SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2qqo'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1BDW_B_DVAB6_0
(GRAMICIDIN A)		 2qqo NEUROPILIN-2
(Homo
sapiens) 		3 / 3 TRP A 578
ALA A 519
VAL A 521
 None
 0.99A 1bdwA-2qqoA:
undetectable
1bdwB-2qqoA:
undetectable		 1bdwA-2qqoA:
4.44
1bdwB-2qqoA:
4.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1D1V_B_H4BB701_1
(BOVINE ENDOTHELIAL
NITRIC OXIDE
SYNTHASE HEME)		 2qqo NEUROPILIN-2
(Homo
sapiens) 		4 / 6 TRP A 372
PHE A 406
GLU A 370
ARG A 405
 None
 1.49A 1d1vA-2qqoA:
0.4
1d1vB-2qqoA:
0.3		 1d1vA-2qqoA:
23.53
1d1vB-2qqoA:
23.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1D1W_B_H4BB601_1
(NITRIC OXIDE
SYNTHASE)		 2qqo NEUROPILIN-2
(Homo
sapiens) 		4 / 6 TRP A 372
PHE A 406
GLU A 370
ARG A 405
 None
 1.49A 1d1wA-2qqoA:
0.5
1d1wB-2qqoA:
0.3		 1d1wA-2qqoA:
23.53
1d1wB-2qqoA:
23.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1DM8_B_H4BB2600_1
(NITRIC OXIDE
SYNTHASE)		 2qqo NEUROPILIN-2
(Homo
sapiens) 		4 / 6 TRP A 372
PHE A 406
GLU A 370
ARG A 405
 None
 1.48A 1dm8A-2qqoA:
0.5
1dm8B-2qqoA:
0.0		 1dm8A-2qqoA:
23.53
1dm8B-2qqoA:
23.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1FOP_B_H4BB2600_1
(NITRIC-OXIDE
SYNTHASE)		 2qqo NEUROPILIN-2
(Homo
sapiens) 		4 / 6 TRP A 372
PHE A 406
GLU A 370
ARG A 405
 None
 1.47A 1fopA-2qqoA:
0.0
1fopB-2qqoA:
0.7		 1fopA-2qqoA:
23.53
1fopB-2qqoA:
23.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MMW_B_H4BB2760_1
(NITRIC-OXIDE
SYNTHASE, BRAIN)		 2qqo NEUROPILIN-2
(Homo
sapiens) 		4 / 7 TRP A 372
PHE A 406
GLU A 370
ARG A 405
 None
 1.49A 1mmwA-2qqoA:
undetectable
1mmwB-2qqoA:
undetectable		 1mmwA-2qqoA:
21.88
1mmwB-2qqoA:
21.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1NSE_A_H4BA600_1
(NITRIC OXIDE
SYNTHASE)		 2qqo NEUROPILIN-2
(Homo
sapiens) 		4 / 6 ARG A 405
TRP A 372
PHE A 406
GLU A 370
 None
 1.47A 1nseA-2qqoA:
0.5
1nseB-2qqoA:
0.0		 1nseA-2qqoA:
23.53
1nseB-2qqoA:
23.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1P6L_B_H4BB761_1
(NITRIC-OXIDE
SYNTHASE,
ENDOTHELIAL)		 2qqo NEUROPILIN-2
(Homo
sapiens) 		4 / 6 TRP A 372
PHE A 406
GLU A 370
ARG A 405
 None
 1.46A 1p6lA-2qqoA:
0.1
1p6lB-2qqoA:
0.4		 1p6lA-2qqoA:
22.41
1p6lB-2qqoA:
22.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1P6M_B_H4BB761_1
(NITRIC-OXIDE
SYNTHASE,
ENDOTHELIAL)		 2qqo NEUROPILIN-2
(Homo
sapiens) 		4 / 6 TRP A 372
PHE A 406
GLU A 370
ARG A 405
 None
 1.48A 1p6mA-2qqoA:
0.5
1p6mB-2qqoA:
0.2		 1p6mA-2qqoA:
22.41
1p6mB-2qqoA:
22.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1P6N_B_H4BB761_1
(NITRIC-OXIDE
SYNTHASE,
ENDOTHELIAL)		 2qqo NEUROPILIN-2
(Homo
sapiens) 		4 / 6 TRP A 372
PHE A 406
GLU A 370
ARG A 405
 None
 1.47A 1p6nA-2qqoA:
0.2
1p6nB-2qqoA:
0.0		 1p6nA-2qqoA:
22.41
1p6nB-2qqoA:
22.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1Q2O_B_H4BB761_1
(NITRIC-OXIDE
SYNTHASE,
ENDOTHELIAL)		 2qqo NEUROPILIN-2
(Homo
sapiens) 		4 / 6 TRP A 372
PHE A 406
GLU A 370
ARG A 405
 None
 1.48A 1q2oA-2qqoA:
0.1
1q2oB-2qqoA:
0.4		 1q2oA-2qqoA:
22.45
1q2oB-2qqoA:
22.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RS8_B_H4BB761_1
(NITRIC-OXIDE
SYNTHASE,
ENDOTHELIAL)		 2qqo NEUROPILIN-2
(Homo
sapiens) 		4 / 6 TRP A 372
PHE A 406
GLU A 370
ARG A 405
 None
 1.46A 1rs8A-2qqoA:
0.4
1rs8B-2qqoA:
0.4		 1rs8A-2qqoA:
22.45
1rs8B-2qqoA:
22.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RS9_A_H4BA760_1
(NITRIC-OXIDE
SYNTHASE,
ENDOTHELIAL)		 2qqo NEUROPILIN-2
(Homo
sapiens) 		4 / 6 ARG A 405
TRP A 372
PHE A 406
GLU A 370
 None
 1.45A 1rs9A-2qqoA:
0.1
1rs9B-2qqoA:
0.2		 1rs9A-2qqoA:
22.45
1rs9B-2qqoA:
22.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RS9_B_H4BB761_1
(NITRIC-OXIDE
SYNTHASE,
ENDOTHELIAL)		 2qqo NEUROPILIN-2
(Homo
sapiens) 		4 / 6 TRP A 372
PHE A 406
GLU A 370
ARG A 405
 None
 1.45A 1rs9A-2qqoA:
0.1
1rs9B-2qqoA:
0.2		 1rs9A-2qqoA:
22.45
1rs9B-2qqoA:
22.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1YAJ_B_BEZB12_0
(CES1 PROTEIN)		 2qqo NEUROPILIN-2
(Homo
sapiens) 		4 / 4 GLY A 218
SER A 246
VAL A 222
LEU A 444
 None
 1.12A 1yajB-2qqoA:
undetectable		 1yajB-2qqoA:
22.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ZZS_B_H4BB761_1
(NITRIC-OXIDE
SYNTHASE,
ENDOTHELIAL)		 2qqo NEUROPILIN-2
(Homo
sapiens) 		4 / 6 TRP A 372
PHE A 406
GLU A 370
ARG A 405
 None
 1.46A 1zzsA-2qqoA:
0.5
1zzsB-2qqoA:
0.7		 1zzsA-2qqoA:
22.45
1zzsB-2qqoA:
22.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ZZT_A_H4BA760_1
(NITRIC-OXIDE
SYNTHASE,
ENDOTHELIAL)		 2qqo NEUROPILIN-2
(Homo
sapiens) 		4 / 6 ARG A 405
TRP A 372
PHE A 406
GLU A 370
