SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2qo3'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1GRM_A_DVAA8_0
(GRAMICIDIN A)		 2qo3 ERYAII ERYTHROMYCIN
POLYKETIDE SYNTHASE
MODULES 3 AND 4
(Saccharopolyspor
a
erythraea) 		4 / 4 GLY A 369
VAL A 334
TRP A 367
TRP A 428
 None
 1.20A 1grmA-2qo3A:
undetectable		 1grmA-2qo3A:
2.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1GRM_B_DVAB8_0
(GRAMICIDIN A)		 2qo3 ERYAII ERYTHROMYCIN
POLYKETIDE SYNTHASE
MODULES 3 AND 4
(Saccharopolyspor
a
erythraea) 		4 / 4 GLY A 369
VAL A 334
TRP A 367
TRP A 428
 None
 1.20A 1grmB-2qo3A:
undetectable		 1grmB-2qo3A:
2.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HRK_A_CHDA1502_0
(FERROCHELATASE)		 2qo3 ERYAII ERYTHROMYCIN
POLYKETIDE SYNTHASE
MODULES 3 AND 4
(Saccharopolyspor
a
erythraea) 		4 / 8 MET A 232
LEU A 247
PRO A  43
GLY A 376
 None
 1.02A 1hrkA-2qo3A:
3.3		 1hrkA-2qo3A:
16.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1JNO_A_DVAA8_0
(GRAMICIDIN A)		 2qo3 ERYAII ERYTHROMYCIN
POLYKETIDE SYNTHASE
MODULES 3 AND 4
(Saccharopolyspor
a
erythraea) 		4 / 4 GLY A 369
VAL A 334
TRP A 367
TRP A 428
 None
 1.39A 1jnoA-2qo3A:
undetectable		 1jnoA-2qo3A:
2.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1JNO_B_DVAB8_0
(GRAMICIDIN A)		 2qo3 ERYAII ERYTHROMYCIN
POLYKETIDE SYNTHASE
MODULES 3 AND 4
(Saccharopolyspor
a
erythraea) 		4 / 4 GLY A 369
VAL A 334
TRP A 367
TRP A 428
 None
 1.39A 1jnoB-2qo3A:
undetectable		 1jnoB-2qo3A:
2.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1JO3_A_DVAA8_0
(GRAMICIDIN B)		 2qo3 ERYAII ERYTHROMYCIN
POLYKETIDE SYNTHASE
MODULES 3 AND 4
(Saccharopolyspor
a
erythraea) 		4 / 4 GLY A 369
VAL A 334
TRP A 367
TRP A 428
 None
 1.36A 1jo3A-2qo3A:
undetectable		 1jo3A-2qo3A:
2.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1JO3_B_DVAB8_0
(GRAMICIDIN B)		 2qo3 ERYAII ERYTHROMYCIN
POLYKETIDE SYNTHASE
MODULES 3 AND 4
(Saccharopolyspor
a
erythraea) 		4 / 4 GLY A 369
VAL A 334
TRP A 367
TRP A 428
 None
 1.36A 1jo3B-2qo3A:
undetectable		 1jo3B-2qo3A:
2.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1JO4_A_DVAA8_0
(GRAMICIDIN C)		 2qo3 ERYAII ERYTHROMYCIN
POLYKETIDE SYNTHASE
MODULES 3 AND 4
(Saccharopolyspor
a
erythraea) 		4 / 4 GLY A 369
VAL A 334
TRP A 367
TRP A 428
 None
 1.34A 1jo4A-2qo3A:
undetectable		 1jo4A-2qo3A:
2.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1JO4_B_DVAB8_0
(GRAMICIDIN C)		 2qo3 ERYAII ERYTHROMYCIN
POLYKETIDE SYNTHASE
MODULES 3 AND 4
(Saccharopolyspor
a
erythraea) 		4 / 4 GLY A 369
VAL A 334
TRP A 367
TRP A 428
 None
 1.34A 1jo4B-2qo3A:
undetectable		 1jo4B-2qo3A:
2.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1N2X_A_SAMA401_1
(S-ADENOSYL-METHYLTRA
NSFERASE MRAW)		 2qo3 ERYAII ERYTHROMYCIN
POLYKETIDE SYNTHASE
MODULES 3 AND 4
(Saccharopolyspor
a
erythraea) 		4 / 4 HIS A  78
ASP A 250
SER A 253
ASP A  91
 None
 1.43A 1n2xA-2qo3A:
0.7		 1n2xA-2qo3A:
17.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1NRM_A_DVAA8_0
(GRAMICIDIN A)		 2qo3 ERYAII ERYTHROMYCIN
POLYKETIDE SYNTHASE
MODULES 3 AND 4
(Saccharopolyspor
a
erythraea) 		4 / 4 GLY A 369
VAL A 334
TRP A 367
TRP A 428
 None
 1.34A 1nrmA-2qo3A:
undetectable		 1nrmA-2qo3A:
2.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1NRM_B_DVAB8_0
(GRAMICIDIN A)		 2qo3 ERYAII ERYTHROMYCIN
POLYKETIDE SYNTHASE
MODULES 3 AND 4
(Saccharopolyspor
a
erythraea) 		4 / 4 GLY A 369
VAL A 334
TRP A 367
TRP A 428
 None
 1.34A 1nrmB-2qo3A:
undetectable		 1nrmB-2qo3A:
2.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1NRU_A_DVAA8_0
(GRAMICIDIN A)		 2qo3 ERYAII ERYTHROMYCIN
POLYKETIDE SYNTHASE
MODULES 3 AND 4
(Saccharopolyspor
