SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2qqk'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1BDW_B_DVAB6_0
(GRAMICIDIN A)		 2qqk NEUROPILIN-2
(Homo
sapiens) 		3 / 3 TRP A 578
ALA A 519
VAL A 521
 None
 0.85A 1bdwA-2qqkA:
undetectable
1bdwB-2qqkA:
undetectable		 1bdwA-2qqkA:
4.44
1bdwB-2qqkA:
4.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1WRL_C_TFPC208_1
(TROPONIN C, SLOW
SKELETAL AND CARDIAC
MUSCLES)		 2qqk NEUROPILIN-2
(Homo
sapiens) 		4 / 5 PHE A 191
LEU A 245
PHE A 260
SER A 150
 None
 1.22A 1wrlC-2qqkA:
undetectable		 1wrlC-2qqkA:
8.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BXM_A_IMNA2001_1
(SERUM ALBUMIN)		 2qqk NEUROPILIN-2
(Homo
sapiens) 		4 / 8 SER A 461
ALA A 465
ALA A 506
ARG A 507
 None
 0.94A 2bxmA-2qqkA:
undetectable		 2bxmA-2qqkA:
20.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2NNK_A_ROCA401_2
(PROTEASE)		 2qqk NEUROPILIN-2
(Homo
sapiens) 		3 / 3 ARG A 518
VAL A 468
THR A 367
 None
 0.87A 2nnkA-2qqkA:
undetectable		 2nnkA-2qqkA:
11.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BJW_G_SVRG506_3
(PHOSPHOLIPASE A2)		 2qqk NEUROPILIN-2
(Homo
sapiens) 		3 / 3 PRO A 546
PHE A 563
LYS A 547
 None
 1.23A 3bjwG-2qqkA:
undetectable		 3bjwG-2qqkA:
14.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3HAV_A_SRYA403_1
(AMINOGLYCOSIDE
PHOSPHOTRANSFERASE)		 2qqk NEUROPILIN-2
(Homo
sapiens) 		4 / 8 ASP A  92
SER A 115
ASP A  99
TRP A 212
 None
 1.27A 3havA-2qqkA:
undetectable		 3havA-2qqkA:
18.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3HCP_B_CHDB4_0
(FERROCHELATASE,
MITOCHONDRIAL)		 2qqk NEUROPILIN-2
(Homo
sapiens) 		3 / 3 GLY A 227
PRO A 235
LEU A 213
 None
 0.57A 3hcpB-2qqkA:
undetectable		 3hcpB-2qqkA:
19.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3K4V_B_ROCB201_2
(HIV-1 PROTEASE)		 2qqk NEUROPILIN-2
(Homo
sapiens) 		3 / 3 ARG A 518
VAL A 468
THR A 367
 None
 0.79A 3k4vA-2qqkA:
undetectable		 3k4vA-2qqkA:
11.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3K4V_D_ROCD201_4
(HIV-1 PROTEASE)		 2qqk NEUROPILIN-2
(Homo
sapiens) 		3 / 3 ARG A 518
VAL A 468
THR A 367
 None
 0.82A 3k4vD-2qqkA:
undetectable		 3k4vD-2qqkA:
11.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NDT_A_ROCA101_2
(PROTEASE)		 2qqk NEUROPILIN-2
(Homo
sapiens) 		3 / 3 ARG A 518
VAL A 468
THR A 367
 None
 0.81A 3ndtA-2qqkA:
undetectable		 3ndtA-2qqkA:
11.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NDU_D_ROCD100_3
(PROTEASE)		 2qqk NEUROPILIN-2
(Homo
sapiens) 		3 / 3 ARG A 518
VAL A 468
THR A 367
 None
 0.86A 3nduD-2qqkA:
undetectable		 3nduD-2qqkA:
11.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3T3C_A_017A201_2
(HIV-1 PROTEASE)		 2qqk NEUROPILIN-2
