SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2qos'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1EPB_A_9CRA165_1
(EPIDIDYMAL RETINOIC
ACID-BINDING PROTEIN)		 2qos COMPLEMENT COMPONENT
8, GAMMA POLYPEPTIDE
(Homo
sapiens) 		6 / 12 PHE C  22
TRP C  31
VAL C  57
VAL C 107
ALA C 116
LYS C 129
 None
 0.91A 1epbA-2qosC:
18.3		 1epbA-2qosC:
23.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2JN3_A_JN3A131_1
(FATTY ACID-BINDING
PROTEIN, LIVER)		 2qos COMPLEMENT COMPONENT
8, GAMMA POLYPEPTIDE
(Homo
sapiens) 		5 / 12 VAL C  57
PHE C  27
THR C  62
VAL C 107
LEU C 118
 None
 1.15A 2jn3A-2qosC:
3.0		 2jn3A-2qosC:
20.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3L4D_B_TPFB490_1
(STEROL 14-ALPHA
DEMETHYLASE)		 2qos COMPLEMENT COMPONENT
8, GAMMA POLYPEPTIDE
(Homo
sapiens) 		5 / 9 TYR C  83
MET C  64
ALA C  28
THR C 110
LEU C 118
 None
 1.43A 3l4dB-2qosC:
undetectable		 3l4dB-2qosC:
17.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QVN_K_BO2K301_1
(PROTEASOME SUBUNIT
BETA TYPE-5
PROTEASOME SUBUNIT
BETA TYPE-6)		 2qos COMPLEMENT COMPONENT
8, GAMMA POLYPEPTIDE
(Homo
sapiens) 		5 / 9 THR C  86
ALA C  63
THR C  62
VAL C 105
GLY C  90
 None
 0.97A 4qvnK-2qosC:
undetectable
4qvnL-2qosC:
undetectable		 4qvnK-2qosC:
22.83
4qvnL-2qosC:
22.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QVN_Y_BO2Y301_1
(PROTEASOME SUBUNIT
BETA TYPE-5
PROTEASOME SUBUNIT
BETA TYPE-6)		 2qos COMPLEMENT COMPONENT
8, GAMMA POLYPEPTIDE
(Homo
sapiens) 		5 / 9 THR C  86
ALA C  63
THR C  62
VAL C 105
GLY C  90
 None
 0.97A 4qvnY-2qosC:
undetectable
4qvnZ-2qosC:
undetectable		 4qvnY-2qosC:
22.83
4qvnZ-2qosC:
22.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5BPH_C_ACTC403_0
(D-ALANINE--D-ALANINE
LIGASE)		 2qos COMPLEMENT COMPONENT
8, GAMMA POLYPEPTIDE
(Homo
sapiens) 		4 / 4 TYR C 161
GLY C 144
SER C 143
LEU C 142
 None
 1.32A 5bphC-2qosC:
undetectable		 5bphC-2qosC:
23.08