SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2qlu'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1FOP_B_H4BB2600_1
(NITRIC-OXIDE
SYNTHASE)		 2qlu ACTIVIN RECEPTOR
TYPE IIB
(Homo
sapiens) 		4 / 6 PHE A 381
GLU A 368
VAL A 369
ARG A 320
 None
 1.42A 1fopA-2qluA:
0.0
1fopB-2qluA:
0.0		 1fopA-2qluA:
22.32
1fopB-2qluA:
22.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1IEP_A_STIA201_1
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE ABL)		 2qlu ACTIVIN RECEPTOR
TYPE IIB
(Homo
sapiens) 		7 / 12 VAL A 204
ALA A 215
THR A 265
PHE A 267
GLY A 271
LEU A 328
ALA A 338
 ADE  A 488 ( 4.9A)
ADE  A 488 (-3.2A)
ADE  A 488 (-4.3A)
ADE  A 488 (-4.3A)
ADE  A 488 ( 4.1A)
ADE  A 488 (-4.4A)
None
 0.77A 1iepA-2qluA:
24.3		 1iepA-2qluA:
24.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1IEP_B_STIB202_1
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE ABL)		 2qlu ACTIVIN RECEPTOR
TYPE IIB
(Homo
sapiens) 		6 / 12 ALA A 215
ILE A 233
THR A 265
PHE A 267
GLY A 271
ALA A 338
 ADE  A 488 (-3.2A)
None
ADE  A 488 (-4.3A)
ADE  A 488 (-4.3A)
ADE  A 488 ( 4.1A)
None
 1.15A 1iepB-2qluA:
24.4		 1iepB-2qluA:
24.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1M17_A_AQ4A999_1
(EPIDERMAL GROWTH
FACTOR RECEPTOR)		 2qlu ACTIVIN RECEPTOR
TYPE IIB
(Homo
sapiens) 		8 / 12 ALA A 215
LYS A 217
GLU A 230
LEU A 263
THR A 265
GLY A 271
LEU A 328
ASP A 339
 ADE  A 488 (-3.2A)
None
None
None
ADE  A 488 (-4.3A)
ADE  A 488 ( 4.1A)
ADE  A 488 (-4.4A)
None
 0.68A 1m17A-2qluA:
26.4		 1m17A-2qluA:
25.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1NSE_B_H4BB600_1
(NITRIC OXIDE
SYNTHASE)		 2qlu ACTIVIN RECEPTOR
TYPE IIB
(Homo
sapiens) 		4 / 6 PHE A 381
GLU A 368
VAL A 369
ARG A 320
 None
 1.43A 1nseA-2qluA:
0.0
1nseB-2qluA:
0.0		 1nseA-2qluA:
22.32
1nseB-2qluA:
22.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1OPJ_A_STIA3_1
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE ABL1)		 2qlu ACTIVIN RECEPTOR
TYPE IIB
(Homo
sapiens) 		6 / 12 VAL A 204
ALA A 215
THR A 265
PHE A 267
LEU A 328
ALA A 338
 ADE  A 488 ( 4.9A)
ADE  A 488 (-3.2A)
ADE  A 488 (-4.3A)
ADE  A 488 (-4.3A)
ADE  A 488 (-4.4A)
None
 0.69A 1opjA-2qluA:
24.2		 1opjA-2qluA:
24.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1OPJ_B_STIB4_1
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE ABL1)		 2qlu ACTIVIN RECEPTOR
TYPE IIB
(Homo
sapiens) 		6 / 12 ALA A 215
GLU A 230
THR A 265
PHE A 267
GLY A 271
ALA A 338
 ADE  A 488 (-3.2A)
None
ADE  A 488 (-4.3A)
ADE  A 488 (-4.3A)
ADE  A 488 ( 4.1A)
None
 0.77A 1opjB-2qluA:
24.0		 1opjB-2qluA:
24.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RS9_A_H4BA760_1
(NITRIC-OXIDE
SYNTHASE,
ENDOTHELIAL)		 2qlu ACTIVIN RECEPTOR
TYPE IIB
(Homo
sapiens) 		4 / 6 VAL A 369
ARG A 320
PHE A 381
GLU A 368
 None
 1.49A 1rs9A-2qluA:
0.0
1rs9B-2qluA:
0.0		 1rs9A-2qluA:
22.72
1rs9B-2qluA:
22.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UWH_A_BAXA1723_1
(B-RAF PROTO-ONCOGENE
SERINE/THREONINE-PRO
TEIN KINASE)		 2qlu ACTIVIN RECEPTOR
TYPE IIB
(Homo
sapiens) 		6 / 12 ALA A 215
GLU A 230
LEU A 245
THR A 265
LEU A 301
HIS A 319
 ADE  A 488 (-3.2A)
None
ADE  A 488 ( 4.5A)
ADE  A 488 (-4.3A)
None
None
 0.82A 1uwhA-2qluA:
25.2		 1uwhA-2qluA:
25.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UWH_B_BAXB1723_1
(B-RAF PROTO-ONCOGENE
SERINE/THREONINE-PRO
TEIN KINASE)		 2qlu ACTIVIN RECEPTOR
TYPE IIB
(Homo
sapiens) 		7 / 12 ALA A 215
LYS A 217
GLU A 230
LEU A 245
THR A 265
LEU A 301
HIS A 319
 ADE  A 488 (-3.2A)
None
None
ADE  A 488 ( 4.5A)
ADE  A 488 (-4.3A)
None
None
 0.82A 1uwhB-2qluA:
25.1		 1uwhB-2qluA:
25.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UWJ_A_BAXA1723_1
(B-RAF PROTO-ONCOGENE
SERINE/THREONINE-PRO
TEIN KINASE)		 2qlu ACTIVIN RECEPTOR
TYPE IIB
(Homo
sapiens) 		7 / 12 VAL A 204
ALA A 215
GLU A 230
LEU A 245
THR A 265
LEU A 301
HIS A 319
 ADE  A 488 ( 4.9A)
ADE  A 488 (-3.2A)
None
ADE  A 488 ( 4.5A)
ADE  A 488 (-4.3A)
None
None
 0.88A 1uwjA-2qluA:
6.5		 1uwjA-2qluA:
25.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UWJ_B_BAXB1723_1
(B-RAF PROTO-ONCOGENE
SERINE/THREONINE-PRO
TEIN KINASE)		 2qlu ACTIVIN RECEPTOR
TYPE IIB
(Homo
sapiens) 		7 / 12 VAL A 204
ALA A 215
GLU A 230
LEU A 245
THR A 265
LEU A 301
HIS A 319
 ADE  A 488 ( 4.9A)
ADE  A 488 (-3.2A)
None
ADE  A 488 ( 4.5A)
ADE  A 488 (-4.3A)
None
None
 0.87A 1uwjB-2qluA:
6.7		 1uwjB-2qluA:
25.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1XKK_A_FMMA91_1
(EPIDERMAL GROWTH
FACTOR RECEPTOR)		 2qlu ACTIVIN RECEPTOR
TYPE IIB
(Homo
sapiens) 		6 / 12 ALA A 215
THR A 265
GLY A 271
ASP A 275
LEU A 328
ASP A 339
 ADE  A 488 (-3.2A)
ADE  A 488 (-4.3A)
ADE  A 488 ( 4.1A)
None
ADE  A 488 (-4.4A)
None
 0.52A 1xkkA-2qluA:
24.9		 1xkkA-2qluA:
25.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1XKK_A_FMMA91_1
(EPIDERMAL GROWTH
FACTOR RECEPTOR)		 2qlu ACTIVIN RECEPTOR
TYPE IIB
(Homo
sapiens) 		6 / 12 ALA A 215
THR A 265
GLY A 271
LEU A 328
ASP A 339
PHE A 340
 ADE  A 488 (-3.2A)
ADE  A 488 (-4.3A)
ADE  A 488 ( 4.1A)
ADE  A 488 (-4.4A)
None
None
 0.87A 1xkkA-2qluA:
24.9		 1xkkA-2qluA:
25.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1YAJ_A_BEZA11_0
(CES1 PROTEIN)		 2qlu ACTIVIN RECEPTOR
TYPE IIB
(Homo
sapiens) 		4 / 4 LEU A 393
SER A 295
LEU A 287
LEU A 453
 None
 1.00A 1yajA-2qluA:
undetectable		 1yajA-2qluA:
21.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2GQG_A_1N1A501_1
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE ABL1)		 2qlu ACTIVIN RECEPTOR
TYPE IIB
(Homo
sapiens) 		8 / 12 ALA A 215
LYS A 217
GLU A 230
THR A 265
PHE A 267
GLY A 271
LEU A 328
ALA A 338
 ADE  A 488 (-3.2A)
None
None
ADE  A 488 (-4.3A)
ADE  A 488 (-4.3A)
ADE  A 488 ( 4.1A)
ADE  A 488 (-4.4A)
None
 0.58A 2gqgA-2qluA:
26.9		 2gqgA-2qluA:
24.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2GQG_B_1N1B502_1
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE ABL1)		 2qlu ACTIVIN RECEPTOR
TYPE IIB
(Homo
sapiens) 		7 / 12 VAL A 204
ALA A 215
GLU A 230
THR A 265
GLY A 271
LEU A 328
ALA A 338
 ADE  A 488 ( 4.9A)
ADE  A 488 (-3.2A)
None
ADE  A 488 (-4.3A)
ADE  A 488 ( 4.1A)
ADE  A 488 (-4.4A)
None
 0.55A 2gqgB-2qluA:
27.3		 2gqgB-2qluA:
24.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2HYY_A_STIA600_1
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE ABL1)		 2qlu ACTIVIN RECEPTOR
TYPE IIB
(Homo
sapiens) 		7 / 12 ALA A 215
ILE A 233
THR A 265
PHE A 267
GLY A 271
LEU A 328
ALA A 338
 ADE  A 488 (-3.2A)
None
ADE  A 488 (-4.3A)
ADE  A 488 (-4.3A)
ADE  A 488 ( 4.1A)
ADE  A 488 (-4.4A)
None
 1.20A 2hyyA-2qluA:
24.9		 2hyyA-2qluA:
24.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2HYY_A_STIA600_1
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE ABL1)		 2qlu ACTIVIN RECEPTOR
TYPE IIB
(Homo
sapiens) 		6 / 12 VAL A 204
ALA A 215
THR A 265
GLY A 271
LEU A 328
ALA A 338
 ADE  A 488 ( 4.9A)
ADE  A 488 (-3.2A)
ADE  A 488 (-4.3A)
ADE  A 488 ( 4.1A)
ADE  A 488 (-4.4A)
None
 0.79A 2hyyA-2qluA:
24.9		 2hyyA-2qluA:
24.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2HYY_B_STIB600_1
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE ABL1)		 2qlu ACTIVIN RECEPTOR
TYPE IIB
(Homo
sapiens) 		7 / 12 ALA A 215
ILE A 233
THR A 265
PHE A 267
GLY A 271
LEU A 328
ALA A 338
 ADE  A 488 (-3.2A)
None
ADE  A 488 (-4.3A)
ADE  A 488 (-4.3A)
ADE  A 488 ( 4.1A)
ADE  A 488 (-4.4A)
None
 1.12A 2hyyB-2qluA:
24.8		 2hyyB-2qluA:
24.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2HYY_B_STIB600_1
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE ABL1)		 2qlu ACTIVIN RECEPTOR
TYPE IIB
(Homo
sapiens) 		7 / 12 VAL A 204
