SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2qob'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1EE2_B_CHDB1250_0
(ALCOHOL
DEHYDROGENASE)		 2qob EPHRIN RECEPTOR
(Homo
sapiens) 		3 / 3 MET A 734
LEU A 737
SER A 738
 None
 0.52A 1ee2A-2qobA:
undetectable		 1ee2A-2qobA:
21.83
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1IEP_B_STIB202_1
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE ABL)		 2qob EPHRIN RECEPTOR
(Homo
sapiens) 		6 / 12 VAL A 635
ALA A 651
GLU A 670
MET A 674
THR A 699
ASP A 764
 BME  A   1 (-4.9A)
PTR  A 701 ( 4.7A)
None
None
None
None
 1.08A 1iepB-2qobA:
26.3		 1iepB-2qobA:
34.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RXC_K_URFK2061_1
(URIDINE
PHOSPHORYLASE)		 2qob EPHRIN RECEPTOR
(Homo
sapiens) 		4 / 8 THR A 699
GLY A 687
ILE A 697
VAL A 688
 None
 0.97A 1rxcK-2qobA:
undetectable		 1rxcK-2qobA:
20.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UWH_A_BAXA1723_2
(B-RAF PROTO-ONCOGENE
SERINE/THREONINE-PRO
TEIN KINASE)		 2qob EPHRIN RECEPTOR
(Homo
sapiens) 		4 / 6 VAL A 813
ILE A 874
ILE A 730
ASP A 806
 None
 0.77A 1uwhA-2qobA:
28.7		 1uwhA-2qobA:
28.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UWH_B_BAXB1723_2
(B-RAF PROTO-ONCOGENE
SERINE/THREONINE-PRO
TEIN KINASE)		 2qob EPHRIN RECEPTOR
(Homo
sapiens) 		4 / 6 VAL A 813
ILE A 874
ILE A 730
ASP A 806
 None
 0.78A 1uwhB-2qobA:
28.4		 1uwhB-2qobA:
28.21
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2GQG_A_1N1A501_1
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE ABL1)		 2qob EPHRIN RECEPTOR
(Homo
sapiens) 		7 / 12 ALA A 651
GLU A 670
MET A 674
ILE A 697
THR A 699
GLY A 705
LEU A 753
 PTR  A 701 ( 4.7A)
None
None
None
None
None
None
 0.72A 2gqgA-2qobA:
27.4		 2gqgA-2qobA:
34.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2HDN_J_TACJ5888_1
(ELONGATION FACTOR
EF-TU)		 2qob EPHRIN RECEPTOR
(Homo
sapiens) 		4 / 6 SER A 738
ASP A 739
SER A 803
VAL A 807
 None
 1.25A 2hdnI-2qobA:
undetectable
2hdnJ-2qobA:
undetectable
2hdnL-2qobA:
undetectable		 2hdnI-2qobA:
8.56
2hdnJ-2qobA:
22.25
2hdnL-2qobA:
22.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2HDN_L_TACL6888_1
(ELONGATION FACTOR
EF-TU)		 2qob EPHRIN RECEPTOR
(Homo
sapiens) 		4 / 6 SER A 803
VAL A 807
SER A 738
ASP A 739
 None
 1.25A 2hdnJ-2qobA:
undetectable
2hdnK-2qobA:
undetectable
2hdnL-2qobA:
undetectable		 2hdnJ-2qobA:
22.25
2hdnK-2qobA:
8.56
2hdnL-2qobA:
22.25
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2HYY_D_STID600_1
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE ABL1)		 2qob EPHRIN RECEPTOR
(Homo
sapiens) 		7 / 12 VAL A 635
ALA A 651
GLU A 670
MET A 674
ILE A 697
THR A 699
ASP A 764
 BME  A   1 (-4.9A)
PTR  A 701 ( 4.7A)
None
None
None
None
None
 1.03A 2hyyD-2qobA:
26.4		 2hyyD-2qobA:
33.91
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2HYY_D_STID600_1
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE ABL1)		 2qob EPHRIN RECEPTOR
(Homo
sapiens) 		6 / 12 VAL A 635
ALA A 651
ILE A 673
ILE A 697
THR A 699
LEU A 753
 BME  A   1 (-4.9A)
PTR  A 701 ( 4.7A)
None
None
None
None
 0.95A 2hyyD-2qobA:
26.4		 2hyyD-2qobA:
33.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2IVU_A_ZD6A3015_1
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE RECEPTOR RET
PRECURSOR)		 2qob EPHRIN RECEPTOR
(Homo
sapiens) 		3 / 3 ALA A 651
GLY A 705
SER A 763
 PTR  A 701 ( 4.7A)
None
None
 0.28A 2ivuA-2qobA:
33.4		 2ivuA-2qobA:
29.02
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2PL0_A_STIA200_1
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE LCK)		 2qob EPHRIN RECEPTOR
(Homo
sapiens) 		7 / 12 VAL A 635
ALA A 651
GLU A 670
MET A 674
ILE A 697
THR A 699
ASP A 764
 BME  A   1 (-4.9A)
PTR  A 701 ( 4.7A)
None
None
None
None
None
 0.94A 2pl0A-2qobA:
18.3		 2pl0A-2qobA:
38.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QD2_A_CHDA426_0
(FERROCHELATASE)		 2qob EPHRIN RECEPTOR
(Homo
sapiens) 		4 / 4 LEU A 901
PRO A 844
LEU A 843
ARG A 789
 None
 1.32A 2qd2A-2qobA:
undetectable		 2qd2A-2qobA:
22.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2V0M_A_KLNA1500_1
(CYTOCHROME P450 3A4)		 2qob EPHRIN RECEPTOR
(Homo
sapiens) 		5 / 11 LEU A 814
ILE A 874
ALA A 731
ARG A 745
LEU A 747
 None
 1.38A 2v0mA-2qobA:
undetectable		 2v0mA-2qobA:
22.24
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2XP2_A_VGHA9000_1
(TYROSINE-PROTEIN
KINASE RECEPTOR)		 2qob EPHRIN RECEPTOR
(Homo
sapiens) 		6 / 9 VAL A 635
ALA A 651
MET A 702
GLY A 705
LEU A 753
ASP A 764
 BME  A   1 (-4.9A)
PTR  A 701 ( 4.7A)
PTR  A 701 ( 3.5A)
None
None
None
 0.47A 2xp2A-2qobA:
34.3		 2xp2A-2qobA:
33.60
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2Y6O_A_1N1A1892_1
(EPHRIN TYPE-A
RECEPTOR 4)		 2qob EPHRIN RECEPTOR
(Homo
sapiens) 		9 / 12 LYS A 625
ALA A 651
GLU A 670
MET A 674
ILE A 697
THR A 699
GLY A 705
LEU A 753
SER A 763
 None
PTR  A 701 ( 4.7A)
None
None
None
None
None
None
None
 1.02A 2y6oA-2qobA:
31.8		 2y6oA-2qobA:
73.81
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2Y6O_A_1N1A1892_1
(EPHRIN TYPE-A
RECEPTOR 4)		 2qob EPHRIN RECEPTOR
(Homo
sapiens) 		9 / 12 LYS A 625
ALA A 651
LYS A 653
GLU A 670
MET A 674
ILE A 697
GLY A 705
LEU A 753
SER A 763
 None
PTR  A 701 ( 4.7A)
None
None
None
None
None
None
None
 1.08A 2y6oA-2qobA:
31.8		 2y6oA-2qobA:
73.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Y7J_A_B49A1294_1
(PHOSPHORYLASE B
KINASE GAMMA
CATALYTIC CHAIN,
TESTIS/LIVER ISOFORM)		 2qob EPHRIN RECEPTOR
(Homo
sapiens) 		6 / 12 VAL A 635
ALA A 651
ILE A 683
MET A 702
GLY A 705
LEU A 753
 BME  A   1 (-4.9A)
PTR  A 701 ( 4.7A)
None
PTR  A 701 ( 3.5A)
None
None
 0.66A 2y7jA-2qobA:
25.5		 2y7jA-2qobA:
20.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Y7J_B_B49B1294_1
(PHOSPHORYLASE B
KINASE GAMMA
CATALYTIC CHAIN,
TESTIS/LIVER ISOFORM)		 2qob EPHRIN RECEPTOR
(Homo
sapiens) 		6 / 10 VAL A 635
ALA A 651
ILE A 683
MET A 702
GLY A 705
LEU A 753
 BME  A   1 (-4.9A)
PTR  A 701 ( 4.7A)
None
PTR  A 701 ( 3.5A)
None
None
 0.59A 2y7jB-2qobA:
20.0		 2y7jB-2qobA:
20.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Y7J_C_B49C1294_1
(PHOSPHORYLASE B
KINASE GAMMA
CATALYTIC CHAIN,
TESTIS/LIVER ISOFORM)		 2qob EPHRIN RECEPTOR
(Homo
sapiens) 		6 / 10 VAL A 635
ALA A 651
ILE A 683
MET A 702
GLY A 705
LEU A 753
 BME  A   1 (-4.9A)
PTR  A 701 ( 4.7A)
None
PTR  A 701 ( 3.5A)
None
None
 0.64A 2y7jC-2qobA:
25.5		 2y7jC-2qobA:
20.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Y7J_D_B49D1294_1
(PHOSPHORYLASE B
KINASE GAMMA
CATALYTIC CHAIN,
TESTIS/LIVER ISOFORM)		 2qob EPHRIN RECEPTOR
(Homo
sapiens) 		6 / 10 VAL A 635
ALA A 651
ILE A 683
MET A 702
GLY A 705
LEU A 753
 BME  A   1 (-4.9A)
PTR  A 701 ( 4.7A)
None
PTR  A 701 ( 3.5A)
None
None
 0.57A 2y7jD-2qobA:
25.9		 2y7jD-2qobA:
20.05
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2YFX_A_VGHA9000_1
(TYROSINE-PROTEIN
KINASE RECEPTOR)		 2qob EPHRIN RECEPTOR
(Homo
sapiens) 		5 / 8 ALA A 651
MET A 702
GLY A 705
LEU A 753
ASP A 764
 PTR  A 701 ( 4.7A)
PTR  A 701 ( 3.5A)
None
None
None
 0.38A 2yfxA-2qobA:
33.8		 2yfxA-2qobA:
33.60
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2ZVA_A_1N1A513_1
(TYROSINE-PROTEIN
KINASE LYN)		 2qob EPHRIN RECEPTOR
(Homo
sapiens) 		9 / 12 ALA A 651
LYS A 653
GLU A 670
MET A 674
ILE A 697
THR A 699
MET A 702
GLY A 705
LEU A 753
 PTR  A 701 ( 4.7A)
None
None
None
None
None
PTR  A 701 ( 3.5A)
None
None
 0.75A 2zvaA-2qobA:
34.4		 2zvaA-2qobA:
37.83
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3BBT_B_FMMB91_1
(RECEPTOR
TYROSINE-PROTEIN
KINASE ERBB-4)		 2qob EPHRIN RECEPTOR
(Homo
sapiens) 		6 / 12 VAL A 635
