SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2qjt'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1C9S_T_TRPT81_0
(TRP RNA-BINDING
ATTENUATION PROTEIN)		 2qjt NICOTINAMIDE-NUCLEOT
IDE
ADENYLYLTRANSFERASE
(Francisella
tularensis) 		4 / 7 GLY B 235
THR B 285
THR B 205
SER B 280
 AMP  B 602 (-3.3A)
None
None
None
 0.90A 1c9sT-2qjtB:
undetectable
1c9sU-2qjtB:
undetectable		 1c9sT-2qjtB:
13.29
1c9sU-2qjtB:
13.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1GTN_E_TRPE81_0
(TRP RNA-BINDING
ATTENUATION PROTEIN)		 2qjt NICOTINAMIDE-NUCLEOT
IDE
ADENYLYLTRANSFERASE
(Francisella
tularensis) 		4 / 6 SER B 280
GLY B 235
THR B 285
THR B 205
 None
AMP  B 602 (-3.3A)
None
None
 0.92A 1gtnD-2qjtB:
undetectable
1gtnE-2qjtB:
undetectable		 1gtnD-2qjtB:
13.29
1gtnE-2qjtB:
13.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2AVV_A_MK1A901_2
(POL POLYPROTEIN)		 2qjt NICOTINAMIDE-NUCLEOT
IDE
ADENYLYLTRANSFERASE
(Francisella
tularensis) 		3 / 3 ASP B 173
VAL B 176
PRO B  48
 None
 0.71A 2avvA-2qjtB:
undetectable		 2avvA-2qjtB:
14.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2DTJ_B_THRB402_0
(ASPARTOKINASE)		 2qjt NICOTINAMIDE-NUCLEOT
IDE
ADENYLYLTRANSFERASE
(Francisella
tularensis) 		5 / 9 ASN B 185
ILE B 188
ILE B  45
GLU B 183
GLN B 143
 None
 1.28A 2dtjA-2qjtB:
undetectable
2dtjB-2qjtB:
undetectable		 2dtjA-2qjtB:
18.95
2dtjB-2qjtB:
18.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2J2P_A_SC2A1290_1
(FICOLIN-2)		 2qjt NICOTINAMIDE-NUCLEOT
IDE
ADENYLYLTRANSFERASE
(Francisella
tularensis) 		4 / 5 ASP B 207
SER B 287
GLY B 235
ARG B 282
 None
None
AMP  B 602 (-3.3A)
None
 1.10A 2j2pA-2qjtB:
undetectable
2j2pB-2qjtB:
undetectable		 2j2pA-2qjtB:
20.45
2j2pB-2qjtB:
20.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2PIW_A_T3A932_1
(ANDROGEN RECEPTOR)		 2qjt NICOTINAMIDE-NUCLEOT
IDE
ADENYLYLTRANSFERASE
(Francisella
tularensis) 		4 / 6 LEU B  91
VAL B  95
ILE B  33
ILE B   8
 None
 0.84A 2piwA-2qjtB:
undetectable		 2piwA-2qjtB:
20.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QD3_A_CHDA502_0
(FERROCHELATASE)		 2qjt NICOTINAMIDE-NUCLEOT
IDE
ADENYLYLTRANSFERASE
(Francisella
tularensis) 		4 / 8 ARG B 249
SER B 280
VAL B 206
GLY B 234
 MN  B 505 ( 4.2A)
None
None
MN  B 507 ( 4.4A)
 1.02A 2qd3A-2qjtB:
3.1		 2qd3A-2qjtB:
19.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3Q95_B_ESLB700_1
(ESTROGEN RECEPTOR)		 2qjt NICOTINAMIDE-NUCLEOT
IDE
ADENYLYLTRANSFERASE
(Francisella
tularensis) 		5 / 12 LEU B 329
GLU B 330
ARG B 282
ILE B 247
GLY B 290
 None
 0.97A 3q95B-2qjtB:
undetectable		 3q95B-2qjtB:
20.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SUF_C_SUEC1201_1
(NS3 PROTEASE, NS4A
PROTEIN)		 2qjt NICOTINAMIDE-NUCLEOT
IDE
ADENYLYLTRANSFERASE
(Francisella
tularensis) 		5 / 11 HIS B 110
GLY B 109
ASP B 131
GLY B   9
ALA B 138
 None
 0.98A 3sufC-2qjtB:
undetectable		 3sufC-2qjtB:
19.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UGR_A_IMNA2001_2
(ALDO-KETO REDUCTASE
FAMILY 1 MEMBER C3)		 2qjt NICOTINAMIDE-NUCLEOT
IDE
ADENYLYLTRANSFERASE
(Francisella
tularensis) 		4 / 7 GLN B  85
TYR B  80
PRO B 277
TYR B 276
 None
 1.29A 3ugrA-2qjtB:
undetectable		 3ugrA-2qjtB:
22.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4A97_A_ZPCA1318_2
(CYS-LOOP
LIGAND-GATED ION
CHANNEL)		 2qjt NICOTINAMIDE-NUCLEOT
IDE
ADENYLYLTRANSFERASE
(Francisella
