB-2qjoA:
2.4		 3g1uB-2qjoA:
21.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3HTH_B_PRLB201_0
(EBRA REPRESSOR)		 2qjo BIFUNCTIONAL NMN
ADENYLYLTRANSFERASE/
NUDIX HYDROLASE
(Synechocystis
sp.
PCC
6803) 		5 / 9 VAL A 108
TYR A 118
TRP A  88
LEU A  89
ASP A  85
 None
NAD  A 601 (-4.8A)
NAD  A 601 (-3.4A)
None
NAD  A 601 (-3.8A)
 1.45A 3hthB-2qjoA:
0.0		 3hthB-2qjoA:
24.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LP0_A_NVPA701_1
(REVERSE
TRANSCRIPTASE/RIBONU
CLEASE H)		 2qjo BIFUNCTIONAL NMN
ADENYLYLTRANSFERASE/
NUDIX HYDROLASE
(Synechocystis
sp.
PCC
6803) 		5 / 9 LEU A  27
VAL A  35
VAL A 107
TYR A  10
GLY A   8
 None
None
None
NAD  A 601 (-4.6A)
None
 1.20A 3lp0A-2qjoA:
undetectable		 3lp0A-2qjoA:
20.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LP1_A_NVPA701_1
(REVERSE
TRANSCRIPTASE/RIBONU
CLEASE H)		 2qjo BIFUNCTIONAL NMN
ADENYLYLTRANSFERASE/
NUDIX HYDROLASE
(Synechocystis
sp.
PCC
6803) 		5 / 10 LEU A  27
VAL A  35
VAL A 107
TYR A  10
GLY A   8
 None
None
None
NAD  A 601 (-4.6A)
None
 1.20A 3lp1A-2qjoA:
undetectable		 3lp1A-2qjoA:
20.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3P2K_A_SAMA6735_1
(16S RRNA METHYLASE)		 2qjo BIFUNCTIONAL NMN
ADENYLYLTRANSFERASE/
NUDIX HYDROLASE
(Synechocystis
sp.
PCC
6803) 		3 / 3 ASP A  80
GLU A 322
SER A 116
 NAD  A 601 (-2.8A)
None
NAD  A 601 ( 4.4A)
 0.73A 3p2kA-2qjoA:
2.8		 3p2kA-2qjoA:
21.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3QT0_A_486A4_2
(PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR GAMMA)		 2qjo BIFUNCTIONAL NMN
ADENYLYLTRANSFERASE/
NUDIX HYDROLASE
(Synechocystis
sp.
PCC
6803) 		4 / 4 LYS A  98
GLN A  93
ILE A  11
LEU A  39
 None
 0.89A 3qt0A-2qjoA:
0.0		 3qt0A-2qjoA:
24.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3W1W_A_SALA1505_1
(FERROCHELATASE,
MITOCHONDRIAL)		 2qjo BIFUNCTIONAL NMN
ADENYLYLTRANSFERASE/
NUDIX HYDROLASE
(Synechocystis
sp.
PCC
6803) 		5 / 9 VAL A 261
PRO A 258
LEU A 262
PRO A 298
LEU A 292
 None
 1.41A 3w1wA-2qjoA:
1.3
3w1wB-2qjoA:
1.4		 3w1wA-2qjoA:
23.06
3w1wB-2qjoA:
23.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4AQ7_A_LEUA902_0
(LEUCINE--TRNA LIGASE)		 2qjo BIFUNCTIONAL NMN
ADENYLYLTRANSFERASE/
NUDIX HYDROLASE
(Synechocystis
sp.
PCC
6803) 		4 / 7 ASP A 114
GLU A 130
HIS A 111
HIS A 133
 POP  A 701 ( 4.8A)
None
NAD  A 601 (-4.3A)
NAD  A 601 (-4.3A)
 1.30A 4aq7A-2qjoA:
undetectable		 4aq7A-2qjoA:
17.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5M66_C_ADNC502_1
(ADENOSYLHOMOCYSTEINA
SE)		 2qjo BIFUNCTIONAL NMN
ADENYLYLTRANSFERASE/
NUDIX HYDROLASE
(Synechocystis
sp.
PCC
6803) 		5 / 12 HIS A 328
GLN A 330
ASP A 205
THR A 203
PHE A 272
 APR  A 501 (-4.0A)
None
APR  A 501 (-2.8A)
APR  A 501 (-3.6A)
None
 1.35A 5m66C-2qjoA:
2.2		 5m66C-2qjoA:
21.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5MZR_E_PFLE409_1
(PROTON-GATED ION
CHANNEL)		 2qjo BIFUNCTIONAL NMN
ADENYLYLTRANSFERASE/
NUDIX HYDROLASE
(Synechocystis
sp.
