SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2qm0'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1EQB_A_GLYA1292_0
(SERINE
HYDROXYMETHYLTRANSFE
RASE)		 2qm0 BES
(Bacillus
cereus) 		4 / 8 HIS A 254
SER A 181
LYS A 158
PHE A  56
 SVY  A 157 ( 3.8A)
None
SVY  A 157 ( 2.9A)
None
 1.00A 1eqbA-2qm0A:
undetectable
1eqbB-2qm0A:
undetectable		 1eqbA-2qm0A:
22.14
1eqbB-2qm0A:
22.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1EQB_B_GLYB2292_0
(SERINE
HYDROXYMETHYLTRANSFE
RASE)		 2qm0 BES
(Bacillus
cereus) 		4 / 8 PHE A  56
HIS A 254
SER A 181
LYS A 158
 None
SVY  A 157 ( 3.8A)
None
SVY  A 157 ( 2.9A)
 1.00A 1eqbA-2qm0A:
undetectable
1eqbB-2qm0A:
undetectable		 1eqbA-2qm0A:
22.14
1eqbB-2qm0A:
22.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1EQB_C_GLYC3292_0
(SERINE
HYDROXYMETHYLTRANSFE
RASE)		 2qm0 BES
(Bacillus
cereus) 		4 / 8 HIS A 254
SER A 181
LYS A 158
PHE A  56
 SVY  A 157 ( 3.8A)
None
SVY  A 157 ( 2.9A)
None
 1.00A 1eqbC-2qm0A:
undetectable
1eqbD-2qm0A:
undetectable		 1eqbC-2qm0A:
22.14
1eqbD-2qm0A:
22.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1EQB_D_GLYD4292_0
(SERINE
HYDROXYMETHYLTRANSFE
RASE)		 2qm0 BES
(Bacillus
cereus) 		4 / 8 PHE A  56
HIS A 254
SER A 181
LYS A 158
 None
SVY  A 157 ( 3.8A)
None
SVY  A 157 ( 2.9A)
 1.00A 1eqbC-2qm0A:
undetectable
1eqbD-2qm0A:
undetectable		 1eqbC-2qm0A:
22.14
1eqbD-2qm0A:
22.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MX1_E_THAE5_1
(LIVER
CARBOXYLESTERASE I)		 2qm0 BES
(Bacillus
cereus) 		5 / 12 LEU A 242
VAL A 211
VAL A 191
LEU A 164
LEU A 192
 None
 1.37A 1mx1E-2qm0A:
12.9		 1mx1E-2qm0A:
19.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MX1_E_THAE5_2
(LIVER
CARBOXYLESTERASE I)		 2qm0 BES
(Bacillus
cereus) 		3 / 3 PHE A 128
LEU A  51
LEU A 153
 None
 0.52A 1mx1E-2qm0A:
12.9		 1mx1E-2qm0A:
19.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ME6_C_CGEC501_1
(CYTOCHROME P450 2B4)		 2qm0 BES
(Bacillus
cereus) 		5 / 9 VAL A  84
PHE A 129
ILE A 132
PHE A 162
ALA A 163
 None
 1.07A 3me6C-2qm0A:
undetectable		 3me6C-2qm0A:
19.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ME6_D_CGED501_1
(CYTOCHROME P450 2B4)		 2qm0 BES
(Bacillus
cereus) 		5 / 9 VAL A  84
PHE A 129
ILE A 132
PHE A 162
ALA A 163
 None
 1.02A 3me6D-2qm0A:
undetectable		 3me6D-2qm0A:
19.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FOG_A_C2FA302_0
(THYMIDYLATE SYNTHASE)		 2qm0 BES
(Bacillus
cereus) 		5 / 11 SER A  34
ILE A  81
LEU A 153
GLY A  53
PHE A  57
 None
 1.19A 4fogA-2qm0A:
undetectable		 4fogA-2qm0A:
23.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FOG_C_C2FC302_0
(THYMIDYLATE SYNTHASE)		 2qm0 BES
(Bacillus
cereus) 		5 / 11 SER A  34
ILE A  81
LEU A 153
GLY A  53
PHE A  57
 None
 1.28A 4fogC-2qm0A:
undetectable		 4fogC-2qm0A:
23.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FOX_B_D16B302_1
(THYMIDYLATE SYNTHASE)		 2qm0 BES
(Bacillus
cereus) 		5 / 12 SER A  34
ILE A  81
LEU A 153
GLY A  53
PHE A  57
 None
 1.22A 4foxB-2qm0A:
undetectable		 4foxB-2qm0A:
23.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FOX_G_D16G301_1
(THYMIDYLATE SYNTHASE)		 2qm0 BES
(Bacillus
cereus) 		5 / 12 SER A  34
ILE A  81
LEU A 153
GLY A  53
PHE A  57
 None
 1.24A 4foxG-2qm0A:
undetectable		 4foxG-2qm0A:
23.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XYZ_A_ACTA103_0
(POLYUBIQUITIN-C)		 2qm0 BES
(Bacillus
cereus) 		4 / 4 LEU A 242
ILE A 199
HIS A 239
VAL A 237
 None
 0.95A 4xyzA-2qm0A:
undetectable		 4xyzA-2qm0A:
15.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5A1R_A_STRA600_1
(CYTOCHROME P450 3A4)		 2qm0 BES
(Bacillus
cereus) 		4 / 5 PHE A  56
PHE A 178
PHE A 154
VAL A 258
 None
 1.17A 5a1rA-2qm0A:
undetectable		 5a1rA-2qm0A:
19.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5AYF_A_C7HA402_1
(HISTONE-LYSINE
N-METHYLTRANSFERASE
SETD7)		 2qm0 BES
(Bacillus
cereus) 		4 / 5 TYR A  29
GLY A 124
TYR A  86
GLY A  94
 None
 0.97A 5ayfA-2qm0A:
undetectable		 5ayfA-2qm0A:
21.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JLC_A_1YNA602_1
(LANOSTEROL 14-ALPHA
DEMETHYLASE)		 2qm0 BES
(Bacillus
cereus) 		5 / 12 ALA A 249
PHE A 128
ILE A 132
GLY A  85
PHE A 178
 None
 1.16A 5jlcA-2qm0A:
undetectable		 5jlcA-2qm0A:
19.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JLC_A_1YNA602_1
(LANOSTEROL 14-ALPHA
DEMETHYLASE)		 2qm0 BES
(Bacillus
cereus) 		5 / 12 PHE A 128
ILE A 132
PHE A 101
GLY A  85
PHE A 178
 None
 1.24A 5jlcA-2qm0A:
undetectable		 5jlcA-2qm0A:
19.00