SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2qpt'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1DZ6_A_CAMA502_0
(CYTOCHROME P450-CAM)		 2qpt EH DOMAIN-CONTAINING
PROTEIN-2
(Mus
musculus) 		4 / 5 PHE A 271
LEU A 218
VAL A 264
ASP A 222
 None
None
None
ANP  A 600 ( 4.6A)
 1.34A 1dz6A-2qptA:
undetectable		 1dz6A-2qptA:
21.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1N49_B_RITB301_1
(PROTEASE)		 2qpt EH DOMAIN-CONTAINING
PROTEIN-2
(Mus
musculus) 		4 / 7 ASP A 198
GLY A 205
ALA A  64
ILE A 157
 None
 0.75A 1n49A-2qptA:
undetectable		 1n49A-2qptA:
10.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1T6Z_A_RBFA296_1
(RIBOFLAVIN
KINASE/FMN
ADENYLYLTRANSFERASE)		 2qpt EH DOMAIN-CONTAINING
PROTEIN-2
(Mus
musculus) 		5 / 11 THR A 154
VAL A 182
VAL A  61
LEU A 207
ILE A 185
 None
 1.31A 1t6zA-2qptA:
undetectable		 1t6zA-2qptA:
21.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2EJF_B_ADNB2002_1
(235AA LONG
HYPOTHETICAL
BIOTIN--[ACETYL-COA-
CARBOXYLASE] LIGASE)		 2qpt EH DOMAIN-CONTAINING
PROTEIN-2
(Mus
musculus) 		4 / 6 ARG A 208
GLU A 202
PRO A 172
ALA A 173
 None
 1.48A 2ejfB-2qptA:
undetectable		 2ejfB-2qptA:
18.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2GJ5_A_VD3A163_1
(BETA-LACTOGLOBULIN)		 2qpt EH DOMAIN-CONTAINING
PROTEIN-2
(Mus
musculus) 		5 / 12 LEU A 278
ILE A 149
LEU A 285
ILE A 151
PHE A 414
 None
 1.09A 2gj5A-2qptA:
undetectable		 2gj5A-2qptA:
15.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3IK3_A_0LIA1_2
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE ABL1)		 2qpt EH DOMAIN-CONTAINING
PROTEIN-2
(Mus
musculus) 		4 / 7 LEU A 158
TYR A  67
VAL A 232
ILE A 196
 None
 1.23A 3ik3A-2qptA:
undetectable		 3ik3A-2qptA:
19.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3IK3_B_0LIB2_2
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE ABL1)		 2qpt EH DOMAIN-CONTAINING
PROTEIN-2
(Mus
musculus) 		4 / 7 LEU A 158
TYR A  67
VAL A 232
ILE A 196
 None
 1.23A 3ik3B-2qptA:
undetectable		 3ik3B-2qptA:
19.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3W67_C_VIVC301_0
(ALPHA-TOCOPHEROL
TRANSFER PROTEIN)		 2qpt EH DOMAIN-CONTAINING
PROTEIN-2
(Mus
musculus) 		5 / 12 ILE A 214
VAL A 244
ILE A 196
LEU A 194
VAL A 232
 None
 1.17A 3w67C-2qptA:
undetectable		 3w67C-2qptA:
18.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4AQ7_A_LEUA902_0
(LEUCINE--TRNA LIGASE)		 2qpt EH DOMAIN-CONTAINING
PROTEIN-2
(Mus
musculus) 		4 / 7 MET A 359
LEU A 362
HIS A 307
HIS A  46
 None
 1.17A 4aq7A-2qptA:
2.5		 4aq7A-2qptA:
22.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4CX7_C_H4BC600_1
(NITRIC OXIDE
SYNTHASE, INDUCIBLE)		 2qpt EH DOMAIN-CONTAINING
PROTEIN-2
(Mus
musculus) 		4 / 8 SER A 148
ILE A 149
PHE A 414
GLU A 147
 None
 1.26A 4cx7C-2qptA:
undetectable
4cx7D-2qptA:
undetectable		 4cx7C-2qptA:
22.18
4cx7D-2qptA:
22.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4M2X_G_TMQG202_1
(DIHYDROFOLATE
