SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2qlz'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1EQB_A_GLYA1292_0
(SERINE
HYDROXYMETHYLTRANSFE
RASE)		 2qlz TRANSCRIPTION FACTOR
PF0095
(Pyrococcus
furiosus) 		4 / 8 SER A  19
SER A  32
HIS A  20
ARG A 187
 None
 1.18A 1eqbA-2qlzA:
undetectable
1eqbB-2qlzA:
undetectable		 1eqbA-2qlzA:
20.34
1eqbB-2qlzA:
20.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1EQB_B_GLYB2292_0
(SERINE
HYDROXYMETHYLTRANSFE
RASE)		 2qlz TRANSCRIPTION FACTOR
PF0095
(Pyrococcus
furiosus) 		4 / 8 SER A  19
SER A  32
HIS A  20
ARG A 187
 None
 1.18A 1eqbA-2qlzA:
undetectable
1eqbB-2qlzA:
undetectable		 1eqbA-2qlzA:
20.34
1eqbB-2qlzA:
20.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1EQB_C_GLYC3292_0
(SERINE
HYDROXYMETHYLTRANSFE
RASE)		 2qlz TRANSCRIPTION FACTOR
PF0095
(Pyrococcus
furiosus) 		4 / 8 SER A  19
SER A  32
HIS A  20
ARG A 187
 None
 1.18A 1eqbC-2qlzA:
undetectable
1eqbD-2qlzA:
undetectable		 1eqbC-2qlzA:
20.34
1eqbD-2qlzA:
20.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1EQB_D_GLYD4292_0
(SERINE
HYDROXYMETHYLTRANSFE
RASE)		 2qlz TRANSCRIPTION FACTOR
PF0095
(Pyrococcus
furiosus) 		4 / 8 SER A  19
SER A  32
HIS A  20
ARG A 187
 None
 1.18A 1eqbC-2qlzA:
undetectable
1eqbD-2qlzA:
undetectable		 1eqbC-2qlzA:
20.34
1eqbD-2qlzA:
20.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1NSI_A_H4BA600_1
(PROTEIN (NITRIC
OXIDE SYNTHASE))		 2qlz TRANSCRIPTION FACTOR
PF0095
(Pyrococcus
furiosus) 		4 / 6 ARG A 102
ILE A 106
PHE A 104
GLU A 133
 None
 1.47A 1nsiA-2qlzA:
undetectable
1nsiB-2qlzA:
undetectable		 1nsiA-2qlzA:
17.36
1nsiB-2qlzA:
17.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1NSI_B_H4BB601_1
(PROTEIN (NITRIC
OXIDE SYNTHASE))		 2qlz TRANSCRIPTION FACTOR
PF0095
(Pyrococcus
furiosus) 		4 / 6 PHE A 104
GLU A 133
ARG A 102
ILE A 106
 None
 1.45A 1nsiA-2qlzA:
undetectable
1nsiB-2qlzA:
undetectable		 1nsiA-2qlzA:
17.36
1nsiB-2qlzA:
17.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1NSI_C_H4BC602_1
(PROTEIN (NITRIC
OXIDE SYNTHASE))		 2qlz TRANSCRIPTION FACTOR
PF0095
(Pyrococcus
furiosus) 		4 / 6 ARG A 102
ILE A 106
PHE A 104
GLU A 133
 None
 1.48A 1nsiC-2qlzA:
undetectable
1nsiD-2qlzA:
undetectable		 1nsiC-2qlzA:
17.36
1nsiD-2qlzA:
17.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1NSI_D_H4BD603_1
(PROTEIN (NITRIC
OXIDE SYNTHASE))		 2qlz TRANSCRIPTION FACTOR
PF0095
(Pyrococcus
furiosus) 		4 / 6 PHE A 104
GLU A 133
ARG A 102
ILE A 106
 None
 1.47A 1nsiC-2qlzA:
undetectable
1nsiD-2qlzA:
undetectable		 1nsiC-2qlzA:
17.36
1nsiD-2qlzA:
17.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2NSI_A_H4BA600_1
(PROTEIN (NITRIC
OXIDE SYNTHASE))		 2qlz TRANSCRIPTION FACTOR
PF0095
(Pyrococcus
