SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2qkc'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1KQW_A_RTLA135_0
(CELLULAR
RETINOL-BINDING
PROTEIN)		 2qkc SUPEROXIDE DISMUTASE
[MN]
(Homo
sapiens) 		5 / 12 ILE A  18
VAL A 189
LEU A  81
LEU A 111
ILE A 158
 None
 1.27A 1kqwA-2qkcA:
undetectable		 1kqwA-2qkcA:
23.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BXC_A_P1ZA2001_1
(SERUM ALBUMIN)		 2qkc SUPEROXIDE DISMUTASE
[MN]
(Homo
sapiens) 		6 / 12 SER A 121
GLN A 143
LEU A  81
HIS A  74
ILE A  22
ALA A 164
 None
MN  A 199 ( 4.9A)
None
MN  A 199 (-3.3A)
None
MN  A 199 ( 4.9A)
 1.15A 2bxcA-2qkcA:
undetectable		 2bxcA-2qkcA:
15.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Q83_A_ADNA1_1
(YTAA PROTEIN)		 2qkc SUPEROXIDE DISMUTASE
[MN]
(Homo
sapiens) 		4 / 7 ILE A  76
TRP A 125
LEU A 111
ILE A 158
 None
 0.88A 2q83A-2qkcA:
1.6		 2q83A-2qkcA:
20.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3CLB_A_TMQA611_1
(DHFR-TS)		 2qkc SUPEROXIDE DISMUTASE
[MN]
(Homo
sapiens) 		6 / 11 VAL A 160
ALA A 164
ILE A  18
ILE A 184
LEU A 156
ILE A 158
 None
MN  A 199 ( 4.9A)
None
None
None
None
 1.32A 3clbA-2qkcA:
undetectable		 3clbA-2qkcA:
17.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3HBB_A_TMQA611_1
(DIHYDROFOLATE
REDUCTASE-THYMIDYLAT
E SYNTHASE)		 2qkc SUPEROXIDE DISMUTASE
[MN]
(Homo
sapiens) 		5 / 10 VAL A 160
ALA A 164
ILE A  18
ILE A 184
LEU A 156
 None
MN  A 199 ( 4.9A)
None
None
None
 1.14A 3hbbA-2qkcA:
undetectable		 3hbbA-2qkcA:
17.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3HBB_C_TMQC613_1
(DIHYDROFOLATE
REDUCTASE-THYMIDYLAT
E SYNTHASE)		 2qkc SUPEROXIDE DISMUTASE
[MN]
(Homo
sapiens) 		6 / 11 VAL A 160
ALA A 164
ILE A  18
ILE A 184
LEU A 156
ILE A 158
 None
MN  A 199 ( 4.9A)
None
None
None
None
 1.33A 3hbbC-2qkcA:
undetectable		 3hbbC-2qkcA:
17.65