 None
 1.46A 1zztA-2qqoA:
0.0
1zztB-2qqoA:
0.0		 1zztA-2qqoA:
22.45
1zztB-2qqoA:
22.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ZZT_B_H4BB761_1
(NITRIC-OXIDE
SYNTHASE,
ENDOTHELIAL)		 2qqo NEUROPILIN-2
(Homo
sapiens) 		4 / 6 TRP A 372
PHE A 406
GLU A 370
ARG A 405
 None
 1.46A 1zztA-2qqoA:
0.0
1zztB-2qqoA:
0.0		 1zztA-2qqoA:
22.45
1zztB-2qqoA:
22.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2EIK_W_CHDW1060_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE
VIIA-HEART
CYTOCHROME C OXIDASE
SUBUNIT 1)		 2qqo NEUROPILIN-2
(Homo
sapiens) 		4 / 8 ILE A 566
PHE A 563
ARG A 572
LEU A 492
 None
 0.93A 2eikN-2qqoA:
undetectable
2eikW-2qqoA:
undetectable		 2eikN-2qqoA:
20.44
2eikW-2qqoA:
8.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2EIL_W_CHDW1060_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE
VIIA-HEART
CYTOCHROME C OXIDASE
SUBUNIT 1)		 2qqo NEUROPILIN-2
(Homo
sapiens) 		4 / 8 ILE A 566
PHE A 563
ARG A 572
LEU A 492
 None
 0.90A 2eilN-2qqoA:
undetectable
2eilW-2qqoA:
undetectable		 2eilN-2qqoA:
20.44
2eilW-2qqoA:
8.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2HX2_A_H4BA760_1
(NITRIC-OXIDE
SYNTHASE)		 2qqo NEUROPILIN-2
(Homo
sapiens) 		4 / 6 ARG A 405
TRP A 372
PHE A 406
GLU A 370
 None
 1.48A 2hx2A-2qqoA:
0.2
2hx2B-2qqoA:
0.1		 2hx2A-2qqoA:
22.45
2hx2B-2qqoA:
22.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2HX2_B_H4BB760_1
(NITRIC-OXIDE
SYNTHASE)		 2qqo NEUROPILIN-2
(Homo
sapiens) 		4 / 6 TRP A 372
PHE A 406
GLU A 370
ARG A 405
 None
 1.47A 2hx2A-2qqoA:
0.2
2hx2B-2qqoA:
0.1		 2hx2A-2qqoA:
22.45
2hx2B-2qqoA:
22.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2NSE_B_H4BB600_1
(NITRIC OXIDE
SYNTHASE)		 2qqo NEUROPILIN-2
(Homo
sapiens) 		4 / 5 TRP A 372
PHE A 406
GLU A 370
ARG A 405
 None
 1.49A 2nseA-2qqoA:
0.0
2nseB-2qqoA:
0.0		 2nseA-2qqoA:
23.53
2nseB-2qqoA:
23.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3AG3_W_CHDW1059_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE 7A1
CYTOCHROME C OXIDASE
SUBUNIT 1)		 2qqo NEUROPILIN-2
(Homo
sapiens) 		4 / 8 ILE A 566
PHE A 563
ARG A 572
LEU A 492
 None
 0.91A 3ag3N-2qqoA:
undetectable
3ag3W-2qqoA:
undetectable		 3ag3N-2qqoA:
20.44
3ag3W-2qqoA:
8.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ASO_W_CHDW1059_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 7A1)		 2qqo NEUROPILIN-2
(Homo
sapiens) 		4 / 8 ILE A 566
PHE A 563
ARG A 572
LEU A 492
 None
 0.92A 3asoN-2qqoA:
undetectable
3asoW-2qqoA:
undetectable		 3asoN-2qqoA:
20.44
3asoW-2qqoA:
8.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BJW_G_SVRG506_3
(PHOSPHOLIPASE A2)		 2qqo NEUROPILIN-2
(Homo
sapiens) 		3 / 3 PRO A 546
PHE A 563
LYS A 547
 None
 1.20A 3bjwG-2qqoA:
undetectable		 3bjwG-2qqoA:
13.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3GYQ_B_SAMB270_0
(RRNA
(ADENOSINE-2'-O-)-ME
THYLTRANSFERASE)		 2qqo NEUROPILIN-2
(Homo
sapiens) 		5 / 11 LEU A 467
ALA A 465
GLY A 439
SER A 463
SER A 469
 None
 0.92A 3gyqB-2qqoA:
undetectable		 3gyqB-2qqoA:
21.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3JWY_A_H4BA600_1
(NITRIC OXIDE
SYNTHASE,
ENDOTHELIAL)		 2qqo NEUROPILIN-2
(Homo
sapiens) 		4 / 6 ARG A 405
TRP A 372
PHE A 406
GLU A 370
 None
 1.48A 3jwyA-2qqoA:
0.0
3jwyB-2qqoA:
0.4		 3jwyA-2qqoA:
23.53
3jwyB-2qqoA:
23.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3JWZ_A_H4BA600_1
(NITRIC OXIDE
SYNTHASE,
ENDOTHELIAL)		 2qqo NEUROPILIN-2
(Homo
sapiens) 		4 / 6 ARG A 405
TRP A 372
PHE A 406
GLU A 370
 None
 1.47A 3jwzA-2qqoA:
0.1
3jwzB-2qqoA:
0.9		 3jwzA-2qqoA:
23.53
3jwzB-2qqoA:
23.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3JWZ_B_H4BB600_1
(NITRIC OXIDE
SYNTHASE,
ENDOTHELIAL)		 2qqo NEUROPILIN-2
(Homo
sapiens) 		4 / 6 TRP A 372
PHE A 406
GLU A 370
ARG A 405
 None
 1.48A 3jwzA-2qqoA:
0.1
3jwzB-2qqoA:
0.9		 3jwzA-2qqoA:
23.53
3jwzB-2qqoA:
23.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3N5R_A_H4BA600_1
(NITRIC OXIDE
SYNTHASE)		 2qqo NEUROPILIN-2
(Homo
sapiens) 		4 / 6 ARG A 405
TRP A 372
PHE A 406
GLU A 370
 None
 1.46A 3n5rA-2qqoA:
0.1
3n5rB-2qqoA:
0.4		 3n5rA-2qqoA:
23.53
3n5rB-2qqoA:
23.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3N5R_B_H4BB600_1
(NITRIC OXIDE
SYNTHASE)		 2qqo NEUROPILIN-2
(Homo
sapiens) 		4 / 6 TRP A 372
PHE A 406
GLU A 370
ARG A 405
 None
 1.47A 3n5rA-2qqoA:
0.1
3n5rB-2qqoA:
0.4		 3n5rA-2qqoA:
23.53
3n5rB-2qqoA:
23.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3N5S_B_H4BB600_1
(NITRIC OXIDE
SYNTHASE)		 2qqo NEUROPILIN-2
(Homo
sapiens) 		4 / 6 TRP A 372
PHE A 406
GLU A 370
ARG A 405
 None
 1.45A 3n5sA-2qqoA:
0.5
