SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2qmi'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1D4Y_A_TPVA501_1
(PROTEIN (HIV-1
PROTEASE))		 2qmi PBP RELATED
BETA-LACTAMASE
(Pyrococcus
abyssi) 		5 / 10 ASP A 436
ILE A 445
GLY A 372
ILE A 377
VAL A 381
 None
 1.11A 1d4yA-2qmiA:
undetectable		 1d4yA-2qmiA:
14.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1FIQ_C_SALC1335_1
(XANTHINE OXIDASE)		 2qmi PBP RELATED
BETA-LACTAMASE
(Pyrococcus
abyssi) 		4 / 8 LEU A 161
VAL A  99
LEU A  92
ALA A 150
 None
 0.93A 1fiqC-2qmiA:
undetectable		 1fiqC-2qmiA:
21.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1FKO_A_EFZA999_1
(HIV-1 RT, A-CHAIN)		 2qmi PBP RELATED
BETA-LACTAMASE
(Pyrococcus
abyssi) 		5 / 10 LEU A  72
VAL A 178
TYR A 183
GLY A 177
LEU A  78
 None
 1.47A 1fkoA-2qmiA:
undetectable		 1fkoA-2qmiA:
23.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MT1_A_AG2A7005_1
(PYRUVOYL-DEPENDENT
ARGININE
DECARBOXYLASE BETA
CHAIN
PYRUVOYL-DEPENDENT
ARGININE
DECARBOXYLASE ALPHA
CHAIN)		 2qmi PBP RELATED
BETA-LACTAMASE
(Pyrococcus
abyssi) 		4 / 6 LEU A 189
ASP A 243
LEU A 244
ILE A  54
 None
 1.06A 1mt1A-2qmiA:
undetectable
1mt1F-2qmiA:
undetectable		 1mt1A-2qmiA:
9.17
1mt1F-2qmiA:
15.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1N13_L_AG2L7014_1
(PYRUVOYL-DEPENDENT
ARGININE
DECARBOXYLASE BETA
CHAIN
PYRUVOYL-DEPENDENT
ARGININE
DECARBOXYLASE ALPHA
CHAIN)		 2qmi PBP RELATED
BETA-LACTAMASE
(Pyrococcus
abyssi) 		4 / 7 LEU A 189
ASP A 243
LEU A 244
ILE A  54
 None
 1.04A 1n13I-2qmiA:
undetectable
1n13L-2qmiA:
undetectable		 1n13I-2qmiA:
9.17
1n13L-2qmiA:
15.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1QZZ_A_SAMA635_0
(ACLACINOMYCIN-10-HYD
ROXYLASE)		 2qmi PBP RELATED
BETA-LACTAMASE
(Pyrococcus
abyssi) 		5 / 12 TYR A 160
GLY A 236
GLY A 235
GLY A  58
PHE A 199
 None
 1.21A 1qzzA-2qmiA:
undetectable		 1qzzA-2qmiA:
21.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Q7L_A_TESA155_1
(ANDROGEN RECEPTOR)		 2qmi PBP RELATED
BETA-LACTAMASE
(Pyrococcus
abyssi) 		5 / 12 LEU A 167
LEU A 168
GLY A 169
MET A 146
THR A 139
 None
 1.48A 2q7lA-2qmiA:
undetectable		 2q7lA-2qmiA:
19.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QQC_I_AG2I671_1
(PYRUVOYL-DEPENDENT
ARGININE
DECARBOXYLASE (EC
4.1.1.19) (PVLARGDC))		 2qmi PBP RELATED
BETA-LACTAMASE
(Pyrococcus
abyssi) 		4 / 7 LEU A 189
ASP A 243
LEU A 244
ILE A  54
 None
 1.04A 2qqcG-2qmiA:
undetectable
2qqcJ-2qmiA:
undetectable		 2qqcG-2qmiA:
8.95
2qqcJ-2qmiA:
13.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2RLC_A_CHDA332_0
(CHOLOYLGLYCINE
HYDROLASE)		 2qmi PBP RELATED
BETA-LACTAMASE
(Pyrococcus
abyssi) 		5 / 12 PHE A 142
PHE A 120
ILE A 231
ASN A 162
THR A 163
 None
 1.15A 2rlcA-2qmiA:
undetectable		 2rlcA-2qmiA:
22.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2V0G_A_LEUA1887_0
(AMINOACYL-TRNA
SYNTHETASE)		 2qmi PBP RELATED
BETA-LACTAMASE
(Pyrococcus
abyssi) 		4 / 8 TYR A 284
TYR A 291
TYR A 312
HIS A 302
