SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2qmx'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1YA3_C_STRC3001_1
(MINERALOCORTICOID
RECEPTOR)		 2qmx PREPHENATE
DEHYDRATASE
(Chlorobaculum
tepidum) 		5 / 12 LEU A 262
ASN A 261
LEU A 259
ALA A 258
LEU A 215
 None
 0.97A 1ya3C-2qmxA:
undetectable		 1ya3C-2qmxA:
21.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2AOU_A_CQAA403_0
(HISTAMINE
N-METHYLTRANSFERASE)		 2qmx PREPHENATE
DEHYDRATASE
(Chlorobaculum
tepidum) 		4 / 8 ASP A  45
LYS A   3
GLY A  24
THR A  77
 None
 0.78A 2aouA-2qmxA:
undetectable		 2aouA-2qmxA:
21.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3CR5_X_PNTX95_0
(PROTEIN S100-B)		 2qmx PREPHENATE
DEHYDRATASE
(Chlorobaculum
tepidum) 		3 / 3 CYH A 109
PHE A 112
PHE A 113
 None
 0.77A 3cr5X-2qmxA:
undetectable		 3cr5X-2qmxA:
13.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LSL_G_PZIG801_0
(GLUTAMATE RECEPTOR 2)		 2qmx PREPHENATE
DEHYDRATASE
(Chlorobaculum
tepidum) 		3 / 3 PRO A 232
SER A 230
ASN A 206
 None
PHE  A 304 (-3.4A)
PHE  A 304 (-3.0A)
 0.78A 3lslG-2qmxA:
5.7		 3lslG-2qmxA:
19.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TVX_B_PNXB902_1
(CAMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE 4A)		 2qmx PREPHENATE
DEHYDRATASE
(Chlorobaculum
tepidum) 		4 / 7 ASN A  53
ILE A  59
PHE A  32
PHE A 173
 None
 1.19A 3tvxB-2qmxA:
undetectable		 3tvxB-2qmxA:
23.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4K17_B_OHBB701_0
(LEUCINE-RICH
REPEAT-CONTAINING
PROTEIN 16A)		 2qmx PREPHENATE
DEHYDRATASE
(Chlorobaculum
tepidum) 		4 / 5 GLU A 122
SER A 101
ARG A 120
SER A 130
 EDO  A 312 ( 4.1A)
None
None
None
 1.45A 4k17B-2qmxA:
undetectable		 4k17B-2qmxA:
18.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LTW_A_STRA301_1
(ANCESTRAL STEROID
RECEPTOR 2)		 2qmx PREPHENATE
DEHYDRATASE
(Chlorobaculum
tepidum) 		5 / 12 LEU A 262
ASN A 261
LEU A 259
ALA A 258
LEU A 215
 None
 0.84A 4ltwA-2qmxA:
undetectable		 4ltwA-2qmxA:
23.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QKN_A_JMSA602_1
(ALPHA-KETOGLUTARATE-
DEPENDENT
DIOXYGENASE FTO)		 2qmx PREPHENATE
DEHYDRATASE
(Chlorobaculum
tepidum) 		4 / 8 LEU A  86
LEU A 163
VAL A  93
HIS A 116
 None
 1.20A 4qknA-2qmxA:
undetectable		 4qknA-2qmxA:
19.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4V2Y_C_EF2C151_1
(CEREBLON ISOFORM 4)		 2qmx PREPHENATE
DEHYDRATASE
(Chlorobaculum
tepidum) 		4 / 7 ASN A  62
PRO A  50
PHE A 173
TYR A 275
 None
 1.40A 4v2yC-2qmxA:
0.0		 4v2yC-2qmxA:
17.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4V2Z_C_Y70C151_1
(CEREBLON ISOFORM 4)		 2qmx PREPHENATE
DEHYDRATASE
(Chlorobaculum
tepidum) 		4 / 8 ASN A  62
PRO A  50
PHE A 173
TYR A 275
 None
 1.41A 4v2zC-2qmxA:
undetectable		 4v2zC-2qmxA:
17.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5AMH_A_EF2A151_1
(CEREBLON ISOFORM 4)		 2qmx PREPHENATE
DEHYDRATASE
(Chlorobaculum
tepidum) 		4 / 7 ASN A  62
PRO A  50
PHE A 173
TYR A 275
 None
 1.43A 5amhA-2qmxA:
0.0		 5amhA-2qmxA:
17.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EB3_A_UEGA202_1
(YFIR)		 2qmx PREPHENATE
DEHYDRATASE
(Chlorobaculum
tepidum) 		4 / 4 LEU A  21
ILE A  18
PRO A  12
LEU A 153
 None
 1.16A 5eb3A-2qmxA:
undetectable		 5eb3A-2qmxA:
20.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5K7U_A_SAMA601_1
(N6-ADENOSINE-METHYLT
RANSFERASE 70 KDA
SUBUNIT)		 2qmx PREPHENATE
DEHYDRATASE
(Chlorobaculum
tepidum) 		3 / 3 ASP A  34
ASN A  62
GLN A  61
 None
 0.79A 5k7uA-2qmxA:
undetectable		 5k7uA-2qmxA:
21.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5LJC_A_RTLA201_0
(RETINOL-BINDING
PROTEIN 1)		 2qmx PREPHENATE
DEHYDRATASE
(Chlorobaculum
tepidum) 		5 / 12 LEU A 262
ALA A 214
LEU A 215
PHE A 218
TYR A 243
 None
 1.14A 5ljcA-2qmxA:
undetectable		 5ljcA-2qmxA:
17.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5OTR_A_ACTA402_0
(CASEIN KINASE II
SUBUNIT ALPHA)		 2qmx PREPHENATE
DEHYDRATASE
(Chlorobaculum
tepidum) 		4 / 5 TYR A  15
VAL A  79
PRO A  50
ALA A  19
 ACT  A 301 (-4.5A)
None
None
None
 1.03A 5otrA-2qmxA:
undetectable		 5otrA-2qmxA:
23.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6MKE_C_FK5C201_0
(PEPTIDYLPROLYL
ISOMERASE)		 2qmx PREPHENATE
DEHYDRATASE
(Chlorobaculum
tepidum) 		4 / 4 ASP A  45
ILE A   6
PRO A  26
LEU A   5
 None
 1.48A 6mkeB-2qmxA:
undetectable		 6mkeB-2qmxA:
13.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6MKE_D_FK5D201_0
(PEPTIDYLPROLYL
ISOMERASE)		 2qmx PREPHENATE
DEHYDRATASE
(Chlorobaculum
tepidum) 		4 / 4 ASP A  45
ILE A   6
PRO A  26
LEU A   5
 None
 1.40A 6mkeA-2qmxA:
undetectable		 6mkeA-2qmxA:
13.67