SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2qp4'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1GMK_A_DVAA8_0
(GRAMICIDIN A)		 2qp4 BILE SALT
SULFOTRANSFERASE
(Homo
sapiens) 		3 / 4 VAL A 128
TRP A 163
TRP A 254
 None
 1.33A 1gmkA-2qp4A:
undetectable
1gmkB-2qp4A:
undetectable		 1gmkA-2qp4A:
4.62
1gmkB-2qp4A:
4.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1LHV_A_NOGA301_1
(SEX HORMONE-BINDING
GLOBULIN)		 2qp4 BILE SALT
SULFOTRANSFERASE
(Homo
sapiens) 		4 / 8 SER A  98
ASP A  28
PHE A  30
LEU A 100
 None
 0.95A 1lhvA-2qp4A:
undetectable		 1lhvA-2qp4A:
22.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UUJ_B_ACTB1077_0
(PLATELET-ACTIVATING
FACTOR
ACETYLHYDROLASE IB
ALPHA SUBUNIT)		 2qp4 BILE SALT
SULFOTRANSFERASE
(Homo
sapiens) 		3 / 3 ARG A 121
TYR A 184
LYS A 188
 None
 0.86A 1uujB-2qp4A:
undetectable		 1uujB-2qp4A:
14.53
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2D06_A_ESTA304_1
(SULFOTRANSFERASE 1A1)		 2qp4 BILE SALT
SULFOTRANSFERASE
(Homo
sapiens) 		5 / 10 PHE A  18
PRO A  43
LYS A  44
HIS A  99
PHE A 133
 AOX  A 286 ( 4.9A)
AOX  A 286 ( 4.4A)
AOX  A 286 (-3.9A)
AOX  A 286 (-3.7A)
AOX  A 286 ( 4.4A)
 0.87A 2d06A-2qp4A:
33.6		 2d06A-2qp4A:
34.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3F78_A_ICFA1_1
(INTEGRIN ALPHA-L)		 2qp4 BILE SALT
SULFOTRANSFERASE
(Homo
sapiens) 		5 / 9 ILE A  53
ILE A 198
LEU A 182
GLU A 186
LEU A 187
 None
 1.14A 3f78A-2qp4A:
undetectable		 3f78A-2qp4A:
20.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3F78_A_ICFA1_1
(INTEGRIN ALPHA-L)		 2qp4 BILE SALT
SULFOTRANSFERASE
(Homo
sapiens) 		5 / 9 ILE A 198
LYS A 197
LEU A 182
GLU A 186
LEU A 187
 None
 1.00A 3f78A-2qp4A:
undetectable		 3f78A-2qp4A:
20.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3F78_B_ICFB2_1
(INTEGRIN ALPHA-L)		 2qp4 BILE SALT
SULFOTRANSFERASE
(Homo
sapiens) 		5 / 9 ILE A  53
ILE A 198
LEU A 182
GLU A 186
LEU A 187
 None
 1.16A 3f78B-2qp4A:
undetectable		 3f78B-2qp4A:
20.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3F78_B_ICFB2_1
(INTEGRIN ALPHA-L)		 2qp4 BILE SALT
SULFOTRANSFERASE
(Homo
sapiens) 		5 / 9 ILE A 198
LYS A 197
LEU A 182
GLU A 186
LEU A 187
 None
 1.06A 3f78B-2qp4A:
undetectable		 3f78B-2qp4A:
20.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KPD_C_SAMC1000_0
(UNCHARACTERIZED
PROTEIN MJ0100)		 2qp4 BILE SALT
SULFOTRANSFERASE
(Homo
sapiens) 		3 / 3 ASN A 230
ASN A  48
GLU A  52
 None
 0.93A 3kpdB-2qp4A:
undetectable		 3kpdB-2qp4A:
21.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3MEC_A_65BA561_0
(P66 REVERSE
TRANSCRIPTASE)		 2qp4 BILE SALT
SULFOTRANSFERASE
(Homo
sapiens) 		5 / 12 LEU A  23
TYR A 160
GLY A  10
PHE A   5
LEU A   6
 None
 1.18A 3mecA-2qp4A:
undetectable		 3mecA-2qp4A:
18.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3MED_A_65BA561_0
(P51 REVERSE
TRANSCRIPTASE
P66 REVERSE
TRANSCRIPTASE)		 2qp4 BILE SALT
SULFOTRANSFERASE
(Homo
sapiens) 		5 / 12 LEU A  23
TYR A 160
GLY A  10
PHE A   5
LEU A   6
 None
 1.22A 3medA-2qp4A:
undetectable
3medB-2qp4A:
undetectable		 3medA-2qp4A:
18.99
3medB-2qp4A:
21.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NXU_A_RITA600_2
(CYTOCHROME P450 3A4)		 2qp4 BILE SALT
SULFOTRANSFERASE
(Homo
sapiens) 		4 / 7 PHE A 105
ILE A  71
LEU A  95
THR A  90
 None
 1.19A 3nxuA-2qp4A:
undetectable		 3nxuA-2qp4A:
20.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3RFM_A_CFFA330_1
(ADENOSINE RECEPTOR
A2A)		 2qp4 BILE SALT
SULFOTRANSFERASE
(Homo
sapiens) 		4 / 7 PHE A 109
MET A 173
LEU A  40
ILE A  38
 None
 0.72A 3rfmA-2qp4A:
undetectable		 3rfmA-2qp4A:
17.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4A7T_A_5FWA1002_1
(SUPEROXIDE DISMUTASE
[CU-ZN])		 2qp4 BILE SALT
SULFOTRANSFERASE
(Homo
sapiens) 		3 / 3 ASN A 122
TRP A 284
ASP A 253
 None
 1.15A 4a7tA-2qp4A:
undetectable
4a7tF-2qp4A:
undetectable		 4a7tA-2qp4A:
20.38
4a7tF-2qp4A:
20.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4F3T_A_IPHA901_0
(PROTEIN ARGONAUTE-2)		 2qp4 BILE SALT
SULFOTRANSFERASE
(Homo
sapiens) 		4 / 4 PHE A 109
VAL A 116
ALA A 114
PHE A 201
 None
 1.30A 4f3tA-2qp4A:
3.2		 4f3tA-2qp4A:
15.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KLR_B_CHDB504_0
(FERROCHELATASE,
MITOCHONDRIAL)		 2qp4 BILE SALT
SULFOTRANSFERASE
(Homo
sapiens) 		3 / 3 LEU A 100
PRO A 101
ARG A  24
 None
 0.68A 4klrB-2qp4A:
undetectable		 4klrB-2qp4A:
21.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KSZ_A_CYSA620_0
(LACTOPEROXIDASE)		 2qp4 BILE SALT
SULFOTRANSFERASE
(Homo
sapiens) 		3 / 3 ARG A  27
GLU A   9
PHE A   8
 None
 0.73A 4kszA-2qp4A:
undetectable		 4kszA-2qp4A:
18.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QRC_A_0LIA802_2
(FIBROBLAST GROWTH
FACTOR RECEPTOR 4)		 2qp4 BILE SALT
SULFOTRANSFERASE
(Homo
sapiens) 		4 / 8 LEU A  95
VAL A  37
LYS A 115
ILE A 198
 None
 0.84A 4qrcA-2qp4A:
undetectable		 4qrcA-2qp4A:
19.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4W5O_A_IPHA906_0
(PROTEIN ARGONAUTE-2)		 2qp4 BILE SALT
SULFOTRANSFERASE
(Homo
sapiens) 		4 / 5 PHE A 109
