SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2qkw'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1FMO_E_ADNE351_1
(CAMP-DEPENDENT
PROTEIN KINASE)		 2qkw PROTEIN KINASE
(Solanum
pimpinellifolium) 		8 / 12 GLY B  48
VAL B  55
ALA B  67
VAL B  98
ASN B 169
LEU B 171
THR B 181
ASP B 182
 None
 0.81A 1fmoE-2qkwB:
22.8		 1fmoE-2qkwB:
24.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1IEP_B_STIB202_2
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE ABL)		 2qkw PROTEIN KINASE
(Solanum
pimpinellifolium) 		4 / 7 VAL B  98
MET B 117
ARG B 163
LEU B 171
 None
None
TPO  B 199 ( 3.5A)
None
 0.72A 1iepB-2qkwB:
23.0		 1iepB-2qkwB:
29.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1M17_A_AQ4A999_1
(EPIDERMAL GROWTH
FACTOR RECEPTOR)		 2qkw PROTEIN KINASE
(Solanum
pimpinellifolium) 		7 / 12 ALA B  67
GLU B  85
LEU B 112
MET B 117
GLY B 120
LEU B 171
THR B 181
 None
 0.70A 1m17A-2qkwB:
26.2		 1m17A-2qkwB:
27.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ONI_A_BEZA502_0
(14.5 KDA
TRANSLATIONAL
INHIBITOR PROTEIN)		 2qkw PROTEIN KINASE
(Solanum
pimpinellifolium) 		4 / 6 ASN B 169
ARG B  71
ILE B 185
GLY B 184
 None
 0.99A 1oniA-2qkwB:
undetectable
1oniB-2qkwB:
undetectable		 1oniA-2qkwB:
21.17
1oniB-2qkwB:
21.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ONI_D_BEZD508_0
(14.5 KDA
TRANSLATIONAL
INHIBITOR PROTEIN)		 2qkw PROTEIN KINASE
(Solanum
pimpinellifolium) 		4 / 6 ASN B 169
ARG B  71
ILE B 185
GLY B 184
 None
 1.04A 1oniD-2qkwB:
undetectable
1oniF-2qkwB:
undetectable		 1oniD-2qkwB:
21.17
1oniF-2qkwB:
21.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UWJ_B_BAXB1723_1
(B-RAF PROTO-ONCOGENE
SERINE/THREONINE-PRO
TEIN KINASE)		 2qkw PROTEIN KINASE
(Solanum
pimpinellifolium) 		6 / 12 ILE B  47
VAL B  55
ALA B  67
GLU B  85
LEU B 155
HIS B 162
 None
 1.09A 1uwjB-2qkwB:
7.1		 1uwjB-2qkwB:
27.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ITO_A_IREA2020_1
(EPIDERMAL GROWTH
FACTOR RECEPTOR)		 2qkw PROTEIN KINASE
(Solanum
pimpinellifolium) 		6 / 12 ALA B  67
LYS B  69
GLU B  85
LEU B 112
GLY B 120
LEU B 171
 None
 0.74A 2itoA-2qkwB:
25.3		 2itoA-2qkwB:
26.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ITY_A_IREA2020_1
(EPIDERMAL GROWTH
FACTOR RECEPTOR)		 2qkw PROTEIN KINASE
(Solanum
pimpinellifolium) 		9 / 12 GLY B  48
VAL B  55
ALA B  67
LYS B  69
GLU B  85
LEU B 112
GLY B 120
LEU B 171
ASP B 182
 None
 1.12A 2ityA-2qkwB:
25.2		 2ityA-2qkwB:
27.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2WGJ_A_VGHA2346_1
(HEPATOCYTE GROWTH
FACTOR RECEPTOR)		 2qkw PROTEIN KINASE
(Solanum
pimpinellifolium) 		7 / 12 GLY B  48
VAL B  55
ALA B  67
TYR B 116
MET B 117
GLY B 120
ASP B 182