ALA A 215
THR A 265
PHE A 267
GLY A 271
LEU A 328
ALA A 338
 ADE  A 488 ( 4.9A)
ADE  A 488 (-3.2A)
ADE  A 488 (-4.3A)
ADE  A 488 (-4.3A)
ADE  A 488 ( 4.1A)
ADE  A 488 (-4.4A)
None
 0.74A 2hyyB-2qluA:
24.8		 2hyyB-2qluA:
24.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2HYY_C_STIC600_1
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE ABL1)		 2qlu ACTIVIN RECEPTOR
TYPE IIB
(Homo
sapiens) 		7 / 12 ALA A 215
ILE A 233
THR A 265
PHE A 267
GLY A 271
LEU A 328
ALA A 338
 ADE  A 488 (-3.2A)
None
ADE  A 488 (-4.3A)
ADE  A 488 (-4.3A)
ADE  A 488 ( 4.1A)
ADE  A 488 (-4.4A)
None
 1.19A 2hyyC-2qluA:
24.9		 2hyyC-2qluA:
24.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2HYY_C_STIC600_1
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE ABL1)		 2qlu ACTIVIN RECEPTOR
TYPE IIB
(Homo
sapiens) 		7 / 12 VAL A 204
ALA A 215
THR A 265
PHE A 267
GLY A 271
LEU A 328
ALA A 338
 ADE  A 488 ( 4.9A)
ADE  A 488 (-3.2A)
ADE  A 488 (-4.3A)
ADE  A 488 (-4.3A)
ADE  A 488 ( 4.1A)
ADE  A 488 (-4.4A)
None
 0.63A 2hyyC-2qluA:
24.9		 2hyyC-2qluA:
24.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2HYY_D_STID600_1
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE ABL1)		 2qlu ACTIVIN RECEPTOR
TYPE IIB
(Homo
sapiens) 		6 / 12 ALA A 215
ILE A 233
THR A 265
PHE A 267
LEU A 328
ALA A 338
 ADE  A 488 (-3.2A)
None
ADE  A 488 (-4.3A)
ADE  A 488 (-4.3A)
ADE  A 488 (-4.4A)
None
 1.17A 2hyyD-2qluA:
24.7		 2hyyD-2qluA:
24.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ITO_A_IREA2020_1
(EPIDERMAL GROWTH
FACTOR RECEPTOR)		 2qlu ACTIVIN RECEPTOR
TYPE IIB
(Homo
sapiens) 		7 / 12 ALA A 215
LYS A 217
GLU A 230
LEU A 263
GLY A 271
ASP A 275
LEU A 328
 ADE  A 488 (-3.2A)
None
None
None
ADE  A 488 ( 4.1A)
None
ADE  A 488 (-4.4A)
 0.73A 2itoA-2qluA:
25.8		 2itoA-2qluA:
25.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ITO_A_IREA2020_1
(EPIDERMAL GROWTH
FACTOR RECEPTOR)		 2qlu ACTIVIN RECEPTOR
TYPE IIB
(Homo
sapiens) 		6 / 12 ALA A 215
LYS A 217
THR A 265
GLY A 271
ASP A 275
LEU A 328
 ADE  A 488 (-3.2A)
None
ADE  A 488 (-4.3A)
ADE  A 488 ( 4.1A)
None
ADE  A 488 (-4.4A)
 0.52A 2itoA-2qluA:
25.8		 2itoA-2qluA:
25.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ITY_A_IREA2020_1
(EPIDERMAL GROWTH
FACTOR RECEPTOR)		 2qlu ACTIVIN RECEPTOR
TYPE IIB
(Homo
sapiens) 		8 / 12 VAL A 204
ALA A 215
LYS A 217
LEU A 263
THR A 265
GLY A 271
LEU A 328
ASP A 339
 ADE  A 488 ( 4.9A)
ADE  A 488 (-3.2A)
None
None
ADE  A 488 (-4.3A)
ADE  A 488 ( 4.1A)
ADE  A 488 (-4.4A)
None
 0.67A 2ityA-2qluA:
25.9		 2ityA-2qluA:
25.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ITZ_A_IREA2021_1
(EPIDERMAL GROWTH
FACTOR RECEPTOR)		 2qlu ACTIVIN RECEPTOR
TYPE IIB
(Homo
sapiens) 		8 / 12 VAL A 204
ALA A 215
LYS A 217
GLU A 230
GLY A 271
ASP A 275
LEU A 328
ASP A 339
 ADE  A 488 ( 4.9A)
ADE  A 488 (-3.2A)
None
None
ADE  A 488 ( 4.1A)
None
ADE  A 488 (-4.4A)
None
 0.74A 2itzA-2qluA:
25.8		 2itzA-2qluA:
25.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ITZ_A_IREA2021_1
(EPIDERMAL GROWTH
FACTOR RECEPTOR)		 2qlu ACTIVIN RECEPTOR
TYPE IIB
(Homo
sapiens) 		8 / 12 VAL A 204
ALA A 215
LYS A 217
THR A 265
GLY A 271
ASP A 275
LEU A 328
ASP A 339
 ADE  A 488 ( 4.9A)
ADE  A 488 (-3.2A)
None
ADE  A 488 (-4.3A)
ADE  A 488 ( 4.1A)
None
ADE  A 488 (-4.4A)
None
 0.64A 2itzA-2qluA:
25.8		 2itzA-2qluA:
25.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2NSE_A_H4BA600_1
(NITRIC OXIDE
SYNTHASE)		 2qlu ACTIVIN RECEPTOR
TYPE IIB
(Homo
sapiens) 		4 / 6 VAL A 369
ARG A 320
PHE A 381
GLU A 368
 None
 1.41A 2nseA-2qluA:
0.0
2nseB-2qluA:
0.0		 2nseA-2qluA:
22.32
2nseB-2qluA:
22.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZVA_A_1N1A513_1
(TYROSINE-PROTEIN
KINASE LYN)		 2qlu ACTIVIN RECEPTOR
TYPE IIB
(Homo
sapiens) 		7 / 12 ALA A 215
LYS A 217
GLU A 230
THR A 265
GLY A 271
LEU A 328
ALA A 338
 ADE  A 488 (-3.2A)
None
None
ADE  A 488 (-4.3A)
ADE  A 488 ( 4.1A)
ADE  A 488 (-4.4A)
None
 0.52A 2zvaA-2qluA:
27.0		 2zvaA-2qluA:
24.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BBT_B_FMMB91_1
(RECEPTOR
TYROSINE-PROTEIN
KINASE ERBB-4)		 2qlu ACTIVIN RECEPTOR
TYPE IIB
(Homo
sapiens) 		7 / 12 VAL A 204
ALA A 215
THR A 265
GLY A 271
LEU A 328
ASP A 339
PHE A 340
 ADE  A 488 ( 4.9A)
ADE  A 488 (-3.2A)
ADE  A 488 (-4.3A)
ADE  A 488 ( 4.1A)
ADE  A 488 (-4.4A)
None
None
 0.90A 3bbtB-2qluA:
24.5		 3bbtB-2qluA:
23.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BBT_D_FMMD91_1
(RECEPTOR
TYROSINE-PROTEIN
KINASE ERBB-4)		 2qlu ACTIVIN RECEPTOR
TYPE IIB
(Homo
sapiens) 		7 / 12 VAL A 204
ALA A 215
LEU A 263
GLY A 271
LEU A 328
ASP A 339
PHE A 340
 ADE  A 488 ( 4.9A)
ADE  A 488 (-3.2A)
None
ADE  A 488 ( 4.1A)
ADE  A 488 (-4.4A)
None
None
 0.93A 3bbtD-2qluA:
24.6		 3bbtD-2qluA:
23.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BBT_D_FMMD91_1
(RECEPTOR
TYROSINE-PROTEIN
KINASE ERBB-4)		 2qlu ACTIVIN RECEPTOR
TYPE IIB
(Homo
sapiens) 		7 / 12 VAL A 204
ALA A 215
LYS A 217
LEU A 263
GLY A 271
LEU A 328
ASP A 339
 ADE  A 488 ( 4.9A)
ADE  A 488 (-3.2A)
None
None
ADE  A 488 ( 4.1A)
ADE  A 488 (-4.4A)
None
 0.82A 3bbtD-2qluA:
24.6		 3bbtD-2qluA:
23.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BBT_D_FMMD91_1
(RECEPTOR
TYROSINE-PROTEIN
KINASE ERBB-4)		 2qlu ACTIVIN RECEPTOR
TYPE IIB
(Homo
sapiens) 		7 / 12 VAL A 204
ALA A 215
LYS A 217
THR A 265
GLY A 271
LEU A 328
ASP A 339
 ADE  A 488 ( 4.9A)
ADE  A 488 (-3.2A)
None
ADE  A 488 (-4.3A)
ADE  A 488 ( 4.1A)
ADE  A 488 (-4.4A)
None
 0.75A 3bbtD-2qluA:
24.6		 3bbtD-2qluA:
23.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BBT_D_FMMD91_1
(RECEPTOR
TYROSINE-PROTEIN
KINASE ERBB-4)		 2qlu ACTIVIN RECEPTOR
TYPE IIB
(Homo
sapiens) 		7 / 12 VAL A 204
ALA A 215
THR A 265
GLY A 271
LEU A 328
ASP A 339
PHE A 340
 ADE  A 488 ( 4.9A)
ADE  A 488 (-3.2A)
ADE  A 488 (-4.3A)
ADE  A 488 ( 4.1A)
ADE  A 488 (-4.4A)
None
None
 0.87A 3bbtD-2qluA:
24.6		 3bbtD-2qluA:
23.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BJW_E_SVRE510_3
(PHOSPHOLIPASE A2)		 2qlu ACTIVIN RECEPTOR
TYPE IIB
(Homo
sapiens) 		4 / 5 VAL A 336
VAL A 327
THR A 265
THR A 334
 None
None
ADE  A 488 (-4.3A)
None
 1.27A 3bjwG-2qluA:
undetectable		 3bjwG-2qluA:
14.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BJW_H_SVRH511_2
(PHOSPHOLIPASE A2)		 2qlu ACTIVIN RECEPTOR
TYPE IIB
(Homo
sapiens) 		4 / 5 VAL A 336
VAL A 327
THR A 265
THR A 334
 None
None
ADE  A 488 (-4.3A)
None
 1.24A 3bjwD-2qluA:
undetectable		 3bjwD-2qluA:
14.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3CE6_A_ADNA500_2
(ADENOSYLHOMOCYSTEINA
SE)		 2qlu ACTIVIN RECEPTOR
TYPE IIB
(Homo
sapiens) 		4 / 5 GLN A 246
THR A 265
HIS A 319
LEU A 301
 None
ADE  A 488 (-4.3A)
None
None
 1.33A 3ce6A-2qluA:
undetectable		 3ce6A-2qluA:
21.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3CE6_C_ADNC500_2
(ADENOSYLHOMOCYSTEINA
SE)		 2qlu ACTIVIN RECEPTOR
TYPE IIB
(Homo
sapiens) 		4 / 5 GLN A 246
THR A 265
HIS A 319
LEU A 301
 None
ADE  A 488 (-4.3A)
None
None
 1.37A 3ce6C-2qluA:
undetectable		 3ce6C-2qluA:
21.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3CS9_A_NILA600_2
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE ABL1)		 2qlu ACTIVIN RECEPTOR
TYPE IIB
(Homo
sapiens) 		6 / 12 ALA A 215
ILE A 233
THR A 265
HIS A 319
LEU A 328
ALA A 338
 ADE  A 488 (-3.2A)
None
ADE  A 488 (-4.3A)
None
ADE  A 488 (-4.4A)
None
 1.08A 3cs9A-2qluA:
24.7		 3cs9A-2qluA:
24.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3CS9_A_NILA600_2
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE ABL1)		 2qlu ACTIVIN RECEPTOR
TYPE IIB
(Homo
sapiens) 		7 / 12 ALA A 215
LEU A 244
THR A 265