3n5sB-2qqoA:
0.8		 3n5sA-2qqoA:
23.53
3n5sB-2qqoA:
23.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3N5T_A_H4BA600_1
(NITRIC OXIDE
SYNTHASE)		 2qqo NEUROPILIN-2
(Homo
sapiens) 		4 / 7 ARG A 405
TRP A 372
PHE A 406
GLU A 370
 None
 1.44A 3n5tA-2qqoA:
undetectable
3n5tB-2qqoA:
undetectable		 3n5tA-2qqoA:
23.53
3n5tB-2qqoA:
23.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3N5T_B_H4BB600_1
(NITRIC OXIDE
SYNTHASE)		 2qqo NEUROPILIN-2
(Homo
sapiens) 		4 / 6 TRP A 372
PHE A 406
GLU A 370
ARG A 405
 None
 1.41A 3n5tA-2qqoA:
0.6
3n5tB-2qqoA:
0.6		 3n5tA-2qqoA:
23.53
3n5tB-2qqoA:
23.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3N67_B_H4BB600_1
(NITRIC OXIDE
SYNTHASE)		 2qqo NEUROPILIN-2
(Homo
sapiens) 		4 / 5 TRP A 372
PHE A 406
GLU A 370
ARG A 405
 None
 1.48A 3n67A-2qqoA:
0.1
3n67B-2qqoA:
0.2		 3n67A-2qqoA:
23.53
3n67B-2qqoA:
23.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3N68_A_H4BA600_1
(NITRIC OXIDE
SYNTHASE)		 2qqo NEUROPILIN-2
(Homo
sapiens) 		4 / 6 ARG A 405
TRP A 372
PHE A 406
GLU A 370
 None
 1.43A 3n68A-2qqoA:
0.4
3n68B-2qqoA:
0.8		 3n68A-2qqoA:
23.53
3n68B-2qqoA:
23.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3N6A_B_H4BB600_1
(NITRIC OXIDE
SYNTHASE)		 2qqo NEUROPILIN-2
(Homo
sapiens) 		4 / 6 TRP A 372
PHE A 406
GLU A 370
ARG A 405
 None
 1.42A 3n6aA-2qqoA:
0.5
3n6aB-2qqoA:
1.3		 3n6aA-2qqoA:
23.53
3n6aB-2qqoA:
23.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3N6E_B_H4BB600_1
(NITRIC OXIDE
SYNTHASE)		 2qqo NEUROPILIN-2
(Homo
sapiens) 		4 / 6 TRP A 372
PHE A 406
GLU A 370
ARG A 405
 None
 1.46A 3n6eA-2qqoA:
0.5
3n6eB-2qqoA:
0.5		 3n6eA-2qqoA:
23.53
3n6eB-2qqoA:
23.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NLG_A_H4BA600_1
(NITRIC OXIDE
SYNTHASE,
ENDOTHELIAL)		 2qqo NEUROPILIN-2
(Homo
sapiens) 		4 / 6 ARG A 405
TRP A 372
PHE A 406
GLU A 370
 None
 1.49A 3nlgA-2qqoA:
0.1
3nlgB-2qqoA:
0.5		 3nlgA-2qqoA:
23.53
3nlgB-2qqoA:
23.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NLG_B_H4BB600_1
(NITRIC OXIDE
SYNTHASE,
ENDOTHELIAL)		 2qqo NEUROPILIN-2
(Homo
sapiens) 		4 / 6 TRP A 372
PHE A 406
GLU A 370
ARG A 405
 None
 1.46A 3nlgA-2qqoA:
0.1
3nlgB-2qqoA:
0.5		 3nlgA-2qqoA:
23.53
3nlgB-2qqoA:
23.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NLT_B_H4BB600_1
(NITRIC OXIDE
SYNTHASE,
ENDOTHELIAL)		 2qqo NEUROPILIN-2
(Homo
sapiens) 		4 / 5 TRP A 372
PHE A 406
GLU A 370
ARG A 405
 None
 1.48A 3nltA-2qqoA:
0.3
3nltB-2qqoA:
0.6		 3nltA-2qqoA:
23.53
3nltB-2qqoA:
23.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NOS_A_H4BA511_1
(ENDOTHELIAL
NITRIC-OXIDE
SYNTHASE)		 2qqo NEUROPILIN-2
(Homo
sapiens) 		4 / 6 ARG A 405
TRP A 372
PHE A 406
GLU A 370
 None
 1.47A 3nosA-2qqoA:
0.0
3nosB-2qqoA:
0.4		 3nosA-2qqoA:
21.34
3nosB-2qqoA:
21.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3RQO_B_H4BB600_1
(NITRIC OXIDE
SYNTHASE,
ENDOTHELIAL)		 2qqo NEUROPILIN-2
(Homo
sapiens) 		4 / 6 TRP A 372
PHE A 406
GLU A 370
ARG A 405
 None
 1.46A 3rqoA-2qqoA:
0.3
3rqoB-2qqoA:
0.0		 3rqoA-2qqoA:
23.53
3rqoB-2qqoA:
23.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4C3A_A_H4BA600_1
(NITRIC OXIDE
SYNTHASE,
ENDOTHELIAL)		 2qqo NEUROPILIN-2
(Homo
sapiens) 		4 / 6 ARG A 405
TRP A 372
PHE A 406
GLU A 370
 None
 1.48A 4c3aA-2qqoA:
0.1
4c3aB-2qqoA:
0.6		 4c3aA-2qqoA:
23.53
4c3aB-2qqoA:
23.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4C3A_B_H4BB600_1
(NITRIC OXIDE
SYNTHASE,
ENDOTHELIAL)		 2qqo NEUROPILIN-2
(Homo
sapiens) 		4 / 6 TRP A 372
PHE A 406
GLU A 370
ARG A 405
 None
 1.48A 4c3aA-2qqoA:
0.1
4c3aB-2qqoA:
0.6		 4c3aA-2qqoA:
23.53
4c3aB-2qqoA:
23.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4CAR_A_H4BA600_1
(NITRIC OXIDE
SYNTHASE,
ENDOTHELIAL)		 2qqo NEUROPILIN-2
(Homo
sapiens) 		4 / 6 ARG A 405
TRP A 372
PHE A 406
GLU A 370
 None
 1.50A 4carA-2qqoA:
0.1
4carB-2qqoA:
0.0		 4carA-2qqoA:
23.53
4carB-2qqoA:
23.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4CAR_B_H4BB600_1
(NITRIC OXIDE
SYNTHASE,
ENDOTHELIAL)		 2qqo NEUROPILIN-2
(Homo
sapiens) 		4 / 6 TRP A 372
PHE A 406
GLU A 370
ARG A 405
 None
 1.50A 4carA-2qqoA:
0.1
4carB-2qqoA:
0.0		 4carA-2qqoA:
23.53
4carB-2qqoA:
23.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4CFT_A_H4BA600_1
(ENDOTHELIAL NITRIC
OXIDE SYNTHASE)		 2qqo NEUROPILIN-2
(Homo
sapiens) 		4 / 6 ARG A 405
TRP A 372
PHE A 406
GLU A 370
 None
 1.49A 4cftA-2qqoA:
0.1
4cftB-2qqoA:
0.9		 4cftA-2qqoA:
23.53
4cftB-2qqoA:
23.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4CTY_A_H4BA600_1
(NITRIC OXIDE
SYNTHASE,
ENDOTHELIAL)		 2qqo NEUROPILIN-2
(Homo
sapiens) 		4 / 6 ARG A 405
