SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2qkx'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HXB_A_ROCA100_1
(HIV-1 PROTEASE)		 2qkx BIFUNCTIONAL PROTEIN
GLMU
(Mycobacterium
tuberculosis) 		5 / 12 GLY A 334
ALA A 335
ILE A 366
GLY A 367
ILE A 331
 None
 0.73A 1hxbA-2qkxA:
undetectable		 1hxbA-2qkxA:
15.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1T7J_A_478A200_1
(POL POLYPROTEIN)		 2qkx BIFUNCTIONAL PROTEIN
GLMU
(Mycobacterium
tuberculosis) 		5 / 11 LEU A 343
GLY A 356
VAL A 378
THR A 347
VAL A 361
 None
 0.89A 1t7jA-2qkxA:
undetectable		 1t7jA-2qkxA:
14.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1T86_A_CAMA1422_0
(CYTOCHROME P450-CAM)		 2qkx BIFUNCTIONAL PROTEIN
GLMU
(Mycobacterium
tuberculosis) 		4 / 8 THR A 111
LEU A  37
VAL A  40
VAL A   9
 None
 0.85A 1t86A-2qkxA:
undetectable		 1t86A-2qkxA:
23.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2AVS_B_MK1B902_3
(POL POLYPROTEIN)		 2qkx BIFUNCTIONAL PROTEIN
GLMU
(Mycobacterium
tuberculosis) 		5 / 12 GLY A 334
ALA A 319
VAL A 304
ILE A 298
GLY A 300
 None
 0.99A 2avsB-2qkxA:
undetectable		 2avsB-2qkxA:
14.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2FUM_D_MIXD3539_2
(PROBABLE
SERINE/THREONINE-PRO
TEIN KINASE PKNB)		 2qkx BIFUNCTIONAL PROTEIN
GLMU
(Mycobacterium
tuberculosis) 		3 / 3 VAL A 238
VAL A 242
ASP A  23
 None
 0.63A 2fumD-2qkxA:
undetectable		 2fumD-2qkxA:
23.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2GJ5_A_VD3A163_1
(BETA-LACTOGLOBULIN)		 2qkx BIFUNCTIONAL PROTEIN
GLMU
(Mycobacterium
tuberculosis) 		5 / 12 VAL A 359
LEU A 355
ILE A 366
ILE A 383
ALA A 381
 None
 0.89A 2gj5A-2qkxA:
undetectable		 2gj5A-2qkxA:
18.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OAX_D_SNLD4001_1
(MINERALOCORTICOID
RECEPTOR)		 2qkx BIFUNCTIONAL PROTEIN
GLMU
(Mycobacterium
tuberculosis) 		5 / 12 LEU A  52
LEU A 100
ALA A  99
ARG A 193
LEU A  12
 None
 1.33A 2oaxD-2qkxA:
undetectable		 2oaxD-2qkxA:
19.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OAX_E_SNLE5001_1
(MINERALOCORTICOID
RECEPTOR)		 2qkx BIFUNCTIONAL PROTEIN
GLMU
(Mycobacterium
tuberculosis) 		5 / 12 LEU A  52
LEU A 100
ALA A  99
ARG A 193
LEU A  12
 None
 1.36A 2oaxE-2qkxA:
undetectable		 2oaxE-2qkxA:
19.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QD2_A_CHDA426_0
(FERROCHELATASE)		 2qkx BIFUNCTIONAL PROTEIN
GLMU
(Mycobacterium
tuberculosis) 		4 / 4 LEU A 117
PRO A 116
LEU A 251
ARG A 253
 None
 1.37A 2qd2A-2qkxA:
2.4		 2qd2A-2qkxA:
21.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZUJ_A_CAMA422_0
