SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2qm8'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1D4F_C_ADNC603_2
(S-ADENOSYLHOMOCYSTEI
NE HYDROLASE)		 2qm8 GTPASE/ATPASE
(Methylobacterium
extorquens) 		4 / 5 THR A  71
GLU A 154
THR A 155
LEU A 173
 None
 1.16A 1d4fC-2qm8A:
3.6		 1d4fC-2qm8A:
23.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OXT_C_SAMC300_1
(NUCLEOSIDE-2'-O-METH
YLTRANSFERASE)		 2qm8 GTPASE/ATPASE
(Methylobacterium
extorquens) 		4 / 4 SER A  77
GLY A  76
HIS A 244
ASP A 204
 None
 1.28A 2oxtC-2qm8A:
undetectable		 2oxtC-2qm8A:
22.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZTH_A_SAMA305_1
(CATECHOL
O-METHYLTRANSFERASE)		 2qm8 GTPASE/ATPASE
(Methylobacterium
extorquens) 		3 / 3 SER A 161
GLU A 154
ASP A  92
 None
 0.85A 2zthA-2qm8A:
2.1		 2zthA-2qm8A:
21.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3FL9_G_TOPG200_1
(DIHYDROFOLATE
REDUCTASE (DHFR))		 2qm8 GTPASE/ATPASE
(Methylobacterium
extorquens) 		5 / 12 LEU A  75
LEU A 152
VAL A 150
ILE A 255
THR A  80
 None
 1.14A 3fl9G-2qm8A:
3.8		 3fl9G-2qm8A:
17.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KK6_B_CELB1701_2
(PROSTAGLANDIN G/H
SYNTHASE 1)		 2qm8 GTPASE/ATPASE
(Methylobacterium
extorquens) 		5 / 6 VAL A 132
LEU A 194
ILE A  60
ALA A 164
LEU A 129
 None
 1.37A 3kk6B-2qm8A:
undetectable		 3kk6B-2qm8A:
20.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KP5_B_KANB2002_1
(TRANSCRIPTIONAL
REGULATOR TCAR)		 2qm8 GTPASE/ATPASE
(Methylobacterium
extorquens) 		3 / 3 ALA A  39
ARG A  38
LYS A 135
 None
PO4  A1502 (-3.8A)
None
 1.08A 3kp5B-2qm8A:
undetectable		 3kp5B-2qm8A:
19.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6C2M_D_SUED1202_0
(NS3 PROTEASE)		 2qm8 GTPASE/ATPASE
(Methylobacterium
extorquens) 		5 / 12 GLY A 242
ILE A 120
GLY A  76
ALA A 110
ALA A 113
 None
 1.06A 6c2mD-2qm8A:
undetectable		 6c2mD-2qm8A:
11.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6CE2_B_SVRB202_1
()		 2qm8 GTPASE/ATPASE
(Methylobacterium
extorquens) 		4 / 8 LEU A  15
LEU A  23
GLY A  53
ARG A  57
 None
 0.93A 6ce2A-2qm8A:
undetectable		 6ce2A-2qm8A:
14.33