SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2qne'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1IOL_A_ESTA400_1
(ESTROGENIC 17-BETA
HYDROXYSTEROID
DEHYDROGENASE)		 2qne PUTATIVE
METHYLTRANSFERASE
(Desulfitobacteri
um
hafniense) 		5 / 11 SER A 196
GLY A 163
MET A  91
TYR A 114
GLU A 136
 None
EDO  A 477 ( 4.6A)
None
None
None
 1.34A 1iolA-2qneA:
undetectable		 1iolA-2qneA:
22.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1OPJ_A_STIA3_2
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE ABL1)		 2qne PUTATIVE
METHYLTRANSFERASE
(Desulfitobacteri
um
hafniense) 		4 / 5 TYR A 217
VAL A 343
ILE A 268
MET A 210
 None
 1.31A 1opjA-2qneA:
undetectable		 1opjA-2qneA:
20.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1Q8J_A_C2FA801_0
(5-METHYLTETRAHYDROFO
LATE S-HOMOCYSTEINE
METHYLTRANSFERASE)		 2qne PUTATIVE
METHYLTRANSFERASE
(Desulfitobacteri
um
hafniense) 		5 / 12 ARG A 106
ASN A 315
ASP A 364
GLY A 348
ILE A 349
 None
 1.30A 1q8jA-2qneA:
15.7		 1q8jA-2qneA:
24.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RK3_A_VDXA500_1
(VITAMIN D3 RECEPTOR)		 2qne PUTATIVE
METHYLTRANSFERASE
(Desulfitobacteri
um
hafniense) 		5 / 12 TYR A 206
LEU A  54
VAL A  59
SER A 256
HIS A  17
 None
 1.47A 1rk3A-2qneA:
undetectable		 1rk3A-2qneA:
22.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1WRL_E_TFPE212_1
(TROPONIN C, SLOW
SKELETAL AND CARDIAC
MUSCLES)		 2qne PUTATIVE
METHYLTRANSFERASE
(Desulfitobacteri
um
hafniense) 		4 / 7 PHE A  40
LEU A 214
PHE A  58
SER A  65
 None
None
EDO  A 481 (-4.8A)
None
 1.07A 1wrlE-2qneA:
undetectable		 1wrlE-2qneA:
12.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QXS_A_RALA600_2
(ESTROGEN RECEPTOR)		 2qne PUTATIVE
METHYLTRANSFERASE
(Desulfitobacteri
um
hafniense) 		4 / 5 LEU A 372
ASP A 365
MET A 333
LEU A 337
 None
 1.31A 2qxsA-2qneA:
undetectable		 2qxsA-2qneA:
18.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Y7W_A_SALA1300_1
(LYSR-TYPE REGULATORY
PROTEIN)		 2qne PUTATIVE
METHYLTRANSFERASE
(Desulfitobacteri
um
hafniense) 		5 / 9 THR A 331
GLY A 313
GLY A 286
PHE A 353
ILE A 285
 None
None
None
EDO  A 478 (-4.7A)
None
 1.43A 2y7wA-2qneA:
undetectable		 2y7wA-2qneA:
15.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZZM_A_SAMA401_0
(UNCHARACTERIZED
PROTEIN MJ0883)		 2qne PUTATIVE
METHYLTRANSFERASE
(Desulfitobacteri
um
hafniense) 		5 / 12 LEU A 181
GLY A 163
ILE A 225
LEU A  72
PHE A  70
 None
EDO  A 477 ( 4.6A)
None
None
None
 0.97A 2zzmA-2qneA:
undetectable		 2zzmA-2qneA:
23.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3A35_A_RBFA191_1
(LUMAZINE PROTEIN)		 2qne PUTATIVE
METHYLTRANSFERASE
(Desulfitobacteri
um
hafniense) 		5 / 12 VAL A  82
LEU A  72
THR A  71
ALA A 223
ILE A 225
 None
 1.05A 3a35A-2qneA:
undetectable		 3a35A-2qneA:
16.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3A35_B_RBFB191_1