GLY A 271
HIS A 319
LEU A 328
ALA A 338
 ADE  A 488 (-3.2A)
None
ADE  A 488 (-4.3A)
ADE  A 488 ( 4.1A)
None
ADE  A 488 (-4.4A)
None
 0.56A 3cs9A-2qluA:
24.7		 3cs9A-2qluA:
24.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3CS9_B_NILB600_1
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE ABL1)		 2qlu ACTIVIN RECEPTOR
TYPE IIB
(Homo
sapiens) 		5 / 12 ALA A 215
GLU A 230
LEU A 244
THR A 265
GLY A 271
 ADE  A 488 (-3.2A)
None
None
ADE  A 488 (-4.3A)
ADE  A 488 ( 4.1A)
 0.62A 3cs9B-2qluA:
25.0		 3cs9B-2qluA:
24.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3CS9_B_NILB600_1
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE ABL1)		 2qlu ACTIVIN RECEPTOR
TYPE IIB
(Homo
sapiens) 		6 / 12 ALA A 215
LEU A 244
THR A 265
GLY A 271
HIS A 319
ALA A 338
 ADE  A 488 (-3.2A)
None
ADE  A 488 (-4.3A)
ADE  A 488 ( 4.1A)
None
None
 0.62A 3cs9B-2qluA:
25.0		 3cs9B-2qluA:
24.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3CS9_C_NILC600_1
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE ABL1)		 2qlu ACTIVIN RECEPTOR
TYPE IIB
(Homo
sapiens) 		5 / 12 ALA A 215
GLU A 230
LEU A 244
THR A 265
PHE A 267
 ADE  A 488 (-3.2A)
None
None
ADE  A 488 (-4.3A)
ADE  A 488 (-4.3A)
 0.68A 3cs9C-2qluA:
24.3		 3cs9C-2qluA:
24.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3CS9_C_NILC600_1
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE ABL1)		 2qlu ACTIVIN RECEPTOR
TYPE IIB
(Homo
sapiens) 		6 / 12 ALA A 215
ILE A 233
THR A 265
PHE A 267
HIS A 319
ALA A 338
 ADE  A 488 (-3.2A)
None
ADE  A 488 (-4.3A)
ADE  A 488 (-4.3A)
None
None
 1.09A 3cs9C-2qluA:
24.3		 3cs9C-2qluA:
24.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3CS9_C_NILC600_1
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE ABL1)		 2qlu ACTIVIN RECEPTOR
TYPE IIB
(Homo
sapiens) 		6 / 12 ALA A 215
LEU A 244
THR A 265
PHE A 267
HIS A 319
ALA A 338
 ADE  A 488 (-3.2A)
None
ADE  A 488 (-4.3A)
ADE  A 488 (-4.3A)
None
None
 0.57A 3cs9C-2qluA:
24.3		 3cs9C-2qluA:
24.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3CS9_D_NILD600_1
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE ABL1)		 2qlu ACTIVIN RECEPTOR
TYPE IIB
(Homo
sapiens) 		6 / 12 ALA A 215
GLU A 230
LEU A 244
THR A 265
PHE A 267
GLY A 271
 ADE  A 488 (-3.2A)
None
None
ADE  A 488 (-4.3A)
ADE  A 488 (-4.3A)
ADE  A 488 ( 4.1A)
 0.59A 3cs9D-2qluA:
23.9		 3cs9D-2qluA:
24.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3CS9_D_NILD600_1
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE ABL1)		 2qlu ACTIVIN RECEPTOR
TYPE IIB
(Homo
sapiens) 		7 / 12 ALA A 215
ILE A 233
THR A 265
PHE A 267
GLY A 271
HIS A 319
ALA A 338
 ADE  A 488 (-3.2A)
None
ADE  A 488 (-4.3A)
ADE  A 488 (-4.3A)
ADE  A 488 ( 4.1A)
None
None
 1.27A 3cs9D-2qluA:
23.9		 3cs9D-2qluA:
24.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3CS9_D_NILD600_1
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE ABL1)		 2qlu ACTIVIN RECEPTOR
TYPE IIB
(Homo
sapiens) 		7 / 12 ALA A 215
LEU A 244
THR A 265
PHE A 267
GLY A 271
HIS A 319
ALA A 338
 ADE  A 488 (-3.2A)
None
ADE  A 488 (-4.3A)
ADE  A 488 (-4.3A)
ADE  A 488 ( 4.1A)
None
None
 0.53A 3cs9D-2qluA:
23.9		 3cs9D-2qluA:
24.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3DQS_A_H4BA760_1
(NITRIC OXIDE
SYNTHASE,
ENDOTHELIAL)		 2qlu ACTIVIN RECEPTOR
TYPE IIB
(Homo
sapiens) 		4 / 6 VAL A 369
ARG A 320
PHE A 381
GLU A 368
 None
 1.43A 3dqsA-2qluA:
0.0
3dqsB-2qluA:
0.0		 3dqsA-2qluA:
22.72
3dqsB-2qluA:
22.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3EYG_A_MI1A1_1
(TYROSINE-PROTEIN
KINASE)		 2qlu ACTIVIN RECEPTOR
TYPE IIB
(Homo
sapiens) 		9 / 12 GLY A 199
GLY A 202
VAL A 204
ALA A 215
LYS A 217
SER A 272
ASN A 326
LEU A 328
ASP A 339
 None
None
ADE  A 488 ( 4.9A)
ADE  A 488 (-3.2A)
None
None
None
ADE  A 488 (-4.4A)
None
 0.69A 3eygA-2qluA:
28.3		 3eygA-2qluA:
26.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3G5D_A_1N1A1_1
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE SRC)		 2qlu ACTIVIN RECEPTOR
TYPE IIB
(Homo
sapiens) 		7 / 12 VAL A 204
ALA A 215
GLU A 230
THR A 265
GLY A 271
LEU A 328
ALA A 338
 ADE  A 488 ( 4.9A)
ADE  A 488 (-3.2A)
None
ADE  A 488 (-4.3A)
ADE  A 488 ( 4.1A)
ADE  A 488 (-4.4A)
None
 0.52A 3g5dA-2qluA:
26.5		 3g5dA-2qluA:
26.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3G5D_B_1N1B1_1
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE SRC)		 2qlu ACTIVIN RECEPTOR
TYPE IIB
(Homo
sapiens) 		8 / 12 VAL A 204
ALA A 215
LYS A 217
GLU A 230
THR A 265
GLY A 271
LEU A 328
ALA A 338
 ADE  A 488 ( 4.9A)
ADE  A 488 (-3.2A)
None
None
ADE  A 488 (-4.3A)
ADE  A 488 ( 4.1A)
ADE  A 488 (-4.4A)
None
 0.59A 3g5dB-2qluA:
26.4		 3g5dB-2qluA:
26.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3IK3_A_0LIA1_1
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE ABL1)		 2qlu ACTIVIN RECEPTOR
TYPE IIB
(Homo
sapiens) 		5 / 12 ALA A 215
LEU A 244
HIS A 319
LEU A 328
ALA A 338
 ADE  A 488 (-3.2A)
None
None
ADE  A 488 (-4.4A)
None
 0.51A 3ik3A-2qluA:
24.7		 3ik3A-2qluA:
23.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3IK3_B_0LIB2_1
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE ABL1)		 2qlu ACTIVIN RECEPTOR
TYPE IIB
(Homo
sapiens) 		5 / 12 ALA A 215
LEU A 244
HIS A 319
LEU A 328
ALA A 338
 ADE  A 488 (-3.2A)
None
None
ADE  A 488 (-4.4A)
None
 0.50A 3ik3B-2qluA:
24.4		 3ik3B-2qluA:
23.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3K5V_A_STIA2_1
(TYROSINE-PROTEIN
KINASE ABL1)		 2qlu ACTIVIN RECEPTOR
TYPE IIB
(Homo
sapiens) 		7 / 12 ALA A 215
ILE A 233
THR A 265
PHE A 267
GLY A 271
LEU A 328
ALA A 338
 ADE  A 488 (-3.2A)
None
ADE  A 488 (-4.3A)
ADE  A 488 (-4.3A)
ADE  A 488 ( 4.1A)
ADE  A 488 (-4.4A)
None
 1.11A 3k5vA-2qluA:
24.1		 3k5vA-2qluA:
24.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3K5V_A_STIA2_1
(TYROSINE-PROTEIN
KINASE ABL1)		 2qlu ACTIVIN RECEPTOR
TYPE IIB
(Homo
sapiens) 		7 / 12 VAL A 204
ALA A 215
GLU A 230
THR A 265
PHE A 267
GLY A 271
ALA A 338
 ADE  A 488 ( 4.9A)
ADE  A 488 (-3.2A)
None
ADE  A 488 (-4.3A)
ADE  A 488 (-4.3A)
ADE  A 488 ( 4.1A)
None
 0.83A 3k5vA-2qluA:
24.1		 3k5vA-2qluA:
24.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3K5V_A_STIA2_1
(TYROSINE-PROTEIN
KINASE ABL1)		 2qlu ACTIVIN RECEPTOR
TYPE IIB
(Homo
sapiens) 		7 / 12 VAL A 204
ALA A 215
THR A 265
PHE A 267
GLY A 271
LEU A 328
ALA A 338
 ADE  A 488 ( 4.9A)
ADE  A 488 (-3.2A)
ADE  A 488 (-4.3A)
ADE  A 488 (-4.3A)
ADE  A 488 ( 4.1A)
ADE  A 488 (-4.4A)
None
 0.72A 3k5vA-2qluA:
24.1		 3k5vA-2qluA:
24.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3K5V_B_STIB2_1
(TYROSINE-PROTEIN
KINASE ABL1)		 2qlu ACTIVIN RECEPTOR
TYPE IIB
(Homo
sapiens) 		7 / 12 ALA A 215
ILE A 233
THR A 265
PHE A 267
GLY A 271
LEU A 328
ALA A 338
 ADE  A 488 (-3.2A)
None
ADE  A 488 (-4.3A)
ADE  A 488 (-4.3A)
ADE  A 488 ( 4.1A)
ADE  A 488 (-4.4A)
None
 1.11A 3k5vB-2qluA:
24.0		 3k5vB-2qluA:
24.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3K5V_B_STIB2_1
(TYROSINE-PROTEIN
KINASE ABL1)		 2qlu ACTIVIN RECEPTOR
TYPE IIB
(Homo
sapiens) 		7 / 12 VAL A 204
ALA A 215
GLU A 230
THR A 265
PHE A 267
GLY A 271
ALA A 338
 ADE  A 488 ( 4.9A)
ADE  A 488 (-3.2A)
None
ADE  A 488 (-4.3A)
ADE  A 488 (-4.3A)
ADE  A 488 ( 4.1A)
None
 0.86A 3k5vB-2qluA:
24.0		 3k5vB-2qluA:
24.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3K5V_B_STIB2_1
(TYROSINE-PROTEIN
KINASE ABL1)		 2qlu ACTIVIN RECEPTOR
TYPE IIB
(Homo
sapiens) 		7 / 12 VAL A 204
ALA A 215
THR A 265
PHE A 267
GLY A 271
LEU A 328
ALA A 338
 ADE  A 488 ( 4.9A)
ADE  A 488 (-3.2A)
ADE  A 488 (-4.3A)
ADE  A 488 (-4.3A)
ADE  A 488 ( 4.1A)
ADE  A 488 (-4.4A)
None