PCC
6803) 		4 / 8 ILE A   9
VAL A 106
THR A 100
ILE A  99
 None
 0.97A 5mzrE-2qjoA:
undetectable		 5mzrE-2qjoA:
15.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UBB_A_SAMA301_0
(ALPHA N-TERMINAL
PROTEIN
METHYLTRANSFERASE 1B)		 2qjo BIFUNCTIONAL NMN
ADENYLYLTRANSFERASE/
NUDIX HYDROLASE
(Synechocystis
sp.
PCC
6803) 		5 / 12 GLY A   8
VAL A  96
LEU A 109
VAL A 107
LEU A 129
 None
 1.26A 5ubbA-2qjoA:
3.1		 5ubbA-2qjoA:
21.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6BSG_A_EFZA601_1
(REVERSE
TRANSCRIPTASE P66
SUBUNIT)		 2qjo BIFUNCTIONAL NMN
ADENYLYLTRANSFERASE/
NUDIX HYDROLASE
(Synechocystis
sp.
PCC
6803) 		5 / 10 LEU A  27
VAL A  35
VAL A 107
TYR A  10
GLY A   8
 None
None
None
NAD  A 601 (-4.6A)
None
 1.10A 6bsgA-2qjoA:
undetectable		 6bsgA-2qjoA:
12.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6BSI_A_EFZA601_1
(REVERSE
TRANSCRIPTASE P66
SUBUNIT)		 2qjo BIFUNCTIONAL NMN
ADENYLYLTRANSFERASE/
NUDIX HYDROLASE
(Synechocystis
sp.
PCC
6803) 		5 / 10 LEU A  27
VAL A  35
VAL A 107
TYR A  10
GLY A   8
 None
None
None
NAD  A 601 (-4.6A)
None
 1.12A 6bsiA-2qjoA:
undetectable		 6bsiA-2qjoA:
12.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6BSJ_A_EFZA601_1
(REVERSE
TRANSCRIPTASE P66
SUBUNIT)		 2qjo BIFUNCTIONAL NMN
ADENYLYLTRANSFERASE/
NUDIX HYDROLASE
(Synechocystis
sp.
PCC
6803) 		5 / 10 LEU A  27
VAL A  35
VAL A 107
TYR A  10
GLY A   8
 None
None
None
NAD  A 601 (-4.6A)
None
 1.07A 6bsjA-2qjoA:
undetectable		 6bsjA-2qjoA:
12.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6HD4_B_STIB602_1
(TYROSINE-PROTEIN
KINASE ABL1)		 2qjo BIFUNCTIONAL NMN
ADENYLYLTRANSFERASE/
NUDIX HYDROLASE
(Synechocystis
sp.
PCC
6803) 		4 / 6 LEU A  25
TYR A  10
VAL A  44
GLY A  20
 None
NAD  A 601 (-4.6A)
None
None
 1.04A 6hd4B-2qjoA:
undetectable		 6hd4B-2qjoA:
11.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6JMJ_A_ASCA201_0
(PHOSPHOPANTETHEINE
ADENYLYLTRANSFERASE)		 2qjo BIFUNCTIONAL NMN
ADENYLYLTRANSFERASE/
NUDIX HYDROLASE
(Synechocystis
sp.
PCC
6803) 		4 / 5 GLY A  12
HIS A  21
SER A 138
SER A 139
 NAD  A 601 (-3.3A)
NAD  A 601 (-4.5A)
POP  A 701 (-2.9A)
POP  A 701 (-3.9A)
 0.56A 6jmjA-2qjoA:
14.5		 6jmjA-2qjoA:
21.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6JNH_A_ASCA201_0
(PHOSPHOPANTETHEINE
ADENYLYLTRANSFERASE)		 2qjo BIFUNCTIONAL NMN
ADENYLYLTRANSFERASE/
NUDIX HYDROLASE
(Synechocystis
sp.
PCC
6803) 		5 / 7 GLY A  12
PHE A  14
HIS A  21
SER A 138
SER A 139
 NAD  A 601 (-3.3A)
NAD  A 601 (-4.8A)
NAD  A 601 (-4.5A)
POP  A 701 (-2.9A)
POP  A 701 (-3.9A)
 0.59A 6jnhA-2qjoA:
14.3		 6jnhA-2qjoA:
21.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6JOG_A_ASCA201_0
(PHOSPHOPANTETHEINE
ADENYLYLTRANSFERASE)		 2qjo BIFUNCTIONAL NMN
ADENYLYLTRANSFERASE/
NUDIX HYDROLASE
(Synechocystis
sp.
PCC
6803) 		4 / 6 GLY A  12
HIS A  21
SER A 138
SER A 139
 NAD  A 601 (-3.3A)
NAD  A 601 (-4.5A)
POP  A 701 (-2.9A)
POP  A 701 (-3.9A)
 0.62A 6jogA-2qjoA:
14.8		 6jogA-2qjoA:
21.49