SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2qm3'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HSH_A_MK1A401_1
(HIV-II PROTEASE)		 2qm3 PREDICTED
METHYLTRANSFERASE
(Pyrococcus
furiosus) 		5 / 12 GLY A 195
ASP A 198
ILE A 174
GLY A 169
ILE A 163
 None
 0.83A 1hshA-2qm3A:
undetectable		 1hshA-2qm3A:
14.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1OIP_A_VIVA1278_0
(ALPHA-TOCOPHEROL
TRANSFER PROTEIN)		 2qm3 PREDICTED
METHYLTRANSFERASE
(Pyrococcus
furiosus) 		5 / 12 LEU A  76
ILE A  51
LEU A  52
VAL A  67
ILE A  37
 None
 0.97A 1oipA-2qm3A:
2.1		 1oipA-2qm3A:
24.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1S19_A_MC9A500_0
(VITAMIN D3 RECEPTOR)		 2qm3 PREDICTED
METHYLTRANSFERASE
(Pyrococcus
furiosus) 		5 / 12 LEU A  25
VAL A  24
ILE A  51
VAL A  67
LEU A 303
 None
 1.15A 1s19A-2qm3A:
undetectable		 1s19A-2qm3A:
23.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1TW4_B_CHDB1130_0
(FATTY ACID-BINDING
PROTEIN)		 2qm3 PREDICTED
METHYLTRANSFERASE
(Pyrococcus
furiosus) 		5 / 12 LEU A 106
LEU A 170
ILE A 152
THR A 220
MET A 141
 None
 1.25A 1tw4B-2qm3A:
undetectable		 1tw4B-2qm3A:
15.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2IJ7_F_TPFF2474_1
(CYTOCHROME P450 121)		 2qm3 PREDICTED
METHYLTRANSFERASE
(Pyrococcus
furiosus) 		5 / 10 THR A 130
VAL A 129
PHE A 110
THR A 161
ALA A 164
 None
 1.50A 2ij7F-2qm3A:
0.0		 2ij7F-2qm3A:
19.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2M56_A_CAMA502_0
(CAMPHOR
5-MONOOXYGENASE)		 2qm3 PREDICTED
METHYLTRANSFERASE
(Pyrococcus
furiosus) 		4 / 5 PHE A 110
LEU A 165
VAL A 138
VAL A 129
 None
 1.23A 2m56A-2qm3A:
undetectable		 2m56A-2qm3A:
20.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2NV4_A_ACTA148_0
(UPF0066 PROTEIN
AF_0241)		 2qm3 PREDICTED
METHYLTRANSFERASE
(Pyrococcus
furiosus) 		3 / 3 VAL A  21
GLU A  18
GLU A  22
 None
 0.81A 2nv4A-2qm3A:
undetectable		 2nv4A-2qm3A:
18.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XAD_E_GCSE710_1
(N-ACYL GLM
PEUDO-TEICOPLANIN
DEACETYLASE
TEICOPLANIN)		 2qm3 PREDICTED
METHYLTRANSFERASE
(Pyrococcus
furiosus) 		4 / 8 ARG A 117
SER A 162
ILE A 163
ASP A 157
 None
 0.99A 2xadA-2qm3A:
5.0		 2xadA-2qm3A:
20.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XAD_F_GCSF710_1
(N-ACYL GLM
PEUDO-TEICOPLANIN
DEACETYLASE
TEICOPLANIN)		 2qm3 PREDICTED
METHYLTRANSFERASE
(Pyrococcus
furiosus) 		4 / 8 ARG A 117
SER A 162
ILE A 163
ASP A 157
 None
 0.98A 2xadB-2qm3A:
3.6		 2xadB-2qm3A:
20.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XAD_G_GCSG710_1
(N-ACYL GLM
PEUDO-TEICOPLANIN
DEACETYLASE
TEICOPLANIN)		 2qm3 PREDICTED
METHYLTRANSFERASE
(Pyrococcus
furiosus) 		4 / 8 ARG A 117
SER A 162
ILE A 163
ASP A 157
 None
 1.00A 2xadC-2qm3A:
4.7		 2xadC-2qm3A:
20.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XAD_H_GCSH710_1
(N-ACYL GLM
PEUDO-TEICOPLANIN
DEACETYLASE
TEICOPLANIN)		 2qm3 PREDICTED
METHYLTRANSFERASE
(Pyrococcus
furiosus) 		4 / 8 ARG A 117
SER A 162
ILE A 163
ASP A 157
 None
 0.98A 2xadD-2qm3A:
4.9		 2xadD-2qm3A:
20.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3CJT_C_SAMC302_0
(RIBOSOMAL PROTEIN
L11
METHYLTRANSFERASE)		 2qm3 PREDICTED
METHYLTRANSFERASE
(Pyrococcus
furiosus) 		5 / 12 LEU A 155
GLY A 156
ASP A 178
ILE A 179
ASP A 180
 None
 0.53A 3cjtC-2qm3A:
12.5		 3cjtC-2qm3A:
23.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3E7G_A_H4BA902_1