 0.72A 3k5vB-2qluA:
24.0		 3k5vB-2qluA:
24.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3MIY_B_B49B2_1
(TYROSINE-PROTEIN
KINASE ITK/TSK)		 2qlu ACTIVIN RECEPTOR
TYPE IIB
(Homo
sapiens) 		5 / 9 ALA A 215
LYS A 217
PHE A 267
GLY A 271
LEU A 328
 ADE  A 488 (-3.2A)
None
ADE  A 488 (-4.3A)
ADE  A 488 ( 4.1A)
ADE  A 488 (-4.4A)
 0.66A 3miyB-2qluA:
25.6		 3miyB-2qluA:
25.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3MS9_A_STIA1_1
(TYROSINE-PROTEIN
KINASE ABL1)		 2qlu ACTIVIN RECEPTOR
TYPE IIB
(Homo
sapiens) 		6 / 12 ALA A 215
ILE A 233
THR A 265
PHE A 267
LEU A 328
ALA A 338
 ADE  A 488 (-3.2A)
None
ADE  A 488 (-4.3A)
ADE  A 488 (-4.3A)
ADE  A 488 (-4.4A)
None
 1.13A 3ms9A-2qluA:
24.3		 3ms9A-2qluA:
24.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3MS9_A_STIA1_1
(TYROSINE-PROTEIN
KINASE ABL1)		 2qlu ACTIVIN RECEPTOR
TYPE IIB
(Homo
sapiens) 		6 / 12 VAL A 204
ALA A 215
THR A 265
PHE A 267
LEU A 328
ALA A 338
 ADE  A 488 ( 4.9A)
ADE  A 488 (-3.2A)
ADE  A 488 (-4.3A)
ADE  A 488 (-4.3A)
ADE  A 488 (-4.4A)
None
 0.79A 3ms9A-2qluA:
24.3		 3ms9A-2qluA:
24.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3MS9_B_STIB1_1
(TYROSINE-PROTEIN
KINASE ABL1)		 2qlu ACTIVIN RECEPTOR
TYPE IIB
(Homo
sapiens) 		7 / 12 ALA A 215
ILE A 233
THR A 265
PHE A 267
GLY A 271
LEU A 328
ALA A 338
 ADE  A 488 (-3.2A)
None
ADE  A 488 (-4.3A)
ADE  A 488 (-4.3A)
ADE  A 488 ( 4.1A)
ADE  A 488 (-4.4A)
None
 1.11A 3ms9B-2qluA:
24.4		 3ms9B-2qluA:
24.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3MS9_B_STIB1_1
(TYROSINE-PROTEIN
KINASE ABL1)		 2qlu ACTIVIN RECEPTOR
TYPE IIB
(Homo
sapiens) 		7 / 12 VAL A 204
ALA A 215
THR A 265
PHE A 267
GLY A 271
LEU A 328
ALA A 338
 ADE  A 488 ( 4.9A)
ADE  A 488 (-3.2A)
ADE  A 488 (-4.3A)
ADE  A 488 (-4.3A)
ADE  A 488 ( 4.1A)
ADE  A 488 (-4.4A)
None
 0.74A 3ms9B-2qluA:
24.4		 3ms9B-2qluA:
24.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3MSS_A_STIA1_1
(TYROSINE-PROTEIN
KINASE ABL1)		 2qlu ACTIVIN RECEPTOR
TYPE IIB
(Homo
sapiens) 		6 / 12 ALA A 215
ILE A 233
THR A 265
PHE A 267
LEU A 328
ALA A 338
 ADE  A 488 (-3.2A)
None
ADE  A 488 (-4.3A)
ADE  A 488 (-4.3A)
ADE  A 488 (-4.4A)
None
 1.16A 3mssA-2qluA:
24.4		 3mssA-2qluA:
24.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3MSS_A_STIA1_1
(TYROSINE-PROTEIN
KINASE ABL1)		 2qlu ACTIVIN RECEPTOR
TYPE IIB
(Homo
sapiens) 		6 / 12 VAL A 204
ALA A 215
THR A 265
PHE A 267
LEU A 328
ALA A 338
 ADE  A 488 ( 4.9A)
ADE  A 488 (-3.2A)
ADE  A 488 (-4.3A)
ADE  A 488 (-4.3A)
ADE  A 488 (-4.4A)
None
 0.80A 3mssA-2qluA:
24.4		 3mssA-2qluA:
24.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3MSS_B_STIB1_1
(TYROSINE-PROTEIN
KINASE ABL1)		 2qlu ACTIVIN RECEPTOR
TYPE IIB
(Homo
sapiens) 		7 / 12 ALA A 215
ILE A 233
THR A 265
PHE A 267
GLY A 271
LEU A 328
ALA A 338
 ADE  A 488 (-3.2A)
None
ADE  A 488 (-4.3A)
ADE  A 488 (-4.3A)
ADE  A 488 ( 4.1A)
ADE  A 488 (-4.4A)
None
 1.06A 3mssB-2qluA:
24.4		 3mssB-2qluA:
24.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3MSS_C_STIC1_1
(TYROSINE-PROTEIN
KINASE ABL1)		 2qlu ACTIVIN RECEPTOR
TYPE IIB
(Homo
sapiens) 		6 / 12 VAL A 204
ALA A 215
THR A 265
PHE A 267
LEU A 328
ALA A 338
 ADE  A 488 ( 4.9A)
ADE  A 488 (-3.2A)
ADE  A 488 (-4.3A)
ADE  A 488 (-4.3A)
ADE  A 488 (-4.4A)
None
 0.80A 3mssC-2qluA:
24.4		 3mssC-2qluA:
24.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3MSS_D_STID1_1
(TYROSINE-PROTEIN
KINASE ABL1)		 2qlu ACTIVIN RECEPTOR
TYPE IIB
(Homo
sapiens) 		7 / 12 ALA A 215
ILE A 233
THR A 265
PHE A 267
GLY A 271
LEU A 328
ALA A 338
 ADE  A 488 (-3.2A)
None
ADE  A 488 (-4.3A)
ADE  A 488 (-4.3A)
ADE  A 488 ( 4.1A)
ADE  A 488 (-4.4A)
None
 1.07A 3mssD-2qluA:
24.3		 3mssD-2qluA:
24.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OG7_A_032A1_1
(AKAP9-BRAF FUSION
PROTEIN)		 2qlu ACTIVIN RECEPTOR
TYPE IIB
(Homo
sapiens) 		6 / 12 VAL A 204
ALA A 215
LYS A 217
LEU A 245
THR A 265
GLY A 341
 ADE  A 488 ( 4.9A)
ADE  A 488 (-3.2A)
None
ADE  A 488 ( 4.5A)
ADE  A 488 (-4.3A)
None
 0.83A 3og7A-2qluA:
25.1		 3og7A-2qluA:
26.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OG7_A_032A1_1
(AKAP9-BRAF FUSION
PROTEIN)		 2qlu ACTIVIN RECEPTOR
TYPE IIB
(Homo
sapiens) 		6 / 12 VAL A 204
ALA A 215
LYS A 217
LEU A 245
THR A 265
PHE A 340
 ADE  A 488 ( 4.9A)
ADE  A 488 (-3.2A)
None
ADE  A 488 ( 4.5A)
ADE  A 488 (-4.3A)
None
 0.85A 3og7A-2qluA:
25.1		 3og7A-2qluA:
26.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OXZ_A_0LIA1_1
(TYROSINE-PROTEIN
KINASE ABL1)		 2qlu ACTIVIN RECEPTOR
TYPE IIB
(Homo
sapiens) 		6 / 12 ALA A 215
GLU A 230
LEU A 244
THR A 265
GLY A 271
ALA A 338
 ADE  A 488 (-3.2A)
None
None
ADE  A 488 (-4.3A)
ADE  A 488 ( 4.1A)
None
 0.65A 3oxzA-2qluA:
25.0		 3oxzA-2qluA:
23.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OXZ_A_0LIA1_1
(TYROSINE-PROTEIN
KINASE ABL1)		 2qlu ACTIVIN RECEPTOR
TYPE IIB
(Homo
sapiens) 		6 / 12 ALA A 215
LEU A 244
THR A 265
GLY A 271
HIS A 319
ALA A 338
 ADE  A 488 (-3.2A)
None
ADE  A 488 (-4.3A)
ADE  A 488 ( 4.1A)
None
None
 0.50A 3oxzA-2qluA:
25.0		 3oxzA-2qluA:
23.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3PYY_A_STIA3_1
(V-ABL ABELSON MURINE
LEUKEMIA VIRAL
ONCOGENE HOMOLOG 1
ISOFORM B VARIANT)		 2qlu ACTIVIN RECEPTOR
TYPE IIB
(Homo
sapiens) 		6 / 12 ALA A 215
THR A 265
PHE A 267
GLY A 271
LEU A 328
ALA A 338
 ADE  A 488 (-3.2A)
ADE  A 488 (-4.3A)
ADE  A 488 (-4.3A)
ADE  A 488 ( 4.1A)
ADE  A 488 (-4.4A)
None
 0.42A 3pyyA-2qluA:
24.5		 3pyyA-2qluA:
27.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3QLG_B_1N1B601_1
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE SRC)		 2qlu ACTIVIN RECEPTOR
TYPE IIB
(Homo
sapiens) 		8 / 12 VAL A 204
ALA A 215
GLU A 230
THR A 265
GLY A 271
LEU A 328
ALA A 338
ASP A 339
 ADE  A 488 ( 4.9A)
ADE  A 488 (-3.2A)
None
ADE  A 488 (-4.3A)
ADE  A 488 ( 4.1A)
ADE  A 488 (-4.4A)
None
None
 0.73A 3qlgB-2qluA:
26.0		 3qlgB-2qluA:
26.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UG2_A_IREA1_1
(EPIDERMAL GROWTH
FACTOR RECEPTOR)		 2qlu ACTIVIN RECEPTOR
TYPE IIB
(Homo
sapiens) 		7 / 12 VAL A 204
ALA A 215
LYS A 217
LEU A 263
GLY A 271
ASP A 275
LEU A 328
 ADE  A 488 ( 4.9A)
ADE  A 488 (-3.2A)
None
None
ADE  A 488 ( 4.1A)
None
ADE  A 488 (-4.4A)
 0.87A 3ug2A-2qluA:
26.0		 3ug2A-2qluA:
24.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3WIP_G_ACTG305_0
(ACETYLCHOLINE-BINDIN
G PROTEIN)		 2qlu ACTIVIN RECEPTOR
TYPE IIB
(Homo
sapiens) 		3 / 3 ASP A 321
ARG A 363
LYS A 323
 None
SO4  A   2 (-2.9A)
SO4  A   2 (-3.0A)
 1.16A 3wipG-2qluA:
undetectable		 3wipG-2qluA:
23.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ZOS_A_0LIA1000_1
(EPITHELIAL DISCOIDIN
DOMAIN-CONTAINING
RECEPTOR 1)		 2qlu ACTIVIN RECEPTOR
TYPE IIB
(Homo
sapiens) 		7 / 12 ALA A 215
LYS A 217
THR A 265
LEU A 301
HIS A 319
LEU A 328
ALA A 338
 ADE  A 488 (-3.2A)
None
ADE  A 488 (-4.3A)
None
None
ADE  A 488 (-4.4A)
None
 0.67A 3zosA-2qluA:
23.7		 3zosA-2qluA:
25.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ZOS_B_0LIB1000_1
(EPITHELIAL DISCOIDIN
DOMAIN-CONTAINING
RECEPTOR 1)		 2qlu ACTIVIN RECEPTOR
TYPE IIB
(Homo
sapiens) 		8 / 12 ALA A 215
LYS A 217
GLU A 230
THR A 265
LEU A 301
HIS A 319
LEU A 328
ALA A 338
 ADE  A 488 (-3.2A)
None
None
ADE  A 488 (-4.3A)
None
None
ADE  A 488 (-4.4A)
None
 0.87A 3zosB-2qluA:
23.9		 3zosB-2qluA:
25.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4AG8_A_AXIA2000_1
(VASCULAR ENDOTHELIAL
GROWTH FACTOR
RECEPTOR 2)		 2qlu ACTIVIN RECEPTOR
TYPE IIB
(Homo
sapiens) 		7 / 12 VAL A 204
ALA A 215
LYS A 217
GLU A 230
PHE A 267
GLY A 271
LEU A 328
 ADE  A 488 ( 4.9A)
ADE  A 488 (-3.2A)
