SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2qqu'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1CEA_A_ACAA90_1
(PLASMINOGEN)		 2qqu BETA-FRUCTOFURANOSID
ASE
(Arabidopsis
thaliana) 		4 / 8 ASP A 206
TYR A 278
ARG A 320
THR A 283
 None
 1.48A 1ceaA-2qquA:
undetectable
1ceaB-2qquA:
undetectable		 1ceaA-2qquA:
9.40
1ceaB-2qquA:
9.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1CEA_A_ACAA90_1
(PLASMINOGEN)		 2qqu BETA-FRUCTOFURANOSID
ASE
(Arabidopsis
thaliana) 		4 / 8 ASP A 206
TYR A 278
TYR A 273
THR A 283
 None
 1.34A 1ceaA-2qquA:
undetectable
1ceaB-2qquA:
undetectable		 1ceaA-2qquA:
9.40
1ceaB-2qquA:
9.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1O86_A_LPRA702_2
(ANGIOTENSIN
CONVERTING ENZYME)		 2qqu BETA-FRUCTOFURANOSID
ASE
(Arabidopsis
thaliana) 		4 / 4 SER A 478
VAL A 527
PHE A 431
VAL A 445
 None
 1.32A 1o86A-2qquA:
undetectable		 1o86A-2qquA:
21.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1R15_C_NCAC439_0
(ADP-RIBOSYL CYCLASE)		 2qqu BETA-FRUCTOFURANOSID
ASE
(Arabidopsis
thaliana) 		3 / 3 TRP A 186
PHE A 183
TRP A 161
 None
 0.75A 1r15C-2qquA:
undetectable		 1r15C-2qquA:
19.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1R15_F_NCAF469_0
(ADP-RIBOSYL CYCLASE)		 2qqu BETA-FRUCTOFURANOSID
ASE
(Arabidopsis
thaliana) 		3 / 3 TRP A 186
PHE A 183
TRP A 161
 None
 0.76A 1r15F-2qquA:
undetectable		 1r15F-2qquA:
19.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1R15_G_NCAG479_0
(ADP-RIBOSYL CYCLASE)		 2qqu BETA-FRUCTOFURANOSID
ASE
(Arabidopsis
thaliana) 		3 / 3 TRP A 186
PHE A 183
TRP A 161
 None
 0.76A 1r15G-2qquA:
undetectable		 1r15G-2qquA:
19.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1R15_H_NCAH489_0
(ADP-RIBOSYL CYCLASE)		 2qqu BETA-FRUCTOFURANOSID
ASE
(Arabidopsis
thaliana) 		3 / 3 TRP A 186
PHE A 183
TRP A 161
 None
 0.75A 1r15H-2qquA:
undetectable		 1r15H-2qquA:
19.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1XOQ_A_ROFA502_1
(CAMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE 4D)		 2qqu BETA-FRUCTOFURANOSID
ASE
(Arabidopsis
thaliana) 		3 / 3 ASN A  22
TRP A  20
GLN A 316
 SUC  A 800 (-3.6A)
None
None
 0.97A 1xoqA-2qquA:
undetectable		 1xoqA-2qquA:
19.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2NV4_A_ACTA148_0
(UPF0066 PROTEIN
AF_0241)		 2qqu BETA-FRUCTOFURANOSID
ASE
(Arabidopsis
thaliana) 		3 / 3 VAL A 308
GLU A 305
GLU A 309
 None
 0.77A 2nv4A-2qquA:
undetectable		 2nv4A-2qquA:
15.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZUL_A_SAMA376_0
(PROBABLE RIBOSOMAL
RNA SMALL SUBUNIT
METHYLTRANSFERASE)		 2qqu BETA-FRUCTOFURANOSID
ASE
(Arabidopsis
thaliana) 		5 / 12 PHE A  37
GLY A  84
ALA A 112
ASP A  23
PRO A  27
 None
None
None
SUC  A 800 (-2.6A)
None
 1.12A 2zulA-2qquA:
undetectable		 2zulA-2qquA:
22.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3IV6_B_SAMB301_0
(PUTATIVE
ZN-DEPENDENT ALCOHOL
DEHYDROGENASE)		 2qqu BETA-FRUCTOFURANOSID
ASE
(Arabidopsis
thaliana) 		5 / 12 GLY A 466
THR A 464
PHE A 468
ASP A 450
ARG A 432
 None
 1.11A 3iv6B-2qquA:
undetectable		 3iv6B-2qquA:
20.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3IV6_D_SAMD301_0
(PUTATIVE
ZN-DEPENDENT ALCOHOL
DEHYDROGENASE)		 2qqu BETA-FRUCTOFURANOSID
ASE
(Arabidopsis
thaliana) 		5 / 12 GLY A 466
THR A 464
PHE A 468
ASP A 450
ARG A 432
 None
 1.15A 3iv6D-2qquA:
undetectable		 3iv6D-2qquA:
20.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3QXV_D_MTXD2000_2
(ANTI-METHOTREXATE
CDR1-4 GRAFT VHH)		 2qqu BETA-FRUCTOFURANOSID
ASE
(Arabidopsis
thaliana) 		3 / 3 LEU A 515
ARG A 480
ASN A 529
 None
 0.76A 3qxvD-2qquA:
undetectable		 3qxvD-2qquA:
15.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SO9_A_017A100_1
(HIV-1 PROTEASE)		 2qqu BETA-FRUCTOFURANOSID
ASE
(Arabidopsis
thaliana) 		5 / 8 ASN A  19
GLY A  44
ALA A  45
ASP A 307