(Homo
sapiens) 		5 / 10 ASP A 491
VAL A 490
ILE A 445
GLY A 443
ALA A 465
 None
 1.05A 3t3cB-2qqkA:
undetectable		 3t3cB-2qqkA:
10.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TL9_A_ROCA401_2
(PROTEASE)		 2qqk NEUROPILIN-2
(Homo
sapiens) 		3 / 3 ARG A 518
VAL A 468
THR A 367
 None
 0.85A 3tl9A-2qqkA:
undetectable		 3tl9A-2qqkA:
11.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4GC9_A_ACTA402_0
(DIMETHYLADENOSINE
TRANSFERASE 1,
MITOCHONDRIAL)		 2qqk NEUROPILIN-2
(Homo
sapiens) 		3 / 3 LYS A 517
TYR A 555
ARG A 518
 None
 1.38A 4gc9A-2qqkA:
undetectable		 4gc9A-2qqkA:
20.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LRH_F_FOLF301_1
(FOLATE RECEPTOR
ALPHA)		 2qqk NEUROPILIN-2
(Homo
sapiens) 		3 / 3 ASP A  99
TRP A 212
SER A 116
 None
 1.10A 4lrhF-2qqkA:
undetectable		 4lrhF-2qqkA:
16.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4N9U_A_RISA404_1
(FARNESYL
PYROPHOSPHATE
SYNTHASE)		 2qqk NEUROPILIN-2
(Homo
sapiens) 		5 / 10 ASP A 301
THR A 298
THR A 305
GLN A 308
ASP A 315
 None
 1.40A 4n9uA-2qqkA:
undetectable		 4n9uA-2qqkA:
18.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4YB6_A_HISA302_0
(ATP
PHOSPHORIBOSYLTRANSF
ERASE)		 2qqk NEUROPILIN-2
(Homo
sapiens) 		5 / 10 GLY A 500
GLU A 588
VAL A 498
LEU A 587
LEU A 492
 None
 1.28A 4yb6A-2qqkA:
undetectable
4yb6E-2qqkA:
undetectable		 4yb6A-2qqkA:
20.92
4yb6E-2qqkA:
20.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4YB6_B_HISB302_0
(ATP
PHOSPHORIBOSYLTRANSF
ERASE)		 2qqk NEUROPILIN-2
(Homo
sapiens) 		5 / 10 GLY A 500
GLU A 588
VAL A 498
LEU A 587
LEU A 492
 None
 1.28A 4yb6B-2qqkA:
undetectable
4yb6C-2qqkA:
undetectable		 4yb6B-2qqkA:
20.92
4yb6C-2qqkA:
20.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4YB6_C_HISC302_0
(ATP
PHOSPHORIBOSYLTRANSF
ERASE)		 2qqk NEUROPILIN-2
(Homo
sapiens) 		5 / 10 GLY A 500
GLU A 588
VAL A 498
LEU A 587
LEU A 492
 None
 1.29A 4yb6C-2qqkA:
undetectable
4yb6F-2qqkA:
undetectable		 4yb6C-2qqkA:
20.92
4yb6F-2qqkA:
20.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4YB6_D_HISD302_0
(ATP
PHOSPHORIBOSYLTRANSF
ERASE)		 2qqk NEUROPILIN-2
(Homo
sapiens) 		5 / 10 LEU A 587
LEU A 492
GLY A 500
GLU A 588
VAL A 498
 None
 1.27A 4yb6A-2qqkA:
undetectable
4yb6D-2qqkA:
undetectable		 4yb6A-2qqkA:
20.92
4yb6D-2qqkA:
20.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4YB6_E_HISE302_0
(ATP
PHOSPHORIBOSYLTRANSF
ERASE)		 2qqk NEUROPILIN-2
(Homo
sapiens) 		5 / 10 LEU A 587
LEU A 492
GLY A 500
GLU A 588
VAL A 498
 None
 1.29A 4yb6D-2qqkA:
undetectable
4yb6E-2qqkA:
undetectable		 4yb6D-2qqkA:
20.92
4yb6E-2qqkA:
20.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4YB6_F_HISF302_0
(ATP
PHOSPHORIBOSYLTRANSF
