SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2qqh'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1IGJ_B_DGXB228_1
(IGG2A-KAPPA 26-10
FAB (LIGHT CHAIN)
IGG2A-KAPPA 26-10
FAB (HEAVY CHAIN))		 2qqh COMPLEMENT COMPONENT
C8 ALPHA CHAIN
(Homo
sapiens) 		5 / 10 TYR A 311
THR A 441
TYR A 142
ASN A 181
TYR A 180
 None
 1.25A 1igjA-2qqhA:
0.0
1igjB-2qqhA:
0.0		 1igjA-2qqhA:
19.22
1igjB-2qqhA:
18.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RX3_A_MTXA161_2
(DIHYDROFOLATE
REDUCTASE)		 2qqh COMPLEMENT COMPONENT
C8 ALPHA CHAIN
(Homo
sapiens) 		3 / 3 LYS A 413
ILE A 320
THR A 268
 None
 0.85A 1rx3A-2qqhA:
undetectable		 1rx3A-2qqhA:
17.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UOB_A_PNNA1311_1
(DEACETOXYCEPHALOSPOR
IN C SYNTHETASE)		 2qqh COMPLEMENT COMPONENT
C8 ALPHA CHAIN
(Homo
sapiens) 		3 / 3 ARG A 454
ARG A 450
ILE A 434
 None
 0.79A 1uobA-2qqhA:
undetectable		 1uobA-2qqhA:
20.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OA1_B_ADNB2005_1
(TRYPTOPHAN
HALOGENASE)		 2qqh COMPLEMENT COMPONENT
C8 ALPHA CHAIN
(Homo
sapiens) 		4 / 7 GLY A 319
GLY A 318
ASP A 428
VAL A 235
 None
 0.78A 2oa1B-2qqhA:
undetectable		 2oa1B-2qqhA:
20.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ETE_B_H3PB552_1
(GLUTAMATE
DEHYDROGENASE)		 2qqh COMPLEMENT COMPONENT
C8 ALPHA CHAIN
(Homo
sapiens) 		3 / 3 TYR A 422
TYR A 185
ILE A 116
 None
 0.84A 3eteA-2qqhA:
undetectable
3eteB-2qqhA:
undetectable		 3eteA-2qqhA:
21.31
3eteB-2qqhA:
21.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3IB2_A_IBPA3960_1
(LACTOTRANSFERRIN)		 2qqh COMPLEMENT COMPONENT
C8 ALPHA CHAIN
(Homo
sapiens) 		4 / 4 GLY A 234
VAL A 220
GLY A 194
THR A 193
 None
 0.86A 3ib2A-2qqhA:
undetectable		 3ib2A-2qqhA:
20.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4GH8_A_MTXA201_2
(DIHYDROFOLATE
REDUCTASE)		 2qqh COMPLEMENT COMPONENT
C8 ALPHA CHAIN
(Homo
sapiens) 		3 / 3 LYS A 413
ILE A 320
THR A 268
 None
 0.87A 4gh8A-2qqhA:
undetectable		 4gh8A-2qqhA:
17.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4OJ4_A_DIFA501_1
(PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR GAMMA)		 2qqh COMPLEMENT COMPONENT
C8 ALPHA CHAIN
(Homo
sapiens) 		4 / 8 SER A 287
LEU A 438
VAL A 437
ILE A 434
 None
 0.91A 4oj4A-2qqhA:
undetectable		 4oj4A-2qqhA:
20.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4PTH_A_FOLA201_1
(DIHYDROFOLATE
REDUCTASE)		 2qqh COMPLEMENT COMPONENT
C8 ALPHA CHAIN
(Homo
sapiens) 		3 / 3 ASP A 242
LEU A 246
PHE A 245
 None
 0.74A 4pthA-2qqhA:
undetectable		 4pthA-2qqhA:
16.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Y1D_D_DVAD5_0
(CYCLIC HEXAPEPTIDE
CYC[NDPOPPKID]
INTEGRASE)		 2qqh COMPLEMENT COMPONENT
C8 ALPHA CHAIN
(Homo
sapiens) 		3 / 3 GLU A 248
LYS A 251
ASN A 247
 None
 1.09A 4y1dA-2qqhA:
undetectable
4y1dD-2qqhA:
undetectable		 4y1dA-2qqhA:
19.52
4y1dD-2qqhA:
2.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5LAK_I_BEZI1_0
(3CL PROTEASE
BEZ-TYR-TYR-ASN-ECC
PEPTIDE INHIBITOR)		 2qqh COMPLEMENT COMPONENT
C8 ALPHA CHAIN
(Homo
sapiens) 		3 / 3 SER A 141
TYR A 142
TYR A 143
 None
 0.90A 5lakA-2qqhA:
undetectable
5lakI-2qqhA:
undetectable		 5lakA-2qqhA:
20.55
5lakI-2qqhA:
7.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5LAK_J_BEZJ1_0
(3CL PROTEASE
BEZ-TYR-TYR-ASN-ECC
PEPTIDE INHIBITOR)		 2qqh COMPLEMENT COMPONENT
C8 ALPHA CHAIN
(Homo
sapiens) 		3 / 3 SER A 141
TYR A 142
TYR A 143
 None
 0.84A 5lakC-2qqhA:
undetectable
5lakJ-2qqhA:
undetectable		 5lakC-2qqhA:
20.55
5lakJ-2qqhA:
7.69