SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2qq4'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2E1Q_A_SALA2006_1
(XANTHINE
DEHYDROGENASE/OXIDAS
E)		 2qq4 IRON-SULFUR CLUSTER
BIOSYNTHESIS PROTEIN
ISCU
(Thermus
thermophilus) 		4 / 6 PHE A  59
THR A  75
LEU A  73
ALA A 129
 None
 0.97A 2e1qA-2qq4A:
4.6		 2e1qA-2qq4A:
7.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2E1Q_C_SALC4006_1
(XANTHINE
DEHYDROGENASE/OXIDAS
E)		 2qq4 IRON-SULFUR CLUSTER
BIOSYNTHESIS PROTEIN
ISCU
(Thermus
thermophilus) 		4 / 6 PHE A  59
THR A  75
LEU A  73
ALA A 129
 None
 0.97A 2e1qC-2qq4A:
4.8		 2e1qC-2qq4A:
7.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3QJ7_A_SPMA264_1
(THYMIDYLATE SYNTHASE)		 2qq4 IRON-SULFUR CLUSTER
BIOSYNTHESIS PROTEIN
ISCU
(Thermus
thermophilus) 		4 / 8 ARG A 138
ALA A 132
LEU A 128
SER A  90
 None
 1.01A 3qj7A-2qq4A:
undetectable
3qj7D-2qq4A:
undetectable		 3qj7A-2qq4A:
19.49
3qj7D-2qq4A:
19.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4X1K_B_LOCB502_1
(TUBULIN ALPHA CHAIN
TUBULIN BETA CHAIN)		 2qq4 IRON-SULFUR CLUSTER
BIOSYNTHESIS PROTEIN
ISCU
(Thermus
thermophilus) 		5 / 12 VAL A 123
LEU A  12
ALA A 112
LEU A 110
ALA A  69
 None
 1.21A 4x1kA-2qq4A:
undetectable
4x1kB-2qq4A:
undetectable		 4x1kA-2qq4A:
16.06
4x1kB-2qq4A:
17.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5DZK_R_BEZR801_0
(ATP-DEPENDENT CLP
PROTEASE PROTEOLYTIC
SUBUNIT 2
BEZ-LEU-LEU)		 2qq4 IRON-SULFUR CLUSTER
BIOSYNTHESIS PROTEIN
ISCU
(Thermus
thermophilus) 		4 / 7 PHE A  22
ALA A  71
HIS A  15
PRO A  19
 None
 1.04A 5dzkD-2qq4A:
undetectable
5dzkR-2qq4A:
undetectable		 5dzkD-2qq4A:
22.22
5dzkR-2qq4A:
15.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JW1_A_CELA602_2
(PROSTAGLANDIN G/H
SYNTHASE 2)		 2qq4 IRON-SULFUR CLUSTER
BIOSYNTHESIS PROTEIN
ISCU
(Thermus
thermophilus) 		4 / 6 VAL A  43
LEU A  73
SER A  70
ILE A  11
 None
 1.00A 5jw1A-2qq4A:
undetectable		 5jw1A-2qq4A:
13.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6BXM_A_SAMA402_0
(DIPHTHAMIDE
BIOSYNTHESIS ENZYME
DPH2)		 2qq4 IRON-SULFUR CLUSTER
BIOSYNTHESIS PROTEIN
ISCU
(Thermus
thermophilus) 		5 / 12 GLY A  40
LEU A 119
VAL A 116
CYH A 125
ILE A  66
 None
None
None
ZN  A 139 (-2.3A)
None
 1.21A 6bxmA-2qq4A:
undetectable		 6bxmA-2qq4A:
17.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6EXI_A_ADNA503_1
(ADENOSYLHOMOCYSTEINA
SE)		 2qq4 IRON-SULFUR CLUSTER
BIOSYNTHESIS PROTEIN
ISCU
(Thermus
thermophilus) 		3 / 3 LEU A  25
GLN A  27
LYS A  79
 None
 0.91A 6exiB-2qq4A:
undetectable		 6exiB-2qq4A:
25.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6EXI_B_ADNB503_0
(ADENOSYLHOMOCYSTEINA
SE)		 2qq4 IRON-SULFUR CLUSTER
BIOSYNTHESIS PROTEIN
ISCU
(Thermus
thermophilus) 		3 / 3 LEU A  25
GLN A  27
LYS A  79
 None
 0.96A 6exiA-2qq4A:
undetectable		 6exiA-2qq4A:
25.42