ALA A 651
LEU A 685
THR A 699
GLY A 705
LEU A 753
 BME  A   1 (-4.9A)
PTR  A 701 ( 4.7A)
None
None
None
None
 0.69A 3bbtB-2qobA:
25.1		 3bbtB-2qobA:
35.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3GCS_A_BAXA401_1
(MITOGEN-ACTIVATED
PROTEIN KINASE 14)		 2qob EPHRIN RECEPTOR
(Homo
sapiens) 		5 / 12 VAL A 635
ALA A 651
GLU A 670
ILE A 683
THR A 699
 BME  A   1 (-4.9A)
PTR  A 701 ( 4.7A)
None
None
None
 0.89A 3gcsA-2qobA:
20.7		 3gcsA-2qobA:
25.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3GCS_A_BAXA401_1
(MITOGEN-ACTIVATED
PROTEIN KINASE 14)		 2qob EPHRIN RECEPTOR
(Homo
sapiens) 		5 / 12 VAL A 635
ALA A 651
ILE A 683
THR A 699
HIS A 744
 BME  A   1 (-4.9A)
PTR  A 701 ( 4.7A)
None
None
None
 0.99A 3gcsA-2qobA:
20.7		 3gcsA-2qobA:
25.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3GP0_A_NILA1_1
(MITOGEN-ACTIVATED
PROTEIN KINASE 11)		 2qob EPHRIN RECEPTOR
(Homo
sapiens) 		6 / 12 ALA A 651
GLU A 670
ILE A 683
THR A 699
HIS A 744
ASP A 764
 PTR  A 701 ( 4.7A)
None
None
None
None
None
 1.26A 3gp0A-2qobA:
21.9		 3gp0A-2qobA:
26.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3GP0_A_NILA1_1
(MITOGEN-ACTIVATED
PROTEIN KINASE 11)		 2qob EPHRIN RECEPTOR
(Homo
sapiens) 		6 / 12 VAL A 635
ALA A 651
GLU A 670
ILE A 683
THR A 699
ASP A 764
 BME  A   1 (-4.9A)
PTR  A 701 ( 4.7A)
None
None
None
None
 1.01A 3gp0A-2qobA:
21.9		 3gp0A-2qobA:
26.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3HCO_A_CHDA3_0
(FERROCHELATASE,
MITOCHONDRIAL)		 2qob EPHRIN RECEPTOR
(Homo
sapiens) 		4 / 4 LEU A 901
PRO A 844
LEU A 843
ARG A 789
 None
 1.40A 3hcoA-2qobA:
undetectable		 3hcoA-2qobA:
22.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3HEC_A_STIA1_1
(MITOGEN-ACTIVATED
PROTEIN KINASE 14)		 2qob EPHRIN RECEPTOR
(Homo
sapiens) 		5 / 12 VAL A 627
ALA A 651
ILE A 683
THR A 699
ASP A 764
 None
PTR  A 701 ( 4.7A)
None
None
None
 0.76A 3hecA-2qobA:
21.1		 3hecA-2qobA:
24.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3HEC_A_STIA1_1
(MITOGEN-ACTIVATED
PROTEIN KINASE 14)		 2qob EPHRIN RECEPTOR
(Homo
sapiens) 		5 / 12 VAL A 627
ALA A 651
LYS A 653
GLU A 670
ILE A 683
 None
PTR  A 701 ( 4.7A)
None
None
None
 0.87A 3hecA-2qobA:
21.1		 3hecA-2qobA:
24.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3HEC_A_STIA1_1
(MITOGEN-ACTIVATED
PROTEIN KINASE 14)		 2qob EPHRIN RECEPTOR
(Homo
sapiens) 		5 / 12 VAL A 627
ALA A 651
LYS A 653
ILE A 683
ASP A 764
 None
PTR  A 701 ( 4.7A)
None
None
None
 0.78A 3hecA-2qobA:
21.1		 3hecA-2qobA:
24.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3HEG_A_BAXA1_1
(MITOGEN-ACTIVATED
PROTEIN KINASE 14)		 2qob EPHRIN RECEPTOR
(Homo
sapiens) 		7 / 12 VAL A 627
VAL A 635
ALA A 651
LYS A 653
GLU A 670
ILE A 683
THR A 699
 None
BME  A   1 (-4.9A)
PTR  A 701 ( 4.7A)
None
None
None
None
 0.84A 3hegA-2qobA:
17.7		 3hegA-2qobA:
24.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3HKU_A_TORA300_2
(CARBONIC ANHYDRASE 2)		 2qob EPHRIN RECEPTOR
(Homo
sapiens) 		3 / 3 GLU A 615
HIS A 610
THR A 690
 None
 0.81A 3hkuA-2qobA:
undetectable		 3hkuA-2qobA:
20.23
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3K54_A_1N1A1_1
(TYROSINE-PROTEIN
KINASE BTK)		 2qob EPHRIN RECEPTOR
(Homo
sapiens) 		8 / 12 ALA A 651
LYS A 653
GLU A 670
MET A 674
ILE A 697
THR A 699
GLY A 705
LEU A 753
 PTR  A 701 ( 4.7A)
None
None
None
None
None
None
None
 0.86A 3k54A-2qobA:
27.6		 3k54A-2qobA:
32.10
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3K54_A_1N1A1_1
(TYROSINE-PROTEIN
KINASE BTK)		 2qob EPHRIN RECEPTOR
(Homo
sapiens) 		8 / 12 ALA A 651
LYS A 653
MET A 674
ILE A 697
THR A 699
GLY A 705
LEU A 753
SER A 763
 PTR  A 701 ( 4.7A)
None
None
None
None
None
None
None
 0.77A 3k54A-2qobA:
27.6		 3k54A-2qobA:
32.10
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3MIY_A_B49A1_1