TRP A 372
PHE A 406
GLU A 370
 None
 1.50A 4ctyA-2qqoA:
0.4
4ctyB-2qqoA:
0.9		 4ctyA-2qqoA:
23.53
4ctyB-2qqoA:
23.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4CU0_A_H4BA600_1
(NITRIC OXIDE
SYNTHASE,
ENDOTHELIAL)		 2qqo NEUROPILIN-2
(Homo
sapiens) 		4 / 6 ARG A 405
TRP A 372
PHE A 406
GLU A 370
 None
 1.48A 4cu0A-2qqoA:
0.5
4cu0B-2qqoA:
1.0		 4cu0A-2qqoA:
23.53
4cu0B-2qqoA:
23.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4CU0_B_H4BB600_1
(NITRIC OXIDE
SYNTHASE,
ENDOTHELIAL)		 2qqo NEUROPILIN-2
(Homo
sapiens) 		4 / 6 TRP A 372
PHE A 406
GLU A 370
ARG A 405
 None
 1.49A 4cu0A-2qqoA:
0.5
4cu0B-2qqoA:
1.0		 4cu0A-2qqoA:
23.53
4cu0B-2qqoA:
23.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4CU1_A_H4BA600_1
(NITRIC OXIDE
SYNTHASE,
ENDOTHELIAL)		 2qqo NEUROPILIN-2
(Homo
sapiens) 		4 / 6 ARG A 405
TRP A 372
PHE A 406
GLU A 370
 None
 1.47A 4cu1A-2qqoA:
0.1
4cu1B-2qqoA:
0.0		 4cu1A-2qqoA:
23.53
4cu1B-2qqoA:
23.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4CU1_B_H4BB600_1
(NITRIC OXIDE
SYNTHASE,
ENDOTHELIAL)		 2qqo NEUROPILIN-2
(Homo
sapiens) 		4 / 6 TRP A 372
PHE A 406
GLU A 370
ARG A 405
 None
 1.45A 4cu1A-2qqoA:
0.2
4cu1B-2qqoA:
0.0		 4cu1A-2qqoA:
23.53
4cu1B-2qqoA:
23.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4CWV_A_H4BA600_1
(NITRIC OXIDE
SYNTHASE,
ENDOTHELIAL)		 2qqo NEUROPILIN-2
(Homo
sapiens) 		4 / 6 ARG A 405
TRP A 372
PHE A 406
GLU A 370
 None
 1.49A 4cwvA-2qqoA:
0.4
4cwvB-2qqoA:
1.3		 4cwvA-2qqoA:
23.53
4cwvB-2qqoA:
23.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4CWV_B_H4BB600_1
(NITRIC OXIDE
SYNTHASE,
ENDOTHELIAL)		 2qqo NEUROPILIN-2
(Homo
sapiens) 		4 / 6 TRP A 372
PHE A 406
GLU A 370
ARG A 405
 None
 1.47A 4cwvA-2qqoA:
0.4
4cwvB-2qqoA:
1.3		 4cwvA-2qqoA:
23.53
4cwvB-2qqoA:
23.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4CWW_A_H4BA600_1
(NITRIC OXIDE
SYNTHASE,
ENDOTHELIAL)		 2qqo NEUROPILIN-2
(Homo
sapiens) 		4 / 6 ARG A 405
TRP A 372
PHE A 406
GLU A 370
 None
 1.46A 4cwwA-2qqoA:
0.4
4cwwB-2qqoA:
0.2		 4cwwA-2qqoA:
23.53
4cwwB-2qqoA:
23.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4CWW_B_H4BB600_1
(NITRIC OXIDE
SYNTHASE,
ENDOTHELIAL)		 2qqo NEUROPILIN-2
(Homo
sapiens) 		4 / 6 TRP A 372
PHE A 406
GLU A 370
ARG A 405
 None
 1.46A 4cwwA-2qqoA:
0.4
4cwwB-2qqoA:
0.2		 4cwwA-2qqoA:
23.53
4cwwB-2qqoA:
23.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4CWX_B_H4BB600_1
(NITRIC OXIDE
SYNTHASE,
ENDOTHELIAL)		 2qqo NEUROPILIN-2
(Homo
sapiens) 		4 / 7 TRP A 372
PHE A 406
GLU A 370
ARG A 405
 None
 1.47A 4cwxA-2qqoA:
undetectable
4cwxB-2qqoA:
1.1		 4cwxA-2qqoA:
23.53
4cwxB-2qqoA:
23.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4CWY_B_H4BB600_1
(NITRIC OXIDE
SYNTHASE,
ENDOTHELIAL)		 2qqo NEUROPILIN-2
(Homo
sapiens) 		4 / 7 TRP A 372
PHE A 406
GLU A 370
ARG A 405
 None
 1.48A 4cwyA-2qqoA:
undetectable
4cwyB-2qqoA:
1.1		 4cwyA-2qqoA:
23.53
4cwyB-2qqoA:
23.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4CWZ_A_H4BA600_1
(NITRIC OXIDE
SYNTHASE,
ENDOTHELIAL)		 2qqo NEUROPILIN-2
(Homo
sapiens) 		4 / 6 ARG A 405
TRP A 372
PHE A 406
GLU A 370
 None
 1.49A 4cwzA-2qqoA:
0.5
4cwzB-2qqoA:
0.7		 4cwzA-2qqoA:
23.53
4cwzB-2qqoA:
23.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4D1O_A_H4BA1481_1
(NITRIC OXIDE
SYNTHASE,
ENDOTHELIAL)		 2qqo NEUROPILIN-2
(Homo
sapiens) 		4 / 6 ARG A 405
TRP A 372
PHE A 406
GLU A 370
 None
 1.48A 4d1oA-2qqoA:
0.1
4d1oB-2qqoA:
0.2		 4d1oA-2qqoA:
22.95
4d1oB-2qqoA:
22.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4D1O_B_H4BB1481_1
(NITRIC OXIDE
SYNTHASE,
ENDOTHELIAL)		 2qqo NEUROPILIN-2
(Homo
sapiens) 		4 / 6 TRP A 372
PHE A 406
GLU A 370
ARG A 405
 None
 1.49A 4d1oA-2qqoA:
0.1
4d1oB-2qqoA:
0.3		 4d1oA-2qqoA:
22.95
4d1oB-2qqoA:
22.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4D1P_A_H4BA600_1
(NITRIC OXIDE
SYNTHASE,
ENDOTHELIAL)		 2qqo NEUROPILIN-2
(Homo
sapiens) 		4 / 5 ARG A 405
TRP A 372
PHE A 406
GLU A 370
 None
 1.48A 4d1pA-2qqoA:
0.1
4d1pB-2qqoA:
0.5		 4d1pA-2qqoA:
22.95
4d1pB-2qqoA:
22.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4D1P_B_H4BB600_1
(NITRIC OXIDE
SYNTHASE,
ENDOTHELIAL)		 2qqo NEUROPILIN-2
(Homo
sapiens) 		4 / 6 TRP A 372
PHE A 406
GLU A 370
ARG A 405
 None
 1.50A 4d1pA-2qqoA:
0.0
4d1pB-2qqoA:
0.6		 4d1pA-2qqoA:
22.95
4d1pB-2qqoA:
22.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4D33_A_H4BA600_1
(NITRIC OXIDE
SYNTHASE,
ENDOTHELIAL)		 2qqo NEUROPILIN-2
(Homo
sapiens) 		4 / 6 ARG A 405
TRP A 372
PHE A 406
GLU A 370
 None
 1.49A 4d33A-2qqoA:
0.0
4d33B-2qqoA:
0.0		 4d33A-2qqoA:
23.53
4d33B-2qqoA:
23.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4D33_B_H4BB600_1
(NITRIC OXIDE
SYNTHASE,
ENDOTHELIAL)		 2qqo NEUROPILIN-2
(Homo
sapiens) 		4 / 6 TRP A 372
PHE A 406
GLU A 370
ARG A 405
 None
 1.46A 4d33A-2qqoA:
0.0
4d33B-2qqoA:
0.0		 4d33A-2qqoA:
23.53
4d33B-2qqoA:
23.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4D34_B_H4BB600_1
(NITRIC OXIDE
SYNTHASE,
ENDOTHELIAL)		 2qqo NEUROPILIN-2
(Homo
sapiens) 		4 / 6 TRP A 372
PHE A 406
GLU A 370
ARG A 405
 None
 1.49A 4d34A-2qqoA:
0.6
4d34B-2qqoA:
0.8		 4d34A-2qqoA:
23.53
4d34B-2qqoA:
23.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4D35_B_H4BB600_1
(NITRIC OXIDE
SYNTHASE,
ENDOTHELIAL)		 2qqo NEUROPILIN-2
(Homo
sapiens) 		4 / 6 TRP A 372
PHE A 406
GLU A 370
ARG A 405
 None
 1.48A 4d35A-2qqoA:
0.2
4d35B-2qqoA:
1.6		 4d35A-2qqoA:
23.53
4d35B-2qqoA:
23.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4D37_A_H4BA600_1
(NITRIC OXIDE
SYNTHASE,
ENDOTHELIAL)		 2qqo NEUROPILIN-2
(Homo
sapiens) 		4 / 6 ARG A 405
TRP A 372
PHE A 406
GLU A 370
 None
 1.47A 4d37A-2qqoA:
0.0
4d37B-2qqoA:
0.3		 4d37A-2qqoA:
23.53
4d37B-2qqoA:
23.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4D39_B_H4BB600_1
(NITRIC OXIDE
SYNTHASE,
ENDOTHELIAL)		 2qqo NEUROPILIN-2
(Homo
sapiens) 		4 / 6 TRP A 372
PHE A 406
GLU A 370
ARG A 405
 None
 1.49A 4d39A-2qqoA:
0.2
4d39B-2qqoA:
0.1		 4d39A-2qqoA:
23.53
4d39B-2qqoA:
23.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4EJG_C_NCTC501_1
(CYTOCHROME P450 2A13)		 2qqo NEUROPILIN-2
(Homo
sapiens) 		4 / 7 PHE A 194
PHE A 191
LEU A 245
LEU A 189
 None
 0.86A 4ejgC-2qqoA:
undetectable		 4ejgC-2qqoA:
20.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4EJG_C_NCTC501_1
(CYTOCHROME P450 2A13)		 2qqo NEUROPILIN-2
(Homo
sapiens) 		4 / 7 PHE A 260
PHE A 194
PHE A 191
LEU A 189
 None
 0.82A 4ejgC-2qqoA:
undetectable		 4ejgC-2qqoA:
20.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FGZ_A_CQAA301_0
(PHOSPHOETHANOLAMINE
N-METHYLTRANSFERASE)		 2qqo NEUROPILIN-2
(Homo
sapiens) 		4 / 8 GLY A 443
GLU A 588
LEU A 492
VAL A 490
 None
 0.93A 4fgzA-2qqoA:
undetectable		 4fgzA-2qqoA:
18.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4IMX_A_H4BA502_1
(SUBUNIT A)		 2qqo NEUROPILIN-2
(Homo
sapiens) 		4 / 6 ARG A 405
TRP A 372
PHE A 406
GLU A 370
 None
 1.48A 4imxA-2qqoA:
0.1
4imxB-2qqoA:
0.1		 4imxA-2qqoA:
23.53
4imxB-2qqoA:
23.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4JSM_A_H4BA502_1
(NITRIC OXIDE
SYNTHASE,
ENDOTHELIAL)		 2qqo NEUROPILIN-2
(Homo
sapiens) 		4 / 6 ARG A 405
TRP A 372
PHE A 406
GLU A 370
 None
 1.46A 4jsmA-2qqoA:
0.6
4jsmB-2qqoA:
0.0		 4jsmA-2qqoA:
23.53
4jsmB-2qqoA:
23.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4JSM_B_H4BB502_1
(NITRIC OXIDE
SYNTHASE,
ENDOTHELIAL)		 2qqo NEUROPILIN-2
(Homo
sapiens) 		4 / 6 TRP A 372
PHE A 406
GLU A 370
ARG A 405
 None
 1.49A 4jsmA-2qqoA:
0.6
4jsmB-2qqoA:
0.0		 4jsmA-2qqoA:
23.53
4jsmB-2qqoA:
23.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4K5H_B_H4BB502_1
(NITRIC OXIDE
SYNTHASE,
ENDOTHELIAL)		 2qqo NEUROPILIN-2
(Homo
sapiens) 		4 / 6 TRP A 372
PHE A 406
GLU A 370
ARG A 405
 None
 1.46A 4k5hA-2qqoA:
0.6
4k5hB-2qqoA:
1.2		 4k5hA-2qqoA:
23.53
4k5hB-2qqoA:
23.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4K5I_A_H4BA502_1
(NITRIC OXIDE
SYNTHASE,
ENDOTHELIAL)		 2qqo NEUROPILIN-2
(Homo
sapiens) 		4 / 6 ARG A 405
TRP A 372
PHE A 406
GLU A 370
 None
 1.49A 4k5iA-2qqoA:
0.0
4k5iB-2qqoA:
0.2		 4k5iA-2qqoA:
23.53
4k5iB-2qqoA:
23.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4K5I_B_H4BB502_1
(NITRIC OXIDE
SYNTHASE,
ENDOTHELIAL)		 2qqo NEUROPILIN-2
(Homo
sapiens) 		4 / 6 TRP A 372
PHE A 406
GLU A 370
ARG A 405
 None
 1.46A 4k5iA-2qqoA:
0.0
4k5iB-2qqoA:
0.2		 4k5iA-2qqoA:
23.53
4k5iB-2qqoA:
23.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4K5J_A_H4BA502_1
(NITRIC OXIDE
SYNTHASE,
ENDOTHELIAL)		 2qqo NEUROPILIN-2
(Homo
sapiens) 		4 / 6 ARG A 405
TRP A 372
PHE A 406
GLU A 370
 None
 1.49A 4k5jA-2qqoA:
0.5
4k5jB-2qqoA:
0.2		 4k5jA-2qqoA:
23.53
4k5jB-2qqoA:
23.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4K5J_B_H4BB502_1
(NITRIC OXIDE
SYNTHASE,
ENDOTHELIAL)		 2qqo NEUROPILIN-2
(Homo
sapiens) 		4 / 7 TRP A 372
PHE A 406
GLU A 370
ARG A 405
 None
 1.47A 4k5jA-2qqoA:
undetectable
4k5jB-2qqoA:
undetectable		 4k5jA-2qqoA:
23.53
4k5jB-2qqoA:
23.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4K5K_A_H4BA502_1
(NITRIC OXIDE
SYNTHASE,
ENDOTHELIAL)		 2qqo NEUROPILIN-2
(Homo
sapiens) 		4 / 6 ARG A 405
TRP A 372
PHE A 406
GLU A 370
 None
 1.48A 4k5kA-2qqoA:
0.0
4k5kB-2qqoA:
0.0		 4k5kA-2qqoA:
23.53
4k5kB-2qqoA:
23.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KCP_B_H4BB502_1
(NITRIC OXIDE
SYNTHASE,
ENDOTHELIAL)		 2qqo NEUROPILIN-2
(Homo
sapiens) 		4 / 6 TRP A 372
PHE A 406
GLU A 370
ARG A 405
 None
 1.49A 4kcpA-2qqoA:
0.5
4kcpB-2qqoA:
0.0		 4kcpA-2qqoA:
23.53
4kcpB-2qqoA:
23.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KCQ_A_H4BA502_1
(NITRIC OXIDE
SYNTHASE,
ENDOTHELIAL)		 2qqo NEUROPILIN-2
(Homo
sapiens) 		4 / 6 ARG A 405
TRP A 372
PHE A 406
GLU A 370
 None
 1.46A 4kcqA-2qqoA:
0.1
4kcqB-2qqoA:
0.0		 4kcqA-2qqoA:
23.53
4kcqB-2qqoA:
23.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KCQ_B_H4BB502_1
(NITRIC OXIDE
SYNTHASE,
ENDOTHELIAL)		 2qqo NEUROPILIN-2
(Homo
sapiens) 		4 / 6 TRP A 372
PHE A 406
GLU A 370
ARG A 405
 None
 1.48A 4kcqA-2qqoA:
0.1
4kcqB-2qqoA:
0.0		 4kcqA-2qqoA:
23.53
4kcqB-2qqoA:
23.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KCR_A_H4BA502_1
(NITRIC OXIDE
SYNTHASE,
ENDOTHELIAL)		 2qqo NEUROPILIN-2
(Homo
sapiens) 		4 / 6 ARG A 405
TRP A 372
PHE A 406
GLU A 370
 None
 1.47A 4kcrA-2qqoA:
0.1
4kcrB-2qqoA:
0.0		 4kcrA-2qqoA:
23.53
4kcrB-2qqoA:
23.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KCR_B_H4BB502_1
(NITRIC OXIDE
SYNTHASE,
ENDOTHELIAL)		 2qqo NEUROPILIN-2
(Homo
sapiens) 		4 / 6 TRP A 372
PHE A 406
GLU A 370
ARG A 405
 None
 1.48A 4kcrA-2qqoA:
0.1
4kcrB-2qqoA:
0.0		 4kcrA-2qqoA:
23.53
4kcrB-2qqoA:
23.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KCS_A_H4BA502_1
(NITRIC OXIDE
SYNTHASE,
ENDOTHELIAL)		 2qqo NEUROPILIN-2
(Homo
sapiens) 		4 / 6 ARG A 405
TRP A 372
PHE A 406
GLU A 370
 None
 1.48A 4kcsA-2qqoA:
0.3
4kcsB-2qqoA:
0.0		 4kcsA-2qqoA:
23.53
4kcsB-2qqoA:
23.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LUW_A_H4BA502_1
(NITRIC OXIDE
SYNTHASE,
ENDOTHELIAL)		 2qqo NEUROPILIN-2
(Homo
sapiens) 		4 / 6 ARG A 405
TRP A 372
PHE A 406
GLU A 370
 None
 1.45A 4luwA-2qqoA:
0.4
4luwB-2qqoA:
0.0		 4luwA-2qqoA:
23.34
4luwB-2qqoA:
23.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4N9U_A_RISA404_1
(FARNESYL
PYROPHOSPHATE
SYNTHASE)		 2qqo NEUROPILIN-2
(Homo
sapiens) 		5 / 10 ASP A 301
THR A 298
THR A 305
GLN A 308
ASP A 315
 None
 1.44A 4n9uA-2qqoA:
undetectable		 4n9uA-2qqoA:
19.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4NOS_B_H4BB1011_1
(INDUCIBLE NITRIC
OXIDE SYNTHASE)		 2qqo NEUROPILIN-2
(Homo
sapiens) 		4 / 7 TRP A 372
PHE A 406
GLU A 370
ARG A 405
 None
 1.40A 4nosA-2qqoA:
undetectable
4nosB-2qqoA:
undetectable		 4nosA-2qqoA:
21.29
4nosB-2qqoA:
21.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4NOS_C_H4BC2011_1
(INDUCIBLE NITRIC
OXIDE SYNTHASE)		 2qqo NEUROPILIN-2
(Homo
sapiens) 		4 / 7 ARG A 405
TRP A 372
PHE A 406
GLU A 370
 None
 1.45A 4nosC-2qqoA:
undetectable
4nosD-2qqoA:
undetectable		 4nosC-2qqoA:
21.29
4nosD-2qqoA:
21.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4UHA_B_H4BB600_1
(NITRIC OXIDE
SYNTHASE,
ENDOTHELIAL)		 2qqo NEUROPILIN-2
(Homo
sapiens) 		4 / 6 TRP A 372
PHE A 406
GLU A 370
ARG A 405
 None
 1.49A 4uhaA-2qqoA:
0.5
4uhaB-2qqoA:
0.6		 4uhaA-2qqoA:
23.53
4uhaB-2qqoA:
23.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4UPQ_A_H4BA600_1
(NITRIC OXIDE
SYNTHASE,
ENDOTHELIAL)		 2qqo NEUROPILIN-2
(Homo
sapiens) 		4 / 6 ARG A 405
TRP A 372
PHE A 406
GLU A 370
 None
 1.44A 4upqA-2qqoA:
0.1
4upqB-2qqoA:
0.4		 4upqA-2qqoA:
23.53
4upqB-2qqoA:
23.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4UPQ_B_H4BB600_1
(NITRIC OXIDE
SYNTHASE,
ENDOTHELIAL)		 2qqo NEUROPILIN-2
(Homo
sapiens) 		4 / 6 TRP A 372
PHE A 406
GLU A 370
ARG A 405
 None
 1.46A 4upqA-2qqoA:
0.1
4upqB-2qqoA:
0.4		 4upqA-2qqoA:
23.53
4upqB-2qqoA:
23.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4YB6_A_HISA302_0
(ATP
PHOSPHORIBOSYLTRANSF
ERASE)		 2qqo NEUROPILIN-2
(Homo
sapiens) 		5 / 10 GLY A 500
GLU A 588
VAL A 498
LEU A 587
LEU A 492
 None
 1.28A 4yb6A-2qqoA:
undetectable
4yb6E-2qqoA:
undetectable		 4yb6A-2qqoA:
21.41
4yb6E-2qqoA:
21.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4YB6_B_HISB302_0
(ATP
PHOSPHORIBOSYLTRANSF
ERASE)		 2qqo NEUROPILIN-2
(Homo
sapiens) 		5 / 10 GLY A 500
GLU A 588
VAL A 498
LEU A 587
LEU A 492
 None
 1.28A 4yb6B-2qqoA:
undetectable
4yb6C-2qqoA:
undetectable		 4yb6B-2qqoA:
21.41
4yb6C-2qqoA:
21.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4YB6_C_HISC302_0
(ATP
PHOSPHORIBOSYLTRANSF
ERASE)		 2qqo NEUROPILIN-2
(Homo
sapiens) 		5 / 10 GLY A 500
GLU A 588
VAL A 498
LEU A 587
LEU A 492
 None
 1.28A 4yb6C-2qqoA:
undetectable
4yb6F-2qqoA:
undetectable		 4yb6C-2qqoA:
21.41
4yb6F-2qqoA:
21.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4YB6_D_HISD302_0