 None
 0.76A 2wgjA-2qkwB:
19.9		 2wgjA-2qkwB:
29.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XP2_A_VGHA9000_1
(TYROSINE-PROTEIN
KINASE RECEPTOR)		 2qkw PROTEIN KINASE
(Solanum
pimpinellifolium) 		6 / 9 VAL B  55
ALA B  67
MET B 117
GLY B 120
LEU B 171
ASP B 182
 None
 0.50A 2xp2A-2qkwB:
6.8		 2xp2A-2qkwB:
27.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Y7J_A_B49A1294_1
(PHOSPHORYLASE B
KINASE GAMMA
CATALYTIC CHAIN,
TESTIS/LIVER ISOFORM)		 2qkw PROTEIN KINASE
(Solanum
pimpinellifolium) 		6 / 12 ILE B  47
VAL B  55
ALA B  67
MET B 117
GLY B 120
LEU B 171
 None
 0.40A 2y7jA-2qkwB:
25.3		 2y7jA-2qkwB:
27.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Y7J_B_B49B1294_1
(PHOSPHORYLASE B
KINASE GAMMA
CATALYTIC CHAIN,
TESTIS/LIVER ISOFORM)		 2qkw PROTEIN KINASE
(Solanum
pimpinellifolium) 		6 / 10 ILE B  47
VAL B  55
ALA B  67
MET B 117
GLY B 120
LEU B 171
 None
 0.42A 2y7jB-2qkwB:
25.7		 2y7jB-2qkwB:
27.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Y7J_C_B49C1294_1
(PHOSPHORYLASE B
KINASE GAMMA
CATALYTIC CHAIN,
TESTIS/LIVER ISOFORM)		 2qkw PROTEIN KINASE
(Solanum
pimpinellifolium) 		6 / 10 ILE B  47
VAL B  55
ALA B  67
MET B 117
GLY B 120
LEU B 171
 None
 0.43A 2y7jC-2qkwB:
20.9		 2y7jC-2qkwB:
27.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Y7J_D_B49D1294_1
(PHOSPHORYLASE B
KINASE GAMMA
CATALYTIC CHAIN,
TESTIS/LIVER ISOFORM)		 2qkw PROTEIN KINASE
(Solanum
pimpinellifolium) 		6 / 10 ILE B  47
VAL B  55
ALA B  67
MET B 117
GLY B 120
LEU B 171
 None
 0.41A 2y7jD-2qkwB:
17.7		 2y7jD-2qkwB:
27.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2YFX_A_VGHA9000_1
(TYROSINE-PROTEIN
KINASE RECEPTOR)		 2qkw PROTEIN KINASE
(Solanum
pimpinellifolium) 		5 / 8 ALA B  67
MET B 117
GLY B 120
LEU B 171
ASP B 182
 None
 0.54A 2yfxA-2qkwB:
24.0		 2yfxA-2qkwB:
27.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3AOX_A_EMHA901_1
(ALK TYROSINE KINASE
RECEPTOR)		 2qkw PROTEIN KINASE
(Solanum
pimpinellifolium) 		6 / 10 ALA B  67
LYS B  69
VAL B  98
MET B 117
GLY B 120
LEU B 171
 None
 0.55A 3aoxA-2qkwB:
17.6		 3aoxA-2qkwB:
28.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BBT_B_FMMB91_1
(RECEPTOR
TYROSINE-PROTEIN
KINASE ERBB-4)		 2qkw PROTEIN KINASE
(Solanum
pimpinellifolium) 		6 / 12 VAL B  55
ALA B  67
LEU B 100
GLY B 120
LEU B 171
THR B 181
 None
 0.55A 3bbtB-2qkwB:
18.3		 3bbtB-2qkwB:
25.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BBT_D_FMMD91_1
(RECEPTOR
TYROSINE-PROTEIN
KINASE ERBB-4)		 2qkw PROTEIN KINASE
(Solanum
pimpinellifolium) 		7 / 12 VAL B  55
ALA B  67
LEU B 112
GLY B 120
LEU B 171
THR B 181
PHE B 183
 None
 0.70A 3bbtD-2qkwB:
22.7		 3bbtD-2qkwB:
25.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3MBG_A_ACTA207_0
(FAD-LINKED
SULFHYDRYL OXIDASE
ALR)		 2qkw PROTEIN KINASE
(Solanum
pimpinellifolium) 		4 / 7 GLU B 211
ASP B 209
ARG B 217
THR B 219
 None
 1.23A 3mbgA-2qkwB:
1.7
3mbgB-2qkwB:
1.7		 3mbgA-2qkwB:
16.10
3mbgB-2qkwB:
16.10
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3MIY_A_B49A1_1
(TYROSINE-PROTEIN
KINASE ITK/TSK)		 2qkw PROTEIN KINASE
(Solanum
pimpinellifolium) 		7 / 11 ILE B  47
ALA B  67
LYS B  69
VAL B  98
MET B 117
GLY B 120
LEU B 171
 None
 0.58A 3miyA-2qkwB:
24.8		 3miyA-2qkwB:
30.79
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3MIY_A_B49A1_1
(TYROSINE-PROTEIN
KINASE ITK/TSK)		 2qkw PROTEIN KINASE
(Solanum
pimpinellifolium) 		6 / 11 ILE B  47
LYS B  69
VAL B  98
MET B 117
LEU B 171
ASP B 182
 None
 0.82A 3miyA-2qkwB:
24.8		 3miyA-2qkwB:
30.79
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3MIY_B_B49B2_1
(TYROSINE-PROTEIN
KINASE ITK/TSK)		 2qkw PROTEIN KINASE
(Solanum
pimpinellifolium) 		6 / 9 ILE B  47
ALA B  67
LYS B  69
MET B 117
GLY B 120
LEU B 171
 None
 0.56A 3miyB-2qkwB:
24.5		 3miyB-2qkwB:
30.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OG7_A_032A1_1
(AKAP9-BRAF FUSION
PROTEIN)		 2qkw PROTEIN KINASE
(Solanum
pimpinellifolium) 		6 / 12 ILE B  47
VAL B  55
ALA B  67
LYS B  69
LEU B  89
PHE B 183
 None
 1.23A 3og7A-2qkwB:
24.3		 3og7A-2qkwB:
28.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SXR_B_1N1B2_1
(CYTOPLASMIC
TYROSINE-PROTEIN
KINASE BMX)		 2qkw PROTEIN KINASE
(Solanum
pimpinellifolium) 		6 / 12 VAL B  55
ALA B  67
VAL B  98
TYR B 116
GLY B 120
LEU B 171
 None
 0.44A 3sxrB-2qkwB:
25.2		 3sxrB-2qkwB:
26.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TI1_A_B49A299_1
(CYCLIN-DEPENDENT
KINASE 2)		 2qkw PROTEIN KINASE
(Solanum
pimpinellifolium) 		5 / 9 ILE B  47
ALA B  67
VAL B  98
LYS B 123
LEU B 171
 None
 0.98A 3ti1A-2qkwB:
20.3		 3ti1A-2qkwB:
25.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3V5W_A_8PRA701_1
(G-PROTEIN COUPLED
RECEPTOR KINASE 2)		 2qkw PROTEIN KINASE
(Solanum
pimpinellifolium) 		7 / 12 GLY B  50
GLY B  53
VAL B  55
ALA B  67
LYS B  69
VAL B  98
LEU B 171
 None
 1.08A 3v5wA-2qkwB:
22.7		 3v5wA-2qkwB:
20.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3V5W_A_8PRA701_1
(G-PROTEIN COUPLED
RECEPTOR KINASE 2)		 2qkw PROTEIN KINASE
(Solanum
pimpinellifolium) 		6 / 12 ILE B  47
GLY B  50
GLY B  53
VAL B  55
ALA B  67
LYS B  69
 None
 0.72A 3v5wA-2qkwB:
22.7		 3v5wA-2qkwB:
20.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3VW1_D_CVID301_1
(PUTATIVE REGULATORY
PROTEIN)		 2qkw AVIRULENCE PROTEIN
(Pseudomonas
syringae) 		3 / 3 TYR A  69
MET A 109
LEU A  80
 None
 0.89A 3vw1D-2qkwA:
undetectable		 3vw1D-2qkwA:
21.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ANQ_A_VGHA9000_1
(ALK TYROSINE KINASE
RECEPTOR)		 2qkw PROTEIN KINASE
(Solanum
pimpinellifolium) 		6 / 9 VAL B  55
ALA B  67
MET B 117
GLY B 120
LEU B 171
ASP B 182
 None
 0.56A 4anqA-2qkwB:
24.2		 4anqA-2qkwB:
27.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ANS_A_VGHA9000_1
(ALK TYROSINE KINASE
RECEPTOR)		 2qkw PROTEIN KINASE
(Solanum
pimpinellifolium) 		6 / 9 VAL B  55
ALA B  67
MET B 117
GLY B 120
LEU B 171
ASP B 182
 None
 0.61A 4ansA-2qkwB:
24.1		 4ansA-2qkwB:
27.20
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4C8B_A_0LIA1000_2
(RECEPTOR-INTERACTING
SERINE/THREONINE-PRO
TEIN KINASE 2)		 2qkw PROTEIN KINASE
(Solanum
pimpinellifolium) 		5 / 5 VAL B  55
ILE B 180
TYR B 116
MET B 117
ILE B 170
 None
 1.16A 4c8bA-2qkwB:
24.8		 4c8bA-2qkwB:
30.09
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4C8B_B_0LIB1000_2
(RECEPTOR-INTERACTING
SERINE/THREONINE-PRO
TEIN KINASE 2)		 2qkw PROTEIN KINASE
(Solanum
pimpinellifolium) 		3 / 3 TYR B 116
MET B 117
ILE B 180
 None
 0.44A 4c8bB-2qkwB:
24.6		 4c8bB-2qkwB:
30.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4HJO_A_AQ4A1001_1
(EPIDERMAL GROWTH
FACTOR RECEPTOR)		 2qkw PROTEIN KINASE
(Solanum
pimpinellifolium) 		6 / 12 VAL B  55
ALA B  67
MET B 117
GLY B 120
LEU B 171
THR B 181
 None
 0.33A 4hjoA-2qkwB:
23.0		 4hjoA-2qkwB:
26.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4I22_A_IREA9001_1
(EPIDERMAL GROWTH
FACTOR RECEPTOR)		 2qkw PROTEIN KINASE
(Solanum
pimpinellifolium) 		8 / 12 GLY B  48
VAL B  55
ALA B  67
LEU B 112
GLY B 120
LEU B 171
THR B 181
ASP B 182
 None
 0.74A 4i22A-2qkwB:
22.2		 4i22A-2qkwB:
26.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KS8_A_B49A701_1
(SERINE/THREONINE-PRO
TEIN KINASE PAK 6)		 2qkw PROTEIN KINASE
(Solanum
pimpinellifolium) 		5 / 10 ILE B  47
ALA B  67
VAL B  98
GLY B 120
LEU B 171
 None
 0.24A 4ks8A-2qkwB:
25.8		 4ks8A-2qkwB:
26.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4L9I_A_8PRA601_1
(RHODOPSIN KINASE)		 2qkw PROTEIN KINASE
(Solanum
pimpinellifolium) 		4 / 7 VAL B  55
ALA B  67
MET B 117
LEU B 171
 None
 0.73A 4l9iA-2qkwB:
19.3		 4l9iA-2qkwB:
22.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4L9I_B_8PRB601_1
(RHODOPSIN KINASE)		 2qkw PROTEIN KINASE
(Solanum
pimpinellifolium) 		6 / 8 GLY B  50
VAL B  55
ALA B  67
LYS B  69
MET B 117
LEU B 171
 None
 0.89A 4l9iB-2qkwB:
17.2		 4l9iB-2qkwB:
22.11
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4MXX_B_DB8B601_1
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE SRC)		 2qkw PROTEIN KINASE
(Solanum
pimpinellifolium) 		8 / 12 VAL B  55
ALA B  67
VAL B  98