(TYROSINE-PROTEIN
KINASE ITK/TSK)		 2qob EPHRIN RECEPTOR
(Homo
sapiens) 		6 / 11 ALA A 651
LYS A 653
MET A 702
GLY A 705
LEU A 753
SER A 763
 PTR  A 701 ( 4.7A)
None
PTR  A 701 ( 3.5A)
None
None
None
 0.52A 3miyA-2qobA:
27.5		 3miyA-2qobA:
38.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3MIY_B_B49B2_1
(TYROSINE-PROTEIN
KINASE ITK/TSK)		 2qob EPHRIN RECEPTOR
(Homo
sapiens) 		6 / 9 ALA A 651
LYS A 653
MET A 702
GLY A 705
LEU A 753
SER A 763
 PTR  A 701 ( 4.7A)
None
PTR  A 701 ( 3.5A)
None
None
None
 0.51A 3miyB-2qobA:
33.0		 3miyB-2qobA:
38.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3MS9_A_STIA1_1
(TYROSINE-PROTEIN
KINASE ABL1)		 2qob EPHRIN RECEPTOR
(Homo
sapiens) 		6 / 12 VAL A 635
ALA A 651
GLU A 670
MET A 674
THR A 699
ASP A 764
 BME  A   1 (-4.9A)
PTR  A 701 ( 4.7A)
None
None
None
None
 1.03A 3ms9A-2qobA:
26.4		 3ms9A-2qobA:
34.29
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3MSS_A_STIA1_1
(TYROSINE-PROTEIN
KINASE ABL1)		 2qob EPHRIN RECEPTOR
(Homo
sapiens) 		6 / 12 VAL A 635
ALA A 651
GLU A 670
MET A 674
THR A 699
ASP A 764
 BME  A   1 (-4.9A)
PTR  A 701 ( 4.7A)
None
None
None
None
 1.08A 3mssA-2qobA:
26.5		 3mssA-2qobA:
34.29
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3MSS_C_STIC1_1
(TYROSINE-PROTEIN
KINASE ABL1)		 2qob EPHRIN RECEPTOR
(Homo
sapiens) 		6 / 12 VAL A 635
ALA A 651
GLU A 670
MET A 674
THR A 699
ASP A 764
 BME  A   1 (-4.9A)
PTR  A 701 ( 4.7A)
None
None
None
None
 1.08A 3mssC-2qobA:
26.5		 3mssC-2qobA:
34.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3N8Y_B_SALB900_1
(PROSTAGLANDIN G/H
SYNTHASE 1)		 2qob EPHRIN RECEPTOR
(Homo
sapiens) 		4 / 5 VAL A 813
LEU A 814
ILE A 874
ALA A 731
 None
 1.00A 3n8yB-2qobA:
undetectable		 3n8yB-2qobA:
21.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OHT_A_1N1A1000_1
(P38A)		 2qob EPHRIN RECEPTOR
(Homo
sapiens) 		7 / 12 VAL A 627
GLY A 628
VAL A 635
ALA A 651
ILE A 683
THR A 699
LEU A 753
 None
None
BME  A   1 (-4.9A)
PTR  A 701 ( 4.7A)
None
None
None
 1.07A 3ohtA-2qobA:
5.7		 3ohtA-2qobA:
24.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OHT_A_1N1A1000_1
(P38A)		 2qob EPHRIN RECEPTOR
(Homo
sapiens) 		7 / 12 VAL A 627
GLY A 628
VAL A 635
ALA A 651
LYS A 653
ILE A 683
LEU A 753
 None
None
BME  A   1 (-4.9A)
PTR  A 701 ( 4.7A)
None
None
None
 1.17A 3ohtA-2qobA:
5.7		 3ohtA-2qobA:
24.46
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3PYY_A_STIA3_1
(V-ABL ABELSON MURINE
LEUKEMIA VIRAL
ONCOGENE HOMOLOG 1
ISOFORM B VARIANT)		 2qob EPHRIN RECEPTOR
(Homo
sapiens) 		6 / 12 VAL A 635
ALA A 651
GLU A 670
MET A 674
THR A 699
ASP A 764
 BME  A   1 (-4.9A)
PTR  A 701 ( 4.7A)
None
None
None
None
 1.08A 3pyyA-2qobA:
26.7		 3pyyA-2qobA:
34.08
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3SXR_A_1N1A1_1
(CYTOPLASMIC
TYROSINE-PROTEIN
KINASE BMX)		 2qob EPHRIN RECEPTOR
(Homo
sapiens) 		7 / 12 VAL A 635
ALA A 651
MET A 674
ILE A 697
THR A 699
GLY A 705
LEU A 753
 BME  A   1 (-4.9A)
PTR  A 701 ( 4.7A)
None
None
None
None
None
 0.66A 3sxrA-2qobA:
32.1		 3sxrA-2qobA:
32.36
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3UE4_A_DB8A601_1
(TYROSINE-PROTEIN
KINASE ABL1)		 2qob EPHRIN RECEPTOR
(Homo
sapiens) 		6 / 12 ALA A 651
ILE A 697
THR A 699
MET A 702
GLY A 705
LEU A 753
 PTR  A 701 ( 4.7A)
None
None
PTR  A 701 ( 3.5A)
None
None
 0.26A 3ue4A-2qobA:
26.7		 3ue4A-2qobA:
34.20
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3UE4_B_DB8B601_1
(TYROSINE-PROTEIN
KINASE ABL1)		 2qob EPHRIN RECEPTOR
(Homo
sapiens) 		7 / 12 VAL A 635
ALA A 651
MET A 674
ILE A 697
THR A 699
GLY A 705
LEU A 753
 BME  A   1 (-4.9A)
PTR  A 701 ( 4.7A)
None
None
None
None
None
 0.84A 3ue4B-2qobA:
27.4		 3ue4B-2qobA:
34.20
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3ZBF_A_VGHA3000_1