a
erythraea) 		4 / 4 GLY A 369
VAL A 334
TRP A 367
TRP A 428
 None
 1.38A 1nruA-2qo3A:
undetectable		 1nruA-2qo3A:
2.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1NRU_B_DVAB8_0
(GRAMICIDIN A)		 2qo3 ERYAII ERYTHROMYCIN
POLYKETIDE SYNTHASE
MODULES 3 AND 4
(Saccharopolyspor
a
erythraea) 		4 / 4 GLY A 369
VAL A 334
TRP A 367
TRP A 428
 None
 1.38A 1nruB-2qo3A:
undetectable		 1nruB-2qo3A:
2.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1OQ5_A_CELA701_2
(CARBONIC ANHYDRASE
II)		 2qo3 ERYAII ERYTHROMYCIN
POLYKETIDE SYNTHASE
MODULES 3 AND 4
(Saccharopolyspor
a
erythraea) 		4 / 4 HIS A 650
VAL A 834
THR A 784
LEU A 817
 None
 1.13A 1oq5A-2qo3A:
undetectable		 1oq5A-2qo3A:
14.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1PNL_B_PACB559_0
(PENICILLIN
AMIDOHYDROLASE)		 2qo3 ERYAII ERYTHROMYCIN
POLYKETIDE SYNTHASE
MODULES 3 AND 4
(Saccharopolyspor
a
erythraea) 		4 / 8 MET A 680
SER A 651
ILE A 758
ASN A 803
 None
ACT  A 950 ( 2.0A)
None
None
 0.84A 1pnlA-2qo3A:
undetectable
1pnlB-2qo3A:
undetectable		 1pnlA-2qo3A:
13.65
1pnlB-2qo3A:
21.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1Q23_C_FUAC701_1
(CHLORAMPHENICOL
ACETYLTRANSFERASE)		 2qo3 ERYAII ERYTHROMYCIN
POLYKETIDE SYNTHASE
MODULES 3 AND 4
(Saccharopolyspor
a
erythraea) 		4 / 4 ALA A 520
VAL A 547
ALA A 521
HIS A 875
 None
 1.13A 1q23A-2qo3A:
undetectable		 1q23A-2qo3A:
11.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1Q23_J_FUAJ711_2
(CHLORAMPHENICOL
ACETYLTRANSFERASE)		 2qo3 ERYAII ERYTHROMYCIN
POLYKETIDE SYNTHASE
MODULES 3 AND 4
(Saccharopolyspor
a
erythraea) 		4 / 4 ALA A 520
VAL A 547
ALA A 521
HIS A 875
 None
 1.13A 1q23K-2qo3A:
1.7		 1q23K-2qo3A:
11.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1V54_J_CHDJ3060_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE I
CYTOCHROME C OXIDASE
POLYPEPTIDE
VIIA-HEART)		 2qo3 ERYAII ERYTHROMYCIN
POLYKETIDE SYNTHASE
MODULES 3 AND 4
(Saccharopolyspor
a
erythraea) 		4 / 6 LEU A 131
ARG A 184
MET A 189
LEU A 191
 None
 0.98A 1v54A-2qo3A:
undetectable
1v54J-2qo3A:
undetectable		 1v54A-2qo3A:
20.35
1v54J-2qo3A:
4.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2AOF_C_FRDC305_2
(POL POLYPROTEIN
PEPTIDE INHIBITOR)		 2qo3 ERYAII ERYTHROMYCIN
POLYKETIDE SYNTHASE
MODULES 3 AND 4
(Saccharopolyspor
a
erythraea) 		4 / 5 LEU A 353
ASP A 354
PRO A 346
ALA A 349
 None
 1.02A 2aofB-2qo3A:
undetectable		 2aofB-2qo3A:
8.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BXG_A_IBPA2001_1
(SERUM ALBUMIN)		 2qo3 ERYAII ERYTHROMYCIN
POLYKETIDE SYNTHASE
MODULES 3 AND 4
(Saccharopolyspor
a
erythraea) 		5 / 11 VAL A 505
GLY A 504
ALA A 500
LEU A 494
ARG A 497
 None
 1.13A 2bxgA-2qo3A:
undetectable		 2bxgA-2qo3A:
20.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2CBR_A_A80A201_1
(PROTEIN (CRABP-I))		 2qo3 ERYAII ERYTHROMYCIN
POLYKETIDE SYNTHASE
MODULES 3 AND 4
(Saccharopolyspor
a
erythraea) 		5 / 12 LEU A 273
VAL A 132
GLY A 227
LEU A  96
ARG A  41
 None
 0.97A 2cbrA-2qo3A:
undetectable		 2cbrA-2qo3A:
9.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2DDW_B_PXLB1005_1
(PYRIDOXINE KINASE)		 2qo3 ERYAII ERYTHROMYCIN
POLYKETIDE SYNTHASE
MODULES 3 AND 4
(Saccharopolyspor
a
erythraea) 		4 / 7 SER A 870
PRO A 832
HIS A 831
GLY A 862
 None
 0.96A 2ddwB-2qo3A:
undetectable		 2ddwB-2qo3A:
15.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2DYR_J_CHDJ60_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE
VIIA-HEART
CYTOCHROME C OXIDASE
SUBUNIT 1)		 2qo3 ERYAII ERYTHROMYCIN
POLYKETIDE SYNTHASE
MODULES 3 AND 4
(Saccharopolyspor
a
erythraea) 		4 / 6 LEU A 131
ARG A 184
MET A 189
LEU A 191
 None
 1.04A 2dyrA-2qo3A:
undetectable
2dyrJ-2qo3A:
undetectable		 2dyrA-2qo3A:
20.35
2dyrJ-2qo3A:
4.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2DYS_J_CHDJ101_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE
VIIA-HEART
CYTOCHROME C OXIDASE
SUBUNIT 1)		 2qo3 ERYAII ERYTHROMYCIN
POLYKETIDE SYNTHASE
MODULES 3 AND 4
(Saccharopolyspor
a
erythraea) 		4 / 6 LEU A 131
ARG A 184
MET A 189
LEU A 191
 None
 1.07A 2dysA-2qo3A:
undetectable
2dysJ-2qo3A:
undetectable		 2dysA-2qo3A:
20.35
2dysJ-2qo3A:
4.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2DYS_W_CHDW101_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE
VIIA-HEART
CYTOCHROME C OXIDASE
SUBUNIT 1)		 2qo3 ERYAII ERYTHROMYCIN
POLYKETIDE SYNTHASE
MODULES 3 AND 4
(Saccharopolyspor
a
erythraea) 		4 / 6 LEU A 131
ARG A 184
MET A 189
LEU A 191
 None
 0.98A 2dysN-2qo3A:
undetectable
2dysW-2qo3A:
undetectable		 2dysN-2qo3A:
20.35
2dysW-2qo3A:
4.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2EIJ_J_CHDJ60_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE
VIIA-HEART
CYTOCHROME C OXIDASE
SUBUNIT 1)		 2qo3 ERYAII ERYTHROMYCIN
POLYKETIDE SYNTHASE
MODULES 3 AND 4
(Saccharopolyspor
a
erythraea) 		4 / 6 LEU A 131
ARG A 184
MET A 189
LEU A 191
 None
 1.00A 2eijA-2qo3A:
undetectable
2eijJ-2qo3A:
undetectable		 2eijA-2qo3A:
20.35
2eijJ-2qo3A:
4.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2EIL_J_CHDJ60_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE
VIIA-HEART
CYTOCHROME C OXIDASE
SUBUNIT 1)		 2qo3 ERYAII ERYTHROMYCIN
POLYKETIDE SYNTHASE
MODULES 3 AND 4
(Saccharopolyspor
a
erythraea) 		4 / 6 LEU A 131
ARG A 184
MET A 189
LEU A 191
 None
 0.96A 2eilA-2qo3A:
1.0
2eilJ-2qo3A:
undetectable		 2eilA-2qo3A:
20.35
2eilJ-2qo3A:
4.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2HS1_B_017B203_1
(HIV-1 PROTEASE)		 2qo3 ERYAII ERYTHROMYCIN
POLYKETIDE SYNTHASE
MODULES 3 AND 4
(Saccharopolyspor
a
erythraea) 		4 / 7 GLU A 126
PRO A 111
LYS A 903
GLY A 101
 None
 1.20A 2hs1B-2qo3A:
undetectable		 2hs1B-2qo3A:
7.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OTH_A_NIMA300_1
(PHOSPHOLIPASE A2
VRV-PL-VIIIA)		 2qo3 ERYAII ERYTHROMYCIN
POLYKETIDE SYNTHASE
MODULES 3 AND 4
(Saccharopolyspor
a
erythraea) 		4 / 5 LEU A 577
ALA A 585
ILE A 588
SER A 632
 None
 1.06A 2othA-2qo3A:
1.5		 2othA-2qo3A:
7.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2PO5_B_CHDB502_0
(FERROCHELATASE,
MITOCHONDRIAL)		 2qo3 ERYAII ERYTHROMYCIN
POLYKETIDE SYNTHASE
MODULES 3 AND 4
(Saccharopolyspor
a
erythraea) 		4 / 8 LEU A  52
ARG A  41
LEU A  96
GLY A 228
 None
 0.98A 2po5B-2qo3A:
2.9		 2po5B-2qo3A:
16.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QD5_A_CHDA701_0
(FERROCHELATASE)		 2qo3 ERYAII ERYTHROMYCIN
POLYKETIDE SYNTHASE
MODULES 3 AND 4
(Saccharopolyspor
a
erythraea) 		4 / 8 LEU A 804
ARG A 760
GLY A 725
MET A 689
 None
None
None
ACT  A 950 ( 4.5A)
 1.12A 2qd5A-2qo3A:
3.6		 2qd5A-2qo3A:
16.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QD5_B_CHDB1103_0
(FERROCHELATASE)		 2qo3 ERYAII ERYTHROMYCIN
POLYKETIDE SYNTHASE
MODULES 3 AND 4
(Saccharopolyspor
a
erythraea) 		4 / 8 ARG A  70
SER A 204
VAL A 269
GLY A 268
 None
 0.87A 2qd5B-2qo3A:
2.4		 2qd5B-2qo3A:
16.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2UXP_B_CLMB1211_0
(HTH-TYPE
TRANSCRIPTIONAL
REGULATOR TTGR)		 2qo3 ERYAII ERYTHROMYCIN
POLYKETIDE SYNTHASE
MODULES 3 AND 4
(Saccharopolyspor
a
erythraea) 		5 / 11 ALA A 544
GLU A 536
GLY A 533
ILE A 537
VAL A 876
 None
 1.28A 2uxpB-2qo3A:
undetectable		 2uxpB-2qo3A:
14.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2X2I_A_QPSA1060_1
(ALPHA-1,4-GLUCAN
LYASE ISOZYME 1)		 2qo3 ERYAII ERYTHROMYCIN