(LUMAZINE PROTEIN)		 2qne PUTATIVE
METHYLTRANSFERASE
(Desulfitobacteri
um
hafniense) 		5 / 12 VAL A  82
LEU A  72
THR A  71
ALA A 223
ILE A 225
 None
 1.08A 3a35B-2qneA:
undetectable		 3a35B-2qneA:
16.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3A3B_A_RBFA191_1
(LUMAZINE PROTEIN)		 2qne PUTATIVE
METHYLTRANSFERASE
(Desulfitobacteri
um
hafniense) 		5 / 12 VAL A  82
LEU A  72
THR A  71
ALA A 223
ILE A 225
 None
 1.07A 3a3bA-2qneA:
undetectable		 3a3bA-2qneA:
16.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3EL4_A_ROCA100_2
(PROTEASE)		 2qne PUTATIVE
METHYLTRANSFERASE
(Desulfitobacteri
um
hafniense) 		5 / 9 ALA A 253
GLY A  28
ILE A  27
PRO A 203
THR A 202
 None
 1.18A 3el4B-2qneA:
undetectable		 3el4B-2qneA:
12.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3J7Z_A_ERYA9000_0
(23S RRNA
50S RIBOSOMAL
PROTEIN L22
ERMCL NASCENT CHAIN)		 2qne PUTATIVE
METHYLTRANSFERASE
(Desulfitobacteri
um
hafniense) 		3 / 3 LYS A 360
ILE A 294
PHE A 293
 None
 0.98A 3j7zS-2qneA:
undetectable
3j7za-2qneA:
undetectable		 3j7zS-2qneA:
14.55
3j7za-2qneA:
3.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3JZ0_B_CLYB900_1
(LINCOSAMIDE
NUCLEOTIDYLTRANSFERA
SE)		 2qne PUTATIVE
METHYLTRANSFERASE
(Desulfitobacteri
um
hafniense) 		4 / 8 TYR A 114
TYR A  94
GLU A 136
ILE A 466
 None
None
None
EDO  A 480 ( 4.3A)
 1.08A 3jz0B-2qneA:
undetectable		 3jz0B-2qneA:
20.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3MTE_B_SAMB220_0
(16S RRNA METHYLASE)		 2qne PUTATIVE
METHYLTRANSFERASE
(Desulfitobacteri
um
hafniense) 		5 / 12 GLY A 311
GLY A 313
ALA A 291
LEU A 344
THR A 338
 None
 1.06A 3mteB-2qneA:
undetectable		 3mteB-2qneA:
19.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3P2K_A_SAMA6735_0
(16S RRNA METHYLASE)		 2qne PUTATIVE
METHYLTRANSFERASE
(Desulfitobacteri
um
hafniense) 		5 / 12 GLY A 311
GLY A 313
ALA A 291
LEU A 344
THR A 338
 None
 1.05A 3p2kA-2qneA:
undetectable		 3p2kA-2qneA:
18.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3PRS_A_RITA1001_1
(ENDOTHIAPEPSIN)		 2qne PUTATIVE
METHYLTRANSFERASE
(Desulfitobacteri
um
hafniense) 		5 / 10 ILE A  23
ALA A 249
LEU A 300
THR A 338
ILE A 225
 None
 1.17A 3prsA-2qneA:
undetectable		 3prsA-2qneA:
22.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3R0L_D_ACTD127_0
(PHOSPHOLIPASE A2 CB)		 2qne PUTATIVE
METHYLTRANSFERASE
(Desulfitobacteri
um
hafniense) 		4 / 5 PHE A 353
ILE A 285
GLY A 313
HIS A 345
 EDO  A 478 (-4.7A)
None
None
EDO  A 478 (-4.7A)
 1.15A 3r0lD-2qneA:
undetectable		 3r0lD-2qneA:
13.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TEH_B_DAHB786_1
(PHENYLALANYL-TRNA
SYNTHETASE BETA
CHAIN)		 2qne PUTATIVE
METHYLTRANSFERASE
(Desulfitobacteri
um
hafniense) 		5 / 7 HIS A 345
LEU A 314
GLY A 348
ALA A 347
PHE A 361
 EDO  A 478 (-4.7A)
None
None
None
None
 1.41A 3tehB-2qneA:
undetectable		 3tehB-2qneA:
23.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3VT3_A_VDXA500_1
(VITAMIN D3 RECEPTOR)		 2qne PUTATIVE
METHYLTRANSFERASE
(Desulfitobacteri
um
hafniense) 		5 / 12 TYR A 206
LEU A  54
VAL A  59
SER A 256
HIS A  17
 None
 1.46A 3vt3A-2qneA:
undetectable		 3vt3A-2qneA:
20.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3VT7_A_VDXA500_1
(VITAMIN D3 RECEPTOR)		 2qne PUTATIVE
METHYLTRANSFERASE
(Desulfitobacteri
um
hafniense) 		5 / 12 TYR A 206
LEU A  54
VAL A  59
SER A 256
HIS A  17
 None
 1.43A 3vt7A-2qneA:
undetectable		 3vt7A-2qneA:
21.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4E1G_A_LNLA701_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		 2qne PUTATIVE
METHYLTRANSFERASE
(Desulfitobacteri
um
hafniense) 		5 / 12 ASN A  19
ILE A  23
GLY A 236
ALA A 232
LEU A 244
 None
 1.06A 4e1gA-2qneA:
undetectable		 4e1gA-2qneA:
22.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4K0B_B_SAMB504_1
(S-ADENOSYLMETHIONINE
SYNTHASE)		 2qne PUTATIVE
METHYLTRANSFERASE
(Desulfitobacteri
um
hafniense) 		4 / 8 ALA A 213
TYR A 217
SER A 174
ASP A 173
 None
 1.01A 4k0bB-2qneA:
undetectable		 4k0bB-2qneA:
23.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4OAD_A_CLMA205_0
(GNAT SUPERFAMILY
ACETYLTRANSFERASE
PA4794)		 2qne PUTATIVE
METHYLTRANSFERASE
(Desulfitobacteri
um
hafniense) 		5 / 12 GLU A 166
ALA A 213
GLY A 212
LEU A 211
TYR A  33
 None
 1.36A 4oadA-2qneA:
1.4		 4oadA-2qneA:
16.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4OKW_A_198A1001_2
(ANDROGEN RECEPTOR)		 2qne PUTATIVE
METHYLTRANSFERASE
(Desulfitobacteri
um
hafniense) 		4 / 7 LEU A 344
MET A 354
LEU A 229
ILE A 225
 None
EDO  A 483 (-3.5A)
EDO  A 478 (-4.7A)
None
 1.04A 4okwA-2qneA:
undetectable		 4okwA-2qneA:
20.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XP1_A_LDPA708_1
(DOPAMINE
TRANSPORTER, ISOFORM
B)		 2qne PUTATIVE
METHYLTRANSFERASE
(Desulfitobacteri
um
hafniense) 		5 / 10 ASP A 113
ALA A 347
TYR A 358
SER A 357
GLY A 348
 None
 1.27A 4xp1A-2qneA:
undetectable		 4xp1A-2qneA:
22.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4YPM_A_BO2A801_1
(LON PROTEASE)		 2qne PUTATIVE
METHYLTRANSFERASE
(Desulfitobacteri
um
hafniense) 		5 / 12 ALA A 274
THR A 272
LEU A 283
GLY A 236
PRO A 237
 None
EDO  A 478 (-3.0A)
None
None
None
 1.22A 4ypmA-2qneA:
undetectable		 4ypmA-2qneA:
22.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EWU_A_BEZA1401_0
(MAGNESIUM-CHELATASE
SUBUNIT CHLH,
CHLOROPLASTIC)		 2qne PUTATIVE
METHYLTRANSFERASE
(Desulfitobacteri
um
hafniense) 		4 / 6 GLY A 339
THR A 338
SER A 308
VAL A 340
 None
 1.12A 5ewuA-2qneA:
undetectable		 5ewuA-2qneA:
22.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EWU_B_BEZB1401_0
(MAGNESIUM-CHELATASE
SUBUNIT CHLH,
CHLOROPLASTIC)		 2qne PUTATIVE
METHYLTRANSFERASE
(Desulfitobacteri
um
hafniense) 		4 / 6 GLY A 339