ERASE)		 2qqk NEUROPILIN-2
(Homo
sapiens) 		5 / 10 LEU A 587
LEU A 492
GLY A 500
GLU A 588
VAL A 498
 None
 1.30A 4yb6B-2qqkA:
undetectable
4yb6F-2qqkA:
undetectable		 4yb6B-2qqkA:
20.92
4yb6F-2qqkA:
20.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5FLC_C_RAPC999_1
(SERINE/THREONINE-PRO
TEIN KINASE MTOR
FKBP)		 2qqk NEUROPILIN-2
(Homo
sapiens) 		4 / 8 GLY A 346
THR A 305
TRP A 318
TYR A 299
 None
 0.92A 5flcB-2qqkA:
undetectable		 5flcB-2qqkA:
17.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5FLC_G_RAPG999_1
(SERINE/THREONINE-PRO
TEIN KINASE MTOR
FKBP)		 2qqk NEUROPILIN-2
(Homo
sapiens) 		4 / 8 GLY A 346
THR A 305
TRP A 318
TYR A 299
 None
 0.91A 5flcF-2qqkA:
undetectable		 5flcF-2qqkA:
17.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5YW0_A_ACTA411_0
(UNCHARACTERIZED
PROTEIN KDOO)		 2qqk NEUROPILIN-2
(Homo
sapiens) 		3 / 3 LYS A 103
LEU A 100
ARG A  91
 None
 0.90A 5yw0A-2qqkA:
undetectable		 5yw0A-2qqkA:
21.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5YW0_A_ACTA412_0
(UNCHARACTERIZED
PROTEIN KDOO)		 2qqk NEUROPILIN-2
(Homo
sapiens) 		3 / 3 LYS A  67
ASN A  65
SER A 146
 None
 1.00A 5yw0A-2qqkA:
undetectable		 5yw0A-2qqkA:
21.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6BKL_G_EU7G101_0
(MATRIX PROTEIN 2)		 2qqk NEUROPILIN-2
(Homo
sapiens) 		5 / 9 ALA A 390
ALA A 419
GLY A 346
GLY A 317
SER A 349
 None
 1.12A 6bklE-2qqkA:
undetectable
6bklF-2qqkA:
undetectable
6bklG-2qqkA:
undetectable
6bklH-2qqkA:
undetectable		 6bklE-2qqkA:
3.36
6bklF-2qqkA:
3.36
6bklG-2qqkA:
3.36
6bklH-2qqkA:
3.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6EW0_F_TA1F502_2
(TUBULIN BETA CHAIN)		 2qqk NEUROPILIN-2
(Homo
sapiens) 		4 / 5 LEU A 441
LEU A 590
THR A 337
PRO A 271
 None
 0.95A 6ew0F-2qqkA:
undetectable		 6ew0F-2qqkA:
10.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6EW0_G_TA1G501_2
(TUBULIN BETA CHAIN)		 2qqk NEUROPILIN-2
(Homo
sapiens) 		4 / 6 LEU A 441
LEU A 590
THR A 337
PRO A 271
 None
 0.95A 6ew0G-2qqkA:
undetectable		 6ew0G-2qqkA:
10.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6F5U_A_CQNA610_1
(ENVELOPE
GLYCOPROTEIN,ENVELOP
E GLYCOPROTEIN,GP1
ENVELOPE
GLYCOPROTEIN)		 2qqk NEUROPILIN-2
(Homo
sapiens) 		5 / 10 VAL A 407
LEU A 339
LEU A 398
LEU A 422
LEU A 424
 None
 0.82A 6f5uA-2qqkA:
undetectable
6f5uB-2qqkA:
undetectable		 6f5uA-2qqkA:
10.04
6f5uB-2qqkA:
11.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6G9B_A_IXXA609_1
(ENVELOPE
GLYCOPROTEIN,ENVELOP
E GLYCOPROTEIN
ENVELOPE
GLYCOPROTEIN)		 2qqk NEUROPILIN-2
(Homo
sapiens) 		4 / 7 VAL A 407
LEU A 339
LEU A 398
LEU A 422
 None
 0.70A 6g9bA-2qqkA:
undetectable
6g9bB-2qqkA:
undetectable		 6g9bA-2qqkA:
10.04
6g9bB-2qqkA:
11.85