SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2qlp'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1I00_A_D16A315_1
(THYMIDYLATE SYNTHASE)		 2qlp DEOXYCYTIDINE
TRIPHOSPHATE
DEAMINASE
(Mycobacterium
tuberculosis) 		5 / 9 GLU A  86
ILE A  32
LEU A  17
GLY A  18
PHE A  88
 None
 1.31A 1i00A-2qlpA:
undetectable		 1i00A-2qlpA:
21.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2TSR_C_D16C509_1
(THYMIDYLATE SYNTHASE)		 2qlp DEOXYCYTIDINE
TRIPHOSPHATE
DEAMINASE
(Mycobacterium
tuberculosis) 		5 / 10 GLU A  86
ILE A  32
LEU A  17
GLY A  18
PHE A  88
 None
 1.29A 2tsrC-2qlpA:
undetectable		 2tsrC-2qlpA:
22.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LM8_A_VIBA223_1
(THIAMINE
PYROPHOSPHOKINASE)		 2qlp DEOXYCYTIDINE
TRIPHOSPHATE
DEAMINASE
(Mycobacterium
tuberculosis) 		4 / 7 LEU A  36
LEU A 128
SER A 131
THR A 114
 None
 1.05A 3lm8A-2qlpA:
undetectable
3lm8C-2qlpA:
undetectable		 3lm8A-2qlpA:
23.21
3lm8C-2qlpA:
23.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TKD_A_CYZA266_2
(GLUTAMATE RECEPTOR 2)		 2qlp DEOXYCYTIDINE
TRIPHOSPHATE
DEAMINASE
(Mycobacterium
tuberculosis) 		4 / 5 ILE A 146
SER A 102
LYS A 101
GLY A 147
 None
 0.97A 3tkdB-2qlpA:
undetectable		 3tkdB-2qlpA:
20.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TKD_B_CYZB267_1
(GLUTAMATE RECEPTOR 2)		 2qlp DEOXYCYTIDINE
TRIPHOSPHATE
DEAMINASE
(Mycobacterium
tuberculosis) 		4 / 5 ILE A 146
SER A 102
LYS A 101
GLY A 147
 None
 1.00A 3tkdA-2qlpA:
undetectable		 3tkdA-2qlpA:
20.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TM4_A_SAMA401_1
(TRNA (GUANINE
N2-)-METHYLTRANSFERA
SE TRM14)		 2qlp DEOXYCYTIDINE
TRIPHOSPHATE
DEAMINASE
(Mycobacterium
tuberculosis) 		4 / 5 HIS A 125
SER A  83
THR A 127
ASP A  23
 None
1PE  A 163 ( 4.6A)
1PE  A 163 ( 4.2A)
None
 1.40A 3tm4A-2qlpA:
undetectable		 3tm4A-2qlpA:
18.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TM4_B_SAMB401_1
(TRNA (GUANINE
N2-)-METHYLTRANSFERA
SE TRM14)		 2qlp DEOXYCYTIDINE
TRIPHOSPHATE
DEAMINASE
(Mycobacterium
tuberculosis) 		4 / 5 HIS A 125
SER A  83
THR A 127
ASP A  23
 None
1PE  A 163 ( 4.6A)
1PE  A 163 ( 4.2A)
None
 1.37A 3tm4B-2qlpA:
undetectable		 3tm4B-2qlpA:
18.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5H3A_B_D16B401_1
(ORF70)		 2qlp DEOXYCYTIDINE
TRIPHOSPHATE
DEAMINASE
(Mycobacterium
tuberculosis) 		4 / 7 ILE A  32
LEU A  17
GLY A  18
PHE A  88
 None
 0.84A 5h3aB-2qlpA:
undetectable		 5h3aB-2qlpA:
21.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KR1_B_017B101_1
(PROTEASE PR5-DRV)		 2qlp DEOXYCYTIDINE
TRIPHOSPHATE
DEAMINASE
(Mycobacterium
tuberculosis) 		5 / 10 LEU A  74
ASN A 132
ALA A 134
GLY A 105
ILE A 138
 None
 1.07A 5kr1A-2qlpA:
undetectable		 5kr1A-2qlpA:
22.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KR2_A_ROCA101_2
(PROTEASE PR5-SQV)		 2qlp DEOXYCYTIDINE
TRIPHOSPHATE
DEAMINASE
(Mycobacterium
tuberculosis) 		5 / 11 LEU A  74
ASN A 132
ALA A 134
GLY A 105
ILE A 138
 None
 0.99A 5kr2B-2qlpA:
undetectable		 5kr2B-2qlpA:
22.30