SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2qq8'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RMT_D_ADND1504_1
(CLASS B ACID
PHOSPHATASE)		 2qq8 TBC1 DOMAIN FAMILY
MEMBER 14
(Homo
sapiens) 		4 / 8 ASP A 565
LEU A 562
THR A 628
TYR A 567
 None
 0.89A 1rmtD-2qq8A:
undetectable		 1rmtD-2qq8A:
21.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1XZ1_A_HLTA2001_1
(FERRITIN LIGHT CHAIN)		 2qq8 TBC1 DOMAIN FAMILY
MEMBER 14
(Homo
sapiens) 		4 / 4 LEU A 575
SER A 577
TYR A 576
LEU A 600
 None
 1.22A 1xz1A-2qq8A:
undetectable		 1xz1A-2qq8A:
21.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2RIW_A_T44A1395_1
(THYROXINE-BINDING
GLOBULIN)		 2qq8 TBC1 DOMAIN FAMILY
MEMBER 14
(Homo
sapiens) 		5 / 10 ALA A 641
LEU A 580
LEU A 634
LEU A 610
LYS A 609
 None
None
None
UNX  A 202 ( 4.2A)
None
 1.14A 2riwA-2qq8A:
undetectable
2riwB-2qq8A:
undetectable		 2riwA-2qq8A:
22.11
2riwB-2qq8A:
7.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XN5_A_FUNA1356_1
(THYROXINE-BINDING
GLOBULIN)		 2qq8 TBC1 DOMAIN FAMILY
MEMBER 14
(Homo
sapiens) 		5 / 11 ALA A 641
LEU A 580
LEU A 634
LEU A 610
LYS A 609
 None
None
None
UNX  A 202 ( 4.2A)
None
 1.06A 2xn5A-2qq8A:
undetectable		 2xn5A-2qq8A:
21.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XN6_A_T44A1370_1
(THYROXINE-BINDING
GLOBULIN)		 2qq8 TBC1 DOMAIN FAMILY
MEMBER 14
(Homo
sapiens) 		5 / 10 ALA A 641
LEU A 580
LEU A 634
LEU A 610
LYS A 609
 None
None
None
UNX  A 202 ( 4.2A)
None
 1.06A 2xn6A-2qq8A:
undetectable
2xn6B-2qq8A:
undetectable		 2xn6A-2qq8A:
21.69
2xn6B-2qq8A:
7.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4G0V_D_MIXD101_1
(DNA TOPOISOMERASE
2-BETA)		 2qq8 TBC1 DOMAIN FAMILY
MEMBER 14
(Homo
sapiens) 		4 / 6 ARG A 392
GLY A 393
ASN A 363
MET A 474
 None
 1.24A 4g0vB-2qq8A:
undetectable		 4g0vB-2qq8A:
17.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4HB6_A_DXCA75_0
(PPCA)		 2qq8 TBC1 DOMAIN FAMILY
MEMBER 14
(Homo
sapiens) 		4 / 8 LEU A 519
ILE A 572
PHE A 573
GLY A 494
 None
 0.85A 4hb6A-2qq8A:
undetectable		 4hb6A-2qq8A:
12.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HNZ_B_TA1B902_2
(TUBULIN BETA-2B
CHAIN)		 2qq8 TBC1 DOMAIN FAMILY
MEMBER 14
(Homo
sapiens) 		3 / 3 LEU A 398
LEU A 367
ARG A 587
 None
 0.50A 5hnzB-2qq8A:
undetectable		 5hnzB-2qq8A:
20.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IL1_A_SAMA601_0
(METTL3)		 2qq8 TBC1 DOMAIN FAMILY
MEMBER 14
(Homo
sapiens) 		5 / 12 ILE A 464
LEU A 504
SER A 477
PHE A 465
GLY A 469
 None
 1.34A 5il1A-2qq8A:
undetectable		 5il1A-2qq8A:
19.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5M24_A_9CRA501_1
(RETINOIC ACID
RECEPTOR GAMMA)		 2qq8 TBC1 DOMAIN FAMILY
MEMBER 14
(Homo
sapiens) 		5 / 12 ALA A 514
LEU A 506
ILE A 503
LEU A 575
ILE A 400
 None
UNX  A 201 ( 4.0A)
None
None
None
 0.99A 5m24A-2qq8A:
undetectable		 5m24A-2qq8A:
22.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5TOA_A_ESTA601_1
(ESTROGEN RECEPTOR
BETA)		 2qq8 TBC1 DOMAIN FAMILY
MEMBER 14
(Homo
sapiens) 		5 / 12 LEU A 605
ALA A 604
LEU A 568
LEU A 562
LEU A 630
 None
 1.02A 5toaA-2qq8A:
undetectable		 5toaA-2qq8A:
21.37