SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2qpx'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1WRL_F_TFPF211_1
(TROPONIN C, SLOW
SKELETAL AND CARDIAC
MUSCLES)		 2qpx PREDICTED
METAL-DEPENDENT
HYDROLASE OF THE
TIM-BARREL FOLD
(Lactobacillus
paracasei) 		4 / 7 LEU A 224
PHE A 252
PHE A 226
LEU A 129
 None
None
None
KCX  A 166 ( 3.8A)
 0.98A 1wrlE-2qpxA:
undetectable
1wrlF-2qpxA:
undetectable		 1wrlE-2qpxA:
11.41
1wrlF-2qpxA:
11.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1YAJ_G_BEZG3385_0
(CES1 PROTEIN)		 2qpx PREDICTED
METAL-DEPENDENT
HYDROLASE OF THE
TIM-BARREL FOLD
(Lactobacillus
paracasei) 		3 / 3 SER A 167
VAL A 259
LEU A 224
 KCX  A 166 ( 4.7A)
None
None
 0.74A 1yajG-2qpxA:
undetectable		 1yajG-2qpxA:
22.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1YAJ_K_BEZK4387_0
(CES1 PROTEIN)		 2qpx PREDICTED
METAL-DEPENDENT
HYDROLASE OF THE
TIM-BARREL FOLD
(Lactobacillus
paracasei) 		3 / 3 TRP A 360
LEU A  13
LYS A 333
 None
 1.36A 1yajK-2qpxA:
undetectable		 1yajK-2qpxA:
22.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2AYL_A_FLPA1701_1
(PROSTAGLANDIN G/H
SYNTHASE 1)		 2qpx PREDICTED
METAL-DEPENDENT
HYDROLASE OF THE
TIM-BARREL FOLD
(Lactobacillus
paracasei) 		5 / 12 LEU A 243
LEU A 175
GLY A 272
ALA A 271
LEU A 261
 None
 1.12A 2aylA-2qpxA:
undetectable		 2aylA-2qpxA:
20.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2LH8_A_VIBA1_1
(MAJOR PRION PROTEIN)		 2qpx PREDICTED
METAL-DEPENDENT
HYDROLASE OF THE
TIM-BARREL FOLD
(Lactobacillus
paracasei) 		4 / 6 PRO A 266
HIS A 263
ASP A 289
TYR A 265
 None
ZN  A 377 (-3.1A)
None
None
 1.46A 2lh8A-2qpxA:
undetectable		 2lh8A-2qpxA:
12.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2PGF_A_ADNA501_1
(ADENOSINE DEAMINASE)		 2qpx PREDICTED
METAL-DEPENDENT
HYDROLASE OF THE
TIM-BARREL FOLD
(Lactobacillus
paracasei) 		5 / 12 ASP A 232
GLY A 231
HIS A 227
SER A 286
ASP A 317
 None
None
ZN  A 377 (-3.1A)
None
ZN  A 376 (-2.6A)
 1.40A 2pgfA-2qpxA:
13.0		 2pgfA-2qpxA:
22.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Q0J_B_BEZB500_0
(QUINOLONE SIGNAL
RESPONSE PROTEIN)		 2qpx PREDICTED
METAL-DEPENDENT
HYDROLASE OF THE
TIM-BARREL FOLD
(Lactobacillus
paracasei) 		5 / 11 HIS A  17
HIS A 263
ASP A 317
LEU A 287
HIS A  19
 ZN  A 376 (-3.3A)
ZN  A 377 (-3.1A)
ZN  A 376 (-2.6A)
None
ZN  A 376 (-3.3A)
 1.29A 2q0jB-2qpxA:
undetectable		 2q0jB-2qpxA:
22.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XAD_E_GCSE710_1
(N-ACYL GLM
PEUDO-TEICOPLANIN
DEACETYLASE
TEICOPLANIN)		 2qpx PREDICTED
METAL-DEPENDENT
HYDROLASE OF THE
TIM-BARREL FOLD
(Lactobacillus
paracasei) 		4 / 8 HIS A  19
ILE A 168
HIS A  17
ASP A 100
 ZN  A 376 (-3.3A)
KCX  A 166 ( 4.9A)
