SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2qlt'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2YLG_A_ASCA130_0
(CYTOCHROME C')		 2qlt (DL)-GLYCEROL-3-PHOS
PHATASE 1
(Saccharomyces
cerevisiae) 		4 / 5 ALA A 207
GLY A 212
CYH A 213
LYS A 214
 None
HG  A 276 (-4.0A)
HG  A 276 (-2.0A)
None
 1.41A 2ylgA-2qltA:
undetectable		 2ylgA-2qltA:
20.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3JB1_A_SAMA1101_0
(STRUCTURAL PROTEIN
VP3)		 2qlt (DL)-GLYCEROL-3-PHOS
PHATASE 1
(Saccharomyces
cerevisiae) 		5 / 12 ILE A 159
GLY A 177
ARG A 178
ALA A  35
ALA A 211
 None
None
HG  A 276 (-2.7A)
None
HG  A 276 (-4.4A)
 1.10A 3jb1A-2qltA:
undetectable		 3jb1A-2qltA:
14.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KHM_A_TPFA501_1
(STEROL 14
ALPHA-DEMETHYLASE)		 2qlt (DL)-GLYCEROL-3-PHOS
PHATASE 1
(Saccharomyces
cerevisiae) 		4 / 8 TYR A 174
ALA A 203
ALA A 201
THR A 221
 None
None
CA  A 278 ( 4.2A)
None
 0.98A 3khmA-2qltA:
undetectable		 3khmA-2qltA:
18.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3L4D_D_TPFD490_1
(STEROL 14-ALPHA
DEMETHYLASE)		 2qlt (DL)-GLYCEROL-3-PHOS
PHATASE 1
(Saccharomyces
cerevisiae) 		4 / 8 TYR A 174
ALA A 203
ALA A 201
THR A 221
 None
None
CA  A 278 ( 4.2A)
None
 0.99A 3l4dD-2qltA:
undetectable		 3l4dD-2qltA:
18.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DRJ_A_RAPA201_2
(PEPTIDYL-PROLYL
CIS-TRANS ISOMERASE
FKBP4
SERINE/THREONINE-PRO
TEIN KINASE MTOR)		 2qlt (DL)-GLYCEROL-3-PHOS
PHATASE 1
(Saccharomyces
cerevisiae) 		4 / 8 LEU A 124
PHE A 147
THR A 136
ASP A  39
 None
None
SO4  A 280 (-3.7A)
CA  A 278 ( 2.2A)
 0.97A 4drjB-2qltA:
undetectable		 4drjB-2qltA:
13.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ZVM_B_DM2B303_1
(RIBOSYLDIHYDRONICOTI
NAMIDE DEHYDROGENASE
[QUINONE])		 2qlt (DL)-GLYCEROL-3-PHOS
PHATASE 1
(Saccharomyces
cerevisiae) 		5 / 11 VAL A 114
PHE A 147
PHE A 158
GLY A 138
ILE A  51
 None
None
None
SO4  A 280 (-4.4A)
None
 1.45A 4zvmA-2qltA:
2.2
4zvmB-2qltA:
2.4		 4zvmA-2qltA:
21.47
4zvmB-2qltA:
21.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IGP_A_ERYA402_0
(MACROLIDE
2'-PHOSPHOTRANSFERAS
E)		 2qlt (DL)-GLYCEROL-3-PHOS
PHATASE 1
(Saccharomyces
cerevisiae) 		5 / 12 ILE A 152
ALA A  35
ALA A  36
LEU A 181
GLY A 177
 None
 1.30A 5igpA-2qltA:
undetectable		 5igpA-2qltA:
22.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JLI_A_ASCA202_0
(CYTOCHROME C')		 2qlt (DL)-GLYCEROL-3-PHOS
PHATASE 1
(Saccharomyces
cerevisiae) 		4 / 5 ALA A 207
GLY A 212
CYH A 213
LYS A 214
 None
HG  A 276 (-4.0A)
HG  A 276 (-2.0A)
None
 1.48A 5jliA-2qltA:
undetectable		 5jliA-2qltA:
20.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DGX_A_017A101_2
(PROTEASE)		 2qlt (DL)-GLYCEROL-3-PHOS
PHATASE 1
(Saccharomyces
cerevisiae) 		3 / 3 GLY A 204
ASP A  39
ILE A 218
 None
CA  A 278 ( 2.2A)
None
 0.62A 6dgxB-2qltA:
undetectable		 6dgxB-2qltA:
17.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DJZ_C_GMJC301_0
(SIGMA NON-OPIOID
INTRACELLULAR
RECEPTOR 1)		 2qlt (DL)-GLYCEROL-3-PHOS
PHATASE 1
(Saccharomyces
cerevisiae) 		5 / 12 ALA A 126
LEU A 124
SER A 241
VAL A 114
VAL A 236
 None
 1.03A 6djzC-2qltA:
undetectable		 6djzC-2qltA:
19.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6FGC_A_ACTA813_0
(GEPHYRIN)		 2qlt (DL)-GLYCEROL-3-PHOS
PHATASE 1
(Saccharomyces
cerevisiae) 		3 / 3 THR A 136
ALA A 143
LYS A 145
 SO4  A 280 (-3.7A)
None
None
 0.75A 6fgcA-2qltA:
undetectable		 6fgcA-2qltA:
20.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6FGD_A_ACTA817_0
(GEPHYRIN)		 2qlt (DL)-GLYCEROL-3-PHOS
PHATASE 1
(Saccharomyces
cerevisiae) 		3 / 3 THR A 136
ALA A 143
LYS A 145
 SO4  A 280 (-3.7A)
None
None
 0.73A 6fgdA-2qltA:
undetectable		 6fgdA-2qltA:
20.98