SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2qqm'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1WRL_C_TFPC208_1
(TROPONIN C, SLOW
SKELETAL AND CARDIAC
MUSCLES)		 2qqm NEUROPILIN-1
(Homo
sapiens) 		4 / 5 PHE A 189
LEU A 243
PHE A 258
SER A 148
 None
 1.21A 1wrlC-2qqmA:
undetectable		 1wrlC-2qqmA:
12.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ITZ_A_IREA2021_2
(EPIDERMAL GROWTH
FACTOR RECEPTOR)		 2qqm NEUROPILIN-1
(Homo
sapiens) 		3 / 3 LEU A 441
LEU A 464
MET A 578
 None
 0.86A 2itzA-2qqmA:
undetectable		 2itzA-2qqmA:
21.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2WEY_B_EV1B1771_1
(CAMP AND
CAMP-INHIBITED CGMP
3', 5'-CYCLIC
PHOSPHODIESTERASE)		 2qqm NEUROPILIN-1
(Homo
sapiens) 		4 / 8 LEU A 551
VAL A 495
ILE A 517
PHE A 515
 None
 0.98A 2weyB-2qqmA:
undetectable		 2weyB-2qqmA:
19.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Y7P_A_SALA1000_1
(LYSR-TYPE REGULATORY
PROTEIN)		 2qqm NEUROPILIN-1
(Homo
sapiens) 		5 / 10 GLY A 436
GLY A 241
PHE A 217
PRO A 222
ILE A 242
 None
None
NAG  A 613 ( 4.7A)
None
None
 1.37A 2y7pA-2qqmA:
undetectable		 2y7pA-2qqmA:
18.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3B9L_A_AZZA1009_1
(SERUM ALBUMIN)		 2qqm NEUROPILIN-1
(Homo
sapiens) 		4 / 8 TYR A 480
GLU A 483
SER A 450
VAL A 510
 None
 1.13A 3b9lA-2qqmA:
undetectable		 3b9lA-2qqmA:
20.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TEG_A_DAHA416_1
(PHENYLALANYL-TRNA
SYNTHETASE,
MITOCHONDRIAL)		 2qqm NEUROPILIN-1
(Homo
sapiens) 		5 / 12 GLU A 579
THR A 466
GLY A 440
GLY A 221
GLY A 436
 None
 0.96A 3tegA-2qqmA:
undetectable		 3tegA-2qqmA:
21.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3W9T_D_W9TD507_1
(HEMOLYTIC LECTIN
CEL-III)		 2qqm NEUROPILIN-1
(Homo
sapiens) 		4 / 5 ASP A 428
GLU A 277
GLY A 423
TYR A 429
 EDO  A 607 (-2.7A)
None
None
None
 1.33A 3w9tD-2qqmA:
undetectable		 3w9tD-2qqmA:
19.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4EJG_C_NCTC501_1
(CYTOCHROME P450 2A13)		 2qqm NEUROPILIN-1
(Homo
sapiens) 		4 / 7 PHE A 258
PHE A 192
PHE A 189
LEU A 187
 None
 0.76A 4ejgC-2qqmA:
undetectable		 4ejgC-2qqmA:
22.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MX0_A_BCZA513_1
(NEURAMINIDASE)		 2qqm NEUROPILIN-1
(Homo
sapiens) 		3 / 3 ARG A 334
ASP A 428
ARG A 237
 EDO  A 605 (-4.1A)
EDO  A 607 (-2.7A)
EDO  A 605 ( 3.4A)
 0.87A 4mx0A-2qqmA:
undetectable		 4mx0A-2qqmA:
22.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4V2Z_C_Y70C151_1
(CEREBLON ISOFORM 4)		 2qqm NEUROPILIN-1
(Homo
sapiens) 		4 / 8 PHE A 561
TRP A 526
TRP A 484
TYR A 565
 None
 1.14A 4v2zC-2qqmA:
undetectable		 4v2zC-2qqmA:
14.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HM8_A_ADNA501_2
(ADENOSYLHOMOCYSTEINA
SE)		 2qqm NEUROPILIN-1
(Homo
sapiens) 		4 / 5 GLU A 586
GLU A 492
THR A 559
LEU A 435
 None
 1.23A 5hm8A-2qqmA:
undetectable		 5hm8A-2qqmA:
21.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HM8_B_ADNB501_2
(ADENOSYLHOMOCYSTEINA
SE)		 2qqm NEUROPILIN-1
(Homo
sapiens) 		4 / 5 GLU A 586
GLU A 492
THR A 559
LEU A 435
 None
 1.23A 5hm8B-2qqmA:
undetectable		 5hm8B-2qqmA:
21.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HM8_C_ADNC501_2
(ADENOSYLHOMOCYSTEINA
SE)		 2qqm NEUROPILIN-1
(Homo
sapiens) 		4 / 5 GLU A 586
GLU A 492
THR A 559
LEU A 435
 None
 1.23A 5hm8C-2qqmA:
undetectable		 5hm8C-2qqmA:
21.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HM8_D_ADND501_2
(ADENOSYLHOMOCYSTEINA
SE)		 2qqm NEUROPILIN-1
(Homo
sapiens) 		4 / 5 GLU A 586
GLU A 492
THR A 559
LEU A 435
 None
 1.23A 5hm8D-2qqmA:
undetectable		 5hm8D-2qqmA:
21.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HM8_E_ADNE501_2
(ADENOSYLHOMOCYSTEINA
SE)		 2qqm NEUROPILIN-1
(Homo
sapiens) 		4 / 5 GLU A 586
GLU A 492
THR A 559
LEU A 435
 None
 1.23A 5hm8E-2qqmA:
undetectable		 5hm8E-2qqmA:
21.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HM8_F_ADNF501_2
(ADENOSYLHOMOCYSTEINA
SE)		 2qqm NEUROPILIN-1
(Homo
sapiens) 		4 / 5 GLU A 586
GLU A 492
THR A 559
LEU A 435
 None
 1.23A 5hm8F-2qqmA:
undetectable		 5hm8F-2qqmA:
21.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HM8_H_ADNH501_2
(ADENOSYLHOMOCYSTEINA
SE)		 2qqm NEUROPILIN-1
(Homo
sapiens) 		4 / 5 GLU A 586
GLU A 492
THR A 559
LEU A 435
 None
 1.22A 5hm8H-2qqmA:
undetectable		 5hm8H-2qqmA:
21.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VOO_C_C2FC702_0
(5-METHYLTETRAHYDROFO
LATE HOMOCYSTEINE
S-METHYLTRANSFERASE)		 2qqm NEUROPILIN-1
(Homo
sapiens) 		5 / 12 GLY A 502
LYS A 509
LEU A 580
SER A 467
ILE A 462
 None
 1.18A 5vooC-2qqmA:
undetectable		 5vooC-2qqmA:
19.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6A94_A_ZOTA3001_0
(5-HYDROXYTRYPTAMINE
RECEPTOR 2A,SOLUBLE
CYTOCHROME B562)		 2qqm NEUROPILIN-1
(Homo
sapiens) 		5 / 12 SER A 244
LEU A 441
GLY A 241
SER A 238
VAL A 220
 None
 1.42A 6a94A-2qqmA:
undetectable		 6a94A-2qqmA:
21.70