(CAMPHOR
5-MONOOXYGENASE)		 2qkx BIFUNCTIONAL PROTEIN
GLMU
(Mycobacterium
tuberculosis) 		4 / 8 LEU A  28
VAL A  54
LEU A  56
VAL A  11
 None
 0.84A 2zujA-2qkxA:
undetectable		 2zujA-2qkxA:
23.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NU5_B_478B401_2
(PROTEASE)		 2qkx BIFUNCTIONAL PROTEIN
GLMU
(Mycobacterium
tuberculosis) 		5 / 12 GLY A 334
ALA A 319
VAL A 304
ILE A 298
GLY A 300
 None
 1.01A 3nu5B-2qkxA:
undetectable		 3nu5B-2qkxA:
14.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3S43_A_478A401_2
(PROTEASE)		 2qkx BIFUNCTIONAL PROTEIN
GLMU
(Mycobacterium
tuberculosis) 		5 / 10 LEU A 349
GLY A 334
ALA A 319
VAL A 304
ILE A 331
 None
 0.94A 3s43B-2qkxA:
undetectable		 3s43B-2qkxA:
13.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SI7_A_ACTA4_0
(CYSTIC FIBROSIS
TRANSMEMBRANE
CONDUCTANCE
REGULATOR)		 2qkx BIFUNCTIONAL PROTEIN
GLMU
(Mycobacterium
tuberculosis) 		4 / 4 LEU A 349
GLY A 350
GLY A 353
THR A 370
 None
 0.72A 3si7A-2qkxA:
undetectable		 3si7A-2qkxA:
21.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SI7_D_ACTD4_0
(CYSTIC FIBROSIS
TRANSMEMBRANE
CONDUCTANCE
REGULATOR)		 2qkx BIFUNCTIONAL PROTEIN
GLMU
(Mycobacterium
tuberculosis) 		4 / 5 LEU A 349
GLY A 350
GLY A 353
THR A 370
 None
 0.70A 3si7C-2qkxA:
undetectable
3si7D-2qkxA:
undetectable		 3si7C-2qkxA:
21.16
3si7D-2qkxA:
21.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ZOS_A_0LIA1004_1
(EPITHELIAL DISCOIDIN
DOMAIN-CONTAINING
RECEPTOR 1)		 2qkx BIFUNCTIONAL PROTEIN
GLMU
(Mycobacterium
tuberculosis) 		5 / 11 VAL A  27
ALA A  13
LEU A  37
VAL A  80
LEU A  56
 None
 0.98A 3zosA-2qkxA:
undetectable
3zosB-2qkxA:
undetectable		 3zosA-2qkxA:
22.94
3zosB-2qkxA:
22.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4C9L_A_CAMA1419_0
(CYTOCHROME P450)		 2qkx BIFUNCTIONAL PROTEIN
GLMU
(Mycobacterium
tuberculosis) 		5 / 12 ILE A  78
LEU A  37
GLY A 113
THR A 111
ILE A  53
 None
 1.01A 4c9lA-2qkxA:
undetectable		 4c9lA-2qkxA:
21.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4C9L_A_CAMA1419_0
(CYTOCHROME P450)		 2qkx BIFUNCTIONAL PROTEIN
GLMU
(Mycobacterium
tuberculosis) 		5 / 12 ILE A  78
LEU A  37
GLY A 113
THR A 111
VAL A   9
 None
 1.00A 4c9lA-2qkxA:
undetectable		 4c9lA-2qkxA:
21.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4C9L_B_CAMB1419_0
(CYTOCHROME P450)		 2qkx BIFUNCTIONAL PROTEIN
GLMU
(Mycobacterium
tuberculosis) 		5 / 12 ILE A  78
LEU A  37
GLY A 113
THR A 111
ILE A  53
 None
 0.97A 4c9lB-2qkxA:
undetectable		 4c9lB-2qkxA:
21.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4C9L_B_CAMB1419_0
(CYTOCHROME P450)		 2qkx BIFUNCTIONAL PROTEIN
GLMU
(Mycobacterium
tuberculosis) 		5 / 12 ILE A  78
LEU A  37
GLY A 113
THR A 111
VAL A   9
 None
 0.96A 4c9lB-2qkxA:
undetectable		 4c9lB-2qkxA:
21.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4C9O_A_CAMA423_0
(CYTOCHROME P450)		 2qkx BIFUNCTIONAL PROTEIN
GLMU
(Mycobacterium
tuberculosis) 		5 / 12 ILE A  78
LEU A  37
GLY A 113
THR A 111
VAL A   9
 None
 1.07A 4c9oA-2qkxA:
undetectable		 4c9oA-2qkxA:
22.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4C9O_B_CAMB423_0
(CYTOCHROME P450)		 2qkx BIFUNCTIONAL PROTEIN
GLMU
(Mycobacterium
tuberculosis) 		5 / 12 ILE A  78
LEU A  37
GLY A 113
THR A 111
VAL A   9
 None
 1.07A 4c9oB-2qkxA:
undetectable		 4c9oB-2qkxA:
22.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4D7H_A_H4BA902_1
(NITRIC OXIDE
SYNTHASE OXYGENASE)		 2qkx BIFUNCTIONAL PROTEIN
GLMU
(Mycobacterium
tuberculosis) 		3 / 3 ARG A 253
THR A 271
TRP A 273
 None
 1.22A 4d7hA-2qkxA:
undetectable		 4d7hA-2qkxA:
21.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4EM2_A_SALA502_1
(UNCHARACTERIZED
HTH-TYPE
TRANSCRIPTIONAL
REGULATOR SAR2349)		 2qkx BIFUNCTIONAL PROTEIN
GLMU
(Mycobacterium
tuberculosis) 		4 / 8 THR A 341
LEU A 343
VAL A 361
VAL A 359
 None
 1.00A 4em2A-2qkxA:
undetectable		 4em2A-2qkxA:
18.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MA7_A_P2ZA301_1
(MAJOR PRION PROTEIN)		 2qkx BIFUNCTIONAL PROTEIN
GLMU
(Mycobacterium
tuberculosis) 		4 / 8 VAL A  93
LEU A 210
ILE A 164
VAL A 224
 None
GN1  A 401 ( 4.9A)
None
None
 0.92A 4ma7A-2qkxA:
undetectable		 4ma7A-2qkxA:
14.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MBS_B_MRVB1101_2
(CHIMERA PROTEIN OF
C-C CHEMOKINE
RECEPTOR TYPE 5 AND
RUBREDOXIN)		 2qkx BIFUNCTIONAL PROTEIN
GLMU
(Mycobacterium
tuberculosis) 		4 / 5 TYR A 386
THR A 324
LEU A 343
THR A 365
 None
 1.28A 4mbsB-2qkxA:
undetectable		 4mbsB-2qkxA:
20.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MGH_A_ACTA1320_0
(PHOSPHORIBOSYLFORMYL
GLYCINAMIDINE
SYNTHASE)		 2qkx BIFUNCTIONAL PROTEIN
GLMU
(Mycobacterium
tuberculosis) 		4 / 5 LEU A 100
ILE A  53
LEU A  52
ARG A  51
 None
 0.81A 4mghA-2qkxA:
undetectable		 4mghA-2qkxA:
16.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4N48_A_SAMA601_0
(CAP-SPECIFIC MRNA
(NUCLEOSIDE-2'-O-)-M
ETHYLTRANSFERASE 1)		 2qkx BIFUNCTIONAL PROTEIN
GLMU
(Mycobacterium
tuberculosis) 		5 / 12 GLY A  15
PRO A  16
GLY A  17
LEU A  56
GLY A 113
 None
 1.23A 4n48A-2qkxA:
undetectable		 4n48A-2qkxA:
21.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4OK1_A_198A1001_1
(ANDROGEN RECEPTOR)		 2qkx BIFUNCTIONAL PROTEIN
GLMU
(Mycobacterium
tuberculosis) 		5 / 12 LEU A 100
LEU A  97
GLY A  96
LEU A  12
VAL A 109
 None
 1.00A 4ok1A-2qkxA:
undetectable		 4ok1A-2qkxA:
21.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4OLM_A_198A1001_1
(ANDROGEN RECEPTOR)		 2qkx BIFUNCTIONAL PROTEIN
GLMU
(Mycobacterium
tuberculosis) 		5 / 12 LEU A 100
LEU A  97
GLY A  96
LEU A  12
VAL A 109
 None
 1.13A 4olmA-2qkxA:
undetectable		 4olmA-2qkxA:
21.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4UG5_A_H4BA902_1
(NITRIC OXIDE
SYNTHASE OXYGENASE)		 2qkx BIFUNCTIONAL PROTEIN
GLMU
(Mycobacterium
tuberculosis) 		3 / 3 ARG A 253
THR A 271
TRP A 273
 None
 1.16A 4ug5A-2qkxA:
undetectable		 4ug5A-2qkxA:
21.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4UGL_A_H4BA902_1
(NITRIC OXIDE
SYNTHASE)		 2qkx BIFUNCTIONAL PROTEIN
GLMU
(Mycobacterium
tuberculosis) 		3 / 3 ARG A 253
THR A 271
TRP A 273
 None
 1.18A 4uglA-2qkxA:
undetectable		 4uglA-2qkxA:
21.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4YB6_A_HISA302_0
(ATP
PHOSPHORIBOSYLTRANSF
ERASE)		 2qkx BIFUNCTIONAL PROTEIN
GLMU
(Mycobacterium
tuberculosis) 		5 / 10 GLY A 379
VAL A 378
THR A 365
VAL A 361
LEU A 355
 None
 1.30A 4yb6A-2qkxA:
undetectable
4yb6E-2qkxA:
undetectable		 4yb6A-2qkxA:
21.22
4yb6E-2qkxA:
21.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4YB6_B_HISB302_0
(ATP
PHOSPHORIBOSYLTRANSF
ERASE)		 2qkx BIFUNCTIONAL PROTEIN
GLMU
(Mycobacterium
tuberculosis) 		5 / 10 GLY A 379
VAL A 378
THR A 365
VAL A 361
LEU A 355
 None
 1.30A 4yb6B-2qkxA:
undetectable
4yb6C-2qkxA:
undetectable		 4yb6B-2qkxA:
21.22
4yb6C-2qkxA:
21.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4YB6_C_HISC302_0
(ATP
PHOSPHORIBOSYLTRANSF
ERASE)		 2qkx BIFUNCTIONAL PROTEIN
GLMU
(Mycobacterium
tuberculosis) 		5 / 10 GLY A 379
VAL A 378
THR A 365
VAL A 361
LEU A 355
 None
 1.34A 4yb6C-2qkxA:
undetectable
4yb6F-2qkxA:
undetectable		 4yb6C-2qkxA:
21.22
4yb6F-2qkxA:
21.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4YB6_D_HISD302_0
(ATP
PHOSPHORIBOSYLTRANSF
ERASE)		 2qkx BIFUNCTIONAL PROTEIN
GLMU
(Mycobacterium
tuberculosis) 		5 / 10 LEU A 355
GLY A 379
VAL A 378
THR A 365
VAL A 361
 None
 1.35A 4yb6A-2qkxA:
undetectable
4yb6D-2qkxA:
undetectable		 4yb6A-2qkxA:
21.22
4yb6D-2qkxA:
21.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4YB6_E_HISE302_0
(ATP
PHOSPHORIBOSYLTRANSF
ERASE)		 2qkx BIFUNCTIONAL PROTEIN