None
None
ADE  A 488 (-4.3A)
ADE  A 488 ( 4.1A)
ADE  A 488 (-4.4A)
 0.76A 4ag8A-2qluA:
24.8		 4ag8A-2qluA:
25.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4AN2_A_EUIA1382_1
(DUAL SPECIFICITY
MITOGEN-ACTIVATED
PROTEIN KINASE
KINASE 1)		 2qlu ACTIVIN RECEPTOR
TYPE IIB
(Homo
sapiens) 		5 / 12 LYS A 217
ASP A 321
LYS A 323
ASN A 326
ASP A 339
 None
None
SO4  A   2 (-3.0A)
None
None
 0.76A 4an2A-2qluA:
22.4		 4an2A-2qluA:
28.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ASD_A_BAXA1500_1
(VASCULAR ENDOTHELIAL
GROWTH FACTOR
RECEPTOR 2)		 2qlu ACTIVIN RECEPTOR
TYPE IIB
(Homo
sapiens) 		8 / 12 VAL A 204
ALA A 215
LYS A 217
GLU A 230
PHE A 267
GLY A 271
LEU A 301
HIS A 319
 ADE  A 488 ( 4.9A)
ADE  A 488 (-3.2A)
None
None
ADE  A 488 (-4.3A)
ADE  A 488 ( 4.1A)
None
None
 0.89A 4asdA-2qluA:
24.3		 4asdA-2qluA:
23.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4C8B_A_0LIA1000_1
(RECEPTOR-INTERACTING
SERINE/THREONINE-PRO
TEIN KINASE 2)		 2qlu ACTIVIN RECEPTOR
TYPE IIB
(Homo
sapiens) 		7 / 12 ALA A 215
LYS A 217
LEU A 245
THR A 265
HIS A 319
LEU A 328
ALA A 338
 ADE  A 488 (-3.2A)
None
ADE  A 488 ( 4.5A)
ADE  A 488 (-4.3A)
None
ADE  A 488 (-4.4A)
None
 0.41A 4c8bA-2qluA:
24.6		 4c8bA-2qluA:
27.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4C8B_B_0LIB1000_1
(RECEPTOR-INTERACTING
SERINE/THREONINE-PRO
TEIN KINASE 2)		 2qlu ACTIVIN RECEPTOR
TYPE IIB
(Homo
sapiens) 		7 / 12 ALA A 215
LYS A 217
LEU A 245
THR A 265
HIS A 319
LEU A 328
ALA A 338
 ADE  A 488 (-3.2A)
None
ADE  A 488 ( 4.5A)
ADE  A 488 (-4.3A)
None
ADE  A 488 (-4.4A)
None
 0.52A 4c8bB-2qluA:
24.9		 4c8bB-2qluA:
27.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4CKI_A_ADNA2022_1
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE RECEPTOR RET)		 2qlu ACTIVIN RECEPTOR
TYPE IIB
(Homo
sapiens) 		6 / 11 GLY A 199
VAL A 204
ALA A 215
GLY A 271
SER A 272
LEU A 328
 None
ADE  A 488 ( 4.9A)
ADE  A 488 (-3.2A)
ADE  A 488 ( 4.1A)
None
ADE  A 488 (-4.4A)
 0.43A 4ckiA-2qluA:
28.5		 4ckiA-2qluA:
23.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4CSV_A_STIA1265_1
(SRC-ABL TYROSINE
KINASE ANCESTOR)		 2qlu ACTIVIN RECEPTOR
TYPE IIB
(Homo
sapiens) 		7 / 12 VAL A 204
ALA A 215
GLU A 230
ILE A 233
THR A 265
LEU A 328
ALA A 338
 ADE  A 488 ( 4.9A)
ADE  A 488 (-3.2A)
None
None
ADE  A 488 (-4.3A)
ADE  A 488 (-4.4A)
None
 0.91A 4csvA-2qluA:
25.2		 4csvA-2qluA:
26.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4CWV_A_H4BA600_1
(NITRIC OXIDE
SYNTHASE,
ENDOTHELIAL)		 2qlu ACTIVIN RECEPTOR
TYPE IIB
(Homo
sapiens) 		4 / 6 VAL A 369
ARG A 320
PHE A 381
GLU A 368
 None
 1.40A 4cwvA-2qluA:
0.0
4cwvB-2qluA:
0.0		 4cwvA-2qluA:
22.37
4cwvB-2qluA:
22.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4CWV_B_H4BB600_1
(NITRIC OXIDE
SYNTHASE,
ENDOTHELIAL)		 2qlu ACTIVIN RECEPTOR
TYPE IIB
(Homo
sapiens) 		4 / 6 PHE A 381
GLU A 368
VAL A 369
ARG A 320
 None
 1.40A 4cwvA-2qluA:
0.0
4cwvB-2qluA:
0.0		 4cwvA-2qluA:
22.37
4cwvB-2qluA:
22.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4CWX_A_H4BA600_1
(NITRIC OXIDE
SYNTHASE,
ENDOTHELIAL)		 2qlu ACTIVIN RECEPTOR
TYPE IIB
(Homo
sapiens) 		4 / 6 VAL A 369
ARG A 320
PHE A 381
GLU A 368
 None
 1.39A 4cwxA-2qluA:
0.0
4cwxB-2qluA:
0.0		 4cwxA-2qluA:
22.37
4cwxB-2qluA:
22.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4CWY_B_H4BB600_1
(NITRIC OXIDE
SYNTHASE,
ENDOTHELIAL)		 2qlu ACTIVIN RECEPTOR
TYPE IIB
(Homo
sapiens) 		4 / 7 PHE A 381
GLU A 368
VAL A 369
ARG A 320
 None
 1.37A 4cwyA-2qluA:
undetectable
4cwyB-2qluA:
undetectable		 4cwyA-2qluA:
22.37
4cwyB-2qluA:
22.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4D33_A_H4BA600_1
(NITRIC OXIDE
SYNTHASE,
ENDOTHELIAL)		 2qlu ACTIVIN RECEPTOR
TYPE IIB
(Homo
sapiens) 		4 / 6 VAL A 369
ARG A 320
PHE A 381
GLU A 368
 None
 1.37A 4d33A-2qluA:
0.0
4d33B-2qluA:
0.0		 4d33A-2qluA:
22.37
4d33B-2qluA:
22.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4D33_B_H4BB600_1
(NITRIC OXIDE
SYNTHASE,
ENDOTHELIAL)		 2qlu ACTIVIN RECEPTOR
TYPE IIB
(Homo
sapiens) 		4 / 6 PHE A 381
GLU A 368
VAL A 369
ARG A 320
 None
 1.38A 4d33A-2qluA:
0.0
4d33B-2qluA:
0.0		 4d33A-2qluA:
22.37
4d33B-2qluA:
22.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4D35_A_H4BA600_1
(NITRIC OXIDE
SYNTHASE,
ENDOTHELIAL)		 2qlu ACTIVIN RECEPTOR
TYPE IIB
(Homo
sapiens) 		4 / 6 VAL A 369
ARG A 320
PHE A 381
GLU A 368
 None
 1.44A 4d35A-2qluA:
0.0
4d35B-2qluA:
0.1		 4d35A-2qluA:
22.37
4d35B-2qluA:
22.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4D35_B_H4BB600_1
(NITRIC OXIDE
SYNTHASE,
ENDOTHELIAL)		 2qlu ACTIVIN RECEPTOR
TYPE IIB
(Homo
sapiens) 		4 / 6 PHE A 381
GLU A 368
VAL A 369
ARG A 320
 None
 1.37A 4d35A-2qluA:
0.0
4d35B-2qluA:
0.1		 4d35A-2qluA:
22.37
4d35B-2qluA:
22.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4D37_A_H4BA600_1
(NITRIC OXIDE
SYNTHASE,
ENDOTHELIAL)		 2qlu ACTIVIN RECEPTOR
TYPE IIB
(Homo
sapiens) 		4 / 6 VAL A 369
ARG A 320
PHE A 381
GLU A 368
 None
 1.42A 4d37A-2qluA:
0.0
4d37B-2qluA:
0.2		 4d37A-2qluA:
22.37
4d37B-2qluA:
22.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4D38_A_H4BA600_1
(NITRIC OXIDE
SYNTHASE,
ENDOTHELIAL)		 2qlu ACTIVIN RECEPTOR
TYPE IIB
(Homo
sapiens) 		4 / 6 VAL A 369
ARG A 320
PHE A 381
GLU A 368
 None
 1.43A 4d38A-2qluA:
0.0
4d38B-2qluA:
0.0		 4d38A-2qluA:
22.37
4d38B-2qluA:
22.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4D38_B_H4BB600_1
(NITRIC OXIDE
SYNTHASE,
ENDOTHELIAL)		 2qlu ACTIVIN RECEPTOR
TYPE IIB
(Homo
sapiens) 		4 / 6 PHE A 381
GLU A 368
VAL A 369
ARG A 320
 None
 1.36A 4d38A-2qluA:
0.0
4d38B-2qluA:
0.0		 4d38A-2qluA:
22.37
4d38B-2qluA:
22.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4HJO_A_AQ4A1001_1
(EPIDERMAL GROWTH
FACTOR RECEPTOR)		 2qlu ACTIVIN RECEPTOR
TYPE IIB
(Homo
sapiens) 		7 / 12 VAL A 204
ALA A 215
LYS A 217
THR A 265
GLY A 271
LEU A 328
ASP A 339
 ADE  A 488 ( 4.9A)
ADE  A 488 (-3.2A)
None
ADE  A 488 (-4.3A)
ADE  A 488 ( 4.1A)
ADE  A 488 (-4.4A)
None
 0.65A 4hjoA-2qluA:
24.9		 4hjoA-2qluA:
26.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4I22_A_IREA9001_1
(EPIDERMAL GROWTH
FACTOR RECEPTOR)		 2qlu ACTIVIN RECEPTOR
TYPE IIB
(Homo
sapiens) 		8 / 12 VAL A 204
ALA A 215
LYS A 217
LEU A 263
GLY A 271
ASP A 275
LEU A 328
ASP A 339
 ADE  A 488 ( 4.9A)
ADE  A 488 (-3.2A)
None
None
ADE  A 488 ( 4.1A)
None
ADE  A 488 (-4.4A)
None
 0.59A 4i22A-2qluA:
24.1		 4i22A-2qluA:
24.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4O0S_A_ADNA500_1
(AURORA KINASE A)		 2qlu ACTIVIN RECEPTOR
TYPE IIB
(Homo
sapiens) 		7 / 11 VAL A 204
ALA A 215
LYS A 217
LEU A 245
ASN A 326
LEU A 328
ASP A 339
 ADE  A 488 ( 4.9A)
ADE  A 488 (-3.2A)
None
ADE  A 488 ( 4.5A)
None
ADE  A 488 (-4.4A)
None
 0.66A 4o0sA-2qluA:
24.5		 4o0sA-2qluA:
26.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4O0U_A_ADNA501_1
(AURORA KINASE A)		 2qlu ACTIVIN RECEPTOR
TYPE IIB
(Homo
sapiens) 		5 / 6 VAL A 204
ALA A 215
LYS A 217
LEU A 245
LEU A 328
 ADE  A 488 ( 4.9A)
ADE  A 488 (-3.2A)
None
ADE  A 488 ( 4.5A)
ADE  A 488 (-4.4A)
 0.65A 4o0uA-2qluA:
7.3		 4o0uA-2qluA:
25.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4OGR_A_ADNA401_1
(CYCLIN-DEPENDENT
KINASE 9)		 2qlu ACTIVIN RECEPTOR
TYPE IIB
(Homo
sapiens) 		6 / 8 GLY A 199
VAL A 204
ALA A 215
ASN A 326
LEU A 328
ASP A 339
 None
ADE  A 488 ( 4.9A)
ADE  A 488 (-3.2A)
None
ADE  A 488 (-4.4A)
None
 0.77A 4ogrA-2qluA:
26.4		 4ogrA-2qluA:
27.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4OGR_I_ADNI401_1
(CYCLIN-DEPENDENT
KINASE 9)		 2qlu ACTIVIN RECEPTOR
TYPE IIB
(Homo
sapiens) 		6 / 9 GLY A 199
VAL A 204
ALA A 215
ASN A 326
LEU A 328
ASP A 339