(ATP
PHOSPHORIBOSYLTRANSF
ERASE)		 2qqo NEUROPILIN-2
(Homo
sapiens) 		5 / 10 LEU A 587
LEU A 492
GLY A 500
GLU A 588
VAL A 498
 None
 1.26A 4yb6A-2qqoA:
undetectable
4yb6D-2qqoA:
undetectable		 4yb6A-2qqoA:
21.41
4yb6D-2qqoA:
21.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4YB6_E_HISE302_0
(ATP
PHOSPHORIBOSYLTRANSF
ERASE)		 2qqo NEUROPILIN-2
(Homo
sapiens) 		5 / 10 LEU A 587
LEU A 492
GLY A 500
GLU A 588
VAL A 498
 None
 1.29A 4yb6D-2qqoA:
undetectable
4yb6E-2qqoA:
undetectable		 4yb6D-2qqoA:
21.41
4yb6E-2qqoA:
21.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4YB6_F_HISF302_0
(ATP
PHOSPHORIBOSYLTRANSF
ERASE)		 2qqo NEUROPILIN-2
(Homo
sapiens) 		5 / 10 LEU A 587
LEU A 492
GLY A 500
GLU A 588
VAL A 498
 None
 1.30A 4yb6B-2qqoA:
undetectable
4yb6F-2qqoA:
undetectable		 4yb6B-2qqoA:
21.41
4yb6F-2qqoA:
21.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ADJ_B_H4BB600_1
(NITRIC OXIDE
SYNTHASE,
ENDOTHELIAL)		 2qqo NEUROPILIN-2
(Homo
sapiens) 		4 / 6 TRP A 372
PHE A 406
GLU A 370
ARG A 405
 None
 1.48A 5adjA-2qqoA:
0.1
5adjB-2qqoA:
0.5		 5adjA-2qqoA:
23.53
5adjB-2qqoA:
23.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ADK_B_H4BB600_1
(NITRIC OXIDE
SYNTHASE,
ENDOTHELIAL)		 2qqo NEUROPILIN-2
(Homo
sapiens) 		4 / 6 TRP A 372
PHE A 406
GLU A 370
ARG A 405
 None
 1.49A 5adkA-2qqoA:
0.4
5adkB-2qqoA:
0.2		 5adkA-2qqoA:
23.53
5adkB-2qqoA:
23.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ADM_B_H4BB600_1
(NITRIC OXIDE
SYNTHASE,
ENDOTHELIAL)		 2qqo NEUROPILIN-2
(Homo
sapiens) 		4 / 6 TRP A 372
PHE A 406
GLU A 370
ARG A 405
 None
 1.48A 5admA-2qqoA:
0.2
5admB-2qqoA:
0.7		 5admA-2qqoA:
23.53
5admB-2qqoA:
23.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ADN_B_H4BB600_1
(NITRIC OXIDE
SYNTHASE,
ENDOTHELIAL)		 2qqo NEUROPILIN-2
(Homo
sapiens) 		4 / 6 TRP A 372
PHE A 406
GLU A 370
ARG A 405
 None
 1.49A 5adnA-2qqoA:
0.8
5adnB-2qqoA:
0.0		 5adnA-2qqoA:
23.53
5adnB-2qqoA:
23.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5FJ2_B_H4BB600_1
(NITRIC OXIDE
SYNTHASE,
ENDOTHELIAL)		 2qqo NEUROPILIN-2
(Homo
sapiens) 		4 / 6 TRP A 372
PHE A 406
GLU A 370
ARG A 405
 None
 1.49A 5fj2A-2qqoA:
0.5
5fj2B-2qqoA:
0.0		 5fj2A-2qqoA:
23.53
5fj2B-2qqoA:
23.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5FJ3_B_H4BB600_1
(NITRIC OXIDE
SYNTHASE,
ENDOTHELIAL)		 2qqo NEUROPILIN-2
(Homo
sapiens) 		4 / 7 TRP A 372
PHE A 406
GLU A 370
ARG A 405
 None
 1.46A 5fj3A-2qqoA:
undetectable
5fj3B-2qqoA:
undetectable		 5fj3A-2qqoA:
23.53
5fj3B-2qqoA:
23.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5FLC_C_RAPC999_1
(SERINE/THREONINE-PRO
TEIN KINASE MTOR
FKBP)		 2qqo NEUROPILIN-2
(Homo
sapiens) 		4 / 8 GLY A 346
THR A 305
TRP A 318
TYR A 299
 None
None
None
TRS  A 602 ( 3.6A)
 0.94A 5flcB-2qqoA:
undetectable		 5flcB-2qqoA:
18.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5FLC_G_RAPG999_1
(SERINE/THREONINE-PRO
TEIN KINASE MTOR
FKBP)		 2qqo NEUROPILIN-2
(Homo
sapiens) 		4 / 8 GLY A 346
THR A 305
TRP A 318
TYR A 299
 None
None
None
TRS  A 602 ( 3.6A)
 0.94A 5flcF-2qqoA:
undetectable		 5flcF-2qqoA:
18.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5FVV_A_H4BA760_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 2qqo NEUROPILIN-2
(Homo
sapiens) 		4 / 7 ARG A 405
TRP A 372
PHE A 406
GLU A 370
 None
 1.46A 5fvvA-2qqoA:
undetectable
5fvvB-2qqoA:
undetectable		 5fvvA-2qqoA:
21.15
5fvvB-2qqoA:
21.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IY5_W_CHDW101_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 7A1,
MITOCHONDRIAL)		 2qqo NEUROPILIN-2
(Homo
sapiens) 		4 / 7 ILE A 566
PHE A 563
ARG A 572
LEU A 492
 None
 0.86A 5iy5N-2qqoA:
undetectable
5iy5W-2qqoA:
undetectable		 5iy5N-2qqoA:
20.44
5iy5W-2qqoA:
8.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UL4_A_SAMA803_0
(OXSB PROTEIN)		 2qqo NEUROPILIN-2
(Homo
sapiens) 		5 / 12 ALA A 581
GLY A 584
GLY A 505
ILE A 503
GLU A 550
 None
 1.00A 5ul4A-2qqoA:
undetectable		 5ul4A-2qqoA:
19.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UO8_A_H4BA502_1
(NITRIC OXIDE
SYNTHASE,
ENDOTHELIAL)		 2qqo NEUROPILIN-2
(Homo
sapiens) 		4 / 6 ARG A 405
TRP A 372
PHE A 406
GLU A 370
 None
 1.49A 5uo8A-2qqoA:
undetectable
5uo8B-2qqoA:
undetectable		 5uo8A-2qqoA:
22.95
5uo8B-2qqoA:
22.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UO9_A_H4BA502_1
(NITRIC OXIDE
SYNTHASE,
ENDOTHELIAL)		 2qqo NEUROPILIN-2
(Homo
sapiens) 		4 / 6 ARG A 405
TRP A 372
PHE A 406
GLU A 370
 None
 1.44A 5uo9A-2qqoA:
0.2
5uo9B-2qqoA:
0.5		 5uo9A-2qqoA:
22.95
5uo9B-2qqoA:
22.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UOD_A_H4BA502_1