POLYKETIDE SYNTHASE
MODULES 3 AND 4
(Saccharopolyspor
a
erythraea) 		5 / 12 PHE A 156
THR A 200
GLY A 228
ALA A 230
GLN A 120
 None
 1.19A 2x2iA-2qo3A:
undetectable		 2x2iA-2qo3A:
21.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2X2I_C_QPSC1060_1
(ALPHA-1,4-GLUCAN
LYASE ISOZYME 1)		 2qo3 ERYAII ERYTHROMYCIN
POLYKETIDE SYNTHASE
MODULES 3 AND 4
(Saccharopolyspor
a
erythraea) 		5 / 12 PHE A 156
THR A 200
GLY A 228
ALA A 230
GLN A 120
 None
 1.19A 2x2iC-2qo3A:
undetectable		 2x2iC-2qo3A:
21.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Y7H_B_SAMB530_0
(TYPE I RESTRICTION
ENZYME ECOKI M
PROTEIN)		 2qo3 ERYAII ERYTHROMYCIN
POLYKETIDE SYNTHASE
MODULES 3 AND 4
(Saccharopolyspor
a
erythraea) 		6 / 12 ILE A 347
ALA A 255
GLY A 340
THR A 341
GLY A 344
THR A 402
 None
 1.47A 2y7hB-2qo3A:
undetectable		 2y7hB-2qo3A:
21.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Y7H_C_SAMC530_0
(TYPE I RESTRICTION
ENZYME ECOKI M
PROTEIN)		 2qo3 ERYAII ERYTHROMYCIN
POLYKETIDE SYNTHASE
MODULES 3 AND 4
(Saccharopolyspor
a
erythraea) 		6 / 12 ILE A 347
ALA A 255
GLY A 340
THR A 341
GLY A 344
THR A 402
 None
 1.47A 2y7hC-2qo3A:
undetectable		 2y7hC-2qo3A:
21.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2YA7_C_ZMRC1776_2
(NEURAMINIDASE A)		 2qo3 ERYAII ERYTHROMYCIN
POLYKETIDE SYNTHASE
MODULES 3 AND 4
(Saccharopolyspor
a
erythraea) 		4 / 6 ARG A 122
ASP A 118
GLN A 379
GLU A 267
 None
 1.30A 2ya7C-2qo3A:
undetectable		 2ya7C-2qo3A:
19.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ASN_J_CHDJ60_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 7A1)		 2qo3 ERYAII ERYTHROMYCIN
POLYKETIDE SYNTHASE
MODULES 3 AND 4
(Saccharopolyspor
a
erythraea) 		4 / 6 LEU A 131
ARG A 184
MET A 189
LEU A 191
 None
 1.06A 3asnA-2qo3A:
undetectable
3asnJ-2qo3A:
undetectable		 3asnA-2qo3A:
20.35
3asnJ-2qo3A:
4.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ASO_J_CHDJ60_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 7A1)		 2qo3 ERYAII ERYTHROMYCIN
POLYKETIDE SYNTHASE
MODULES 3 AND 4
(Saccharopolyspor
a
erythraea) 		4 / 6 LEU A 131
ARG A 184
MET A 189
LEU A 191
 None
 1.04A 3asoA-2qo3A:
undetectable
3asoJ-2qo3A:
undetectable		 3asoA-2qo3A:
20.35
3asoJ-2qo3A:
4.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3CO4_A_GCSA401_1
(CHITINASE)		 2qo3 ERYAII ERYTHROMYCIN
POLYKETIDE SYNTHASE
MODULES 3 AND 4
(Saccharopolyspor
a
erythraea) 		3 / 3 GLU A 105
HIS A 516
HIS A 518
 None
 0.93A 3co4A-2qo3A:
undetectable		 3co4A-2qo3A:
15.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3DH0_B_SAMB300_0
(SAM DEPENDENT
METHYLTRANSFERASE)		 2qo3 ERYAII ERYTHROMYCIN
POLYKETIDE SYNTHASE
MODULES 3 AND 4
(Saccharopolyspor
a
erythraea) 		6 / 12 LEU A 151
GLY A 152
PHE A 150
GLN A 120
THR A 270
LEU A  42
 None
 1.34A 3dh0B-2qo3A:
2.2		 3dh0B-2qo3A:
13.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3DH0_B_SAMB300_0
(SAM DEPENDENT
METHYLTRANSFERASE)		 2qo3 ERYAII ERYTHROMYCIN
POLYKETIDE SYNTHASE
MODULES 3 AND 4
(Saccharopolyspor
a
erythraea) 		5 / 12 LEU A 388
GLY A 383
GLY A 386
VAL A 451
ALA A 381
 None
 1.11A 3dh0B-2qo3A:
2.2		 3dh0B-2qo3A:
13.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3DLC_A_SAMA220_0
(PUTATIVE
S-ADENOSYL-L-METHION
INE-DEPENDENT
METHYLTRANSFERASE)		 2qo3 ERYAII ERYTHROMYCIN
POLYKETIDE SYNTHASE
MODULES 3 AND 4
(Saccharopolyspor
a
erythraea) 		5 / 12 PHE A 265
GLY A 376
GLY A  94
HIS A 337
SER A 253
 None
None
None
CER  A 960 ( 4.2A)
None
 1.37A 3dlcA-2qo3A:
undetectable		 3dlcA-2qo3A:
11.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OU6_A_SAMA300_0
(SAM-DEPENDENT
METHYLTRANSFERASE)		 2qo3 ERYAII ERYTHROMYCIN
