SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2ql2'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ERR_B_RALB600_1
(ESTROGEN RECEPTOR)		 2ql2 NEUROGENIC
DIFFERENTIATION
FACTOR 1
TRANSCRIPTION FACTOR
E2-ALPHA
(Mus
musculus) 		5 / 12 ALA A 561
GLU A 564
LEU A 565
LEU B 124
LEU A 585
 None
 1.00A 1errB-2ql2A:
undetectable		 1errB-2ql2A:
14.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2J5M_A_ACTA1321_0
(CHLOROPEROXIDASE)		 2ql2 TRANSCRIPTION FACTOR
E2-ALPHA
NEUROGENIC
DIFFERENTIATION
FACTOR 1
(Mus
musculus;
Mus
musculus) 		4 / 6 LEU B 124
PHE A 562
ILE A 584
ALA A 588
 None
 0.84A 2j5mA-2ql2B:
undetectable		 2j5mA-2ql2B:
15.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4EIX_A_NIMA201_1
(PHOSPHOLIPASE A2
VRV-PL-VIIIA)		 2ql2 NEUROGENIC
DIFFERENTIATION
FACTOR 1
TRANSCRIPTION FACTOR
E2-ALPHA
(Mus
musculus) 		4 / 4 LEU B 143
ALA A 588
ILE A 584
LYS B 139
 None
 1.14A 4eixA-2ql2B:
undetectable		 4eixA-2ql2B:
16.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4O7G_A_ASCA303_0
(PROBABLE
TRANSMEMBRANE
ASCORBATE
FERRIREDUCTASE 2)		 2ql2 TRANSCRIPTION FACTOR
E2-ALPHA
NEUROGENIC
DIFFERENTIATION
FACTOR 1
(Mus
musculus;
Mus
musculus) 		4 / 7 PHE A 562
ILE A 558
ASN B 118
ARG A 554
 None
 1.18A 4o7gA-2ql2A:
undetectable
4o7gB-2ql2A:
undetectable		 4o7gA-2ql2A:
14.66
4o7gB-2ql2A:
14.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HW8_C_FK5C201_1
(FK506-BINDING
PROTEIN 1)		 2ql2 NEUROGENIC
DIFFERENTIATION
FACTOR 1
TRANSCRIPTION FACTOR
E2-ALPHA
(Mus
musculus) 		5 / 10 ARG B 113
VAL A 555
ILE A 558
LEU B 143
PHE A 562
 None
 1.24A 5hw8C-2ql2B:
undetectable
5hw8H-2ql2B:
undetectable		 5hw8C-2ql2B:
16.95
5hw8H-2ql2B:
16.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6A60_D_9CRD501_0
(RETINOIC ACID
RECEPTOR RXR-ALPHA)		 2ql2 TRANSCRIPTION FACTOR
E2-ALPHA
NEUROGENIC
DIFFERENTIATION
FACTOR 1
(Mus
musculus;
Mus
musculus) 		5 / 12 LEU A 583
ILE B 150
CYH A 569
HIS A 572
LEU A 573
 None
 1.02A 6a60D-2ql2A:
undetectable		 6a60D-2ql2A:
25.29