 None
 1.34A 2v0gA-2qmiA:
undetectable		 2v0gA-2qmiA:
21.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2V0G_D_LEUD1883_0
(AMINOACYL-TRNA
SYNTHETASE)		 2qmi PBP RELATED
BETA-LACTAMASE
(Pyrococcus
abyssi) 		4 / 5 TYR A 284
TYR A 291
TYR A 312
HIS A 302
 None
 1.24A 2v0gD-2qmiA:
undetectable		 2v0gD-2qmiA:
21.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XRZ_B_ACTB1463_0
(DEOXYRIBODIPYRIMIDIN
E PHOTOLYASE)		 2qmi PBP RELATED
BETA-LACTAMASE
(Pyrococcus
abyssi) 		4 / 7 VAL A 325
ILE A 337
ALA A 341
VAL A 323
 None
 0.75A 2xrzB-2qmiA:
undetectable		 2xrzB-2qmiA:
25.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3FRQ_B_ERYB195_0
(REPRESSOR PROTEIN
MPHR(A))		 2qmi PBP RELATED
BETA-LACTAMASE
(Pyrococcus
abyssi) 		5 / 12 LEU A 244
TYR A 332
MET A 339
ILE A 313
ILE A 278
 None
 0.99A 3frqB-2qmiA:
undetectable		 3frqB-2qmiA:
17.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3Q5P_A_TACA7101_1
(MULTIDRUG-EFFLUX
TRANSPORTER 1
REGULATOR)		 2qmi PBP RELATED
BETA-LACTAMASE
(Pyrococcus
abyssi) 		5 / 12 PRO A 317
ILE A 252
TYR A 315
GLU A 268
ILE A 290
 None
 1.26A 3q5pA-2qmiA:
undetectable		 3q5pA-2qmiA:
21.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3Q5R_A_KANA2002_1
(MULTIDRUG-EFFLUX
TRANSPORTER 1
REGULATOR)		 2qmi PBP RELATED
BETA-LACTAMASE
(Pyrococcus
abyssi) 		5 / 11 PRO A 317
ILE A 252
TYR A 315
GLU A 268
ILE A 290
 None
 1.37A 3q5rA-2qmiA:
0.0		 3q5rA-2qmiA:
21.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3W9T_A_W9TA1001_1
(HEMOLYTIC LECTIN
CEL-III)		 2qmi PBP RELATED
BETA-LACTAMASE
(Pyrococcus
abyssi) 		4 / 5 ASP A 122
VAL A 125
GLY A 126
ASP A 128
 None
 1.49A 3w9tA-2qmiA:
undetectable		 3w9tA-2qmiA:
22.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3W9T_B_W9TB503_1
(HEMOLYTIC LECTIN
CEL-III)		 2qmi PBP RELATED
BETA-LACTAMASE
(Pyrococcus
abyssi) 		4 / 5 ASP A 122
VAL A 125
GLY A 126
ASP A 128
 None
 1.48A 3w9tB-2qmiA:
undetectable		 3w9tB-2qmiA:
22.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3W9T_C_W9TC1001_1
(HEMOLYTIC LECTIN
CEL-III)		 2qmi PBP RELATED
BETA-LACTAMASE
(Pyrococcus
abyssi) 		4 / 5 ASP A 122
VAL A 125
GLY A 126
ASP A 128
 None
 1.49A 3w9tC-2qmiA:
undetectable		 3w9tC-2qmiA:
22.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3W9T_D_W9TD502_1
(HEMOLYTIC LECTIN
CEL-III)		 2qmi PBP RELATED
BETA-LACTAMASE
(Pyrococcus
abyssi) 		4 / 5 ASP A 122
VAL A 125
GLY A 126
ASP A 128
 None
 1.48A 3w9tD-2qmiA:
undetectable		 3w9tD-2qmiA:
22.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3W9T_E_W9TE504_1
(HEMOLYTIC LECTIN
CEL-III)		 2qmi PBP RELATED
BETA-LACTAMASE
(Pyrococcus
abyssi) 		4 / 5 ASP A 122
VAL A 125
GLY A 126
ASP A 128
 None
 1.48A 3w9tE-2qmiA:
undetectable		 3w9tE-2qmiA:
22.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3W9T_F_W9TF504_1
(HEMOLYTIC LECTIN
CEL-III)		 2qmi PBP RELATED
BETA-LACTAMASE
(Pyrococcus
abyssi) 		4 / 5 ASP A 122
VAL A 125
GLY A 126
ASP A 128
 None
 1.48A 3w9tF-2qmiA:
undetectable		 3w9tF-2qmiA:
22.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3W9T_G_W9TG504_1
(HEMOLYTIC LECTIN
CEL-III)		 2qmi PBP RELATED
BETA-LACTAMASE
(Pyrococcus
abyssi) 		4 / 5 ASP A 122
VAL A 125
GLY A 126
ASP A 128
 None
 1.48A 3w9tG-2qmiA:
undetectable		 3w9tG-2qmiA:
22.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4JX1_B_CAMB502_0
(CAMPHOR
5-MONOOXYGENASE)		 2qmi PBP RELATED
BETA-LACTAMASE
(Pyrococcus
abyssi) 		5 / 10 THR A 163
GLY A 169
VAL A  84
ILE A  90
VAL A  88
 None
 1.19A 4jx1B-2qmiA:
undetectable		 4jx1B-2qmiA:
22.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4UYM_A_VORA590_1
(14-ALPHA STEROL
DEMETHYLASE)		 2qmi PBP RELATED
BETA-LACTAMASE
(Pyrococcus
abyssi) 		4 / 7 TYR A 312
ALA A 343
LEU A 299
PHE A 294
 None
 0.97A 4uymA-2qmiA:
undetectable		 4uymA-2qmiA:
22.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4YDQ_A_HFGA802_0
(PROLINE--TRNA LIGASE)		 2qmi PBP RELATED
BETA-LACTAMASE
(Pyrococcus
abyssi) 		5 / 12 LEU A 222
VAL A  43
PRO A  20
SER A 305
GLY A 311
 None
 1.35A 4ydqA-2qmiA:
undetectable		 4ydqA-2qmiA:
21.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5D0Y_A_FOLA201_1
(CONSERVED
HYPOTHETICAL
MEMBRANE PROTEIN)		 2qmi PBP RELATED
BETA-LACTAMASE
(Pyrococcus
abyssi) 		3 / 3 ARG A 221
LYS A 218
GLU A 219
 None
 0.74A 5d0yA-2qmiA:
undetectable		 5d0yA-2qmiA:
19.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5DLV_A_5D5A930_0
(ECTONUCLEOTIDE
PYROPHOSPHATASE/PHOS
PHODIESTERASE FAMILY
MEMBER 2)		 2qmi PBP RELATED
BETA-LACTAMASE
(Pyrococcus
abyssi) 		5 / 12 THR A 417
PHE A 404
LEU A 403
ILE A 362
TYR A 389
 None
 1.50A 5dlvA-2qmiA:
undetectable		 5dlvA-2qmiA:
20.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5F9Z_A_HFGA702_0
(AMINOACYL-TRNA
SYNTHETASE)		 2qmi PBP RELATED
BETA-LACTAMASE
(Pyrococcus
abyssi) 		5 / 12 LEU A 222
VAL A  43
PRO A  20
SER A 305
GLY A 311
 None
 1.35A 5f9zA-2qmiA:
undetectable		 5f9zA-2qmiA:
21.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5FSA_B_X2NB590_1
(CYP51 VARIANT1)		 2qmi PBP RELATED
BETA-LACTAMASE
(Pyrococcus
abyssi) 		5 / 12 TYR A 284
ILE A 215
GLY A 307
THR A 310
HIS A 302
 None
 1.29A 5fsaB-2qmiA:
undetectable		 5fsaB-2qmiA:
22.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VC0_A_RITA602_2
(CYTOCHROME P450 3A4)		 2qmi PBP RELATED
BETA-LACTAMASE
(Pyrococcus
abyssi) 		4 / 7 ARG A 391
LEU A 437
PHE A 439
THR A 417
 None
 0.86A 5vc0A-2qmiA:
undetectable		 5vc0A-2qmiA:
23.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ZHM_B_SAMB301_1
(TRNA
(GUANINE-N(1)-)-METH
YLTRANSFERASE)		 2qmi PBP RELATED
BETA-LACTAMASE
(Pyrococcus
abyssi) 		6 / 12 LEU A 237
GLY A  58
GLY A 304
ILE A 184
GLY A 235
GLY A 236
 None
 1.28A 5zhmB-2qmiA:
undetectable		 5zhmB-2qmiA:
21.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ZWR_A_9KLA402_0
(EST-Y29)		 2qmi PBP RELATED
BETA-LACTAMASE
(Pyrococcus
abyssi) 		5 / 12 TYR A 180
PHE A 199
ILE A 184
LEU A 189
GLY A  58
 None
 1.22A 5zwrA-2qmiA:
34.6		 5zwrA-2qmiA:
25.66