ZN  A 376 (-3.3A)
KCX  A 166 ( 3.8A)
 1.05A 2xadA-2qpxA:
undetectable		 2xadA-2qpxA:
24.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XAD_F_GCSF710_1
(N-ACYL GLM
PEUDO-TEICOPLANIN
DEACETYLASE
TEICOPLANIN)		 2qpx PREDICTED
METAL-DEPENDENT
HYDROLASE OF THE
TIM-BARREL FOLD
(Lactobacillus
paracasei) 		4 / 8 HIS A  19
ILE A 168
HIS A  17
ASP A 100
 ZN  A 376 (-3.3A)
KCX  A 166 ( 4.9A)
ZN  A 376 (-3.3A)
KCX  A 166 ( 3.8A)
 1.05A 2xadB-2qpxA:
undetectable		 2xadB-2qpxA:
24.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XAD_G_GCSG710_1
(N-ACYL GLM
PEUDO-TEICOPLANIN
DEACETYLASE
TEICOPLANIN)		 2qpx PREDICTED
METAL-DEPENDENT
HYDROLASE OF THE
TIM-BARREL FOLD
(Lactobacillus
paracasei) 		4 / 8 HIS A  19
ILE A 168
HIS A  17
ASP A 100
 ZN  A 376 (-3.3A)
KCX  A 166 ( 4.9A)
ZN  A 376 (-3.3A)
KCX  A 166 ( 3.8A)
 1.05A 2xadC-2qpxA:
undetectable		 2xadC-2qpxA:
24.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XAD_H_GCSH710_1
(N-ACYL GLM
PEUDO-TEICOPLANIN
DEACETYLASE
TEICOPLANIN)		 2qpx PREDICTED
METAL-DEPENDENT
HYDROLASE OF THE
TIM-BARREL FOLD
(Lactobacillus
paracasei) 		4 / 8 HIS A  19
ILE A 168
HIS A  17
ASP A 100
 ZN  A 376 (-3.3A)
KCX  A 166 ( 4.9A)
ZN  A 376 (-3.3A)
KCX  A 166 ( 3.8A)
 1.02A 2xadD-2qpxA:
undetectable		 2xadD-2qpxA:
24.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ABL_C_CHDC271_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE 7A1
CYTOCHROME C OXIDASE
SUBUNIT 3)		 2qpx PREDICTED
METAL-DEPENDENT
HYDROLASE OF THE
TIM-BARREL FOLD
(Lactobacillus
paracasei) 		4 / 5 GLN A  10
PHE A   7
LEU A 336
PHE A 332
 None
 1.24A 3ablC-2qpxA:
undetectable
3ablJ-2qpxA:
undetectable		 3ablC-2qpxA:
20.58
3ablJ-2qpxA:
11.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ABL_P_CHDP1271_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE 7A1
CYTOCHROME C OXIDASE
SUBUNIT 3)		 2qpx PREDICTED
METAL-DEPENDENT
HYDROLASE OF THE
TIM-BARREL FOLD
(Lactobacillus
paracasei) 		4 / 6 GLN A  10
PHE A   7
LEU A 336
PHE A 332
 None
 1.17A 3ablP-2qpxA:
undetectable
3ablW-2qpxA:
undetectable		 3ablP-2qpxA:
20.58
3ablW-2qpxA:
11.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3CFQ_A_DIFA1_1
(TRANSTHYRETIN)		 2qpx PREDICTED
METAL-DEPENDENT
HYDROLASE OF THE
TIM-BARREL FOLD
(Lactobacillus
paracasei) 		4 / 6 LEU A 291
ALA A 328
LEU A 287
SER A 286
 None
 1.04A 3cfqA-2qpxA:
undetectable		 3cfqA-2qpxA:
16.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3EM0_A_CHDA153_0
(ILEAL BILE
ACID-BINDING PROTEIN)		 2qpx PREDICTED
METAL-DEPENDENT
HYDROLASE OF THE
TIM-BARREL FOLD
(Lactobacillus
paracasei) 		4 / 5 ILE A  99
PHE A 314
PHE A  94
TYR A 325
 None
 1.38A 3em0A-2qpxA:
undetectable		 3em0A-2qpxA:
17.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KO0_F_TFPF201_1
(PROTEIN S100-A4)		 2qpx PREDICTED
METAL-DEPENDENT
HYDROLASE OF THE
TIM-BARREL FOLD
(Lactobacillus
paracasei) 		4 / 5 PHE A 332
PHE A 314
PHE A  92
PHE A  94
 None
 1.48A 3ko0F-2qpxA:
0.0
3ko0G-2qpxA:
0.0		 3ko0F-2qpxA:
14.65
3ko0G-2qpxA:
14.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3PGH_A_FLPA701_1
(CYCLOOXYGENASE-2)		 2qpx PREDICTED
METAL-DEPENDENT
HYDROLASE OF THE
TIM-BARREL FOLD
(Lactobacillus
paracasei) 		5 / 12 LEU A 243
LEU A 175
GLY A 272
ALA A 271
LEU A 261
 None
 1.10A 3pghA-2qpxA:
undetectable		 3pghA-2qpxA:
22.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3PHA_A_ACRA701_2
(ALPHA-GLUCOSIDASE)		 2qpx PREDICTED
METAL-DEPENDENT
HYDROLASE OF THE
TIM-BARREL FOLD
(Lactobacillus
paracasei) 		4 / 5 PRO A 215
ILE A 218
TYR A 208
TRP A 146
 None
 1.15A 3phaA-2qpxA:
4.2		 3phaA-2qpxA:
21.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3RV5_A_DXCA91_0
(TROPONIN C, SLOW
SKELETAL AND CARDIAC
MUSCLES)		 2qpx PREDICTED
METAL-DEPENDENT
HYDROLASE OF THE
TIM-BARREL FOLD
(Lactobacillus
paracasei) 		3 / 3 PHE A 314
GLN A 225
PHE A  94
 None
KCX  A 166 ( 4.9A)
None
 0.83A 3rv5A-2qpxA:
0.0		 3rv5A-2qpxA:
12.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SG8_A_TOYA305_1
(APH(2'')-ID)		 2qpx PREDICTED
METAL-DEPENDENT
HYDROLASE OF THE
TIM-BARREL FOLD
(Lactobacillus
paracasei) 		5 / 12 ASP A 284
SER A 286
ASP A 317
HIS A 263
TYR A 367
 None
None
ZN  A 376 (-2.6A)
ZN  A 377 (-3.1A)
None
 1.35A 3sg8A-2qpxA:
0.0		 3sg8A-2qpxA:
19.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SG8_B_TOYB305_1
(APH(2'')-ID)		 2qpx PREDICTED
METAL-DEPENDENT
HYDROLASE OF THE
TIM-BARREL FOLD
(Lactobacillus
paracasei) 		5 / 12 ASP A 284
SER A 286
ASP A 317
HIS A 263
TYR A 367
 None
None
ZN  A 376 (-2.6A)
ZN  A 377 (-3.1A)
None
 1.37A 3sg8B-2qpxA:
0.3		 3sg8B-2qpxA:
19.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SUF_B_SUEB1201_2
(NS3 PROTEASE, NS4A
PROTEIN)		 2qpx PREDICTED
METAL-DEPENDENT
HYDROLASE OF THE
TIM-BARREL FOLD
(Lactobacillus
paracasei) 		3 / 3 TYR A 273
LEU A 288
ARG A 269
 None
 0.73A 3sufB-2qpxA:
undetectable		 3sufB-2qpxA:
18.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DFU_A_KANA401_1
(APH(2')-ID)		 2qpx PREDICTED
METAL-DEPENDENT
HYDROLASE OF THE
TIM-BARREL FOLD
(Lactobacillus
paracasei) 		5 / 12 ASP A 284
SER A 286
ASP A 317
HIS A 263
TYR A 367
 None
None
ZN  A 376 (-2.6A)
ZN  A 377 (-3.1A)
None
 1.33A 4dfuA-2qpxA:
undetectable		 4dfuA-2qpxA:
18.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DFU_B_KANB402_1
(APH(2')-ID)		 2qpx PREDICTED
METAL-DEPENDENT
HYDROLASE OF THE
TIM-BARREL FOLD
(Lactobacillus
paracasei) 		5 / 12 ASP A 284
SER A 286
ASP A 317
