SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2qkd'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1IG3_A_VIBA502_1
(THIAMIN
PYROPHOSPHOKINASE)		 2qkd ZINC FINGER PROTEIN
ZPR1
(Mus
musculus) 		4 / 8 LEU A 232
SER A 122
ASP A 197
THR A 125
 None
 1.05A 1ig3A-2qkdA:
undetectable
1ig3B-2qkdA:
2.0		 1ig3A-2qkdA:
21.13
1ig3B-2qkdA:
21.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1KQW_A_RTLA135_0
(CELLULAR
RETINOL-BINDING
PROTEIN)		 2qkd ZINC FINGER PROTEIN
ZPR1
(Mus
musculus) 		5 / 12 PHE A 403
THR A 366
VAL A 365
LEU A 342
ILE A 335
 None
 1.28A 1kqwA-2qkdA:
undetectable		 1kqwA-2qkdA:
16.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RQP_C_SAMC500_0
(5'-FLUORO-5'-DEOXYAD
ENOSINE SYNTHASE)		 2qkd ZINC FINGER PROTEIN
ZPR1
(Mus
musculus) 		4 / 8 ASP A 198
PHE A 137
ARG A 224
ALA A 136
 None
 1.15A 1rqpA-2qkdA:
undetectable		 1rqpA-2qkdA:
22.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BDM_A_TMIA502_1
(CYTOCHROME P450 2B4)		 2qkd ZINC FINGER PROTEIN
ZPR1
(Mus
musculus) 		5 / 12 LEU A 391
ILE A 394
LEU A 354
THR A 353
LEU A 357
 None
 0.90A 2bdmA-2qkdA:
undetectable		 2bdmA-2qkdA:
22.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2TSR_B_D16B409_1
(THYMIDYLATE SYNTHASE)		 2qkd ZINC FINGER PROTEIN
ZPR1
(Mus
musculus) 		4 / 8 ARG A 126
ILE A 134
LEU A 157
GLY A 156
 None
 0.80A 2tsrB-2qkdA:
undetectable		 2tsrB-2qkdA:
22.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3EIG_A_MTXA200_1
(DIHYDROFOLATE
REDUCTASE)		 2qkd ZINC FINGER PROTEIN
ZPR1
(Mus
musculus) 		5 / 12 ILE A 361
LEU A 325
GLU A 334
SER A 412
ASN A 406
 None
None
FMT  A 778 (-4.4A)
None
FMT  A 778 (-3.8A)
 1.43A 3eigA-2qkdA:
undetectable		 3eigA-2qkdA:
19.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3M0W_A_P77A203_1
(PROTEIN S100-A4)		 2qkd ZINC FINGER PROTEIN
ZPR1
(Mus
musculus) 		5 / 10 ASP A 121
SER A 122
LEU A 143
SER A 203
PHE A 204
 None
 1.43A 3m0wA-2qkdA:
undetectable
3m0wB-2qkdA:
undetectable
3m0wI-2qkdA:
undetectable
3m0wJ-2qkdA:
undetectable		 3m0wA-2qkdA:
12.88
3m0wB-2qkdA:
12.88
3m0wI-2qkdA:
12.88
3m0wJ-2qkdA:
12.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3M0W_H_P77H203_1
(PROTEIN S100-A4)		 2qkd ZINC FINGER PROTEIN
ZPR1
(Mus
musculus) 		5 / 10 LEU A 143
SER A 203
PHE A 204
ASP A 121
SER A 122
 None
 1.39A 3m0wE-2qkdA:
undetectable
3m0wF-2qkdA:
undetectable
3m0wG-2qkdA:
undetectable
3m0wH-2qkdA:
undetectable		 3m0wE-2qkdA:
12.88
3m0wF-2qkdA:
12.88
3m0wG-2qkdA:
12.88
3m0wH-2qkdA:
12.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3W1W_A_CHDA1504_0
(FERROCHELATASE,
MITOCHONDRIAL)		 2qkd ZINC FINGER PROTEIN
ZPR1
(Mus
musculus) 		4 / 4 PRO A 199
LEU A 232
ILE A  96
ARG A  95
 None
 1.47A 3w1wA-2qkdA:
undetectable		 3w1wA-2qkdA:
22.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MK4_A_CHDA503_0
(FERROCHELATASE,
MITOCHONDRIAL)		 2qkd ZINC FINGER PROTEIN
ZPR1
(Mus
musculus) 		5 / 10 LEU A 357
LEU A 354
LEU A 313
ILE A 361
THR A 316
 None
 1.40A 4mk4A-2qkdA:
undetectable		 4mk4A-2qkdA:
22.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4NKX_B_STRB601_2
(STEROID
17-ALPHA-HYDROXYLASE
/17,20 LYASE)		 2qkd ZINC FINGER PROTEIN
ZPR1
(Mus
musculus) 		4 / 5 ILE A 154
LEU A 182
GLU A 147
VAL A 107
 None
 1.05A 4nkxB-2qkdA:
undetectable		 4nkxB-2qkdA:
21.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Y4D_A_CFFA411_1
(ENDOTHIAPEPSIN)		 2qkd ZINC FINGER PROTEIN
ZPR1
(Mus
musculus) 		4 / 6 LEU A 338
LEU A 358
ILE A 404
PHE A 403
 None
None
FMT  A 778 (-3.9A)
None
 1.25A 4y4dA-2qkdA:
undetectable		 4y4dA-2qkdA:
20.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5B6I_A_ADNA302_1
(FLUORINASE)		 2qkd ZINC FINGER PROTEIN
ZPR1
(Mus
musculus) 		4 / 7 THR A 330
PRO A 408
THR A 309
SER A 412
 None
 1.29A 5b6iA-2qkdA:
undetectable		 5b6iA-2qkdA:
23.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IEP_A_VDYA201_2
(CDL2.3B)		 2qkd ZINC FINGER PROTEIN
ZPR1
(Mus
musculus) 		5 / 9 ILE A 335
PRO A 336
LEU A 414
ILE A 311
LEU A 391
 None
 1.47A 5iepA-2qkdA:
undetectable		 5iepA-2qkdA:
18.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IK1_A_CAMA503_0
(CAMPHOR
5-MONOOXYGENASE)		 2qkd ZINC FINGER PROTEIN
ZPR1
(Mus
musculus) 		4 / 7 GLY A 349
VAL A 273
ILE A 282
VAL A 281
 None
 0.79A 5ik1A-2qkdA:
undetectable		 5ik1A-2qkdA:
22.27