tularensis) 		4 / 7 PHE B  51
ILE B  33
ASN B  94
GLU B  52
 None
 1.14A 4a97E-2qjtB:
undetectable		 4a97E-2qjtB:
22.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4A97_D_ZPCD1318_1
(CYS-LOOP
LIGAND-GATED ION
CHANNEL)		 2qjt NICOTINAMIDE-NUCLEOT
IDE
ADENYLYLTRANSFERASE
(Francisella
tularensis) 		4 / 8 PHE B  51
ILE B  33
ASN B  94
GLU B  52
 None
 1.07A 4a97C-2qjtB:
undetectable		 4a97C-2qjtB:
22.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4M2V_A_BZ1A302_2
(CARBONIC ANHYDRASE 2)		 2qjt NICOTINAMIDE-NUCLEOT
IDE
ADENYLYLTRANSFERASE
(Francisella
tularensis) 		3 / 3 HIS B  20
VAL B  72
LEU B  26
 None
 0.75A 4m2vA-2qjtB:
undetectable		 4m2vA-2qjtB:
19.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MX0_A_BCZA513_1
(NEURAMINIDASE)		 2qjt NICOTINAMIDE-NUCLEOT
IDE
ADENYLYLTRANSFERASE
(Francisella
tularensis) 		3 / 3 ARG B  10
ASP B  79
ARG B  54
 None
 0.97A 4mx0A-2qjtB:
undetectable		 4mx0A-2qjtB:
20.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4PXM_B_ESTB2000_1
(ESTROGEN RECEPTOR)		 2qjt NICOTINAMIDE-NUCLEOT
IDE
ADENYLYLTRANSFERASE
(Francisella
tularensis) 		5 / 11 LEU B 329
GLU B 330
ARG B 282
ILE B 247
GLY B 290
 None
 1.10A 4pxmB-2qjtB:
undetectable		 4pxmB-2qjtB:
20.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5GS4_A_ESTA603_1
(ESTROGEN RECEPTOR)		 2qjt NICOTINAMIDE-NUCLEOT
IDE
ADENYLYLTRANSFERASE
(Francisella
tularensis) 		5 / 12 LEU B 329
GLU B 330
ARG B 282
ILE B 247
GLY B 290
 None
 1.08A 5gs4A-2qjtB:
undetectable		 5gs4A-2qjtB:
19.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KLA_A_ACTA1505_0
(MATERNAL PROTEIN
PUMILIO)		 2qjt NICOTINAMIDE-NUCLEOT
IDE
ADENYLYLTRANSFERASE
(Francisella
tularensis) 		3 / 3 HIS B  15
LYS B  16
PHE B 136
 None
 1.32A 5klaA-2qjtB:
undetectable		 5klaA-2qjtB:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5LG3_A_Z80A401_1
(GAMMA-AMINOBUTYRIC-A
CID RECEPTOR SUBUNIT
BETA-1)		 2qjt NICOTINAMIDE-NUCLEOT
IDE
ADENYLYLTRANSFERASE
(Francisella
tularensis) 		5 / 11 ILE B 303
ILE B 257
VAL B 312
GLU B 250
ALA B 208
 None
None
None
MN  B 506 (-2.7A)
None
 0.88A 5lg3A-2qjtB:
undetectable		 5lg3A-2qjtB:
22.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5LG3_E_Z80E401_1
(GAMMA-AMINOBUTYRIC-A
CID RECEPTOR SUBUNIT
BETA-1)		 2qjt NICOTINAMIDE-NUCLEOT
IDE
ADENYLYLTRANSFERASE
(Francisella
tularensis) 		5 / 12 ILE B 303
ILE B 257
VAL B 312
GLU B 250
ALA B 208
 None
None
None
MN  B 506 (-2.7A)
None
 0.90A 5lg3E-2qjtB:
undetectable		 5lg3E-2qjtB:
22.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5M66_C_ADNC502_1
(ADENOSYLHOMOCYSTEINA
SE)		 2qjt NICOTINAMIDE-NUCLEOT
IDE
ADENYLYLTRANSFERASE
(Francisella
tularensis) 		5 / 12 HIS B 332
GLN B 334
ASP B 207
THR B 205
PHE B 274
 None
 1.49A 5m66C-2qjtB:
undetectable		 5m66C-2qjtB:
20.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5SYE_B_TA1B502_1
(TUBULIN BETA CHAIN)		 2qjt NICOTINAMIDE-NUCLEOT
IDE
ADENYLYLTRANSFERASE
(Francisella
tularensis) 		5 / 12 VAL B 130
ASP B 131
LEU B  62
ALA B  25
GLY B   9
 None
 1.26A 5syeB-2qjtB:
undetectable		 5syeB-2qjtB:
21.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Y9Y_A_ACTA412_0
(UNCHARACTERIZED
PROTEIN KDOO)		 2qjt NICOTINAMIDE-NUCLEOT
IDE
ADENYLYLTRANSFERASE
(Francisella
tularensis) 		3 / 3 ARG B 221
PHE B 236
ARG B 282
 MN  B 507 ( 4.8A)
AMP  B 602 (-3.4A)
None
 1.22A 5y9yA-2qjtB:
undetectable		 5y9yA-2qjtB:
20.49