HIS A 263
TYR A 367
 None
None
ZN  A 376 (-2.6A)
ZN  A 377 (-3.1A)
None
 1.37A 4dfuB-2qpxA:
undetectable		 4dfuB-2qpxA:
18.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4GBO_A_CUA301_0
(E7)		 2qpx PREDICTED
METAL-DEPENDENT
HYDROLASE OF THE
TIM-BARREL FOLD
(Lactobacillus
paracasei) 		4 / 5 HIS A  17
ALA A 315
HIS A  16
GLN A 225
 ZN  A 376 (-3.3A)
None
None
KCX  A 166 ( 4.9A)
 1.08A 4gboA-2qpxA:
undetectable		 4gboA-2qpxA:
20.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QZU_C_RTLC201_0
(RETINOL-BINDING
PROTEIN 2)		 2qpx PREDICTED
METAL-DEPENDENT
HYDROLASE OF THE
TIM-BARREL FOLD
(Lactobacillus
paracasei) 		5 / 12 ALA A 214
VAL A 228
LEU A 177
LEU A 281
LEU A 249
 None
 1.06A 4qzuC-2qpxA:
undetectable		 4qzuC-2qpxA:
15.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5AXD_A_RBVA502_2
(ADENOSYLHOMOCYSTEINA
SE)		 2qpx PREDICTED
METAL-DEPENDENT
HYDROLASE OF THE
TIM-BARREL FOLD
(Lactobacillus
paracasei) 		3 / 3 THR A 253
HIS A 227
LEU A 175
 None
ZN  A 377 (-3.1A)
None
 0.81A 5axdA-2qpxA:
undetectable		 5axdA-2qpxA:
20.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5AXD_C_RBVC502_2
(ADENOSYLHOMOCYSTEINA
SE)		 2qpx PREDICTED
METAL-DEPENDENT
HYDROLASE OF THE
TIM-BARREL FOLD
(Lactobacillus
paracasei) 		3 / 3 THR A 253
HIS A 227
LEU A 175
 None
ZN  A 377 (-3.1A)
None
 0.86A 5axdC-2qpxA:
undetectable		 5axdC-2qpxA:
20.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5C0O_F_SAMF301_0
(TRNA
(ADENINE(58)-N(1))-M
ETHYLTRANSFERASE
TRMI)		 2qpx PREDICTED
METAL-DEPENDENT
HYDROLASE OF THE
TIM-BARREL FOLD
(Lactobacillus
paracasei) 		5 / 12 GLY A  57
GLY A 292
LEU A 291
ALA A  62
LEU A  33
 None
 0.80A 5c0oF-2qpxA:
undetectable		 5c0oF-2qpxA:
21.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UIZ_A_CUA301_0
(AA10A)		 2qpx PREDICTED
METAL-DEPENDENT
HYDROLASE OF THE
TIM-BARREL FOLD
(Lactobacillus
paracasei) 		4 / 5 HIS A  17
ALA A 315
HIS A  16
GLN A 225
 ZN  A 376 (-3.3A)
None
None
KCX  A 166 ( 4.9A)
 1.10A 5uizA-2qpxA:
undetectable		 5uizA-2qpxA:
20.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Z84_P_CHDP305_0
(CYTOCHROME C OXIDASE
SUBUNIT 3
CYTOCHROME C OXIDASE
SUBUNIT 7A1,
MITOCHONDRIAL)		 2qpx PREDICTED
METAL-DEPENDENT
HYDROLASE OF THE
TIM-BARREL FOLD
(Lactobacillus
paracasei) 		4 / 6 GLN A  10
PHE A   7
LEU A 336
PHE A 332
 None
 1.08A 5z84P-2qpxA:
undetectable
5z84W-2qpxA:
undetectable		 5z84P-2qpxA:
20.58
5z84W-2qpxA:
11.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Z85_P_CHDP307_0
(CYTOCHROME C OXIDASE
SUBUNIT 3
CYTOCHROME C OXIDASE
SUBUNIT 7A1,
MITOCHONDRIAL)		 2qpx PREDICTED
METAL-DEPENDENT
HYDROLASE OF THE
TIM-BARREL FOLD
(Lactobacillus
paracasei) 		4 / 6 GLN A  10
PHE A   7
LEU A 336