REDUCTASE)		 2qpt EH DOMAIN-CONTAINING
PROTEIN-2
(Mus
musculus) 		5 / 12 ILE A 185
ALA A  64
LEU A 240
VAL A 243
ILE A 214
 None
 1.04A 4m2xG-2qptA:
undetectable		 4m2xG-2qptA:
15.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4O1Z_A_MXMA807_1
(PROSTAGLANDIN G/H
SYNTHASE 1)		 2qpt EH DOMAIN-CONTAINING
PROTEIN-2
(Mus
musculus) 		5 / 12 ILE A 151
VAL A  63
GLY A  70
LEU A  78
LEU A  79
 None
None
ANP  A 600 (-3.0A)
None
None
 0.97A 4o1zA-2qptA:
undetectable		 4o1zA-2qptA:
22.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4PEV_B_ADNB501_1
(MEMBRANE LIPOPROTEIN
FAMILY PROTEIN)		 2qpt EH DOMAIN-CONTAINING
PROTEIN-2
(Mus
musculus) 		5 / 12 VAL A 217
SER A  73
GLY A 255
ASP A 222
GLY A  70
 None
ANP  A 600 (-2.6A)
None
ANP  A 600 ( 4.6A)
ANP  A 600 (-3.0A)
 1.37A 4pevB-2qptA:
3.9		 4pevB-2qptA:
23.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4WG0_J_CHDJ103_0
(NUCLEAR RECEPTOR
COACTIVATOR 2)		 2qpt EH DOMAIN-CONTAINING
PROTEIN-2
(Mus
musculus) 		5 / 11 LEU A 526
LEU A 508
GLU A 514
ALA A 515
LEU A 512
 None
 1.10A 4wg0J-2qptA:
undetectable
4wg0K-2qptA:
undetectable
4wg0L-2qptA:
undetectable		 4wg0J-2qptA:
2.84
4wg0K-2qptA:
2.84
4wg0L-2qptA:
2.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4X20_D_LOCD502_1
(TUBULIN ALPHA CHAIN
TUBULIN BETA CHAIN)		 2qpt EH DOMAIN-CONTAINING
PROTEIN-2
(Mus
musculus) 		3 / 3 SER A 150
ALA A  99
VAL A  98
 None
 0.65A 4x20C-2qptA:
undetectable		 4x20C-2qptA:
21.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XYZ_A_ACTA103_0
(POLYUBIQUITIN-C)		 2qpt EH DOMAIN-CONTAINING
PROTEIN-2
(Mus
musculus) 		4 / 4 LEU A 303
ILE A 310
HIS A 307
VAL A 306
 None
 1.11A 4xyzA-2qptA:
undetectable		 4xyzA-2qptA:
10.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5H8T_A_RTLA201_0
(RETINOL-BINDING
PROTEIN 1)		 2qpt EH DOMAIN-CONTAINING
PROTEIN-2
(Mus
musculus) 		5 / 12 TYR A 233
ALA A 221
ILE A 214
TYR A 253
LEU A 240
 None
 1.12A 5h8tA-2qptA:
undetectable		 5h8tA-2qptA:
12.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HYR_B_ESTB601_1
(ESTROGEN RECEPTOR)		 2qpt EH DOMAIN-CONTAINING
PROTEIN-2
(Mus
musculus) 		5 / 11 LEU A  50
ALA A  49
LEU A  34
LEU A  33
HIS A 307
 None
 1.35A 5hyrB-2qptA:
undetectable		 5hyrB-2qptA:
17.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IFU_B_GBMB801_1
(PROLINE--TRNA LIGASE)		 2qpt EH DOMAIN-CONTAINING
PROTEIN-2
(Mus
musculus) 		5 / 9 ILE A 185
GLU A 211
ARG A 208
ILE A 204
GLY A 205
 None
 1.39A 5ifuB-2qptA:
2.2		 5ifuB-2qptA:
20.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6AG0_C_ACRC608_1
(ALPHA-AMYLASE)		 2qpt EH DOMAIN-CONTAINING
PROTEIN-2
(Mus
musculus) 		3 / 3 TYR A 233
ALA A 239
LEU A 240
 None
 0.70A 6ag0C-2qptA:
2.6		 6ag0C-2qptA:
9.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6F88_B_STRB502_1
(CYTOCHROME P450
CYP260A1)		 2qpt EH DOMAIN-CONTAINING
PROTEIN-2
(Mus
musculus) 		4 / 6 LEU A 207
ALA A 206
LEU A  62
THR A 154
 None
 0.94A 6f88B-2qptA:
undetectable		 6f88B-2qptA:
8.41