TYR B 116
MET B 117
GLY B 120
LEU B 171
THR B 181
 None
 0.75A 4mxxB-2qkwB:
23.5		 4mxxB-2qkwB:
30.40
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4MXY_A_DB8A601_1
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE SRC)		 2qkw PROTEIN KINASE
(Solanum
pimpinellifolium) 		8 / 12 VAL B  55
ALA B  67
GLU B  85
VAL B  98
TYR B 116
GLY B 120
LEU B 171
ASP B 182
 None
 0.66A 4mxyA-2qkwB:
26.0		 4mxyA-2qkwB:
30.40
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4MXY_B_DB8B601_1
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE SRC)		 2qkw PROTEIN KINASE
(Solanum
pimpinellifolium) 		8 / 12 VAL B  55
ALA B  67
GLU B  85
VAL B  98
TYR B 116
GLY B 120
LEU B 171
ASP B 182
 None
 0.69A 4mxyB-2qkwB:
20.6		 4mxyB-2qkwB:
30.40
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4MXZ_A_DB8A601_1
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE SRC)		 2qkw PROTEIN KINASE
(Solanum
pimpinellifolium) 		8 / 12 VAL B  55
ALA B  67
GLU B  85
VAL B  98
TYR B 116
GLY B 120
LEU B 171
ASP B 182
 None
 0.66A 4mxzA-2qkwB:
26.0		 4mxzA-2qkwB:
30.40
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4MXZ_B_DB8B601_1
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE SRC)		 2qkw PROTEIN KINASE
(Solanum
pimpinellifolium) 		8 / 12 VAL B  55
ALA B  67
GLU B  85
VAL B  98
TYR B 116
GLY B 120
LEU B 171
ASP B 182
 None
 0.69A 4mxzB-2qkwB:
20.6		 4mxzB-2qkwB:
30.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QMN_A_DB8A401_1
(SERINE/THREONINE-PRO
TEIN KINASE 24)		 2qkw PROTEIN KINASE
(Solanum
pimpinellifolium) 		6 / 12 ILE B  47
ALA B  67
GLU B  85
TYR B 116
LEU B 171
ASP B 182
 None
 0.83A 4qmnA-2qkwB:
25.9		 4qmnA-2qkwB:
28.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QMZ_A_B49A401_1
(SERINE/THREONINE-PRO
TEIN KINASE 24)		 2qkw PROTEIN KINASE
(Solanum
pimpinellifolium) 		6 / 12 ILE B  47
GLY B  48
VAL B  55
ALA B  67
TYR B 116
LEU B 171
 None
 0.59A 4qmzA-2qkwB:
26.3		 4qmzA-2qkwB:
28.87
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4U5J_A_RXTA601_1
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE SRC)		 2qkw PROTEIN KINASE
(Solanum
pimpinellifolium) 		9 / 11 GLY B  50
VAL B  55
ALA B  67
TYR B 116
MET B 117
GLY B 120
ASN B 169
LEU B 171
ASP B 182
 None
 0.54A 4u5jA-2qkwB:
26.5		 4u5jA-2qkwB:
30.18
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4U5J_B_RXTB601_1
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE SRC)		 2qkw PROTEIN KINASE
(Solanum
pimpinellifolium) 		7 / 9 VAL B  55
ALA B  67
TYR B 116
MET B 117
GLY B 120
LEU B 171
ASP B 182
 None
 0.75A 4u5jB-2qkwB:
25.6		 4u5jB-2qkwB:
30.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XLI_A_1N1A601_1
(NON-SPECIFIC
PROTEIN-TYROSINE