VAL A 116
ALA A 114
PHE A 201
 None
 1.34A 4w5oA-2qp4A:
undetectable		 4w5oA-2qp4A:
15.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4W5Q_A_IPHA904_0
(PROTEIN ARGONAUTE-2)		 2qp4 BILE SALT
SULFOTRANSFERASE
(Homo
sapiens) 		4 / 4 PHE A 109
VAL A 116
ALA A 114
PHE A 201
 None
 1.32A 4w5qA-2qp4A:
3.0		 4w5qA-2qp4A:
15.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4W5R_A_IPHA904_0
(PROTEIN ARGONAUTE-2)		 2qp4 BILE SALT
SULFOTRANSFERASE
(Homo
sapiens) 		4 / 4 PHE A 109
VAL A 116
ALA A 114
PHE A 201
 None
 1.34A 4w5rA-2qp4A:
3.0		 4w5rA-2qp4A:
15.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4W5T_A_IPHA904_0
(PROTEIN ARGONAUTE-2)		 2qp4 BILE SALT
SULFOTRANSFERASE
(Homo
sapiens) 		4 / 4 PHE A 109
VAL A 116
ALA A 114
PHE A 201
 None
 1.35A 4w5tA-2qp4A:
0.0		 4w5tA-2qp4A:
15.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Z4E_A_IPHA906_0
(PROTEIN ARGONAUTE-2)		 2qp4 BILE SALT
SULFOTRANSFERASE
(Homo
sapiens) 		4 / 5 PHE A 109
VAL A 116
ALA A 114
PHE A 201
 None
 1.34A 4z4eA-2qp4A:
3.0		 4z4eA-2qp4A:
15.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Z4G_A_IPHA904_0
(PROTEIN ARGONAUTE-2)		 2qp4 BILE SALT
SULFOTRANSFERASE
(Homo
sapiens) 		4 / 4 PHE A 109
VAL A 116
ALA A 114
PHE A 201
 None
 1.35A 4z4gA-2qp4A:
2.1		 4z4gA-2qp4A:
15.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KI6_A_IPHA902_0
(PROTEIN ARGONAUTE-2)		 2qp4 BILE SALT
SULFOTRANSFERASE
(Homo
sapiens) 		4 / 4 PHE A 109
VAL A 116
ALA A 114
PHE A 201
 None
 1.33A 5ki6A-2qp4A:
2.9		 5ki6A-2qp4A:
15.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5MZJ_A_TEPA2401_1
(ADENOSINE RECEPTOR
A2A,SOLUBLE
CYTOCHROME
B562,ADENOSINE
RECEPTOR A2A)		 2qp4 BILE SALT
SULFOTRANSFERASE
(Homo
sapiens) 		4 / 8 PHE A 109
MET A 173
LEU A  40
ILE A  38
 None
 0.91A 5mzjA-2qp4A:
undetectable		 5mzjA-2qp4A:
18.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5MZP_A_CFFA2401_1
(ADENOSINE RECEPTOR
A2A,SOLUBLE
CYTOCHROME
B562,ADENOSINE
RECEPTOR A2A)		 2qp4 BILE SALT
SULFOTRANSFERASE
(Homo
sapiens) 		5 / 9 ILE A  32
PHE A 109
MET A 173
LEU A  40
ILE A  38
 None
 1.12A 5mzpA-2qp4A:
undetectable		 5mzpA-2qp4A:
19.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Z84_C_CHDC307_0
(CYTOCHROME C OXIDASE
SUBUNIT 3
CYTOCHROME C OXIDASE
SUBUNIT 7A1,
MITOCHONDRIAL)		 2qp4 BILE SALT
SULFOTRANSFERASE
(Homo
sapiens) 		5 / 7 LEU A 269
GLN A 271
PHE A 270
PHE A 164
PHE A 150
 None
 1.47A 5z84C-2qp4A:
undetectable
5z84J-2qp4A:
undetectable		 5z84C-2qp4A:
20.83
5z84J-2qp4A:
11.51