 None
ADE  A 488 ( 4.9A)
ADE  A 488 (-3.2A)
None
ADE  A 488 (-4.4A)
None
 0.74A 4ogrI-2qluA:
26.8		 4ogrI-2qluA:
27.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4OTW_A_DB8A1101_1
(RECEPTOR
TYROSINE-PROTEIN
KINASE ERBB-3)		 2qlu ACTIVIN RECEPTOR
TYPE IIB
(Homo
sapiens) 		7 / 12 VAL A 204
LYS A 217
THR A 265
GLY A 271
LEU A 328
ALA A 338
ASP A 339
 ADE  A 488 ( 4.9A)
None
ADE  A 488 (-4.3A)
ADE  A 488 ( 4.1A)
ADE  A 488 (-4.4A)
None
None
 0.62A 4otwA-2qluA:
24.3		 4otwA-2qluA:
24.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4R7I_A_STIA1001_1
(MACROPHAGE
COLONY-STIMULATING
FACTOR 1 RECEPTOR)		 2qlu ACTIVIN RECEPTOR
TYPE IIB
(Homo
sapiens) 		6 / 12 VAL A 204
ALA A 215
LYS A 217
GLU A 230
THR A 265
LEU A 328
 ADE  A 488 ( 4.9A)
ADE  A 488 (-3.2A)
None
None
ADE  A 488 (-4.3A)
ADE  A 488 (-4.4A)
 0.67A 4r7iA-2qluA:
24.6		 4r7iA-2qluA:
26.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4RZV_A_032A801_1
(SERINE/THREONINE-PRO
TEIN KINASE B-RAF)		 2qlu ACTIVIN RECEPTOR
TYPE IIB
(Homo
sapiens) 		6 / 12 ALA A 215
LYS A 217
LEU A 245
THR A 265
SER A 272
PHE A 340
 ADE  A 488 (-3.2A)
None
ADE  A 488 ( 4.5A)
ADE  A 488 (-4.3A)
None
None
 0.86A 4rzvA-2qluA:
6.8		 4rzvA-2qluA:
25.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4RZV_B_032B801_1
(SERINE/THREONINE-PRO
TEIN KINASE B-RAF)		 2qlu ACTIVIN RECEPTOR
TYPE IIB
(Homo
sapiens) 		6 / 12 VAL A 204
ALA A 215
LYS A 217
LEU A 245
THR A 265
PHE A 340
 ADE  A 488 ( 4.9A)
ADE  A 488 (-3.2A)
None
ADE  A 488 ( 4.5A)
ADE  A 488 (-4.3A)
None
 0.85A 4rzvB-2qluA:
25.8		 4rzvB-2qluA:
25.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4RZV_B_032B801_1
(SERINE/THREONINE-PRO
TEIN KINASE B-RAF)		 2qlu ACTIVIN RECEPTOR
TYPE IIB
(Homo
sapiens) 		6 / 12 VAL A 204
ALA A 215
LYS A 217
LEU A 245
THR A 265
SER A 272
 ADE  A 488 ( 4.9A)
ADE  A 488 (-3.2A)
None
ADE  A 488 ( 4.5A)
ADE  A 488 (-4.3A)
None
 0.61A 4rzvB-2qluA:
25.8		 4rzvB-2qluA:
25.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4RZV_B_032B801_1
(SERINE/THREONINE-PRO
TEIN KINASE B-RAF)		 2qlu ACTIVIN RECEPTOR
TYPE IIB
(Homo
sapiens) 		5 / 12 VAL A 204
ALA A 215
LYS A 217
SER A 272
GLY A 341
 ADE  A 488 ( 4.9A)
ADE  A 488 (-3.2A)
None
None
None
 0.83A 4rzvB-2qluA:
25.8		 4rzvB-2qluA:
25.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4U0I_A_0LIA1001_2
(MAST/STEM CELL
GROWTH FACTOR
RECEPTOR
KIT,MAST/STEM CELL
GROWTH FACTOR
RECEPTOR KIT)		 2qlu ACTIVIN RECEPTOR
TYPE IIB
(Homo
sapiens) 		6 / 12 ALA A 215
LYS A 217
THR A 265
GLY A 271
HIS A 319
LEU A 328
 ADE  A 488 (-3.2A)
None
ADE  A 488 (-4.3A)
ADE  A 488 ( 4.1A)
None
ADE  A 488 (-4.4A)
 0.47A 4u0iA-2qluA:
25.1		 4u0iA-2qluA:
25.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4V04_A_0LIA1772_1
(FIBROBLAST GROWTH
FACTOR RECEPTOR 1
(FMS-RELATED
TYROSINE KINASE 2,
PFEIFFER SYNDROME),
ISOFORM CRA_B)		 2qlu ACTIVIN RECEPTOR
TYPE IIB
(Homo
sapiens) 		6 / 12 VAL A 204
ALA A 215
GLU A 230
LEU A 301
HIS A 319
ALA A 338
 ADE  A 488 ( 4.9A)
ADE  A 488 (-3.2A)
None
None
None
None
 0.95A 4v04A-2qluA:
24.2		 4v04A-2qluA:
26.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4V04_B_0LIB1771_2
(FIBROBLAST GROWTH
FACTOR RECEPTOR 1
(FMS-RELATED
TYROSINE KINASE 2,
PFEIFFER SYNDROME),
ISOFORM CRA_B)		 2qlu ACTIVIN RECEPTOR
TYPE IIB
(Homo
sapiens) 		5 / 12 ALA A 215
GLU A 230
LEU A 301
HIS A 319
ALA A 338
 ADE  A 488 (-3.2A)
None
None
None
None
 0.90A 4v04B-2qluA:
24.4		 4v04B-2qluA:
26.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4WA9_A_AXIA9000_1
(TYROSINE-PROTEIN
KINASE ABL1)		 2qlu ACTIVIN RECEPTOR
TYPE IIB
(Homo
sapiens) 		6 / 11 ALA A 215
THR A 265
GLY A 271
ASN A 326
LEU A 328
ALA A 338
 ADE  A 488 (-3.2A)
ADE  A 488 (-4.3A)
ADE  A 488 ( 4.1A)
None
ADE  A 488 (-4.4A)
None
 0.58A 4wa9A-2qluA:
23.6		 4wa9A-2qluA:
25.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4WA9_B_AXIB9000_1
(TYROSINE-PROTEIN
KINASE ABL1)		 2qlu ACTIVIN RECEPTOR
TYPE IIB
(Homo
sapiens) 		7 / 12 VAL A 204
ALA A 215
LYS A 217
THR A 265
PHE A 267
LEU A 328
ALA A 338
 ADE  A 488 ( 4.9A)
ADE  A 488 (-3.2A)
None
ADE  A 488 (-4.3A)
ADE  A 488 (-4.3A)
ADE  A 488 (-4.4A)
None
 0.96A 4wa9B-2qluA:
26.2		 4wa9B-2qluA:
25.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4WA9_B_AXIB9000_1
(TYROSINE-PROTEIN
KINASE ABL1)		 2qlu ACTIVIN RECEPTOR
TYPE IIB
(Homo
sapiens) 		8 / 12 VAL A 204
ALA A 215
THR A 265
PHE A 267
GLY A 271
ASN A 326
LEU A 328
ALA A 338
 ADE  A 488 ( 4.9A)
ADE  A 488 (-3.2A)
ADE  A 488 (-4.3A)
ADE  A 488 (-4.3A)
ADE  A 488 ( 4.1A)
None
ADE  A 488 (-4.4A)
None
 0.74A 4wa9B-2qluA:
26.2		 4wa9B-2qluA:
25.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4WKQ_A_IREA1101_1
(EPIDERMAL GROWTH
FACTOR RECEPTOR)		 2qlu ACTIVIN RECEPTOR
TYPE IIB
(Homo
sapiens) 		7 / 12 ALA A 215
LYS A 217
GLU A 230
LEU A 263
GLY A 271
ASP A 275
LEU A 328
 ADE  A 488 (-3.2A)
None
None
None
ADE  A 488 ( 4.1A)
None
ADE  A 488 (-4.4A)
 0.69A 4wkqA-2qluA:
26.8		 4wkqA-2qluA:
24.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4WKQ_A_IREA1101_1
(EPIDERMAL GROWTH
FACTOR RECEPTOR)		 2qlu ACTIVIN RECEPTOR
TYPE IIB
(Homo
sapiens) 		6 / 12 ALA A 215
LYS A 217
THR A 265
GLY A 271
ASP A 275
LEU A 328
 ADE  A 488 (-3.2A)
None
ADE  A 488 (-4.3A)
ADE  A 488 ( 4.1A)
None
ADE  A 488 (-4.4A)
 0.52A 4wkqA-2qluA:
26.8		 4wkqA-2qluA:
24.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XEY_A_1N1A601_1
(TYROSINE-PROTEIN
KINASE ABL1)		 2qlu ACTIVIN RECEPTOR
TYPE IIB
(Homo
sapiens) 		8 / 12 VAL A 204
ALA A 215
LYS A 217
THR A 265
PHE A 267
GLY A 271
LEU A 328
ALA A 338
 ADE  A 488 ( 4.9A)
ADE  A 488 (-3.2A)
None
ADE  A 488 (-4.3A)
ADE  A 488 (-4.3A)
ADE  A 488 ( 4.1A)
ADE  A 488 (-4.4A)
None
 0.56A 4xeyA-2qluA:
26.7		 4xeyA-2qluA:
23.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XEY_B_1N1B601_1
(TYROSINE-PROTEIN
KINASE ABL1)		 2qlu ACTIVIN RECEPTOR
TYPE IIB
(Homo
sapiens) 		8 / 12 VAL A 204
ALA A 215
LYS A 217
THR A 265
PHE A 267
GLY A 271
LEU A 328
ALA A 338
 ADE  A 488 ( 4.9A)
ADE  A 488 (-3.2A)
None
ADE  A 488 (-4.3A)
ADE  A 488 (-4.3A)
ADE  A 488 ( 4.1A)
ADE  A 488 (-4.4A)
None
 0.58A 4xeyB-2qluA:
26.5		 4xeyB-2qluA:
23.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XLI_B_1N1B600_1
(NON-SPECIFIC
PROTEIN-TYROSINE
KINASE)		 2qlu ACTIVIN RECEPTOR
TYPE IIB
(Homo
sapiens) 		7 / 12 ALA A 215
LYS A 217
GLU A 230
THR A 265
GLY A 271
LEU A 328
ALA A 338
 ADE  A 488 (-3.2A)
None
None
ADE  A 488 (-4.3A)
ADE  A 488 ( 4.1A)
ADE  A 488 (-4.4A)
None
 0.60A 4xliB-2qluA:
27.3		 4xliB-2qluA:
24.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XV2_A_P06A801_1
(SERINE/THREONINE-PRO
TEIN KINASE B-RAF)		 2qlu ACTIVIN RECEPTOR
TYPE IIB
(Homo
sapiens) 		7 / 12 VAL A 204
ALA A 215
LYS A 217
LEU A 245
THR A 265
ASP A 339
PHE A 340
 ADE  A 488 ( 4.9A)
ADE  A 488 (-3.2A)
None
ADE  A 488 ( 4.5A)
ADE  A 488 (-4.3A)
None
None
 0.85A 4xv2A-2qluA:
25.3		 4xv2A-2qluA:
27.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XV2_B_P06B801_1
(SERINE/THREONINE-PRO
TEIN KINASE B-RAF)		 2qlu ACTIVIN RECEPTOR
TYPE IIB
(Homo
sapiens) 		6 / 12 ALA A 215
LYS A 217
LEU A 245
THR A 265
ASP A 339
PHE A 340
 ADE  A 488 (-3.2A)
None
ADE  A 488 ( 4.5A)
ADE  A 488 (-4.3A)
None
None
 0.87A 4xv2B-2qluA:
25.6		 4xv2B-2qluA:
27.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ZE1_A_X2NA602_2
(LANOSTEROL 14-ALPHA
DEMETHYLASE)		 2qlu ACTIVIN RECEPTOR
TYPE IIB
(Homo
sapiens) 		4 / 5 VAL A 455
TYR A 410
PRO A 438
THR A 361
 None
None
None
SO4  A   2 ( 4.2A)
 1.03A 4ze1A-2qluA:
undetectable		 4ze1A-2qluA:
18.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ADN_A_H4BA600_1
(NITRIC OXIDE
SYNTHASE,