furiosus) 		4 / 7 ARG A 102
ILE A 106
PHE A 104
GLU A 133
 None
 1.49A 2nsiA-2qlzA:
undetectable
2nsiB-2qlzA:
undetectable		 2nsiA-2qlzA:
17.36
2nsiB-2qlzA:
17.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2NSI_B_H4BB601_1
(PROTEIN (NITRIC
OXIDE SYNTHASE))		 2qlz TRANSCRIPTION FACTOR
PF0095
(Pyrococcus
furiosus) 		4 / 7 PHE A 104
GLU A 133
ARG A 102
ILE A 106
 None
 1.47A 2nsiA-2qlzA:
undetectable
2nsiB-2qlzA:
undetectable		 2nsiA-2qlzA:
17.36
2nsiB-2qlzA:
17.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2NSI_C_H4BC602_1
(PROTEIN (NITRIC
OXIDE SYNTHASE))		 2qlz TRANSCRIPTION FACTOR
PF0095
(Pyrococcus
furiosus) 		4 / 7 ARG A 102
ILE A 106
PHE A 104
GLU A 133
 None
 1.49A 2nsiC-2qlzA:
1.5
2nsiD-2qlzA:
undetectable		 2nsiC-2qlzA:
17.36
2nsiD-2qlzA:
17.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2NSI_D_H4BD603_1
(PROTEIN (NITRIC
OXIDE SYNTHASE))		 2qlz TRANSCRIPTION FACTOR
PF0095
(Pyrococcus
furiosus) 		4 / 7 PHE A 104
GLU A 133
ARG A 102
ILE A 106
 None
 1.48A 2nsiC-2qlzA:
1.5
2nsiD-2qlzA:
undetectable		 2nsiC-2qlzA:
17.36
2nsiD-2qlzA:
17.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2VMY_B_GLYB502_0
(SERINE
HYDROXYMETHYLTRANSFE
RASE)		 2qlz TRANSCRIPTION FACTOR
PF0095
(Pyrococcus
furiosus) 		4 / 8 SER A  19
SER A  32
HIS A  20
ARG A 187
 None
 1.12A 2vmyA-2qlzA:
undetectable
2vmyB-2qlzA:
undetectable		 2vmyA-2qlzA:
18.63
2vmyB-2qlzA:
18.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3E7G_A_H4BA902_1
(NITRIC OXIDE
SYNTHASE, INDUCIBLE)		 2qlz TRANSCRIPTION FACTOR
PF0095
(Pyrococcus
furiosus) 		4 / 7 ARG A 102
ILE A 106
PHE A 104
GLU A 133
 None
 1.48A 3e7gA-2qlzA:
undetectable
3e7gB-2qlzA:
1.6		 3e7gA-2qlzA:
17.14
3e7gB-2qlzA:
17.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3E7G_B_H4BB1902_1
(NITRIC OXIDE
SYNTHASE, INDUCIBLE)		 2qlz TRANSCRIPTION FACTOR
PF0095
(Pyrococcus
furiosus) 		4 / 7 PHE A 104
GLU A 133
ARG A 102
ILE A 106
 None
 1.48A 3e7gA-2qlzA:
undetectable
3e7gB-2qlzA:
1.6		 3e7gA-2qlzA:
17.14
3e7gB-2qlzA:
17.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3E7G_C_H4BC2902_1
(NITRIC OXIDE
SYNTHASE, INDUCIBLE)		 2qlz TRANSCRIPTION FACTOR
PF0095
(Pyrococcus
furiosus) 		4 / 7 ARG A 102
ILE A 106
PHE A 104
GLU A 133
 None
 1.47A 3e7gC-2qlzA:
undetectable
3e7gD-2qlzA:
undetectable		 3e7gC-2qlzA:
17.14
3e7gD-2qlzA:
17.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3E7G_D_H4BD3902_1
(NITRIC OXIDE
SYNTHASE, INDUCIBLE)		 2qlz TRANSCRIPTION FACTOR
PF0095
(Pyrococcus
furiosus) 		4 / 8 PHE A 104
GLU A 133
ARG A 102
ILE A 106
 None
 1.47A 3e7gC-2qlzA:
undetectable
3e7gD-2qlzA:
undetectable		 3e7gC-2qlzA:
17.14
3e7gD-2qlzA:
17.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ELZ_A_CHDA152_0
(ILEAL BILE
ACID-BINDING PROTEIN)		 2qlz TRANSCRIPTION FACTOR