KINASE)		 2qkw PROTEIN KINASE
(Solanum
pimpinellifolium) 		7 / 12 ALA B  67
GLU B  85
VAL B  98
TYR B 116
MET B 117
GLY B 120
LEU B 171
 None
 0.63A 4xliA-2qkwB:
27.1		 4xliA-2qkwB:
26.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5AAA_A_VGHA9000_1
(ALK TYROSINE KINASE
RECEPTOR)		 2qkw PROTEIN KINASE
(Solanum
pimpinellifolium) 		6 / 9 VAL B  55
ALA B  67
MET B 117
GLY B 120
LEU B 171
ASP B 182
 None
 0.51A 5aaaA-2qkwB:
24.6		 5aaaA-2qkwB:
27.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5AAC_A_VGHA9000_1
(ALK TYROSINE KINASE
RECEPTOR)		 2qkw PROTEIN KINASE
(Solanum
pimpinellifolium) 		6 / 10 VAL B  55
ALA B  67
MET B 117
GLY B 120
LEU B 171
ASP B 182
 None
 0.54A 5aacA-2qkwB:
24.2		 5aacA-2qkwB:
27.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5AJQ_B_DB8B800_1
(SERINE/THREONINE-PRO
TEIN KINASE 10)		 2qkw PROTEIN KINASE
(Solanum
pimpinellifolium) 		4 / 10 ALA B  67
GLY B 120
LEU B 171
ASP B 182
 None
 0.34A 5ajqB-2qkwB:
20.7		 5ajqB-2qkwB:
27.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5I9X_A_DB8A1001_1
(EPHRIN TYPE-A
RECEPTOR 2)		 2qkw PROTEIN KINASE
(Solanum
pimpinellifolium) 		6 / 12 ILE B  47
ALA B  67
GLU B  85
TYR B 116
GLY B 120
LEU B 171
 None
 0.52A 5i9xA-2qkwB:
24.6		 5i9xA-2qkwB:
28.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5I9Y_A_1N1A1001_1
(EPHRIN TYPE-A
RECEPTOR 2)		 2qkw PROTEIN KINASE
(Solanum
pimpinellifolium) 		6 / 12 ILE B  47
ALA B  67
GLU B  85
TYR B 116
GLY B 120
LEU B 171
 None
 0.50A 5i9yA-2qkwB:
24.4		 5i9yA-2qkwB:
28.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5I9Y_A_1N1A1001_1
(EPHRIN TYPE-A
RECEPTOR 2)		 2qkw PROTEIN KINASE
(Solanum
pimpinellifolium) 		6 / 12 ILE B  47
ALA B  67
LYS B  69
GLU B  85
TYR B 116
GLY B 120
 None
 0.67A 5i9yA-2qkwB:
24.4		 5i9yA-2qkwB:
28.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5LW1_B_ADNB401_1
(MITOGEN-ACTIVATED
PROTEIN KINASE 8)		 2qkw PROTEIN KINASE
(Solanum
pimpinellifolium) 		6 / 9 ILE B  47
GLY B  48
VAL B  55
ALA B  67
MET B 117
ASN B 121
 None
 0.52A 5lw1B-2qkwB:
14.2		 5lw1B-2qkwB:
13.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5LW1_E_ADNE401_1
(MITOGEN-ACTIVATED
PROTEIN KINASE 8)		 2qkw PROTEIN KINASE
(Solanum
pimpinellifolium) 		5 / 10 GLY B  48
VAL B  55
ALA B  67
MET B 117
ASN B 121
 None
 0.46A 5lw1E-2qkwB:
15.2		 5lw1E-2qkwB:
13.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5LW1_H_ADNH401_1
(MITOGEN-ACTIVATED
PROTEIN KINASE 8)		 2qkw PROTEIN KINASE
(Solanum
pimpinellifolium) 		5 / 9 GLY B  48
VAL B  55
ALA B  67
MET B 117
ASN B 121
 None
 0.40A 5lw1H-2qkwB:
20.9		 5lw1H-2qkwB:
13.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5MAF_A_XINA403_1
(MATERNAL EMBRYONIC