PHE A 332
 None
 1.06A 5z85P-2qpxA:
undetectable
5z85W-2qpxA:
undetectable		 5z85P-2qpxA:
20.58
5z85W-2qpxA:
11.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Z86_C_CHDC306_0
(CYTOCHROME C OXIDASE
SUBUNIT 3
CYTOCHROME C OXIDASE
SUBUNIT 7A1,
MITOCHONDRIAL)		 2qpx PREDICTED
METAL-DEPENDENT
HYDROLASE OF THE
TIM-BARREL FOLD
(Lactobacillus
paracasei) 		4 / 6 GLN A  10
PHE A   7
LEU A 336
PHE A 332
 None
 1.13A 5z86C-2qpxA:
undetectable
5z86J-2qpxA:
undetectable		 5z86C-2qpxA:
20.58
5z86J-2qpxA:
11.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Z86_P_CHDP307_0
(CYTOCHROME C OXIDASE
SUBUNIT 3
CYTOCHROME C OXIDASE
SUBUNIT 7A1,
MITOCHONDRIAL)		 2qpx PREDICTED
METAL-DEPENDENT
HYDROLASE OF THE
TIM-BARREL FOLD
(Lactobacillus
paracasei) 		4 / 6 GLN A  10
PHE A   7
LEU A 336
PHE A 332
 None
 1.08A 5z86P-2qpxA:
undetectable
5z86W-2qpxA:
undetectable		 5z86P-2qpxA:
20.58
5z86W-2qpxA:
11.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ZCO_P_CHDP305_0
(CYTOCHROME C OXIDASE
SUBUNIT 3
CYTOCHROME C OXIDASE
SUBUNIT 7A1,
MITOCHONDRIAL)		 2qpx PREDICTED
METAL-DEPENDENT
HYDROLASE OF THE
TIM-BARREL FOLD
(Lactobacillus
paracasei) 		4 / 6 GLN A  10
PHE A   7
LEU A 336
PHE A 332
 None
 1.11A 5zcoP-2qpxA:
undetectable
5zcoW-2qpxA:
undetectable		 5zcoP-2qpxA:
20.58
5zcoW-2qpxA:
11.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ZCP_C_CHDC306_0
(CYTOCHROME C OXIDASE
SUBUNIT 3
CYTOCHROME C OXIDASE
SUBUNIT 7A1,
MITOCHONDRIAL)		 2qpx PREDICTED
METAL-DEPENDENT
HYDROLASE OF THE
TIM-BARREL FOLD
(Lactobacillus
paracasei) 		4 / 6 GLN A  10
PHE A   7
LEU A 336
PHE A 332
 None
 1.12A 5zcpC-2qpxA:
undetectable
5zcpJ-2qpxA:
undetectable		 5zcpC-2qpxA:
20.58
5zcpJ-2qpxA:
11.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ZCP_P_CHDP306_0
(CYTOCHROME C OXIDASE
SUBUNIT 3
CYTOCHROME C OXIDASE
SUBUNIT 7A1,
MITOCHONDRIAL)		 2qpx PREDICTED
METAL-DEPENDENT
HYDROLASE OF THE
TIM-BARREL FOLD
(Lactobacillus
paracasei) 		4 / 6 GLN A  10
PHE A   7
LEU A 336
PHE A 332
 None
 1.11A 5zcpP-2qpxA:
undetectable
5zcpW-2qpxA:
undetectable		 5zcpP-2qpxA:
20.58
5zcpW-2qpxA:
11.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6BNI_A_ADNA602_1
(LYSINE--TRNA LIGASE)		 2qpx PREDICTED
METAL-DEPENDENT
HYDROLASE OF THE
TIM-BARREL FOLD
(Lactobacillus
paracasei) 		5 / 10 ARG A 298
GLU A 302
HIS A 268
GLY A 292
ILE A 285
 None
 1.17A 6bniA-2qpxA:
undetectable		 6bniA-2qpxA:
13.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6BNI_B_ADNB602_1
(LYSINE--TRNA LIGASE)		 2qpx PREDICTED
METAL-DEPENDENT
HYDROLASE OF THE
TIM-BARREL FOLD
(Lactobacillus
paracasei) 		5 / 10 ARG A 298
GLU A 302
HIS A 268
GLY A 292
ILE A 285
 None
 1.19A 6bniB-2qpxA:
undetectable		 6bniB-2qpxA:
13.50