POLYKETIDE SYNTHASE
MODULES 3 AND 4
(Saccharopolyspor
a
erythraea) 		5 / 12 LEU A 206
ALA A 380
GLY A 228
GLY A 383
ALA A 154
 None
 1.11A 3ou6A-2qo3A:
undetectable		 3ou6A-2qo3A:
13.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OU6_B_SAMB300_0
(SAM-DEPENDENT
METHYLTRANSFERASE)		 2qo3 ERYAII ERYTHROMYCIN
POLYKETIDE SYNTHASE
MODULES 3 AND 4
(Saccharopolyspor
a
erythraea) 		5 / 12 LEU A 206
ALA A 380
GLY A 228
GLY A 383
ALA A 154
 None
 1.13A 3ou6B-2qo3A:
undetectable		 3ou6B-2qo3A:
13.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OU7_B_SAMB300_0
(SAM-DEPENDENT
METHYLTRANSFERASE)		 2qo3 ERYAII ERYTHROMYCIN
POLYKETIDE SYNTHASE
MODULES 3 AND 4
(Saccharopolyspor
a
erythraea) 		5 / 12 LEU A 206
ALA A 380
GLY A 228
GLY A 383
ALA A 154
 None
 1.12A 3ou7B-2qo3A:
undetectable		 3ou7B-2qo3A:
13.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3P2K_A_SAMA6735_1
(16S RRNA METHYLASE)		 2qo3 ERYAII ERYTHROMYCIN
POLYKETIDE SYNTHASE
MODULES 3 AND 4
(Saccharopolyspor
a
erythraea) 		3 / 3 ASP A 118
GLU A 160
SER A 182
 None
 0.83A 3p2kA-2qo3A:
undetectable		 3p2kA-2qo3A:
13.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3P6G_A_IZPA133_1
(FATTY ACID-BINDING
PROTEIN, ADIPOCYTE)		 2qo3 ERYAII ERYTHROMYCIN
POLYKETIDE SYNTHASE
MODULES 3 AND 4
(Saccharopolyspor
a
erythraea) 		5 / 12 PHE A 627
VAL A 660
ILE A 588
VAL A 603
CYH A 591
 None
 1.47A 3p6gA-2qo3A:
undetectable		 3p6gA-2qo3A:
8.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3U7S_A_017A202_2
(POL POLYPROTEIN)		 2qo3 ERYAII ERYTHROMYCIN
POLYKETIDE SYNTHASE
MODULES 3 AND 4
(Saccharopolyspor
a
erythraea) 		5 / 9 GLY A 262
ALA A 248
ASP A 250
GLY A 376
VAL A  90
 None
 1.06A 3u7sB-2qo3A:
undetectable		 3u7sB-2qo3A:
8.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4E47_C_SAMC800_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
SETD7)		 2qo3 ERYAII ERYTHROMYCIN
POLYKETIDE SYNTHASE
MODULES 3 AND 4
(Saccharopolyspor
a
erythraea) 		5 / 11 GLY A  60
GLU A  58
GLY A 424
ASN A 425
ASN A 374
 None
 1.11A 4e47C-2qo3A:
undetectable		 4e47C-2qo3A:
14.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FGZ_A_CQAA301_0
(PHOSPHOETHANOLAMINE
N-METHYLTRANSFERASE)		 2qo3 ERYAII ERYTHROMYCIN
POLYKETIDE SYNTHASE
MODULES 3 AND 4
(Saccharopolyspor
a
erythraea) 		4 / 8 GLY A 338
GLY A 369
GLU A 335
LEU A 422
 None
 0.87A 4fgzA-2qo3A:
undetectable		 4fgzA-2qo3A:
14.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FGZ_B_CQAB301_0
(PHOSPHOETHANOLAMINE
N-METHYLTRANSFERASE)		 2qo3 ERYAII ERYTHROMYCIN
POLYKETIDE SYNTHASE
MODULES 3 AND 4
(Saccharopolyspor
a
erythraea) 		4 / 8 GLY A 338
GLY A 369
GLU A 335
LEU A 422
 None
 0.87A 4fgzB-2qo3A:
undetectable		 4fgzB-2qo3A:
14.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4JDS_C_SAMC401_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
SETD7)		 2qo3 ERYAII ERYTHROMYCIN
POLYKETIDE SYNTHASE
MODULES 3 AND 4
(Saccharopolyspor
a
erythraea) 		5 / 11 GLY A  60
GLU A  58
GLY A 424
ASN A 425
ASN A 374
 None
 1.11A 4jdsC-2qo3A:
undetectable		 4jdsC-2qo3A:
14.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4JLG_A_SAMA401_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
SETD7)		 2qo3 ERYAII ERYTHROMYCIN
POLYKETIDE SYNTHASE
MODULES 3 AND 4
(Saccharopolyspor
a
erythraea) 		5 / 12 GLY A  60
GLU A  58
GLY A 424
ASN A 425
ASN A 374
 None
 1.08A 4jlgA-2qo3A:
undetectable		 4jlgA-2qo3A:
14.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KLA_A_CHDA502_0
(FERROCHELATASE,
MITOCHONDRIAL)		 2qo3 ERYAII ERYTHROMYCIN
POLYKETIDE SYNTHASE
MODULES 3 AND 4
(Saccharopolyspor
a
erythraea) 		4 / 8 LEU A 392
LEU A  56
ILE A  35
VAL A 439
 None
 0.86A 4klaA-2qo3A:
undetectable		 4klaA-2qo3A:
16.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KRH_A_SAMA900_0
(PHOSPHOETHANOLAMINE
N-METHYLTRANSFERASE
2)		 2qo3 ERYAII ERYTHROMYCIN
POLYKETIDE SYNTHASE
MODULES 3 AND 4
(Saccharopolyspor
a
erythraea) 		5 / 12 GLY A 340
GLY A 338
SER A 373
ASP A 250
ALA A 248
 None
 1.05A 4krhA-2qo3A:
2.6		 4krhA-2qo3A:
18.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LS7_A_1X9A504_1
(3-OXOACYL-[ACYL-CARR
IER-PROTEIN]
SYNTHASE 2)		 2qo3 ERYAII ERYTHROMYCIN
POLYKETIDE SYNTHASE
MODULES 3 AND 4
(Saccharopolyspor
a
erythraea) 		7 / 12 ALA A 201
CYH A 202
PHE A 241
HIS A 337
THR A 339
HIS A 377
GLY A 443
 None
CER  A 960 ( 1.7A)
None
CER  A 960 ( 4.2A)
CER  A 960 ( 4.2A)
CER  A 960 ( 3.8A)
CER  A 960 ( 4.2A)
 0.86A 4ls7A-2qo3A:
40.1		 4ls7A-2qo3A:
18.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LS7_B_1X9B503_1
(3-OXOACYL-[ACYL-CARR
IER-PROTEIN]
SYNTHASE 2)		 2qo3 ERYAII ERYTHROMYCIN
POLYKETIDE SYNTHASE
MODULES 3 AND 4
(Saccharopolyspor
a
erythraea) 		7 / 12 ALA A 201
CYH A 202
PHE A 241
HIS A 337
THR A 339
HIS A 377
GLY A 443
 None
CER  A 960 ( 1.7A)
None
CER  A 960 ( 4.2A)
CER  A 960 ( 4.2A)
CER  A 960 ( 3.8A)
CER  A 960 ( 4.2A)
 0.87A 4ls7A-2qo3A:
40.1
4ls7B-2qo3A:
39.9		 4ls7A-2qo3A:
18.74
4ls7B-2qo3A:
18.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4M93_B_ACTB303_0
(S25-26 FAB (IGG1K)
HEAVY CHAIN
S25-26 FAB (IGG1K)
LIGHT CHAIN)		 2qo3 ERYAII ERYTHROMYCIN
POLYKETIDE SYNTHASE
MODULES 3 AND 4
(Saccharopolyspor
a
erythraea) 		4 / 5 GLY A 821
SER A 820
ALA A 818
GLU A 819
 None
 1.02A 4m93B-2qo3A:
undetectable
4m93C-2qo3A:
undetectable		 4m93B-2qo3A:
12.21
4m93C-2qo3A:
11.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MMA_A_CXXA603_1
(TRANSPORTER)		 2qo3 ERYAII ERYTHROMYCIN
POLYKETIDE SYNTHASE
MODULES 3 AND 4
(Saccharopolyspor
a
erythraea) 		5 / 11 VAL A 207
ALA A 208
SER A 197
GLY A 152
THR A 447
 None
 1.17A 4mmaA-2qo3A:
undetectable		 4mmaA-2qo3A:
20.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4O2B_D_LOCD503_2
(TUBULIN BETA-2B
CHAIN)		 2qo3 ERYAII ERYTHROMYCIN
POLYKETIDE SYNTHASE
MODULES 3 AND 4
(Saccharopolyspor
a
erythraea) 		5 / 12 ALA A 208
LEU A 151
THR A 127
ALA A 224
ILE A 185
 None
 0.78A 4o2bD-2qo3A:
undetectable		 4o2bD-2qo3A:
18.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QRC_A_0LIA802_2
(FIBROBLAST GROWTH
FACTOR RECEPTOR 4)		 2qo3 ERYAII ERYTHROMYCIN
POLYKETIDE SYNTHASE
MODULES 3 AND 4
(Saccharopolyspor
a
erythraea) 		4 / 8 LEU A 509
VAL A 505
ALA A 488
LEU A 534
 None
 0.86A 4qrcA-2qo3A:
undetectable		 4qrcA-2qo3A:
17.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4X20_B_LOCB502_1
(TUBULIN BETA CHAIN)		 2qo3 ERYAII ERYTHROMYCIN
POLYKETIDE SYNTHASE
MODULES 3 AND 4
(Saccharopolyspor
a
erythraea) 		5 / 12 ALA A 208
LEU A 151
THR A 127
ALA A 224
ILE A 185
 None
 0.90A 4x20B-2qo3A:
undetectable		 4x20B-2qo3A:
18.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5A06_D_SORD1341_0
(ALDOSE-ALDOSE
OXIDOREDUCTASE)		 2qo3 ERYAII ERYTHROMYCIN
POLYKETIDE SYNTHASE
MODULES 3 AND 4
(Saccharopolyspor
a
erythraea) 		4 / 6 CYH A  40
GLY A  44
GLY A  45
ASP A  97
 None
 0.77A 5a06D-2qo3A:
undetectable		 5a06D-2qo3A:
16.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5AYF_A_SAMA401_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
SETD7)		 2qo3 ERYAII ERYTHROMYCIN
POLYKETIDE SYNTHASE
MODULES 3 AND 4
(Saccharopolyspor
a
erythraea) 		5 / 11 GLY A  60
GLU A  58
GLY A 424
ASN A 425
ASN A 374
 None
 1.07A 5ayfA-2qo3A:
undetectable		 5ayfA-2qo3A:
13.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ESL_A_1YNA701_2
(LANOSTEROL 14-ALPHA
DEMETHYLASE)		 2qo3 ERYAII ERYTHROMYCIN
