SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2ql6'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1FO4_B_SALB4005_1
(XANTHINE
DEHYDROGENASE)		 2ql6 NICOTINAMIDE
RIBOSIDE KINASE 1
(Homo
sapiens) 		4 / 7 ARG A 129
PHE A 143
THR A  12
VAL A  11
 TIZ  A 302 ( 2.8A)
None
TIZ  A 302 ( 4.2A)
None
 1.01A 1fo4B-2ql6A:
undetectable		 1fo4B-2ql6A:
9.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2X7H_A_PFNA1375_1
(ZINC-BINDING ALCOHOL
DEHYDROGENASE
DOMAIN-CONTAINING
PROTEIN 2)		 2ql6 NICOTINAMIDE
RIBOSIDE KINASE 1
(Homo
sapiens) 		4 / 5 SER A   9
TYR A 154
PHE A 117
VAL A 165
 None
 1.01A 2x7hA-2ql6A:
undetectable		 2x7hA-2ql6A:
20.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2X7H_B_PFNB1372_1
(ZINC-BINDING ALCOHOL
DEHYDROGENASE
DOMAIN-CONTAINING
PROTEIN 2)		 2ql6 NICOTINAMIDE
RIBOSIDE KINASE 1
(Homo
sapiens) 		4 / 5 SER A   9
TYR A 154
PHE A 117
VAL A 165
 None
 0.99A 2x7hB-2ql6A:
undetectable		 2x7hB-2ql6A:
20.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LP9_D_SPMD230_1
(LS-24)		 2ql6 NICOTINAMIDE
RIBOSIDE KINASE 1
(Homo
sapiens) 		3 / 3 GLU A  44
GLU A  64
ASN A  62
 None
 0.84A 3lp9B-2ql6A:
undetectable
3lp9D-2ql6A:
undetectable		 3lp9B-2ql6A:
20.40
3lp9D-2ql6A:
20.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3N8Y_A_DIFA701_1
(PROSTAGLANDIN G/H
SYNTHASE 1)		 2ql6 NICOTINAMIDE
RIBOSIDE KINASE 1
(Homo
sapiens) 		5 / 11 VAL A 181
LEU A 185
ILE A  96
GLY A   7
LEU A 118
 None
 0.95A 3n8yA-2ql6A:
undetectable		 3n8yA-2ql6A:
15.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UNI_A_SALA1344_1
(XANTHINE
DEHYDROGENASE/OXIDAS
E)		 2ql6 NICOTINAMIDE
RIBOSIDE KINASE 1
(Homo
sapiens) 		4 / 7 ARG A 129
PHE A 143
THR A  12
VAL A  11
 TIZ  A 302 ( 2.8A)
None
TIZ  A 302 ( 4.2A)
None
 1.00A 3uniA-2ql6A:
undetectable		 3uniA-2ql6A:
9.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4TVT_A_ASCA301_0
(THAUMATIN-1)		 2ql6 NICOTINAMIDE
RIBOSIDE KINASE 1
(Homo
sapiens) 		3 / 3 THR A  12
ASN A  13
SER A  14
 TIZ  A 302 ( 4.2A)
ADP  A 301 ( 4.1A)
ADP  A 301 ( 3.4A)
 0.76A 4tvtA-2ql6A:
undetectable		 4tvtA-2ql6A:
18.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5NR3_A_95EA401_0
(DNA
(CYTOSINE-5)-METHYLT
RANSFERASE 3B)		 2ql6 NICOTINAMIDE
RIBOSIDE KINASE 1
(Homo
sapiens) 		4 / 7 ILE A 161
PHE A 103
TRP A 112
TRP A 163
 None
 1.28A 5nr3A-2ql6A:
undetectable		 5nr3A-2ql6A:
21.78