THR A 338
SER A 308
VAL A 340
 None
 1.12A 5ewuB-2qneA:
undetectable		 5ewuB-2qneA:
22.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5MSD_A_BEZA1202_0
(CARBOXYLIC ACID
REDUCTASE)		 2qne PUTATIVE
METHYLTRANSFERASE
(Desulfitobacteri
um
hafniense) 		4 / 5 ILE A 349
PHE A 117
SER A 357
ALA A  96
 None
 1.22A 5msdA-2qneA:
undetectable		 5msdA-2qneA:
18.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5NWU_A_ACAA18_1
(WTFP-TAG,GP41)		 2qne PUTATIVE
METHYLTRANSFERASE
(Desulfitobacteri
um
hafniense) 		5 / 12 ALA A 232
GLY A 236
GLU A 250
LEU A 204
GLU A  30
 None
 1.02A 5nwuA-2qneA:
undetectable		 5nwuA-2qneA:
5.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5O96_E_SAME501_0
(RIBOSOMAL RNA SMALL
SUBUNIT
METHYLTRANSFERASE E)		 2qne PUTATIVE
METHYLTRANSFERASE
(Desulfitobacteri
um
hafniense) 		5 / 9 LEU A  63
GLY A 305
SER A 256
VAL A 251
GLN A 247
 None
 1.43A 5o96E-2qneA:
1.5
5o96F-2qneA:
undetectable		 5o96E-2qneA:
19.48
5o96F-2qneA:
19.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5TE8_A_08JA602_1
(CYTOCHROME P450 3A4)		 2qne PUTATIVE
METHYLTRANSFERASE
(Desulfitobacteri
um
hafniense) 		4 / 7 LEU A 150
ALA A 178
ILE A 458
LEU A 462
 EDO  A 477 (-4.3A)
None
None
None
 0.95A 5te8A-2qneA:
undetectable		 5te8A-2qneA:
22.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6B0I_B_TA1B502_1
(TUBULIN BETA CHAIN)		 2qne PUTATIVE
METHYLTRANSFERASE
(Desulfitobacteri
um
hafniense) 		5 / 12 ASP A 364
LEU A 446
SER A 124
PRO A  92
GLY A  93
 None
 1.02A 6b0iB-2qneA:
undetectable		 6b0iB-2qneA:
9.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6BC9_A_ETSA302_2
(CARBONIC ANHYDRASE 2)		 2qne PUTATIVE
METHYLTRANSFERASE
(Desulfitobacteri
um
hafniense) 		4 / 5 HIS A 345
HIS A 128
LEU A  72
VAL A  81
 EDO  A 478 (-4.7A)
None
None
None
 1.14A 6bc9A-2qneA:
undetectable		 6bc9A-2qneA:
10.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6BRD_B_RFPB502_1
(RIFAMPIN
MONOOXYGENASE)		 2qne PUTATIVE
METHYLTRANSFERASE
(Desulfitobacteri
um
hafniense) 		5 / 12 GLY A 132
PHE A 361
THR A 346
GLY A 312
GLY A 313
 EDO  A 477 (-3.2A)
None
None
None
None
 1.11A 6brdB-2qneA:
undetectable		 6brdB-2qneA:
8.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6MN5_A_LLLA301_0
(AMINOGLYCOSIDE
N(3)-ACETYLTRANSFERA
SE, AAC(3)-IVA)		 2qne PUTATIVE
METHYLTRANSFERASE
(Desulfitobacteri
um
hafniense) 		4 / 6 ASP A 321
TYR A 326
GLU A 327
ASP A 316
 None
 1.49A 6mn5A-2qneA:
undetectable		 6mn5A-2qneA:
12.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6NMF_W_CHDW101_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 7A1,
MITOCHONDRIAL)		 2qne PUTATIVE
METHYLTRANSFERASE
(Desulfitobacteri
um
hafniense) 		4 / 6 ILE A 225
LEU A 197
MET A  91
THR A 346
 None
EDO  A 478 ( 4.7A)
None
None
 1.14A 6nmfN-2qneA:
undetectable
6nmfW-2qneA:
undetectable		 6nmfN-2qneA:
21.42
6nmfW-2qneA:
9.77