SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2qmw'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ISM_B_NCAB305_0
(BONE MARROW STROMAL
CELL ANTIGEN 1)		 2qmw PREPHENATE
DEHYDRATASE
(Staphylococcus
aureus) 		4 / 7 LEU A 214
SER A 215
ASP A 236
PHE A 188
 None
 1.15A 1ismB-2qmwA:
undetectable		 1ismB-2qmwA:
23.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1USQ_B_CLMB1143_0
(DR HEMAGGLUTININ
STRUCTURAL SUBUNIT)		 2qmw PREPHENATE
DEHYDRATASE
(Staphylococcus
aureus) 		5 / 6 PRO A  30
GLY A   7
PRO A   8
ILE A 129
GLY A  10
 None
 1.44A 1usqB-2qmwA:
undetectable		 1usqB-2qmwA:
18.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1USQ_C_CLMC1143_0
(DR HEMAGGLUTININ
STRUCTURAL SUBUNIT)		 2qmw PREPHENATE
DEHYDRATASE
(Staphylococcus
aureus) 		5 / 6 PRO A  30
GLY A   7
PRO A   8
ILE A 129
GLY A  10
 None
 1.45A 1usqC-2qmwA:
undetectable		 1usqC-2qmwA:
18.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1USQ_D_CLMD1142_0
(DR HEMAGGLUTININ
STRUCTURAL SUBUNIT)		 2qmw PREPHENATE
DEHYDRATASE
(Staphylococcus
aureus) 		5 / 6 PRO A  30
GLY A   7
PRO A   8
ILE A 129
GLY A  10
 None
 1.44A 1usqD-2qmwA:
undetectable		 1usqD-2qmwA:
18.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1USQ_E_CLME1143_0
(DR HEMAGGLUTININ
STRUCTURAL SUBUNIT)		 2qmw PREPHENATE
DEHYDRATASE
(Staphylococcus
aureus) 		5 / 6 PRO A  30
GLY A   7
PRO A   8
ILE A 129
GLY A  10
 None
 1.43A 1usqE-2qmwA:
undetectable		 1usqE-2qmwA:
18.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1USQ_F_CLMF1144_0
(DR HEMAGGLUTININ
STRUCTURAL SUBUNIT)		 2qmw PREPHENATE
DEHYDRATASE
(Staphylococcus
aureus) 		5 / 7 PRO A  30
GLY A   7
PRO A   8
ILE A 129
GLY A  10
 None
 1.42A 1usqF-2qmwA:
undetectable		 1usqF-2qmwA:
18.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2JKJ_A_CLMA1141_0
(DR HEMAGGLUTININ
STRUCTURAL SUBUNIT)		 2qmw PREPHENATE
DEHYDRATASE
(Staphylococcus
aureus) 		5 / 6 PRO A  30
GLY A   7
PRO A   8
ILE A 129
GLY A  10
 None
 1.43A 2jkjA-2qmwA:
undetectable		 2jkjA-2qmwA:
18.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2JKJ_B_CLMB1141_0
(DR HEMAGGLUTININ
STRUCTURAL SUBUNIT)		 2qmw PREPHENATE
DEHYDRATASE
(Staphylococcus
aureus) 		5 / 6 PRO A  30
GLY A   7
PRO A   8
ILE A 129
GLY A  10
 None
 1.43A 2jkjB-2qmwA:
undetectable		 2jkjB-2qmwA:
18.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2JKJ_C_CLMC1141_0
(DR HEMAGGLUTININ
STRUCTURAL SUBUNIT)		 2qmw PREPHENATE
DEHYDRATASE
(Staphylococcus
aureus) 		5 / 6 PRO A  30
GLY A   7
PRO A   8
ILE A 129
GLY A  10
 None
 1.44A 2jkjC-2qmwA:
undetectable		 2jkjC-2qmwA:
18.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2JKJ_E_CLME1141_0
(DR HEMAGGLUTININ