GLMU
(Mycobacterium
tuberculosis) 		5 / 10 LEU A 355
GLY A 379
VAL A 378
THR A 365
VAL A 361
 None
 1.34A 4yb6D-2qkxA:
undetectable
4yb6E-2qkxA:
undetectable		 4yb6D-2qkxA:
21.22
4yb6E-2qkxA:
21.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4YB6_F_HISF302_0
(ATP
PHOSPHORIBOSYLTRANSF
ERASE)		 2qkx BIFUNCTIONAL PROTEIN
GLMU
(Mycobacterium
tuberculosis) 		5 / 10 LEU A 355
GLY A 379
VAL A 378
THR A 365
VAL A 361
 None
 1.29A 4yb6B-2qkxA:
undetectable
4yb6F-2qkxA:
undetectable		 4yb6B-2qkxA:
21.22
4yb6F-2qkxA:
21.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ZF8_A_MYTA502_1
(BIFUNCTIONAL
P-450/NADPH-P450
REDUCTASE)		 2qkx BIFUNCTIONAL PROTEIN
GLMU
(Mycobacterium
tuberculosis) 		5 / 6 VAL A  80
LEU A  37
ILE A  63
ALA A  64
ALA A  71
 None
 0.93A 4zf8A-2qkxA:
undetectable		 4zf8A-2qkxA:
24.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5G6C_A_H4BA902_1
(NITRIC OXIDE
SYNTHASE OXYGENASE)		 2qkx BIFUNCTIONAL PROTEIN
GLMU
(Mycobacterium
tuberculosis) 		3 / 3 ARG A 253
THR A 271
TRP A 273
 None
 1.21A 5g6cA-2qkxA:
undetectable		 5g6cA-2qkxA:
21.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5LG3_F_Z80F401_1
(GAMMA-AMINOBUTYRIC-A
CID RECEPTOR SUBUNIT
BETA-1)		 2qkx BIFUNCTIONAL PROTEIN
GLMU
(Mycobacterium
tuberculosis) 		5 / 10 ILE A 274
ILE A 286
VAL A 278
THR A 296
ILE A 298
 None
 1.28A 5lg3F-2qkxA:
undetectable		 5lg3F-2qkxA:
22.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5LG3_G_Z80G401_1
(GAMMA-AMINOBUTYRIC-A
CID RECEPTOR SUBUNIT
BETA-1)		 2qkx BIFUNCTIONAL PROTEIN
GLMU
(Mycobacterium
tuberculosis) 		5 / 10 ILE A 274
ILE A 286
VAL A 278
THR A 296
ILE A 298
 None
 1.24A 5lg3G-2qkxA:
undetectable		 5lg3G-2qkxA:
22.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UUN_A_ACTA305_0
(GLUTATHIONE
S-TRANSFERASE-LIKE
PROTEIN)		 2qkx BIFUNCTIONAL PROTEIN
GLMU
(Mycobacterium
tuberculosis) 		3 / 3 THR A  30
MET A  36
HIS A  39
 None
 0.89A 5uunA-2qkxA:
undetectable		 5uunA-2qkxA:
22.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ZNI_A_YMZA302_0
(PURINE NUCLEOSIDE
PHOSPHORYLASE)		 2qkx BIFUNCTIONAL PROTEIN
GLMU
(Mycobacterium
tuberculosis) 		5 / 9 VAL A 137
GLY A  90
TYR A 185
VAL A  93
ASP A 212
 None
 1.20A 5zniA-2qkxA:
3.2		 5zniA-2qkxA:
11.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6H1L_A_FJQA501_0
(BIFUNCTIONAL
CYTOCHROME
P450/NADPH--P450
REDUCTASE)		 2qkx BIFUNCTIONAL PROTEIN
GLMU
(Mycobacterium
tuberculosis) 		5 / 10 LEU A 192
VAL A 108
VAL A  93
ILE A  53
LEU A 100
 None
 1.20A 6h1lA-2qkxA:
undetectable		 6h1lA-2qkxA:
22.38