POLYKETIDE SYNTHASE
MODULES 3 AND 4
(Saccharopolyspor
a
erythraea) 		4 / 5 ALA A 752
TYR A 751
GLY A 855
LEU A 626
 None
ACT  A 950 ( 4.5A)
None
None
 0.98A 5eslA-2qo3A:
0.7		 5eslA-2qo3A:
20.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EYP_B_LOCB502_2
(TUBULIN BETA CHAIN)		 2qo3 ERYAII ERYTHROMYCIN
POLYKETIDE SYNTHASE
MODULES 3 AND 4
(Saccharopolyspor
a
erythraea) 		5 / 12 ALA A 208
LEU A 151
THR A 127
ALA A 224
ILE A 185
 None
 0.79A 5eypB-2qo3A:
undetectable		 5eypB-2qo3A:
18.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5I71_A_68PA701_1
(SODIUM-DEPENDENT
SEROTONIN
TRANSPORTER)		 2qo3 ERYAII ERYTHROMYCIN
POLYKETIDE SYNTHASE
MODULES 3 AND 4
(Saccharopolyspor
a
erythraea) 		5 / 12 ILE A 747
ALA A 690
GLY A 688
LEU A 730
GLY A 567
 None
 1.16A 5i71A-2qo3A:
undetectable		 5i71A-2qo3A:
20.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5I75_A_68PA701_1
(SODIUM-DEPENDENT
SEROTONIN
TRANSPORTER)		 2qo3 ERYAII ERYTHROMYCIN
POLYKETIDE SYNTHASE
MODULES 3 AND 4
(Saccharopolyspor
a
erythraea) 		5 / 12 ILE A 747
ALA A 690
GLY A 688
LEU A 730
GLY A 567
 None
 1.19A 5i75A-2qo3A:
undetectable		 5i75A-2qo3A:
20.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5J2T_C_VLBC503_2
(TUBULIN ALPHA-1B
CHAIN)		 2qo3 ERYAII ERYTHROMYCIN
POLYKETIDE SYNTHASE
MODULES 3 AND 4
(Saccharopolyspor
a
erythraea) 		6 / 12 LEU A 887
PRO A 473
ILE A 491
ALA A 488
VAL A 505
GLY A 504
 None
 1.43A 5j2tC-2qo3A:
undetectable		 5j2tC-2qo3A:
19.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JW1_B_CELB602_2
(PROSTAGLANDIN G/H
SYNTHASE 2)		 2qo3 ERYAII ERYTHROMYCIN
POLYKETIDE SYNTHASE
MODULES 3 AND 4
(Saccharopolyspor
a
erythraea) 		4 / 6 VAL A 749
VAL A 722
SER A 724
PHE A 733
 None
 0.95A 5jw1B-2qo3A:
undetectable		 5jw1B-2qo3A:
19.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KGP_A_GCSA407_1
(PREDICTED
ACETYLTRANSFERASE)		 2qo3 ERYAII ERYTHROMYCIN
POLYKETIDE SYNTHASE
MODULES 3 AND 4
(Saccharopolyspor
a
erythraea) 		4 / 8 GLU A 267
PRO A  67
ASP A  69
TRP A 906
 None
 1.01A 5kgpA-2qo3A:
undetectable		 5kgpA-2qo3A:
15.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KGP_B_GCSB405_1
(PREDICTED
ACETYLTRANSFERASE)		 2qo3 ERYAII ERYTHROMYCIN
POLYKETIDE SYNTHASE
MODULES 3 AND 4
(Saccharopolyspor
a
erythraea) 		4 / 8 GLU A 267
PRO A  67
ASP A  69
TRP A 906
 None
 0.99A 5kgpB-2qo3A:
undetectable		 5kgpB-2qo3A:
15.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5M5C_B_TA1B502_1
(TUBULIN BETA-2B
CHAIN)		 2qo3 ERYAII ERYTHROMYCIN
POLYKETIDE SYNTHASE
MODULES 3 AND 4
(Saccharopolyspor
a
erythraea) 		5 / 12 LEU A 273
ALA A 224
THR A 127
GLY A 152
LEU A 151
 None
 1.13A 5m5cB-2qo3A:
undetectable		 5m5cB-2qo3A:
17.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5M5C_E_TA1E502_1
(TUBULIN BETA-2B
CHAIN)		 2qo3 ERYAII ERYTHROMYCIN
POLYKETIDE SYNTHASE
MODULES 3 AND 4
(Saccharopolyspor
a
erythraea) 		5 / 10 LEU A 273
ALA A 224
THR A 127
GLY A 152
LEU A 151
 None
 1.12A 5m5cE-2qo3A:
undetectable		 5m5cE-2qo3A:
17.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5MSD_A_BEZA1202_0
(CARBOXYLIC ACID
REDUCTASE)		 2qo3 ERYAII ERYTHROMYCIN
POLYKETIDE SYNTHASE
MODULES 3 AND 4
(Saccharopolyspor
a
erythraea) 		4 / 5 HIS A 450
ILE A 317
PHE A 442
ALA A 351
 None
 0.81A 5msdA-2qo3A:
undetectable		 5msdA-2qo3A:
25.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5NM5_B_LOCB502_2
(TUBULIN BETA-2B
CHAIN)		 2qo3 ERYAII ERYTHROMYCIN
POLYKETIDE SYNTHASE
MODULES 3 AND 4
(Saccharopolyspor
a
erythraea) 		5 / 12 ALA A 208
LEU A 151
THR A 127
ALA A 224
ILE A 185
 None
 0.82A 5nm5B-2qo3A:
undetectable		 5nm5B-2qo3A:
18.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5V5Z_A_1YNA602_1
