SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2qnk'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)

Filter list by:

	DrReposER ID / Desc.	Hit PDBID	Hit Macromolecule	Res. Matches	Interface	HETATM	RMSD	Dali Z-score	Seq. Identity (%)
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3QL6_A_NIMA614_1 (LACTOPEROXIDASE)	2qnk	3-HYDROXYANTHRANILAT E 3,4-DIOXYGENASE (Homo sapiens)	4 / 7	HIS A 91 GLU A 129 PHE A 170 PRO A 169	NI A 287 (-3.3A) None None None	1.35A	3ql6A-2qnkA: undetectable	3ql6A-2qnkA: 19.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3W1W_B_CHDB506_0 (FERROCHELATASE, MITOCHONDRIAL)	2qnk	3-HYDROXYANTHRANILAT E 3,4-DIOXYGENASE (Homo sapiens)	3 / 3	ARG A 107 ARG A 108 LYS A 33	PO4 A 288 (-3.8A) None PO4 A 288 (-2.9A)	1.45A	3w1wA-2qnkA: undetectable 3w1wB-2qnkA: undetectable	3w1wA-2qnkA: 25.00 3w1wB-2qnkA: 25.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4HVR_A_SALA203_1 (3-HYDROXYANTHRANILAT E 3,4-DIOXYGENASE)	2qnk	3-HYDROXYANTHRANILAT E 3,4-DIOXYGENASE (Homo sapiens)	6 / 7	HIS A 47 GLU A 53 HIS A 91 PRO A 93 VAL A 103 GLU A 105	NI A 287 (-3.2A) NI A 287 (-1.9A) NI A 287 (-3.3A) None None NI A 287 ( 4.6A)	0.38A	4hvrA-2qnkA: 17.2	4hvrA-2qnkA: 24.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	5FSA_B_X2NB590_2 (CYP51 VARIANT1)	2qnk	3-HYDROXYANTHRANILAT E 3,4-DIOXYGENASE (Homo sapiens)	3 / 3	PRO A 86 LEU A 172 SER A 176	None	0.76A	5fsaB-2qnkA: undetectable	5fsaB-2qnkA: 20.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	5SYJ_B_NIZB810_1 (CATALASE-PEROXIDASE)	2qnk	3-HYDROXYANTHRANILAT E 3,4-DIOXYGENASE (Homo sapiens)	4 / 6	ARG A 3 TRP A 229 HIS A 28 SER A 1	None	1.50A	5syjB-2qnkA: undetectable	5syjB-2qnkA: 16.30

[["DrReposER ID","Desc.","Hit PDB","Hit molecule","Hit organism","Res. no.","Interface","HETATM","RMSD","Z-score","Seq ID"],["3QL6_A_NIMA614_1","LACTOPEROXIDASE","2qnk","3-HYDROXYANTHRANILATE 3,4-DIOXYGENASE","Homo sapiens",4,"HIS A  91;GLU A 129;PHE A 170;PRO A 169"," NI A 287 (-3.3A);None;None;None","1.35A","3ql6A-2qnkA:undetectable","3ql6A-2qnkA:19.06"],["3W1W_B_CHDB506_0","FERROCHELATASE, MITOCHONDRIAL","2qnk","3-HYDROXYANTHRANILATE 3,4-DIOXYGENASE","Homo sapiens",3,"ARG A 107;ARG A 108;LYS A  33","PO4 A 288 (-3.8A);None;PO4 A 288 (-2.9A)","1.45A","3w1wA-2qnkA:undetectable;3w1wB-2qnkA:undetectable","3w1wA-2qnkA:25.00;3w1wB-2qnkA:25.00"],["4HVR_A_SALA203_1","3-HYDROXYANTHRANILATE 3,4-DIOXYGENASE","2qnk","3-HYDROXYANTHRANILATE 3,4-DIOXYGENASE","Homo sapiens",6,"HIS A  47;GLU A  53;HIS A  91;PRO A  93;VAL A 103;GLU A 105"," NI A 287 (-3.2A); NI A 287 (-1.9A); NI A 287 (-3.3A);None;None; NI A 287 ( 4.6A)","0.38A","4hvrA-2qnkA:17.2","4hvrA-2qnkA:24.83"],["5FSA_B_X2NB590_2","CYP51 VARIANT1","2qnk","3-HYDROXYANTHRANILATE 3,4-DIOXYGENASE","Homo sapiens",3,"PRO A  86;LEU A 172;SER A 176","None","0.76A","5fsaB-2qnkA:undetectable","5fsaB-2qnkA:20.16"],["5SYJ_B_NIZB810_1","CATALASE-PEROXIDASE","2qnk","3-HYDROXYANTHRANILATE 3,4-DIOXYGENASE","Homo sapiens",4,"ARG A   3;TRP A 229;HIS A  28;SER A   1","None","1.50A","5syjB-2qnkA:undetectable","5syjB-2qnkA:16.30"]]