STRUCTURAL SUBUNIT)		 2qmw PREPHENATE
DEHYDRATASE
(Staphylococcus
aureus) 		5 / 7 PRO A  30
GLY A   7
PRO A   8
ILE A 129
GLY A  10
 None
 1.44A 2jkjE-2qmwA:
undetectable		 2jkjE-2qmwA:
18.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2JKL_B_CLMB1144_0
(DR HEMAGGLUTININ
STRUCTURAL SUBUNIT)		 2qmw PREPHENATE
DEHYDRATASE
(Staphylococcus
aureus) 		5 / 6 PRO A  30
GLY A   7
PRO A   8
ILE A 129
GLY A  10
 None
 1.42A 2jklB-2qmwA:
undetectable		 2jklB-2qmwA:
18.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2JKL_E_CLME1143_0
(DR HEMAGGLUTININ
STRUCTURAL SUBUNIT)		 2qmw PREPHENATE
DEHYDRATASE
(Staphylococcus
aureus) 		5 / 7 PRO A  30
GLY A   7
PRO A   8
ILE A 129
GLY A  10
 None
 1.42A 2jklE-2qmwA:
undetectable		 2jklE-2qmwA:
18.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2NNH_A_9CRA501_1
(CYTOCHROME P450 2C8)		 2qmw PREPHENATE
DEHYDRATASE
(Staphylococcus
aureus) 		5 / 11 SER A  13
ILE A  61
SER A  56
ALA A  65
ILE A 173
 None
None
EDO  A 321 (-4.0A)
None
None
 1.11A 2nnhA-2qmwA:
undetectable		 2nnhA-2qmwA:
20.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3AOD_C_RFPC2002_1
(ACRIFLAVINE
RESISTANCE PROTEIN B)		 2qmw PREPHENATE
DEHYDRATASE
(Staphylococcus
aureus) 		5 / 12 PHE A  85
ALA A 143
THR A 158
PHE A 120
GLY A  89
 None
 1.41A 3aodC-2qmwA:
5.4		 3aodC-2qmwA:
14.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BJW_C_SVRC505_2
(PHOSPHOLIPASE A2)		 2qmw PREPHENATE
DEHYDRATASE
(Staphylococcus
aureus) 		4 / 5 VAL A  51
VAL A  50
PHE A  74
ARG A  80
 None
 1.26A 3bjwH-2qmwA:
undetectable		 3bjwH-2qmwA:
17.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ICX_E_SC2E1_1
(CETUXIMAB FAB LIGHT
CHAIN
MEDITOPE)		 2qmw PREPHENATE
DEHYDRATASE
(Staphylococcus
aureus) 		3 / 3 VAL A  50
GLN A  19
CYH A  17
 None
 0.72A 5icxA-2qmwA:
undetectable
5icxE-2qmwA:
undetectable		 5icxA-2qmwA:
23.57
5icxE-2qmwA:
3.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VEU_B_RITB602_1
(CYTOCHROME P450 3A5)		 2qmw PREPHENATE
DEHYDRATASE
(Staphylococcus
aureus) 		5 / 12 SER A 131
LEU A 132
ALA A 107
THR A 111
ILE A  95
 None
 1.00A 5veuB-2qmwA:
undetectable		 5veuB-2qmwA:
19.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ZWR_B_9KLB402_0
(EST-Y29)		 2qmw PREPHENATE
DEHYDRATASE
(Staphylococcus
aureus) 		5 / 12 SER A 237
PHE A 188
ILE A 247
ALA A 235
LEU A 214
 None
 1.34A 5zwrB-2qmwA:
undetectable		 5zwrB-2qmwA:
21.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DEB_B_MTXB303_1
(BIFUNCTIONAL PROTEIN
FOLD)		 2qmw PREPHENATE
DEHYDRATASE
(Staphylococcus
aureus) 		4 / 5 TYR A 114
GLN A 117
GLY A 138
ILE A 156
 None
 1.48A 6debB-2qmwA:
undetectable		 6debB-2qmwA:
17.58