SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2qks'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ERR_A_CCSA381_0
(ESTROGEN RECEPTOR)		 2qks KIR3.1-PROKARYOTIC
KIR CHANNEL CHIMERA
(Mus
musculus;
Paraburkholderia
xenovorans) 		4 / 5 HIS A 293
GLU A 145
ALA A 147
HIS A 272
 None
 1.32A 1errA-2qksA:
undetectable
1errB-2qksA:
undetectable		 1errA-2qksA:
22.43
1errB-2qksA:
22.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2DTT_C_H4BC1002_1
(HYPOTHETICAL PROTEIN
PH0634)		 2qks KIR3.1-PROKARYOTIC
KIR CHANNEL CHIMERA
(Mus
musculus;
Paraburkholderia
xenovorans) 		4 / 6 PHE A  85
THR A  89
GLU A 112
GLU A  88
 None
 1.43A 2dttB-2qksA:
undetectable
2dttC-2qksA:
undetectable		 2dttB-2qksA:
16.84
2dttC-2qksA:
16.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2IVU_A_ZD6A3015_1
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE RECEPTOR RET
PRECURSOR)		 2qks KIR3.1-PROKARYOTIC
KIR CHANNEL CHIMERA
(Mus
musculus;
Paraburkholderia
xenovorans) 		3 / 3 ALA A 259
GLY A 163
SER A 168
 None
 0.56A 2ivuA-2qksA:
undetectable		 2ivuA-2qksA:
23.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3WRI_A_CAMA502_0
(CAMPHOR
5-MONOOXYGENASE)		 2qks KIR3.1-PROKARYOTIC
KIR CHANNEL CHIMERA
(Mus
musculus;
Paraburkholderia
xenovorans) 		4 / 5 LEU A 211
GLY A 163
ILE A 278
VAL A 277
 None
 0.83A 3wriA-2qksA:
undetectable		 3wriA-2qksA:
20.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3WRI_B_CAMB502_0
(CAMPHOR
5-MONOOXYGENASE)		 2qks KIR3.1-PROKARYOTIC
KIR CHANNEL CHIMERA
(Mus
musculus;
Paraburkholderia
xenovorans) 		4 / 5 LEU A 211
GLY A 163
ILE A 278
VAL A 277
 None
 0.84A 3wriB-2qksA:
undetectable		 3wriB-2qksA:
20.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4E0F_A_RBFA301_2
(RIBOFLAVIN SYNTHASE
SUBUNIT ALPHA)		 2qks KIR3.1-PROKARYOTIC
KIR CHANNEL CHIMERA
(Mus
musculus;
Paraburkholderia
xenovorans) 		3 / 3 LYS A  11
THR A 261
ILE A 217
 None
 0.90A 4e0fB-2qksA:
0.6		 4e0fB-2qksA:
20.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4UBS_A_DIFA502_1
(PENTALENIC ACID
SYNTHASE)		 2qks KIR3.1-PROKARYOTIC
KIR CHANNEL CHIMERA
(Mus
musculus;
Paraburkholderia
xenovorans) 		5 / 9 LEU A  56
SER A  86
THR A  89
LEU A  90
ILE A 113
 None
 1.02A 4ubsA-2qksA:
undetectable		 4ubsA-2qksA:
22.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VC0_A_RITA602_2
(CYTOCHROME P450 3A4)		 2qks KIR3.1-PROKARYOTIC
KIR CHANNEL CHIMERA
(Mus
musculus;
Paraburkholderia
xenovorans) 		4 / 7 ILE A 245
LEU A 180
PHE A   8
ARG A  14
 None
 0.88A 5vc0A-2qksA:
undetectable		 5vc0A-2qksA:
22.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DJZ_A_GMJA301_1
(SIGMA NON-OPIOID
INTRACELLULAR
RECEPTOR 1)		 2qks KIR3.1-PROKARYOTIC
KIR CHANNEL CHIMERA
(Mus
musculus;
Paraburkholderia
xenovorans) 		4 / 6 ASP A 266
GLN A 239
GLU A 267
THR A 261
 None
 1.38A 6djzA-2qksA:
undetectable		 6djzA-2qksA:
20.94