SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2ql3'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1J7K_A_ACTA701_0
(HOLLIDAY JUNCTION
DNA HELICASE RUVB)		 2ql3 PROBABLE
TRANSCRIPTIONAL
REGULATOR, LYSR
FAMILY PROTEIN
(Rhodococcus
jostii) 		4 / 4 GLY A 242
LEU A 263
GLY A 244
ARG A 243
 None
 1.27A 1j7kA-2ql3A:
undetectable		 1j7kA-2ql3A:
21.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2JN3_A_JN3A131_1
(FATTY ACID-BINDING
PROTEIN, LIVER)		 2ql3 PROBABLE
TRANSCRIPTIONAL
REGULATOR, LYSR
FAMILY PROTEIN
(Rhodococcus
jostii) 		5 / 12 VAL A 301
ILE A 155
LEU A 111
CYH A 107
VAL A 105
 None
 1.29A 2jn3A-2ql3A:
undetectable		 2jn3A-2ql3A:
18.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OZ7_A_CA4A1_2
(ANDROGEN RECEPTOR)		 2ql3 PROBABLE
TRANSCRIPTIONAL
REGULATOR, LYSR
FAMILY PROTEIN
(Rhodococcus
jostii) 		4 / 6 LEU A 251
TRP A 247
MET A 202
LEU A 204
 None
 1.18A 2oz7A-2ql3A:
undetectable		 2oz7A-2ql3A:
19.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KP6_B_SALB3008_1
(TRANSCRIPTIONAL
REGULATOR TCAR)		 2ql3 PROBABLE
TRANSCRIPTIONAL
REGULATOR, LYSR
FAMILY PROTEIN
(Rhodococcus
jostii) 		4 / 7 GLU A 133
VAL A 105
VAL A 293
ALA A 130
 None
 1.04A 3kp6B-2ql3A:
undetectable		 3kp6B-2ql3A:
21.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NDT_A_ROCA101_2
(PROTEASE)		 2ql3 PROBABLE
TRANSCRIPTIONAL
REGULATOR, LYSR
FAMILY PROTEIN
(Rhodococcus
jostii) 		3 / 3 ARG A 230
VAL A 241
THR A 248
 None
 0.82A 3ndtA-2ql3A:
undetectable		 3ndtA-2ql3A:
17.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4NC3_A_ERMA1202_1
(CHIMERA PROTEIN OF
HUMAN
5-HYDROXYTRYPTAMINE
RECEPTOR 2B AND E.
COLI SOLUBLE
CYTOCHROME B562)		 2ql3 PROBABLE
TRANSCRIPTIONAL
REGULATOR, LYSR
FAMILY PROTEIN
(Rhodococcus
jostii) 		5 / 12 LEU A 111
SER A 118
VAL A 156
PHE A 134
VAL A 301
 None
 1.30A 4nc3A-2ql3A:
undetectable		 4nc3A-2ql3A:
18.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4NC3_A_ERMA1202_1
(CHIMERA PROTEIN OF
HUMAN
5-HYDROXYTRYPTAMINE
RECEPTOR 2B AND E.
COLI SOLUBLE
CYTOCHROME B562)		 2ql3 PROBABLE
TRANSCRIPTIONAL
REGULATOR, LYSR
FAMILY PROTEIN
(Rhodococcus
jostii) 		5 / 12 LEU A 111
VAL A 156
PHE A 134
PHE A 297
VAL A 301
 None
 1.32A 4nc3A-2ql3A:
undetectable		 4nc3A-2ql3A:
18.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5DBY_A_ACTA617_0
(SERUM ALBUMIN)		 2ql3 PROBABLE
TRANSCRIPTIONAL
REGULATOR, LYSR
FAMILY PROTEIN
(Rhodococcus
jostii) 		3 / 3 TRP A 165
ARG A 143
LEU A 151
 None
 0.88A 5dbyA-2ql3A:
undetectable		 5dbyA-2ql3A:
17.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HBS_A_RTLA201_0
(RETINOL-BINDING
PROTEIN 1)		 2ql3 PROBABLE
TRANSCRIPTIONAL
REGULATOR, LYSR
FAMILY PROTEIN
(Rhodococcus
jostii) 		5 / 12 PHE A 234
LEU A 111
ALA A 110
ILE A 270
SER A 210
 None
 1.20A 5hbsA-2ql3A:
undetectable		 5hbsA-2ql3A:
21.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5M0O_A_EPAA502_1
(TERMINAL
OLEFIN-FORMING FATTY
ACID DECARBOXYLASE)		 2ql3 PROBABLE
TRANSCRIPTIONAL
REGULATOR, LYSR
FAMILY PROTEIN
(Rhodococcus
jostii) 		5 / 10 PRO A 225
LEU A 197
PRO A 184
ALA A 186
VAL A 241
 None
 1.27A 5m0oA-2ql3A:
undetectable		 5m0oA-2ql3A:
20.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6CZM_A_HISA402_0
(ATP
PHOSPHORIBOSYLTRANSF
ERASE CATALYTIC
SUBUNIT)		 2ql3 PROBABLE
TRANSCRIPTIONAL
REGULATOR, LYSR
FAMILY PROTEIN
(Rhodococcus
jostii) 		5 / 10 GLY A 180
THR A 248
VAL A 178
VAL A 203
ALA A 237
 None
 1.04A 6czmA-2ql3A:
8.4
6czmC-2ql3A:
7.5		 6czmA-2ql3A:
21.99
6czmC-2ql3A:
21.99