ENDOTHELIAL)		 2qlu ACTIVIN RECEPTOR
TYPE IIB
(Homo
sapiens) 		4 / 6 VAL A 369
ARG A 320
PHE A 381
GLU A 368
 None
 1.44A 5adnA-2qluA:
0.2
5adnB-2qluA:
0.0		 5adnA-2qluA:
22.37
5adnB-2qluA:
22.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ADN_B_H4BB600_1
(NITRIC OXIDE
SYNTHASE,
ENDOTHELIAL)		 2qlu ACTIVIN RECEPTOR
TYPE IIB
(Homo
sapiens) 		4 / 6 PHE A 381
GLU A 368
VAL A 369
ARG A 320
 None
 1.42A 5adnA-2qluA:
0.2
5adnB-2qluA:
0.0		 5adnA-2qluA:
22.37
5adnB-2qluA:
22.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5AJQ_B_DB8B800_1
(SERINE/THREONINE-PRO
TEIN KINASE 10)		 2qlu ACTIVIN RECEPTOR
TYPE IIB
(Homo
sapiens) 		5 / 10 ALA A 215
GLY A 271
LEU A 328
ALA A 338
ASP A 339
 ADE  A 488 (-3.2A)
ADE  A 488 ( 4.1A)
ADE  A 488 (-4.4A)
None
None
 0.54A 5ajqB-2qluA:
22.5		 5ajqB-2qluA:
24.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5AJQ_B_DB8B800_1
(SERINE/THREONINE-PRO
TEIN KINASE 10)		 2qlu ACTIVIN RECEPTOR
TYPE IIB
(Homo
sapiens) 		5 / 10 ALA A 215
PHE A 267
GLY A 271
LEU A 328
ALA A 338
 ADE  A 488 (-3.2A)
ADE  A 488 (-4.3A)
ADE  A 488 ( 4.1A)
ADE  A 488 (-4.4A)
None
 0.54A 5ajqB-2qluA:
22.5		 5ajqB-2qluA:
24.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5BVW_A_1N1A1009_1
(EPITHELIAL DISCOIDIN
DOMAIN-CONTAINING
RECEPTOR 1)		 2qlu ACTIVIN RECEPTOR
TYPE IIB
(Homo
sapiens) 		8 / 12 VAL A 204
ALA A 215
LYS A 217
GLU A 230
THR A 265
GLY A 271
LEU A 328
ALA A 338
 ADE  A 488 ( 4.9A)
ADE  A 488 (-3.2A)
None
None
ADE  A 488 (-4.3A)
ADE  A 488 ( 4.1A)
ADE  A 488 (-4.4A)
None
 0.82A 5bvwA-2qluA:
24.5		 5bvwA-2qluA:
24.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5CSW_A_P06A801_1
(SERINE/THREONINE-PRO
TEIN KINASE B-RAF)		 2qlu ACTIVIN RECEPTOR
TYPE IIB
(Homo
sapiens) 		6 / 12 VAL A 204
ALA A 215
LYS A 217
LEU A 245
THR A 265
PHE A 340
 ADE  A 488 ( 4.9A)
ADE  A 488 (-3.2A)
None
ADE  A 488 ( 4.5A)
ADE  A 488 (-4.3A)
None
 0.81A 5cswA-2qluA:
25.3		 5cswA-2qluA:
25.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5CSW_B_P06B801_1
(SERINE/THREONINE-PRO
TEIN KINASE B-RAF)		 2qlu ACTIVIN RECEPTOR
TYPE IIB
(Homo
sapiens) 		6 / 12 VAL A 204
ALA A 215
LYS A 217
LEU A 245
THR A 265
PHE A 340
 ADE  A 488 ( 4.9A)
ADE  A 488 (-3.2A)
None
ADE  A 488 ( 4.5A)
ADE  A 488 (-4.3A)
None
 0.88A 5cswB-2qluA:
25.0		 5cswB-2qluA:
25.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5FVY_B_H4BB600_1
(NITRIC OXIDE
SYNTHASE,
ENDOTHELIAL)		 2qlu ACTIVIN RECEPTOR
TYPE IIB
(Homo
sapiens) 		4 / 6 PHE A 381
GLU A 368
VAL A 369
ARG A 320
 None
 1.36A 5fvyA-2qluA:
0.0
5fvyB-2qluA:
0.0		 5fvyA-2qluA:
22.37
5fvyB-2qluA:
22.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5GWK_D_EVPD102_1
(DNA TOPOISOMERASE
2-ALPHA)		 2qlu ACTIVIN RECEPTOR
TYPE IIB
(Homo
sapiens) 		4 / 4 GLY A 202
ASP A 223
ARG A 200
MET A 239
 None
 1.24A 5gwkB-2qluA:
1.2		 5gwkB-2qluA:
17.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5H2U_B_1N1B501_1
(PROTEIN-TYROSINE
KINASE 6)		 2qlu ACTIVIN RECEPTOR
TYPE IIB
(Homo
sapiens) 		6 / 12 ALA A 215
LEU A 245
THR A 265
GLY A 271
LEU A 328
ASP A 339
 ADE  A 488 (-3.2A)
ADE  A 488 ( 4.5A)
ADE  A 488 (-4.3A)
ADE  A 488 ( 4.1A)
ADE  A 488 (-4.4A)
None
 0.58A 5h2uB-2qluA:
24.8		 5h2uB-2qluA:
25.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5H2U_B_1N1B501_1
(PROTEIN-TYROSINE
KINASE 6)		 2qlu ACTIVIN RECEPTOR
TYPE IIB
(Homo
sapiens) 		6 / 12 VAL A 204
ALA A 215
THR A 265
GLY A 271
LEU A 328
ASP A 339
 ADE  A 488 ( 4.9A)
ADE  A 488 (-3.2A)
ADE  A 488 (-4.3A)
ADE  A 488 ( 4.1A)
ADE  A 488 (-4.4A)
None
 0.73A 5h2uB-2qluA:
24.8		 5h2uB-2qluA:
25.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5H2U_C_1N1C501_1
(PROTEIN-TYROSINE
KINASE 6)		 2qlu ACTIVIN RECEPTOR
TYPE IIB
(Homo
sapiens) 		6 / 12 ALA A 215
LEU A 245
THR A 265
GLY A 271
LEU A 328
ASP A 339
 ADE  A 488 (-3.2A)
ADE  A 488 ( 4.5A)
ADE  A 488 (-4.3A)
ADE  A 488 ( 4.1A)
ADE  A 488 (-4.4A)
None
 0.62A 5h2uC-2qluA:
24.6		 5h2uC-2qluA:
25.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5H2U_D_1N1D504_1
(PROTEIN-TYROSINE
KINASE 6)		 2qlu ACTIVIN RECEPTOR
TYPE IIB
(Homo
sapiens) 		6 / 12 ALA A 215
LEU A 245
THR A 265
GLY A 271
LEU A 328
ASP A 339
 ADE  A 488 (-3.2A)
ADE  A 488 ( 4.5A)
ADE  A 488 (-4.3A)
ADE  A 488 ( 4.1A)
ADE  A 488 (-4.4A)
None
 0.58A 5h2uD-2qluA:
24.7		 5h2uD-2qluA:
25.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HES_A_032A401_1
(MITOGEN-ACTIVATED
PROTEIN KINASE
KINASE KINASE MLT)		 2qlu ACTIVIN RECEPTOR
TYPE IIB
(Homo
sapiens) 		6 / 12 VAL A 204
ALA A 215
THR A 265
ASP A 275
PHE A 340
GLY A 341
 ADE  A 488 ( 4.9A)
ADE  A 488 (-3.2A)
ADE  A 488 (-4.3A)
None
None
None
 1.10A 5hesA-2qluA:
8.7		 5hesA-2qluA:
29.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HES_A_032A401_2
(MITOGEN-ACTIVATED
PROTEIN KINASE
KINASE KINASE MLT)		 2qlu ACTIVIN RECEPTOR
TYPE IIB
(Homo
sapiens) 		4 / 6 LYS A 217
PHE A 247
SER A 272
ASP A 339
 None
 0.68A 5hesA-2qluA:
8.7		 5hesA-2qluA:
29.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HES_B_032B401_1
(MITOGEN-ACTIVATED
PROTEIN KINASE
KINASE KINASE MLT)		 2qlu ACTIVIN RECEPTOR
TYPE IIB
(Homo
sapiens) 		6 / 12 VAL A 204
ALA A 215
LYS A 217
THR A 265
ASP A 275
GLY A 341
 ADE  A 488 ( 4.9A)
ADE  A 488 (-3.2A)
None
ADE  A 488 (-4.3A)
None
None
 0.88A 5hesB-2qluA:
24.6		 5hesB-2qluA:
29.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HES_B_032B401_1
(MITOGEN-ACTIVATED
PROTEIN KINASE
KINASE KINASE MLT)		 2qlu ACTIVIN RECEPTOR
TYPE IIB
(Homo
sapiens) 		6 / 12 VAL A 204
ALA A 215
LYS A 217
THR A 265
ASP A 275
PHE A 340
 ADE  A 488 ( 4.9A)
ADE  A 488 (-3.2A)
None
ADE  A 488 (-4.3A)
None
None
 0.84A 5hesB-2qluA:
24.6		 5hesB-2qluA:
29.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HI2_A_BAXA801_1
(SERINE/THREONINE-PRO
TEIN KINASE B-RAF)		 2qlu ACTIVIN RECEPTOR
TYPE IIB
(Homo
sapiens) 		6 / 12 ALA A 215
LYS A 217
GLU A 230
LEU A 245
THR A 265
LEU A 301
 ADE  A 488 (-3.2A)
None
None
ADE  A 488 ( 4.5A)
ADE  A 488 (-4.3A)
None
 0.84A 5hi2A-2qluA:
25.5		 5hi2A-2qluA:
27.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HI2_A_BAXA801_1
(SERINE/THREONINE-PRO
TEIN KINASE B-RAF)		 2qlu ACTIVIN RECEPTOR
TYPE IIB
(Homo
sapiens) 		6 / 12 ALA A 215
LYS A 217
LEU A 245
THR A 265
LEU A 301
HIS A 319
 ADE  A 488 (-3.2A)
None
ADE  A 488 ( 4.5A)
ADE  A 488 (-4.3A)
None
None
 0.73A 5hi2A-2qluA:
25.5		 5hi2A-2qluA:
27.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HIE_A_P06A801_1
(SERINE/THREONINE-PRO
TEIN KINASE B-RAF)		 2qlu ACTIVIN RECEPTOR
TYPE IIB
(Homo
sapiens) 		6 / 12 GLY A 199
VAL A 204
ALA A 215
LYS A 217
LEU A 245
THR A 265
 None
ADE  A 488 ( 4.9A)
ADE  A 488 (-3.2A)
None
ADE  A 488 ( 4.5A)
ADE  A 488 (-4.3A)
 0.61A 5hieA-2qluA:
25.7		 5hieA-2qluA:
28.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HIE_B_P06B801_1
(SERINE/THREONINE-PRO
TEIN KINASE B-RAF)		 2qlu ACTIVIN RECEPTOR
TYPE IIB
(Homo
sapiens) 		6 / 12 GLY A 199
VAL A 204
ALA A 215
LYS A 217
LEU A 245
THR A 265
 None
ADE  A 488 ( 4.9A)
ADE  A 488 (-3.2A)
None
ADE  A 488 ( 4.5A)
ADE  A 488 (-4.3A)
 0.61A 5hieB-2qluA:
25.6		 5hieB-2qluA:
28.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HIE_C_P06C801_1
(SERINE/THREONINE-PRO
TEIN KINASE B-RAF)		 2qlu ACTIVIN RECEPTOR
TYPE IIB
(Homo
sapiens) 		6 / 12 GLY A 199
VAL A 204
ALA A 215
LYS A 217
LEU A 245
THR A 265
 None
ADE  A 488 ( 4.9A)
ADE  A 488 (-3.2A)
None
ADE  A 488 ( 4.5A)
ADE  A 488 (-4.3A)
 0.60A 5hieC-2qluA:
26.1		 5hieC-2qluA:
28.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HIE_C_P06C801_1
(SERINE/THREONINE-PRO
TEIN KINASE B-RAF)		 2qlu ACTIVIN RECEPTOR
TYPE IIB
(Homo
sapiens) 		6 / 12 VAL A 204
ALA A 215
LYS A 217
LEU A 245