(NITRIC OXIDE
SYNTHASE, INDUCIBLE)		 2qm3 PREDICTED
METHYLTRANSFERASE
(Pyrococcus
furiosus) 		4 / 7 ILE A 267
TRP A 264
PHE A 252
GLU A 227
 None
 1.44A 3e7gA-2qm3A:
undetectable
3e7gB-2qm3A:
undetectable		 3e7gA-2qm3A:
22.45
3e7gB-2qm3A:
22.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3E7G_B_H4BB1902_1
(NITRIC OXIDE
SYNTHASE, INDUCIBLE)		 2qm3 PREDICTED
METHYLTRANSFERASE
(Pyrococcus
furiosus) 		4 / 7 PHE A 252
GLU A 227
ILE A 267
TRP A 264
 None
 1.43A 3e7gA-2qm3A:
undetectable
3e7gB-2qm3A:
undetectable		 3e7gA-2qm3A:
22.45
3e7gB-2qm3A:
22.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3E7G_C_H4BC2902_1
(NITRIC OXIDE
SYNTHASE, INDUCIBLE)		 2qm3 PREDICTED
METHYLTRANSFERASE
(Pyrococcus
furiosus) 		4 / 7 ILE A 267
TRP A 264
PHE A 252
GLU A 227
 None
 1.47A 3e7gC-2qm3A:
undetectable
3e7gD-2qm3A:
undetectable		 3e7gC-2qm3A:
22.45
3e7gD-2qm3A:
22.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3IA4_C_MTXC164_2
(DIHYDROFOLATE
REDUCTASE)		 2qm3 PREDICTED
METHYLTRANSFERASE
(Pyrococcus
furiosus) 		4 / 4 ILE A 163
ARG A 182
ILE A 187
THR A 134
 None
 1.28A 3ia4C-2qm3A:
2.0		 3ia4C-2qm3A:
16.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3JQA_D_DX4D270_0
(PTERIDINE REDUCTASE
1)		 2qm3 PREDICTED
METHYLTRANSFERASE
(Pyrococcus
furiosus) 		4 / 6 SER A 317
ASP A 159
TYR A 289
PRO A 226
 None
CA  A 350 ( 4.5A)
None
None
 1.31A 3jqaD-2qm3A:
5.5		 3jqaD-2qm3A:
24.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KP3_B_AICB2002_1
(TRANSCRIPTIONAL
REGULATOR TCAR)		 2qm3 PREDICTED
METHYLTRANSFERASE
(Pyrococcus
furiosus) 		3 / 3 ALA A  50
ARG A 299
LYS A 302
 None
 0.91A 3kp3B-2qm3A:
6.2		 3kp3B-2qm3A:
16.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KW4_A_TICA600_1
(CYTOCHROME P450 2B4)		 2qm3 PREDICTED
METHYLTRANSFERASE
(Pyrococcus
furiosus) 		5 / 11 ILE A 279
ILE A 232
ILE A 240
VAL A 236
GLY A 237
 None
 0.91A 3kw4A-2qm3A:
undetectable		 3kw4A-2qm3A:
23.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3R24_A_SAMA302_1
(2'-O-METHYL
TRANSFERASE)		 2qm3 PREDICTED
METHYLTRANSFERASE
(Pyrococcus
furiosus) 		3 / 3 TYR A 196
ASP A 151
ASP A 198
 None
 0.83A 3r24A-2qm3A:
7.8		 3r24A-2qm3A:
24.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4M5M_A_DX4A401_0
(2-AMINO-4-HYDROXY-6-
HYDROXYMETHYLDIHYDRO
PTERIDINE
PYROPHOSPHOKINASE)		 2qm3 PREDICTED
METHYLTRANSFERASE
(Pyrococcus
furiosus) 		4 / 8 THR A 133
LEU A 140
ASN A 287
PHE A 286
 None
 1.12A 4m5mA-2qm3A:
undetectable		 4m5mA-2qm3A:
18.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5MUG_A_VIVA301_0
(ALPHA-TOCOPHEROL
TRANSFER PROTEIN)		 2qm3 PREDICTED
METHYLTRANSFERASE
(Pyrococcus
furiosus) 		5 / 12 LEU A  76
ILE A  51
LEU A  52
VAL A  67
ILE A  37
 None
 0.92A 5mugA-2qm3A:
2.2		 5mugA-2qm3A:
21.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6BQG_A_ERMA1201_2
(5-HYDROXYTRYPTAMINE
RECEPTOR 2C,SOLUBLE
CYTOCHROME B562)		 2qm3 PREDICTED
METHYLTRANSFERASE
(Pyrococcus
furiosus) 		4 / 5 VAL A   8
THR A  12
LEU A  55
VAL A  67
 None
 0.74A 6bqgA-2qm3A:
undetectable		 6bqgA-2qm3A:
12.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6BXM_A_SAMA402_0
(DIPHTHAMIDE
BIOSYNTHESIS ENZYME
DPH2)		 2qm3 PREDICTED
METHYLTRANSFERASE
(Pyrococcus
furiosus) 		5 / 12 LEU A 155
GLY A 156
LEU A 140
VAL A 138
ASP A 159
 None
None
None
None
CA  A 350 ( 4.5A)
 1.26A 6bxmA-2qm3A:
3.2		 6bxmA-2qm3A:
22.19