SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2qq5'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1JHQ_A_NIOA991_1
(NICOTINATE
MONONUCLEOTIDE:5,6-D
IMETHYLBENZIMIDAZOLE
PHOSPHORIBOSYLTRANSF
ERASE)		 2qq5 DEHYDROGENASE/REDUCT
ASE SDR FAMILY
MEMBER 1
(Homo
sapiens) 		4 / 8 GLY A  14
GLY A 126
SER A  65
GLY A 123
 None
 0.76A 1jhqA-2qq5A:
2.3		 1jhqA-2qq5A:
21.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1JHV_A_NIOA991_1
(NICOTINATE
MONONUCLEOTIDE:5,6-D
IMETHYLBENZIMIDAZOLE
PHOSPHORIBOSYLTRANSF
ERASE)		 2qq5 DEHYDROGENASE/REDUCT
ASE SDR FAMILY
MEMBER 1
(Homo
sapiens) 		4 / 8 GLY A  14
GLY A 126
SER A  65
GLY A 123
 None
 0.76A 1jhvA-2qq5A:
2.3		 1jhvA-2qq5A:
21.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MZ9_A_VDYA1002_4
(CARTILAGE OLIGOMERIC
MATRIX PROTEIN)		 2qq5 DEHYDROGENASE/REDUCT
ASE SDR FAMILY
MEMBER 1
(Homo
sapiens) 		4 / 5 LEU A  86
CYH A 188
ALA A 174
CYH A 177
 None
 1.09A 1mz9D-2qq5A:
undetectable		 1mz9D-2qq5A:
11.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RS7_A_ACTA860_0
(NITRIC-OXIDE
SYNTHASE, BRAIN)		 2qq5 DEHYDROGENASE/REDUCT
ASE SDR FAMILY
MEMBER 1
(Homo
sapiens) 		4 / 5 GLY A  22
ILE A  23
VAL A 196
SER A 232
 None
 0.97A 1rs7A-2qq5A:
undetectable		 1rs7A-2qq5A:
20.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RS7_B_ACTB861_0
(NITRIC-OXIDE
SYNTHASE, BRAIN)		 2qq5 DEHYDROGENASE/REDUCT
ASE SDR FAMILY
MEMBER 1
(Homo
sapiens) 		4 / 6 GLY A  22
ILE A  23
VAL A 196
SER A 232
 None
 1.04A 1rs7B-2qq5A:
undetectable		 1rs7B-2qq5A:
20.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ZQ9_A_SAMA4000_0
(PROBABLE
DIMETHYLADENOSINE
TRANSFERASE)		 2qq5 DEHYDROGENASE/REDUCT
ASE SDR FAMILY
MEMBER 1
(Homo
sapiens) 		5 / 12 HIS A 184
GLY A 144
LEU A 137
ASP A  79
PRO A 140
 None
 0.95A 1zq9A-2qq5A:
5.5		 1zq9A-2qq5A:
19.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ZQ9_B_SAMB4001_0
(PROBABLE
DIMETHYLADENOSINE
TRANSFERASE)		 2qq5 DEHYDROGENASE/REDUCT
ASE SDR FAMILY
MEMBER 1
(Homo
sapiens) 		5 / 12 HIS A 184
GLY A 144
LEU A 137
ASP A  79
PRO A 140
 None
 0.96A 1zq9B-2qq5A:
5.2		 1zq9B-2qq5A:
19.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4EAH_A_ACTA1002_0
(ACTIN, ALPHA
SKELETAL MUSCLE
FORMIN-LIKE PROTEIN
3)		 2qq5 DEHYDROGENASE/REDUCT
ASE SDR FAMILY
MEMBER 1
(Homo
sapiens) 		4 / 5 ARG A  21
GLN A  26
GLU A 230
THR A 229
 None
 1.24A 4eahA-2qq5A:
0.0
4eahE-2qq5A:
0.0
4eahG-2qq5A:
3.0		 4eahA-2qq5A:
20.10
4eahE-2qq5A:
20.10
4eahG-2qq5A:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4EAH_C_ACTC1002_0
(ACTIN, ALPHA
SKELETAL MUSCLE
FORMIN-LIKE PROTEIN
3)		 2qq5 DEHYDROGENASE/REDUCT
ASE SDR FAMILY
MEMBER 1
(Homo
sapiens) 		4 / 4 ARG A  21
GLN A  26
GLU A 230
THR A 229
 None
 1.24A 4eahC-2qq5A:
1.4
4eahH-2qq5A:
3.0		 4eahC-2qq5A:
20.10
4eahH-2qq5A:
20.00