(LANOSTEROL 14-ALPHA
DEMETHYLASE)		 2qo3 ERYAII ERYTHROMYCIN
POLYKETIDE SYNTHASE
MODULES 3 AND 4
(Saccharopolyspor
a
erythraea) 		5 / 12 ILE A 375
PHE A 238
GLY A 268
PHE A  66
MET A 232
 None
 1.40A 5v5zA-2qo3A:
undetectable		 5v5zA-2qo3A:
19.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VC0_A_RITA602_1
(CYTOCHROME P450 3A4)		 2qo3 ERYAII ERYTHROMYCIN
POLYKETIDE SYNTHASE
MODULES 3 AND 4
(Saccharopolyspor
a
erythraea) 		5 / 12 PHE A 156
ASP A 118
LEU A 387
ALA A 449
ALA A 201
 None
 1.19A 5vc0A-2qo3A:
undetectable		 5vc0A-2qo3A:
18.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5X1F_J_CHDJ101_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 7A1,
MITOCHONDRIAL)		 2qo3 ERYAII ERYTHROMYCIN
POLYKETIDE SYNTHASE
MODULES 3 AND 4
(Saccharopolyspor
a
erythraea) 		4 / 6 LEU A 131
ARG A 184
MET A 189
LEU A 191
 None
 1.10A 5x1fA-2qo3A:
undetectable
5x1fJ-2qo3A:
undetectable		 5x1fA-2qo3A:
20.35
5x1fJ-2qo3A:
4.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5XIW_B_LOCB504_2
(TUBULIN BETA CHAIN)		 2qo3 ERYAII ERYTHROMYCIN
POLYKETIDE SYNTHASE
MODULES 3 AND 4
(Saccharopolyspor
a
erythraea) 		5 / 12 ALA A 208
LEU A 151
THR A 127
ALA A 224
ILE A 185
 None
 0.86A 5xiwB-2qo3A:
undetectable		 5xiwB-2qo3A:
6.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5YCN_A_8LXA501_1
(PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR GAMMA)		 2qo3 ERYAII ERYTHROMYCIN
POLYKETIDE SYNTHASE
MODULES 3 AND 4
(Saccharopolyspor
a
erythraea) 		4 / 6 PHE A 627
CYH A 591
SER A 594
HIS A 659
 None
 1.32A 5ycnA-2qo3A:
0.0		 5ycnA-2qo3A:
14.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ZCP_W_CHDW101_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 7A1,
MITOCHONDRIAL)		 2qo3 ERYAII ERYTHROMYCIN
POLYKETIDE SYNTHASE
MODULES 3 AND 4
(Saccharopolyspor
a
erythraea) 		4 / 8 LEU A 131
ARG A 184
MET A 189
LEU A 191
 None
 0.91A 5zcpN-2qo3A:
undetectable
5zcpW-2qo3A:
undetectable		 5zcpN-2qo3A:
20.35
5zcpW-2qo3A:
4.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6BKL_C_EU7C101_0
(MATRIX PROTEIN 2)		 2qo3 ERYAII ERYTHROMYCIN
POLYKETIDE SYNTHASE
MODULES 3 AND 4
(Saccharopolyspor
a
erythraea) 		5 / 9 ALA A 813
VAL A 838
ALA A 841
VAL A 834
GLY A 717
 None
 1.12A 6bklA-2qo3A:
undetectable
6bklB-2qo3A:
undetectable
6bklC-2qo3A:
undetectable
6bklD-2qo3A:
undetectable		 6bklA-2qo3A:
3.82
6bklB-2qo3A:
3.82
6bklC-2qo3A:
3.82
6bklD-2qo3A:
3.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6FBV_D_FI8D1904_1
(DNA-DIRECTED RNA
POLYMERASE SUBUNIT
BETA')		 2qo3 ERYAII ERYTHROMYCIN
POLYKETIDE SYNTHASE
MODULES 3 AND 4
(Saccharopolyspor
a
erythraea) 		4 / 8 ASP A 736
ARG A 709
VAL A 721
ARG A 805
 None
 1.24A 6fbvD-2qo3A:
undetectable		 6fbvD-2qo3A:
24.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6N91_A_DCFA401_0
(ADENOSINE DEAMINASE)		 2qo3 ERYAII ERYTHROMYCIN
POLYKETIDE SYNTHASE
MODULES 3 AND 4
(Saccharopolyspor
a
erythraea) 		5 / 12 LEU A 352
LEU A 366
ILE A 452
ALA A 438
HIS A 450
 None
 1.22A 6n91A-2qo3A:
undetectable		 6n91A-2qo3A:
7.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6N91_B_DCFB401_0
(ADENOSINE DEAMINASE)		 2qo3 ERYAII ERYTHROMYCIN
POLYKETIDE SYNTHASE
MODULES 3 AND 4
(Saccharopolyspor
a
erythraea) 		5 / 12 LEU A 352
LEU A 366
ILE A 452
ALA A 438
HIS A 450
 None
 1.30A 6n91B-2qo3A:
undetectable		 6n91B-2qo3A:
7.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
7DFR_A_FOLA161_1
(DIHYDROFOLATE
REDUCTASE)		 2qo3 ERYAII ERYTHROMYCIN
POLYKETIDE SYNTHASE
MODULES 3 AND 4
(Saccharopolyspor
a
erythraea) 		3 / 3 ASP A  73
LEU A  77
ARG A 243
 None
 0.75A 7dfrA-2qo3A:
undetectable		 7dfrA-2qo3A:
9.66