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE ROS)		 2qob EPHRIN RECEPTOR
(Homo
sapiens) 		5 / 12 ALA A 651
MET A 702
GLY A 705
LEU A 753
ASP A 764
 PTR  A 701 ( 4.7A)
PTR  A 701 ( 3.5A)
None
None
None
 0.42A 3zbfA-2qobA:
34.7		 3zbfA-2qobA:
34.14
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3ZOS_A_0LIA1000_2
(EPITHELIAL DISCOIDIN
DOMAIN-CONTAINING
RECEPTOR 1)		 2qob EPHRIN RECEPTOR
(Homo
sapiens) 		5 / 9 ILE A 673
MET A 674
ILE A 682
ILE A 683
MET A 702
 None
None
None
None
PTR  A 701 ( 3.5A)
 0.77A 3zosA-2qobA:
24.3		 3zosA-2qobA:
34.36
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4ANQ_A_VGHA9000_1
(ALK TYROSINE KINASE
RECEPTOR)		 2qob EPHRIN RECEPTOR
(Homo
sapiens) 		6 / 9 VAL A 635
ALA A 651
MET A 702
GLY A 705
LEU A 753
ASP A 764
 BME  A   1 (-4.9A)
PTR  A 701 ( 4.7A)
PTR  A 701 ( 3.5A)
None
None
None
 0.43A 4anqA-2qobA:
34.1		 4anqA-2qobA:
32.56
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4ANS_A_VGHA9000_1
(ALK TYROSINE KINASE
RECEPTOR)		 2qob EPHRIN RECEPTOR
(Homo
sapiens) 		6 / 9 VAL A 635
ALA A 651
MET A 702
GLY A 705
LEU A 753
ASP A 764
 BME  A   1 (-4.9A)
PTR  A 701 ( 4.7A)
PTR  A 701 ( 3.5A)
None
None
None
 0.41A 4ansA-2qobA:
34.0		 4ansA-2qobA:
32.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4AQ7_A_LEUA902_0
(LEUCINE--TRNA LIGASE)		 2qob EPHRIN RECEPTOR
(Homo
sapiens) 		4 / 7 LEU A 685
SER A 672
GLU A 615
HIS A 610
 None
 1.28A 4aq7A-2qobA:
undetectable		 4aq7A-2qobA:
17.94
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4BKJ_A_STIA1000_1
(EPITHELIAL DISCOIDIN
DOMAIN-CONTAINING
RECEPTOR 1)		 2qob EPHRIN RECEPTOR
(Homo
sapiens) 		6 / 12 VAL A 635
ALA A 651
ILE A 673
ILE A 683
THR A 699
ASP A 764
 BME  A   1 (-4.9A)
PTR  A 701 ( 4.7A)
None
None
None
None
 0.77A 4bkjA-2qobA:
24.6		 4bkjA-2qobA:
34.36
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4BKJ_B_STIB1000_1
(EPITHELIAL DISCOIDIN
DOMAIN-CONTAINING
RECEPTOR 1)		 2qob EPHRIN RECEPTOR
(Homo
sapiens) 		8 / 12 VAL A 635
ALA A 651
GLU A 670
ILE A 673
MET A 674
ILE A 683
THR A 699
ASP A 764
 BME  A   1 (-4.9A)
PTR  A 701 ( 4.7A)
None
None
None
None
None
None
 1.06A 4bkjB-2qobA:
24.7		 4bkjB-2qobA:
34.36
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4BKJ_B_STIB1000_1
(EPITHELIAL DISCOIDIN
DOMAIN-CONTAINING
RECEPTOR 1)		 2qob EPHRIN RECEPTOR
(Homo
sapiens) 		7 / 12 VAL A 635
ALA A 651
ILE A 673
MET A 674
ILE A 683
THR A 699
LEU A 753
 BME  A   1 (-4.9A)
PTR  A 701 ( 4.7A)
None
None
None
None
None
 1.16A 4bkjB-2qobA:
24.7		 4bkjB-2qobA:
34.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4C8B_A_0LIA1000_1
(RECEPTOR-INTERACTING
SERINE/THREONINE-PRO
TEIN KINASE 2)		 2qob EPHRIN RECEPTOR
(Homo
sapiens) 		7 / 12 ALA A 651
LYS A 653
GLU A 670
ILE A 697
THR A 699
HIS A 744
ASP A 764
 PTR  A 701 ( 4.7A)
None
None
None
None
None
None
 1.18A 4c8bA-2qobA:
27.4		 4c8bA-2qobA:
26.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4C8B_A_0LIA1000_1
(RECEPTOR-INTERACTING
SERINE/THREONINE-PRO
TEIN KINASE 2)		 2qob EPHRIN RECEPTOR
(Homo
sapiens) 		7 / 12 ALA A 651
LYS A 653
ILE A 697
THR A 699
HIS A 744
LEU A 753
ASP A 764
 PTR  A 701 ( 4.7A)
None
None
None
None
None
None
 0.92A 4c8bA-2qobA:
27.4		 4c8bA-2qobA:
26.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4CKI_A_ADNA2022_1
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE RECEPTOR RET)		 2qob EPHRIN RECEPTOR
(Homo
sapiens) 		6 / 11 GLY A 628
GLY A 630
VAL A 635
ALA A 651
GLY A 705
LEU A 753
 None
None
BME  A   1 (-4.9A)
PTR  A 701 ( 4.7A)
None
None
 0.92A 4ckiA-2qobA:
33.6		 4ckiA-2qobA:
29.29
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4CSV_A_STIA1265_1
(SRC-ABL TYROSINE
KINASE ANCESTOR)		 2qob EPHRIN RECEPTOR
(Homo
sapiens) 		7 / 12 VAL A 635
ALA A 651
GLU A 670
ILE A 673
MET A 674
THR A 699
ASP A 764