(NITRIC OXIDE
SYNTHASE,
ENDOTHELIAL)		 2qqo NEUROPILIN-2
(Homo
sapiens) 		4 / 6 ARG A 405
TRP A 372
PHE A 406
GLU A 370
 None
 1.49A 5uodA-2qqoA:
0.1
5uodB-2qqoA:
0.1		 5uodA-2qqoA:
23.53
5uodB-2qqoA:
23.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UOD_B_H4BB502_1
(NITRIC OXIDE
SYNTHASE,
ENDOTHELIAL)		 2qqo NEUROPILIN-2
(Homo
sapiens) 		4 / 6 TRP A 372
PHE A 406
GLU A 370
ARG A 405
 None
 1.44A 5uodA-2qqoA:
0.1
5uodB-2qqoA:
0.1		 5uodA-2qqoA:
23.53
5uodB-2qqoA:
23.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VV6_B_H4BB502_1
(NITRIC OXIDE
SYNTHASE,
ENDOTHELIAL)		 2qqo NEUROPILIN-2
(Homo
sapiens) 		4 / 6 TRP A 372
PHE A 406
GLU A 370
ARG A 405
 None
 1.46A 5vv6A-2qqoA:
0.6
5vv6B-2qqoA:
0.1		 5vv6A-2qqoA:
23.53
5vv6B-2qqoA:
23.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VV8_B_H4BB502_1
(NITRIC OXIDE
SYNTHASE,
ENDOTHELIAL)		 2qqo NEUROPILIN-2
(Homo
sapiens) 		4 / 6 TRP A 372
PHE A 406
GLU A 370
ARG A 405
 None
 1.46A 5vv8A-2qqoA:
0.7
5vv8B-2qqoA:
0.0		 5vv8A-2qqoA:
23.53
5vv8B-2qqoA:
23.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VV9_B_H4BB502_1
(NITRIC OXIDE
SYNTHASE,
ENDOTHELIAL)		 2qqo NEUROPILIN-2
(Homo
sapiens) 		4 / 6 TRP A 372
PHE A 406
GLU A 370
ARG A 405
 None
 1.48A 5vv9A-2qqoA:
0.1
5vv9B-2qqoA:
0.8		 5vv9A-2qqoA:
23.53
5vv9B-2qqoA:
23.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VVA_A_H4BA502_1
(NITRIC OXIDE
SYNTHASE,
ENDOTHELIAL)		 2qqo NEUROPILIN-2
(Homo
sapiens) 		4 / 7 ARG A 405
TRP A 372
PHE A 406
GLU A 370
 None
 1.47A 5vvaA-2qqoA:
undetectable
5vvaB-2qqoA:
undetectable		 5vvaA-2qqoA:
23.53
5vvaB-2qqoA:
23.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VVA_B_H4BB502_1
(NITRIC OXIDE
SYNTHASE,
ENDOTHELIAL)		 2qqo NEUROPILIN-2
(Homo
sapiens) 		4 / 6 TRP A 372
PHE A 406
GLU A 370
ARG A 405
 None
 1.50A 5vvaA-2qqoA:
0.0
5vvaB-2qqoA:
0.1		 5vvaA-2qqoA:
23.53
5vvaB-2qqoA:
23.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VVB_C_H4BC502_1
(NITRIC OXIDE
SYNTHASE,
ENDOTHELIAL)		 2qqo NEUROPILIN-2
(Homo
sapiens) 		4 / 5 ARG A 405
TRP A 372
PHE A 406
GLU A 370
 None
 1.48A 5vvbC-2qqoA:
0.1
5vvbD-2qqoA:
0.6		 5vvbC-2qqoA:
22.95
5vvbD-2qqoA:
22.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6BKL_G_EU7G101_0
(MATRIX PROTEIN 2)		 2qqo NEUROPILIN-2
(Homo
sapiens) 		5 / 9 ALA A 390
ALA A 419
GLY A 346
GLY A 317
SER A 349
 None
TRS  A 602 ( 4.7A)
None
None
None
 1.12A 6bklE-2qqoA:
undetectable
6bklF-2qqoA:
undetectable
6bklG-2qqoA:
undetectable
6bklH-2qqoA:
undetectable		 6bklE-2qqoA:
4.25
6bklF-2qqoA:
4.25
6bklG-2qqoA:
4.25
6bklH-2qqoA:
4.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6CIE_B_H4BB502_0
(NITRIC OXIDE
SYNTHASE,
ENDOTHELIAL)		 2qqo NEUROPILIN-2
(Homo
sapiens) 		4 / 7 TRP A 372
PHE A 406
GLU A 370
ARG A 405
 None
 1.50A 6cieA-2qqoA:
undetectable
6cieB-2qqoA:
undetectable		 6cieA-2qqoA:
11.34
6cieB-2qqoA:
11.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6CIF_A_H4BA502_0
(NITRIC OXIDE
SYNTHASE,
ENDOTHELIAL)		 2qqo NEUROPILIN-2
(Homo
sapiens) 		4 / 6 ARG A 405
TRP A 372
PHE A 406
GLU A 370
 None
 1.48A 6cifA-2qqoA:
0.0
6cifB-2qqoA:
0.9		 6cifA-2qqoA:
11.34
6cifB-2qqoA:
11.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6CIF_D_H4BD502_0
(NITRIC OXIDE
SYNTHASE,
ENDOTHELIAL)		 2qqo NEUROPILIN-2
(Homo
sapiens) 		4 / 6 TRP A 372
PHE A 406
GLU A 370
ARG A 405
 None
 1.46A 6cifC-2qqoA:
0.1
6cifD-2qqoA:
0.3		 6cifC-2qqoA:
11.34
6cifD-2qqoA:
11.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DJZ_A_GMJA301_1
(SIGMA NON-OPIOID
INTRACELLULAR
RECEPTOR 1)		 2qqo NEUROPILIN-2
(Homo
sapiens) 		4 / 6 SER A 470
ASP A 371
GLN A 504
GLU A 370
 None
 1.49A 6djzA-2qqoA:
2.3		 6djzA-2qqoA:
19.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6F5U_A_CQNA610_1
(ENVELOPE
GLYCOPROTEIN,ENVELOP
E GLYCOPROTEIN,GP1
ENVELOPE
GLYCOPROTEIN)		 2qqo NEUROPILIN-2
(Homo
sapiens) 		5 / 10 VAL A 407
LEU A 339
LEU A 398
LEU A 422
LEU A 424
 None
 0.83A 6f5uA-2qqoA:
undetectable
6f5uB-2qqoA:
undetectable		 6f5uA-2qqoA:
12.17
6f5uB-2qqoA:
10.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
8NSE_B_H4BB601_1
(PROTEIN (NITRIC
OXIDE SYNTHASE))		 2qqo NEUROPILIN-2
(Homo
sapiens) 		4 / 6 TRP A 372
PHE A 406
GLU A 370
ARG A 405
 None
 1.44A 8nseA-2qqoA:
0.4
8nseB-2qqoA:
0.5		 8nseA-2qqoA:
23.53
8nseB-2qqoA:
23.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
9NSE_B_H4BB601_1
(PROTEIN (NITRIC
OXIDE SYNTHASE))		 2qqo NEUROPILIN-2
(Homo
sapiens) 		4 / 6 TRP A 372
PHE A 406
GLU A 370
ARG A 405
 None
 1.49A 9nseA-2qqoA:
0.0
9nseB-2qqoA:
0.7		 9nseA-2qqoA:
23.53
9nseB-2qqoA:
23.53