SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2qkb'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ICU_C_NIOC225_1
(OXYGEN-INSENSITIVE
NAD(P)H
NITROREDUCTASE)		 2qkb RIBONUCLEASE H1
(Homo
sapiens) 		4 / 6 SER A 211
PHE A 213
PHE A 244
GLY A 217
 None
 1.16A 1icuC-2qkbA:
undetectable
1icuD-2qkbA:
undetectable		 1icuC-2qkbA:
18.26
1icuD-2qkbA:
18.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1S9P_B_DESB459_2
(ESTROGEN-RELATED
RECEPTOR GAMMA)		 2qkb RIBONUCLEASE H1
(Homo
sapiens) 		3 / 3 LEU A 250
HIS A 188
ILE A 187
 None
 0.56A 1s9pB-2qkbA:
undetectable		 1s9pB-2qkbA:
19.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2CC8_A_RBFA1067_1
(VNG1446H)		 2qkb RIBONUCLEASE H1
(Homo
sapiens) 		3 / 3 PHE A 244
VAL A 222
TRP A 225
 None
 0.84A 2cc8A-2qkbA:
undetectable		 2cc8A-2qkbA:
16.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2CCB_A_RBFA1067_1
(VNG1446H)		 2qkb RIBONUCLEASE H1
(Homo
sapiens) 		3 / 3 PHE A 244
VAL A 222
TRP A 225
 None
 0.86A 2ccbA-2qkbA:
undetectable		 2ccbA-2qkbA:
16.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2VX9_A_RBFA1064_1
(DODECIN)		 2qkb RIBONUCLEASE H1
(Homo
sapiens) 		3 / 3 PHE A 244
VAL A 222
TRP A 225
 None
 0.85A 2vx9A-2qkbA:
undetectable		 2vx9A-2qkbA:
16.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3A50_A_VD3A2001_1
(VITAMIN D
HYDROXYLASE)		 2qkb RIBONUCLEASE H1
(Homo
sapiens) 		5 / 12 ILE A 218
LEU A 247
ILE A 187
ALA A 190
THR A 144
 None
 1.20A 3a50A-2qkbA:
undetectable		 3a50A-2qkbA:
17.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3CZH_A_D2VA602_2
(CYTOCHROME P450 2R1)		 2qkb RIBONUCLEASE H1
(Homo
sapiens) 		3 / 3 LEU A 176
GLU A 186
ILE A 187
 None
A  C  11 ( 3.9A)
None
 0.59A 3czhA-2qkbA:
undetectable		 3czhA-2qkbA:
16.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4AE1_A_NCAA1536_0
(DIPHTHERIA TOXIN)		 2qkb RIBONUCLEASE H1
(Homo
sapiens) 		4 / 6 GLY A 161
TYR A 163
ALA A 277
GLU A 272
 None
 0.92A 4ae1A-2qkbA:
undetectable		 4ae1A-2qkbA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DJE_B_C2FB302_0
(5-METHYLTETRAHYDROFO
LATE CORRINOID/IRON
SULFUR PROTEIN
METHYLTRANSFERASE)		 2qkb RIBONUCLEASE H1
(Homo
sapiens) 		5 / 12 ASP A 274
ASP A 145
ASN A 210
SER A 149
GLN A 180
 None
C  C  12 ( 2.9A)
A  C  11 ( 3.1A)
U  C  14 ( 4.9A)
None
 1.39A 4djeB-2qkbA:
undetectable		 4djeB-2qkbA:
20.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5L66_K_BO2K301_1
(PROTEASOME SUBUNIT
BETA
TYPE-8,PROTEASOME
SUBUNIT BETA TYPE-5
PROTEASOME SUBUNIT
BETA
TYPE-6,PROTEASOME
SUBUNIT BETA
TYPE-1,PROTEASOME
SUBUNIT BETA
TYPE-6,PROTEASOME
SUBUNIT BETA
TYPE-1,PROTEASOME
SUBUNIT BETA TYPE-6)		 2qkb RIBONUCLEASE H1
(Homo
sapiens) 		5 / 10 ALA A 189
THR A 144
GLY A 173
ALA A 277
ASP A 274
 None
 1.39A 5l66K-2qkbA:
undetectable
5l66L-2qkbA:
undetectable		 5l66K-2qkbA:
20.85
5l66L-2qkbA:
21.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5L66_Y_BO2Y301_1
(PROTEASOME SUBUNIT
BETA
TYPE-8,PROTEASOME
SUBUNIT BETA TYPE-5
PROTEASOME SUBUNIT
BETA
TYPE-6,PROTEASOME
SUBUNIT BETA
TYPE-1,PROTEASOME
SUBUNIT BETA
TYPE-6,PROTEASOME
SUBUNIT BETA
TYPE-1,PROTEASOME
SUBUNIT BETA TYPE-6)		 2qkb RIBONUCLEASE H1
(Homo
sapiens) 		5 / 10 ALA A 189
THR A 144
GLY A 173
ALA A 277
ASP A 274
 None
 1.40A 5l66Y-2qkbA:
undetectable
5l66Z-2qkbA:
undetectable		 5l66Y-2qkbA:
20.85
5l66Z-2qkbA:
21.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5N0S_B_SAMB501_0
(PEPTIDE
N-METHYLTRANSFERASE)		 2qkb RIBONUCLEASE H1
(Homo
sapiens) 		5 / 12 ILE A 202
HIS A 135
GLN A 257
ILE A 194
ALA A 197
 None
 1.13A 5n0sB-2qkbA:
undetectable		 5n0sB-2qkbA:
16.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5W7B_B_PA1B204_1
(ACYLOXYACYL
HYDROLASE SMALL
SUBUNIT
ACYLOXYACYL
HYDROLASE LARGE
SUBUNIT)		 2qkb RIBONUCLEASE H1
(Homo
sapiens) 		3 / 3 GLY A 167
ASN A 171
ARG A 275
 None
 0.71A 5w7bD-2qkbA:
undetectable		 5w7bD-2qkbA:
17.65