PF0095
(Pyrococcus
furiosus) 		3 / 3 VAL A 195
LYS A 198
HIS A 171
 None
 0.76A 3elzA-2qlzA:
undetectable		 3elzA-2qlzA:
21.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3IW1_A_ASDA1223_1
(CYTOCHROME P450
CYP125)		 2qlz TRANSCRIPTION FACTOR
PF0095
(Pyrococcus
furiosus) 		5 / 12 ILE A 161
GLN A 166
ILE A 210
VAL A 208
VAL A 206
 None
 1.04A 3iw1A-2qlzA:
undetectable		 3iw1A-2qlzA:
19.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UG8_A_IMNA2001_2
(ALDO-KETO REDUCTASE
FAMILY 1 MEMBER C3)		 2qlz TRANSCRIPTION FACTOR
PF0095
(Pyrococcus
furiosus) 		3 / 3 TYR A  91
GLU A  52
TYR A   7
 None
 1.00A 3ug8A-2qlzA:
undetectable		 3ug8A-2qlzA:
21.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4CX7_D_H4BD600_1
(NITRIC OXIDE
SYNTHASE, INDUCIBLE)		 2qlz TRANSCRIPTION FACTOR
PF0095
(Pyrococcus
furiosus) 		4 / 7 PHE A 104
GLU A 133
ARG A 102
ILE A 106
 None
 1.46A 4cx7C-2qlzA:
undetectable
4cx7D-2qlzA:
undetectable		 4cx7C-2qlzA:
17.36
4cx7D-2qlzA:
17.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4HTF_A_ACTA303_0
(S-ADENOSYLMETHIONINE
-DEPENDENT
METHYLTRANSFERASE)		 2qlz TRANSCRIPTION FACTOR
PF0095
(Pyrococcus
furiosus) 		3 / 3 TYR A   7
HIS A  45
ARG A  14
 None
 0.75A 4htfA-2qlzA:
undetectable		 4htfA-2qlzA:
21.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4K4Y_I_ACTI503_0
(RNA-DEPENDENT RNA
POLYMERASE)		 2qlz TRANSCRIPTION FACTOR
PF0095
(Pyrococcus
furiosus) 		4 / 5 LEU A 136
GLU A 137
LEU A  94
LYS A  92
 None
 1.33A 4k4yI-2qlzA:
undetectable		 4k4yI-2qlzA:
20.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4NOS_B_H4BB1011_1
(INDUCIBLE NITRIC
OXIDE SYNTHASE)		 2qlz TRANSCRIPTION FACTOR
PF0095
(Pyrococcus
furiosus) 		4 / 7 PHE A 104
GLU A 133
ARG A 102
ILE A 106
 None
 1.48A 4nosA-2qlzA:
0.9
4nosB-2qlzA:
undetectable		 4nosA-2qlzA:
16.86
4nosB-2qlzA:
16.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4NOS_C_H4BC2011_1
(INDUCIBLE NITRIC
OXIDE SYNTHASE)		 2qlz TRANSCRIPTION FACTOR
PF0095
(Pyrococcus
furiosus) 		4 / 7 ARG A 102
ILE A 106
PHE A 104
GLU A 133
 None
 1.49A 4nosC-2qlzA:
undetectable
4nosD-2qlzA:
undetectable		 4nosC-2qlzA:
16.86
4nosD-2qlzA:
16.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4NOS_D_H4BD3011_1
(INDUCIBLE NITRIC
OXIDE SYNTHASE)		 2qlz TRANSCRIPTION FACTOR
PF0095
(Pyrococcus
furiosus) 		4 / 6 PHE A 104
GLU A 133
ARG A 102
ILE A 106
 None
 1.43A 4nosC-2qlzA:
undetectable
4nosD-2qlzA:
undetectable		 4nosC-2qlzA:
16.86
4nosD-2qlzA:
16.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5A06_A_SORA1343_0
(ALDOSE-ALDOSE
OXIDOREDUCTASE)		 2qlz TRANSCRIPTION FACTOR
PF0095
(Pyrococcus
furiosus) 		4 / 6 ARG A 187
ASP A  16
LYS A  12
ARG A  15
 None
 1.37A 5a06A-2qlzA:
undetectable		 5a06A-2qlzA:
21.26