 BME  A   1 (-4.9A)
PTR  A 701 ( 4.7A)
None
None
None
None
None
 0.94A 4csvA-2qobA:
27.5		 4csvA-2qobA:
39.70
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4HJO_A_AQ4A1001_1
(EPIDERMAL GROWTH
FACTOR RECEPTOR)		 2qob EPHRIN RECEPTOR
(Homo
sapiens) 		6 / 12 VAL A 635
ALA A 651
THR A 699
MET A 702
GLY A 705
LEU A 753
 BME  A   1 (-4.9A)
PTR  A 701 ( 4.7A)
None
PTR  A 701 ( 3.5A)
None
None
 0.44A 4hjoA-2qobA:
30.1		 4hjoA-2qobA:
33.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4J7X_A_SASA806_1
(SEPIAPTERIN
REDUCTASE)		 2qob EPHRIN RECEPTOR
(Homo
sapiens) 		5 / 12 SER A 809
LEU A 747
PHE A 871
ASP A 739
GLY A 741
 None
 1.44A 4j7xA-2qobA:
undetectable		 4j7xA-2qobA:
21.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4J7X_F_SASF805_1
(SEPIAPTERIN
REDUCTASE)		 2qob EPHRIN RECEPTOR
(Homo
sapiens) 		5 / 12 SER A 809
LEU A 747
PHE A 871
ASP A 739
GLY A 741
 None
 1.43A 4j7xF-2qobA:
undetectable		 4j7xF-2qobA:
21.94
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4MKC_A_4MKA1503_1
(ALK TYROSINE KINASE
RECEPTOR)		 2qob EPHRIN RECEPTOR
(Homo
sapiens) 		7 / 12 VAL A 635
ALA A 651
LYS A 653
GLY A 705
SER A 709
LEU A 753
ASP A 764
 BME  A   1 (-4.9A)
PTR  A 701 ( 4.7A)
None
None
None
None
None
 0.68A 4mkcA-2qobA:
34.2		 4mkcA-2qobA:
33.16
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4MXO_A_DB8A601_1
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE SRC)		 2qob EPHRIN RECEPTOR
(Homo
sapiens) 		7 / 12 VAL A 635
ALA A 651
GLU A 670
MET A 674
ILE A 697
THR A 699
GLY A 705
 BME  A   1 (-4.9A)
PTR  A 701 ( 4.7A)
None
None
None
None
None
 0.68A 4mxoA-2qobA:
28.1		 4mxoA-2qobA:
39.26
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4MXX_A_DB8A601_1
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE SRC)		 2qob EPHRIN RECEPTOR
(Homo
sapiens) 		7 / 12 ALA A 651
GLU A 670
MET A 674
ILE A 697
THR A 699
GLY A 705
LEU A 753
 PTR  A 701 ( 4.7A)
None
None
None
None
None
None
 0.71A 4mxxA-2qobA:
28.0		 4mxxA-2qobA:
39.26
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4MXX_B_DB8B601_1
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE SRC)		 2qob EPHRIN RECEPTOR
(Homo
sapiens) 		7 / 12 VAL A 635
ALA A 651
LYS A 653
THR A 699
MET A 702
GLY A 705
LEU A 753
 BME  A   1 (-4.9A)
PTR  A 701 ( 4.7A)
None
None
PTR  A 701 ( 3.5A)
None
None
 0.61A 4mxxB-2qobA:
26.3		 4mxxB-2qobA:
39.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QB9_D_PARD500_1
(ENHANCED
INTRACELLULAR
SURVIVAL PROTEIN)		 2qob EPHRIN RECEPTOR
(Homo
sapiens) 		4 / 8 PHE A 871
SER A 809
GLU A 670
ASP A 764
 None
 1.41A 4qb9D-2qobA:
undetectable		 4qb9D-2qobA:
21.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4R7I_A_STIA1001_1
(MACROPHAGE
COLONY-STIMULATING
FACTOR 1 RECEPTOR)		 2qob EPHRIN RECEPTOR
(Homo
sapiens) 		7 / 12 VAL A 635
ALA A 651
LYS A 653
GLU A 670
MET A 674
THR A 699
ASP A 764
 BME  A   1 (-4.9A)
PTR  A 701 ( 4.7A)
None
None
None
None
None
 1.02A 4r7iA-2qobA:
31.7		 4r7iA-2qobA:
29.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4RZV_A_032A801_1
(SERINE/THREONINE-PRO
TEIN KINASE B-RAF)		 2qob EPHRIN RECEPTOR
(Homo
sapiens) 		5 / 12 ALA A 651
LYS A 653
ILE A 697
THR A 699
SER A 706
 PTR  A 701 ( 4.7A)
None
None
None
None
 0.52A 4rzvA-2qobA:
26.4		 4rzvA-2qobA:
27.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4RZV_A_032A801_1
(SERINE/THREONINE-PRO
TEIN KINASE B-RAF)		 2qob EPHRIN RECEPTOR
(Homo
sapiens) 		5 / 12 ALA A 651
LYS A 653
THR A 699
SER A 706
PHE A 765
 PTR  A 701 ( 4.7A)
None
None
None
None
 0.92A 4rzvA-2qobA:
26.4		 4rzvA-2qobA:
27.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4RZV_B_032B801_1
(SERINE/THREONINE-PRO
TEIN KINASE B-RAF)		 2qob EPHRIN RECEPTOR
(Homo
sapiens) 		5 / 12 VAL A 635
ALA A 651
LYS A 653
THR A 699
SER A 706
 BME  A   1 (-4.9A)