THR A 265
ASP A 339
 ADE  A 488 ( 4.9A)
ADE  A 488 (-3.2A)
None
ADE  A 488 ( 4.5A)
ADE  A 488 (-4.3A)
None
 0.58A 5hieC-2qluA:
26.1		 5hieC-2qluA:
28.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HIE_D_P06D801_1
(SERINE/THREONINE-PRO
TEIN KINASE B-RAF)		 2qlu ACTIVIN RECEPTOR
TYPE IIB
(Homo
sapiens) 		6 / 12 GLY A 199
VAL A 204
ALA A 215
LYS A 217
LEU A 245
THR A 265
 None
ADE  A 488 ( 4.9A)
ADE  A 488 (-3.2A)
None
ADE  A 488 ( 4.5A)
ADE  A 488 (-4.3A)
 0.61A 5hieD-2qluA:
25.7		 5hieD-2qluA:
28.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5I9Y_A_1N1A1001_1
(EPHRIN TYPE-A
RECEPTOR 2)		 2qlu ACTIVIN RECEPTOR
TYPE IIB
(Homo
sapiens) 		6 / 12 ALA A 215
LYS A 217
GLU A 230
THR A 265
GLY A 271
LEU A 328
 ADE  A 488 (-3.2A)
None
None
ADE  A 488 (-4.3A)
ADE  A 488 ( 4.1A)
ADE  A 488 (-4.4A)
 0.55A 5i9yA-2qluA:
24.9		 5i9yA-2qluA:
24.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ICX_E_SC2E1_1
(CETUXIMAB FAB LIGHT
CHAIN
MEDITOPE)		 2qlu ACTIVIN RECEPTOR
TYPE IIB
(Homo
sapiens) 		3 / 3 VAL A 397
GLN A 452
CYH A 454
 None
 0.84A 5icxA-2qluA:
undetectable
5icxE-2qluA:
undetectable		 5icxA-2qluA:
20.44
5icxE-2qluA:
5.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VCY_A_DB8A401_1
(MEMBRANE-ASSOCIATED
TYROSINE- AND
THREONINE-SPECIFIC
CDC2-INHIBITORY
KINASE)		 2qlu ACTIVIN RECEPTOR
TYPE IIB
(Homo
sapiens) 		6 / 12 VAL A 204
ALA A 215
LYS A 217
GLU A 230
LEU A 263
THR A 265
 ADE  A 488 ( 4.9A)
ADE  A 488 (-3.2A)
None
None
None
ADE  A 488 (-4.3A)
 0.80A 5vcyA-2qluA:
22.9		 5vcyA-2qluA:
28.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VV6_A_H4BA502_1
(NITRIC OXIDE
SYNTHASE,
ENDOTHELIAL)		 2qlu ACTIVIN RECEPTOR
TYPE IIB
(Homo
sapiens) 		4 / 6 VAL A 369
ARG A 320
PHE A 381
GLU A 368
 None
 1.42A 5vv6A-2qluA:
0.0
5vv6B-2qluA:
0.0		 5vv6A-2qluA:
22.37
5vv6B-2qluA:
22.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VV8_A_H4BA502_1
(NITRIC OXIDE
SYNTHASE,
ENDOTHELIAL)		 2qlu ACTIVIN RECEPTOR
TYPE IIB
(Homo
sapiens) 		4 / 6 VAL A 369
ARG A 320
PHE A 381
GLU A 368
 None
 1.43A 5vv8A-2qluA:
0.0
5vv8B-2qluA:
0.0		 5vv8A-2qluA:
22.37
5vv8B-2qluA:
22.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VV9_A_H4BA502_1
(NITRIC OXIDE
SYNTHASE,
ENDOTHELIAL)		 2qlu ACTIVIN RECEPTOR
TYPE IIB
(Homo
sapiens) 		4 / 7 VAL A 369
ARG A 320
PHE A 381
GLU A 368
 None
 1.41A 5vv9A-2qluA:
undetectable
5vv9B-2qluA:
undetectable		 5vv9A-2qluA:
22.37
5vv9B-2qluA:
22.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VVA_A_H4BA502_1
(NITRIC OXIDE
SYNTHASE,
ENDOTHELIAL)		 2qlu ACTIVIN RECEPTOR
TYPE IIB
(Homo
sapiens) 		4 / 7 VAL A 369
ARG A 320
PHE A 381
GLU A 368
 None
 1.29A 5vvaA-2qluA:
undetectable
5vvaB-2qluA:
undetectable		 5vvaA-2qluA:
22.37
5vvaB-2qluA:
22.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VVG_A_H4BA502_1
(NITRIC OXIDE
SYNTHASE,
ENDOTHELIAL)		 2qlu ACTIVIN RECEPTOR
TYPE IIB
(Homo
sapiens) 		4 / 6 VAL A 369
ARG A 320
PHE A 381
GLU A 368
 None
 1.40A 5vvgA-2qluA:
0.2
5vvgB-2qluA:
0.0		 5vvgA-2qluA:
22.37
5vvgB-2qluA:
22.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VVN_A_H4BA502_1
(NITRIC OXIDE
SYNTHASE,
ENDOTHELIAL)		 2qlu ACTIVIN RECEPTOR
TYPE IIB
(Homo
sapiens) 		4 / 6 VAL A 369
ARG A 320
PHE A 381
GLU A 368
 None
 1.41A 5vvnA-2qluA:
0.0
5vvnB-2qluA:
0.0		 5vvnA-2qluA:
22.37
5vvnB-2qluA:
22.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5YU9_B_1E8B1101_1
(EPIDERMAL GROWTH
FACTOR RECEPTOR)		 2qlu ACTIVIN RECEPTOR
TYPE IIB
(Homo
sapiens) 		7 / 12 VAL A 204
ALA A 215
LYS A 217
LEU A 263
ASP A 275
LEU A 328
ASP A 339
 ADE  A 488 ( 4.9A)
ADE  A 488 (-3.2A)
None
None
None
ADE  A 488 (-4.4A)
None
 0.93A 5yu9B-2qluA:
23.9		 5yu9B-2qluA:
14.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5YU9_C_1E8C1101_1
(EPIDERMAL GROWTH
FACTOR RECEPTOR)		 2qlu ACTIVIN RECEPTOR
TYPE IIB
(Homo
sapiens) 		6 / 12 VAL A 204
ALA A 215
LEU A 263
GLY A 271
ASP A 275
ASP A 339
 ADE  A 488 ( 4.9A)
ADE  A 488 (-3.2A)
None
ADE  A 488 ( 4.1A)
None
None
 0.82A 5yu9C-2qluA:
23.7		 5yu9C-2qluA:
14.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5YU9_C_1E8C1101_1
(EPIDERMAL GROWTH
FACTOR RECEPTOR)		 2qlu ACTIVIN RECEPTOR
TYPE IIB
(Homo
sapiens) 		6 / 12 VAL A 204
ALA A 215
LYS A 217
LEU A 263
ASP A 275
ASP A 339
 ADE  A 488 ( 4.9A)
ADE  A 488 (-3.2A)
None
None
None
None
 0.97A 5yu9C-2qluA:
23.7		 5yu9C-2qluA:
14.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5YU9_D_1E8D1101_1
(EPIDERMAL GROWTH
FACTOR RECEPTOR)		 2qlu ACTIVIN RECEPTOR
TYPE IIB
(Homo
sapiens) 		6 / 12 VAL A 204
ALA A 215
GLY A 271
ASP A 275
LEU A 328
ASP A 339
 ADE  A 488 ( 4.9A)
ADE  A 488 (-3.2A)
ADE  A 488 ( 4.1A)
None
ADE  A 488 (-4.4A)
None
 0.64A 5yu9D-2qluA:
24.3		 5yu9D-2qluA:
14.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5YU9_D_1E8D1101_1
(EPIDERMAL GROWTH
FACTOR RECEPTOR)		 2qlu ACTIVIN RECEPTOR
TYPE IIB
(Homo
sapiens) 		6 / 12 VAL A 204
ALA A 215
LYS A 217
ASP A 275
LEU A 328
ASP A 339
 ADE  A 488 ( 4.9A)
ADE  A 488 (-3.2A)
None
None
ADE  A 488 (-4.4A)
None
 0.86A 5yu9D-2qluA:
24.3		 5yu9D-2qluA:
14.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ZCO_P_CHDP305_0
(CYTOCHROME C OXIDASE
SUBUNIT 3
CYTOCHROME C OXIDASE
SUBUNIT 7A1,
MITOCHONDRIAL)		 2qlu ACTIVIN RECEPTOR
TYPE IIB
(Homo
sapiens) 		4 / 6 GLN A 225
PHE A 219
LEU A 263
PHE A 234
 None
 1.13A 5zcoP-2qluA:
3.1
5zcoW-2qluA:
undetectable		 5zcoP-2qluA:
21.49
5zcoW-2qluA:
14.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6CIE_B_H4BB502_0
(NITRIC OXIDE
SYNTHASE,
ENDOTHELIAL)		 2qlu ACTIVIN RECEPTOR
TYPE IIB
(Homo
sapiens) 		4 / 7 PHE A 381
GLU A 368
VAL A 369
ARG A 320
 None
 1.38A 6cieA-2qluA:
undetectable
6cieB-2qluA:
undetectable		 6cieA-2qluA:
13.56
6cieB-2qluA:
13.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6CIE_C_H4BC502_0
(NITRIC OXIDE
SYNTHASE,
ENDOTHELIAL)		 2qlu ACTIVIN RECEPTOR
TYPE IIB
(Homo
sapiens) 		4 / 6 VAL A 369
ARG A 320
PHE A 381
GLU A 368
 None
 1.40A 6cieC-2qluA:
0.0
6cieD-2qluA:
0.0		 6cieC-2qluA:
13.56
6cieD-2qluA:
13.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6CIF_C_H4BC502_0
(NITRIC OXIDE
SYNTHASE,
ENDOTHELIAL)		 2qlu ACTIVIN RECEPTOR
TYPE IIB
(Homo
sapiens) 		4 / 7 VAL A 369
ARG A 320
PHE A 381
GLU A 368
 None
 1.26A 6cifC-2qluA:
undetectable
6cifD-2qluA:
0.0		 6cifC-2qluA:
13.56
6cifD-2qluA:
13.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6CIF_D_H4BD502_0
(NITRIC OXIDE
SYNTHASE,
ENDOTHELIAL)		 2qlu ACTIVIN RECEPTOR
TYPE IIB
(Homo
sapiens) 		4 / 6 PHE A 381
GLU A 368
VAL A 369
ARG A 320
 None
 1.37A 6cifC-2qluA:
0.0
6cifD-2qluA:
0.0		 6cifC-2qluA:
13.56
6cifD-2qluA:
13.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6FNM_A_1N1A1001_1
(-)		 2qlu ACTIVIN RECEPTOR
TYPE IIB
(Homo
sapiens) 		7 / 12 VAL A 204
ALA A 215
LYS A 217
GLU A 230
THR A 265
GLY A 271
LEU A 328
 ADE  A 488 ( 4.9A)
ADE  A 488 (-3.2A)
None
None
ADE  A 488 (-4.3A)
ADE  A 488 ( 4.1A)
ADE  A 488 (-4.4A)
 0.83A 6fnmA-2qluA:
26.0		 6fnmA-2qluA:
26.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6HD6_A_STIA603_0
(TYROSINE-PROTEIN
KINASE ABL1)		 2qlu ACTIVIN RECEPTOR
TYPE IIB
(Homo
sapiens) 		7 / 12 VAL A 204
ALA A 215
GLU A 230
THR A 265
PHE A 267
LEU A 328
ALA A 338
 ADE  A 488 ( 4.9A)
ADE  A 488 (-3.2A)
None
ADE  A 488 (-4.3A)
ADE  A 488 (-4.3A)
ADE  A 488 (-4.4A)
None
 0.88A 6hd6A-2qluA:
24.1		 6hd6A-2qluA:
15.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
9NSE_B_H4BB601_1
(PROTEIN (NITRIC
OXIDE SYNTHASE))		 2qlu ACTIVIN RECEPTOR
TYPE IIB
(Homo
sapiens) 		4 / 6 PHE A 381
GLU A 368
VAL A 369
ARG A 320
 None
 1.44A 9nseA-2qluA:
0.0
9nseB-2qluA:
0.0		 9nseA-2qluA:
22.32
9nseB-2qluA:
22.32