LEUCINE ZIPPER
KINASE)		 2qkw PROTEIN KINASE
(Solanum
pimpinellifolium) 		8 / 12 ILE B  47
GLY B  48
VAL B  55
ALA B  67
LYS B  69
GLU B  85
TYR B 116
GLY B 120
 None
 0.60A 5mafA-2qkwB:
23.5		 5mafA-2qkwB:
15.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5MO4_A_NILA601_2
(TYROSINE-PROTEIN
KINASE ABL1)		 2qkw PROTEIN KINASE
(Solanum
pimpinellifolium) 		5 / 12 ALA B  67
LEU B  97
VAL B  98
HIS B 162
LEU B 171
 None
 0.64A 5mo4A-2qkwB:
20.1		 5mo4A-2qkwB:
21.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5N3H_A_NCAA401_0
(CAMP-DEPENDENT
PROTEIN KINASE
CATALYTIC SUBUNIT
ALPHA)		 2qkw PROTEIN KINASE
(Solanum
pimpinellifolium) 		6 / 10 VAL B  55
ALA B  67
VAL B  98
TYR B 116
LEU B 171
THR B 181
 None
 0.67A 5n3hA-2qkwB:
22.9		 5n3hA-2qkwB:
24.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VC3_A_DB8A601_1
(WEE1-LIKE PROTEIN
KINASE)		 2qkw PROTEIN KINASE
(Solanum
pimpinellifolium) 		7 / 12 ILE B  47
GLY B  48
ALA B  67
GLU B  85
TYR B 116
GLY B 120
ASP B 182
 None
 0.82A 5vc3A-2qkwB:
19.2		 5vc3A-2qkwB:
24.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5YU9_A_1E8A1101_1
(EPIDERMAL GROWTH
FACTOR RECEPTOR)		 2qkw PROTEIN KINASE
(Solanum
pimpinellifolium) 		7 / 12 GLY B  48
VAL B  55
ALA B  67
LYS B  69
LEU B 112
LEU B 171
THR B 181
 None
 0.85A 5yu9A-2qkwB:
22.1		 5yu9A-2qkwB:
15.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5YU9_B_1E8B1101_1
(EPIDERMAL GROWTH
FACTOR RECEPTOR)		 2qkw PROTEIN KINASE
(Solanum
pimpinellifolium) 		7 / 12 GLY B  48
VAL B  55
ALA B  67
LYS B  69
LEU B 112
LEU B 171
THR B 181
 None
 0.80A 5yu9B-2qkwB:
22.4		 5yu9B-2qkwB:
15.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5YU9_C_1E8C1101_1
(EPIDERMAL GROWTH
FACTOR RECEPTOR)		 2qkw PROTEIN KINASE
(Solanum
pimpinellifolium) 		6 / 12 VAL B  55
ALA B  67
LYS B  69
LEU B 112
GLY B 120
THR B 181
 None
 0.72A 5yu9C-2qkwB:
21.9		 5yu9C-2qkwB:
15.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5YU9_D_1E8D1101_1
(EPIDERMAL GROWTH
FACTOR RECEPTOR)		 2qkw PROTEIN KINASE
(Solanum
pimpinellifolium) 		6 / 12 VAL B  55
ALA B  67
LYS B  69
GLY B 120
LEU B 171
THR B 181
 None
 0.68A 5yu9D-2qkwB:
22.4		 5yu9D-2qkwB:
15.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ZV2_B_LEVB801_2
(FIBROBLAST GROWTH
FACTOR RECEPTOR 1)		 2qkw PROTEIN KINASE
(Solanum
pimpinellifolium) 		3 / 3 TYR B 116
LEU B 171
ASP B 182
 None
 0.70A 5zv2B-2qkwB:
23.3		 5zv2B-2qkwB:
15.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6FNM_A_1N1A1001_1
(-)		 2qkw PROTEIN KINASE
(Solanum
pimpinellifolium) 		8 / 12 ILE B  47
VAL B  55
ALA B  67
LYS B  69
GLU B  85
MET B 117
GLY B 120
LEU B 171
 None
 0.65A 6fnmA-2qkwB:
24.7		 6fnmA-2qkwB:
27.63