PTR  A 701 ( 4.7A)
None
None
None
 0.73A 4rzvB-2qobA:
25.9		 4rzvB-2qobA:
27.59
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4U5J_B_RXTB601_1
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE SRC)		 2qob EPHRIN RECEPTOR
(Homo
sapiens) 		6 / 9 VAL A 635
ALA A 651
MET A 702
GLY A 705
LEU A 753
ASP A 764
 BME  A   1 (-4.9A)
PTR  A 701 ( 4.7A)
PTR  A 701 ( 3.5A)
None
None
None
 0.36A 4u5jB-2qobA:
28.1		 4u5jB-2qobA:
39.54
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4WA9_A_AXIA9000_1
(TYROSINE-PROTEIN
KINASE ABL1)		 2qob EPHRIN RECEPTOR
(Homo
sapiens) 		6 / 11 ALA A 651
THR A 699
MET A 702
GLY A 705
ASN A 751
LEU A 753
 PTR  A 701 ( 4.7A)
None
PTR  A 701 ( 3.5A)
None
None
None
 0.30A 4wa9A-2qobA:
29.0		 4wa9A-2qobA:
34.49
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4WA9_B_AXIB9000_1
(TYROSINE-PROTEIN
KINASE ABL1)		 2qob EPHRIN RECEPTOR
(Homo
sapiens) 		7 / 12 VAL A 635
ALA A 651
THR A 699
MET A 702
GLY A 705
ASN A 751
LEU A 753
 BME  A   1 (-4.9A)
PTR  A 701 ( 4.7A)
None
PTR  A 701 ( 3.5A)
None
None
None
 0.77A 4wa9B-2qobA:
32.1		 4wa9B-2qobA:
34.49
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5AAA_A_VGHA9000_1
(ALK TYROSINE KINASE
RECEPTOR)		 2qob EPHRIN RECEPTOR
(Homo
sapiens) 		6 / 9 VAL A 635
ALA A 651
MET A 702
GLY A 705
LEU A 753
ASP A 764
 BME  A   1 (-4.9A)
PTR  A 701 ( 4.7A)
PTR  A 701 ( 3.5A)
None
None
None
 0.49A 5aaaA-2qobA:
34.5		 5aaaA-2qobA:
33.60
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5AAB_A_VGHA9000_1
(ALK TYROSINE KINASE
RECEPTOR)		 2qob EPHRIN RECEPTOR
(Homo
sapiens) 		7 / 10 VAL A 635
ALA A 651
LYS A 653
MET A 702
GLY A 705
LEU A 753
ASP A 764
 BME  A   1 (-4.9A)
PTR  A 701 ( 4.7A)
None
PTR  A 701 ( 3.5A)
None
None
None
 0.88A 5aabA-2qobA:
34.2		 5aabA-2qobA:
33.87
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5AAC_A_VGHA9000_1
(ALK TYROSINE KINASE
RECEPTOR)		 2qob EPHRIN RECEPTOR
(Homo
sapiens) 		7 / 10 VAL A 635
ALA A 651
LYS A 653
MET A 702
GLY A 705
LEU A 753
ASP A 764
 BME  A   1 (-4.9A)
PTR  A 701 ( 4.7A)
None
PTR  A 701 ( 3.5A)
None
None
None
 0.90A 5aacA-2qobA:
34.0		 5aacA-2qobA:
33.87
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5H2U_B_1N1B501_1
(PROTEIN-TYROSINE
KINASE 6)		 2qob EPHRIN RECEPTOR
(Homo
sapiens) 		6 / 12 VAL A 635
ALA A 651
ILE A 697
THR A 699
GLY A 705
LEU A 753
 BME  A   1 (-4.9A)
PTR  A 701 ( 4.7A)
None
None
None
None
 0.60A 5h2uB-2qobA:
24.2		 5h2uB-2qobA:
33.04
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5HES_A_032A401_1
(MITOGEN-ACTIVATED
PROTEIN KINASE
KINASE KINASE MLT)		 2qob EPHRIN RECEPTOR
(Homo
sapiens) 		5 / 12 VAL A 635
ALA A 651
ILE A 683
ILE A 697
THR A 699
 BME  A   1 (-4.9A)
PTR  A 701 ( 4.7A)
None
None
None
 0.54A 5hesA-2qobA:
11.7		 5hesA-2qobA:
31.58
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5HIE_A_P06A801_1
(SERINE/THREONINE-PRO
TEIN KINASE B-RAF)		 2qob EPHRIN RECEPTOR
(Homo
sapiens) 		5 / 12 GLY A 630
VAL A 635
ALA A 651
ILE A 697
THR A 699
 None
BME  A   1 (-4.9A)
PTR  A 701 ( 4.7A)
None
None
 0.74A 5hieA-2qobA:
26.2		 5hieA-2qobA:
31.55
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5HIE_B_P06B801_1
(SERINE/THREONINE-PRO
TEIN KINASE B-RAF)		 2qob EPHRIN RECEPTOR
(Homo
sapiens) 		5 / 12 GLY A 630
VAL A 635
ALA A 651
ILE A 697
THR A 699
 None
BME  A   1 (-4.9A)
PTR  A 701 ( 4.7A)
None
None
 0.76A 5hieB-2qobA:
26.3		 5hieB-2qobA:
31.55
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5HIE_D_P06D801_1
(SERINE/THREONINE-PRO
TEIN KINASE B-RAF)		 2qob EPHRIN RECEPTOR
(Homo
sapiens) 		5 / 12 GLY A 630
VAL A 635
ALA A 651
ILE A 697
THR A 699
 None
BME  A   1 (-4.9A)
PTR  A 701 ( 4.7A)
None
None
 0.75A 5hieD-2qobA:
26.3		 5hieD-2qobA:
31.55
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5I9X_A_DB8A1001_1
(EPHRIN TYPE-A
