SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2qnr'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2E1Q_A_SALA2006_1
(XANTHINE
DEHYDROGENASE/OXIDAS
E)		 2qnr SEPTIN-2
(Homo
sapiens) 		4 / 6 ARG A 145
PHE A 126
THR A 291
LEU A 294
 None
 0.93A 2e1qA-2qnrA:
undetectable		 2e1qA-2qnrA:
12.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2E1Q_C_SALC4006_1
(XANTHINE
DEHYDROGENASE/OXIDAS
E)		 2qnr SEPTIN-2
(Homo
sapiens) 		4 / 6 ARG A 145
PHE A 126
THR A 291
LEU A 294
 None
 1.01A 2e1qC-2qnrA:
undetectable		 2e1qC-2qnrA:
12.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2E1Q_D_SALD5006_1
(XANTHINE
DEHYDROGENASE/OXIDAS
E)		 2qnr SEPTIN-2
(Homo
sapiens) 		4 / 5 ARG A 145
PHE A 126
THR A 291
LEU A 294
 None
 0.93A 2e1qD-2qnrA:
undetectable		 2e1qD-2qnrA:
12.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2NV4_A_SAMA201_0
(UPF0066 PROTEIN
AF_0241)		 2qnr SEPTIN-2
(Homo
sapiens) 		5 / 12 ALA A 166
PRO A 103
GLY A  44
LEU A  48
ASP A 164
 None
 1.13A 2nv4A-2qnrA:
undetectable		 2nv4A-2qnrA:
19.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2NV4_A_SAMA201_0
(UPF0066 PROTEIN
AF_0241)		 2qnr SEPTIN-2
(Homo
sapiens) 		5 / 12 ALA A 166
TYR A 151
PRO A 103
GLY A  44
ASP A 164
 None
 1.15A 2nv4A-2qnrA:
undetectable		 2nv4A-2qnrA:
19.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XKK_E_MFXE1100_1
(TOPOISOMERASE IV
DNA)		 2qnr SEPTIN-2
(Homo
sapiens) 		3 / 3 ARG A 277
GLU A 269
SER A  56
 None
 0.92A 2xkkA-2qnrA:
3.2
2xkkC-2qnrA:
3.0		 2xkkA-2qnrA:
17.89
2xkkC-2qnrA:
17.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UNI_A_SALA1344_1
(XANTHINE
DEHYDROGENASE/OXIDAS
E)		 2qnr SEPTIN-2
(Homo
sapiens) 		4 / 7 ARG A 145
PHE A 126
THR A 291
LEU A 294
 None
 0.99A 3uniA-2qnrA:
undetectable		 3uniA-2qnrA:
11.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5MVS_A_ADNA401_1
(HISTONE-LYSINE
N-METHYLTRANSFERASE,
H3 LYSINE-79
SPECIFIC)		 2qnr SEPTIN-2
(Homo
sapiens) 		4 / 7 GLY A 241
LYS A 183
ALA A 182
ASN A  55
 GDP  A1401 (-3.9A)
GDP  A1401 (-3.2A)
None
None
 0.85A 5mvsA-2qnrA:
undetectable		 5mvsA-2qnrA:
21.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5YCP_A_BRLA501_0
(PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR GAMMA)		 2qnr SEPTIN-2
(Homo
sapiens) 		5 / 12 PHE A 150
CYH A 149
ILE A 118
LEU A 280
LEU A 287
 None
 1.42A 5ycpA-2qnrA:
undetectable		 5ycpA-2qnrA:
16.52