RECEPTOR 2)		 2qob EPHRIN RECEPTOR
(Homo
sapiens) 		7 / 12 ALA A 651
GLU A 670
ILE A 683
ILE A 697
THR A 699
GLY A 705
LEU A 753
 PTR  A 701 ( 4.7A)
None
None
None
None
None
None
 0.57A 5i9xA-2qobA:
37.5		 5i9xA-2qobA:
68.99
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5I9Y_A_1N1A1001_1
(EPHRIN TYPE-A
RECEPTOR 2)		 2qob EPHRIN RECEPTOR
(Homo
sapiens) 		8 / 12 ALA A 651
LYS A 653
GLU A 670
MET A 674
THR A 699
GLY A 705
LEU A 753
SER A 763
 PTR  A 701 ( 4.7A)
None
None
None
None
None
None
None
 0.74A 5i9yA-2qobA:
29.2		 5i9yA-2qobA:
68.99
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5I9Y_A_1N1A1001_2
(EPHRIN TYPE-A
RECEPTOR 2)		 2qob EPHRIN RECEPTOR
(Homo
sapiens) 		3 / 3 ILE A 683
ILE A 697
MET A 702
 None
None
PTR  A 701 ( 3.5A)
 0.39A 5i9yA-2qobA:
29.2		 5i9yA-2qobA:
68.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IWU_A_ERYA404_1
(MACROLIDE
2'-PHOSPHOTRANSFERAS
E II)		 2qob EPHRIN RECEPTOR
(Homo
sapiens) 		4 / 6 GLY A 821
ASP A 746
ILE A 788
ARG A 789
 None
 1.10A 5iwuA-2qobA:
7.9		 5iwuA-2qobA:
22.52
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5P9I_A_1E8A701_1
(TYROSINE-PROTEIN
KINASE BTK)		 2qob EPHRIN RECEPTOR
(Homo
sapiens) 		6 / 12 GLY A 630
VAL A 635
ALA A 651
ILE A 697
THR A 699
PHE A 765
 None
BME  A   1 (-4.9A)
PTR  A 701 ( 4.7A)
None
None
None
 0.86A 5p9iA-2qobA:
25.2		 5p9iA-2qobA:
32.95
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5P9I_A_1E8A701_1
(TYROSINE-PROTEIN
KINASE BTK)		 2qob EPHRIN RECEPTOR
(Homo
sapiens) 		9 / 12 VAL A 635
ALA A 651
LYS A 653
ILE A 697
THR A 699
GLY A 705
LEU A 753
SER A 763
PHE A 765
 BME  A   1 (-4.9A)
PTR  A 701 ( 4.7A)
None
None
None
None
None
None
None
 1.06A 5p9iA-2qobA:
25.2		 5p9iA-2qobA:
32.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6BSD_A_1N1A901_0
(EPITHELIAL DISCOIDIN
DOMAIN-CONTAINING
RECEPTOR 1)		 2qob EPHRIN RECEPTOR
(Homo
sapiens) 		7 / 12 ALA A 651
MET A 674
ILE A 683
THR A 699
MET A 702
GLY A 705
LEU A 753
 PTR  A 701 ( 4.7A)
None
None
None
PTR  A 701 ( 3.5A)
None
None
 0.74A 6bsdA-2qobA:
23.9		 6bsdA-2qobA:
13.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6BSD_A_1N1A901_0
(EPITHELIAL DISCOIDIN
DOMAIN-CONTAINING
RECEPTOR 1)		 2qob EPHRIN RECEPTOR
(Homo
sapiens) 		7 / 12 VAL A 635
ALA A 651
ILE A 683
THR A 699
MET A 702
GLY A 705
LEU A 753
 BME  A   1 (-4.9A)
PTR  A 701 ( 4.7A)
None
None
PTR  A 701 ( 3.5A)
None
None
 0.68A 6bsdA-2qobA:
23.9		 6bsdA-2qobA:
13.35
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
6FNM_A_1N1A1001_1
(-)		 2qob EPHRIN RECEPTOR
(Homo
sapiens) 		10 / 12 VAL A 635
ALA A 651
LYS A 653
GLU A 670
MET A 674
ILE A 697
THR A 699
MET A 702
GLY A 705
LEU A 753
 BME  A   1 (-4.9A)
PTR  A 701 ( 4.7A)
None
None
None
None
None
PTR  A 701 ( 3.5A)
None
None
 0.60A 6fnmA-2qobA:
30.9		 6fnmA-2qobA:
69.35
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
6FNM_A_1N1A1001_1
(-)		 2qob EPHRIN RECEPTOR
(Homo
sapiens) 		8 / 12 VAL A 635
ALA A 651
LYS A 653
GLU A 670
MET A 702
GLY A 705
LEU A 753
SER A 763
 BME  A   1 (-4.9A)
PTR  A 701 ( 4.7A)
None
None
PTR  A 701 ( 3.5A)
None
None
None
 0.77A 6fnmA-2qobA:
30.9		 6fnmA-2qobA:
69.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6HD4_A_STIA604_0
(TYROSINE-PROTEIN
KINASE ABL1)		 2qob EPHRIN RECEPTOR
(Homo
sapiens) 		7 / 12 VAL A 635
ALA A 651
GLU A 670
MET A 674
ILE A 697
THR A 699
ASP A 764
 BME  A   1 (-4.9A)
PTR  A 701 ( 4.7A)
None
None
None
None
None
 1.04A 6hd4A-2qobA:
26.1		 6hd4A-2qobA:
13.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6HD4_B_STIB602_0
(TYROSINE-PROTEIN
KINASE ABL1)		 2qob EPHRIN RECEPTOR
(Homo
sapiens) 		7 / 12 VAL A 635
ALA A 651
GLU A 670
MET A 674
ILE A 697
THR A 699
ASP A 764
 BME  A   1 (-4.9A)
PTR  A 701 ( 4.7A)
None
None
None
None
None
 1.02A 6hd4B-2qobA:
26.2		 6hd4B-2qobA:
13.16