ILE A  50
 None
None
None
None
SUC  A 800 ( 4.6A)
 1.38A 3so9A-2qquA:
undetectable		 3so9A-2qquA:
9.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SUE_A_SUEA1201_2
(NS3 PROTEASE, NS4A
PROTEIN)		 2qqu BETA-FRUCTOFURANOSID
ASE
(Arabidopsis
thaliana) 		4 / 4 PHE A 258
TYR A 246
ARG A 148
LEU A 174
 None
None
SUC  A 800 (-3.9A)
None
 1.22A 3sueA-2qquA:
0.0		 3sueA-2qquA:
16.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3V4T_D_ACTD502_0
(UDP-N-ACETYLGLUCOSAM
INE
1-CARBOXYVINYLTRANSF
ERASE)		 2qqu BETA-FRUCTOFURANOSID
ASE
(Arabidopsis
thaliana) 		3 / 3 GLY A 214
THR A 211
ASN A 216
 None
 0.72A 3v4tD-2qquA:
undetectable		 3v4tD-2qquA:
21.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4AZT_A_SAMA1472_1
(METHYLTRANSFERASE
WBDD)		 2qqu BETA-FRUCTOFURANOSID
ASE
(Arabidopsis
thaliana) 		3 / 3 GLN A  15
ASP A 484
GLN A 370
 None
 0.85A 4aztA-2qquA:
undetectable		 4aztA-2qquA:
22.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DA7_A_AC2A301_1
(PURINE NUCLEOSIDE
PHOSPHORYLASE
DEOD-TYPE)		 2qqu BETA-FRUCTOFURANOSID
ASE
(Arabidopsis
thaliana) 		5 / 10 ARG A 320
ALA A 481
VAL A 488
GLU A 489
VAL A 503
 None
 1.22A 4da7A-2qquA:
undetectable		 4da7A-2qquA:
19.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4IKI_A_IMNA201_1
(TRANSTHYRETIN)		 2qqu BETA-FRUCTOFURANOSID
ASE
(Arabidopsis
thaliana) 		3 / 3 LYS A 348
LEU A 350
ALA A 532
 None
 0.73A 4ikiA-2qquA:
undetectable		 4ikiA-2qquA:
15.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4UDC_A_DEXA1778_2
(GLUCOCORTICOID
RECEPTOR)		 2qqu BETA-FRUCTOFURANOSID
ASE
(Arabidopsis
thaliana) 		3 / 3 MET A 402
GLN A 451
TYR A 465
 None
 1.05A 4udcA-2qquA:
undetectable		 4udcA-2qquA:
19.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ZZC_C_ACTC401_0
(PROTON-GATED ION
CHANNEL)		 2qqu BETA-FRUCTOFURANOSID
ASE
(Arabidopsis
thaliana) 		4 / 5 PHE A 491
ARG A 480
ILE A 318
GLU A 489
 None
 1.48A 4zzcC-2qquA:
0.0
4zzcD-2qquA:
0.0		 4zzcC-2qquA:
21.68
4zzcD-2qquA:
21.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ZZC_E_ACTE401_0
(PROTON-GATED ION
CHANNEL)		 2qqu BETA-FRUCTOFURANOSID
ASE
(Arabidopsis
thaliana) 		4 / 5 ILE A 318
GLU A 489
PHE A 491
ARG A 480
 None
 1.49A 4zzcA-2qquA:
0.0
4zzcE-2qquA:
0.0		 4zzcA-2qquA:
21.68
4zzcE-2qquA:
21.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5GSN_A_MMZA503_1
(FLAVIN-CONTAINING
MONOOXYGENASE)		 2qqu BETA-FRUCTOFURANOSID
ASE
(Arabidopsis
thaliana) 		3 / 3 ASN A 460
SER A 455
SER A 454
 None
 0.71A 5gsnA-2qquA:
undetectable		 5gsnA-2qquA:
21.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HFJ_G_SAMG301_0
(ADENINE SPECIFIC DNA
METHYLTRANSFERASE
(DPNA))		 2qqu BETA-FRUCTOFURANOSID
ASE
(Arabidopsis
thaliana) 		5 / 12 ALA A 175
ASP A 267
GLY A 200
THR A 241
SER A 167
 None
 1.43A 5hfjG-2qquA:
undetectable		 5hfjG-2qquA:
19.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5K9D_A_ACTA405_0
(DIHYDROOROTATE
DEHYDROGENASE
(QUINONE),
MITOCHONDRIAL)		 2qqu BETA-FRUCTOFURANOSID
ASE
(Arabidopsis
thaliana) 		3 / 3 GLN A 451
THR A 464
ASP A 450
 None
 0.85A 5k9dA-2qquA:
undetectable		 5k9dA-2qquA:
21.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5X2T_I_PEMI202_1
(HEMOGLOBIN SUBUNIT
ALPHA
HEMOGLOBIN SUBUNIT
BETA)		 2qqu BETA-FRUCTOFURANOSID
ASE
(Arabidopsis
thaliana) 		4 / 8 PRO A 150
ALA A 135
THR A  99
ALA A 112
 None
 0.99A 5x2tI-2qquA:
undetectable
5x2tJ-2qquA:
undetectable
5x2tK-2qquA:
undetectable
5x2tL-2qquA:
undetectable		 5x2tI-2qquA:
14.48
5x2tJ-2qquA:
14.89
5x2tK-2qquA:
14.48
5x2tL-2qquA:
14.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5X80_A_SALA201_1
(UNCHARACTERIZED
HTH-TYPE
TRANSCRIPTIONAL
REGULATOR RV2887)		 2qqu BETA-FRUCTOFURANOSID
ASE
(Arabidopsis
thaliana) 		4 / 5 VAL A 469
PRO A 395
GLY A 466
TYR A 275
 None
 1.30A 5x80A-2qquA:
undetectable
5x80B-2qquA:
undetectable		 5x80A-2qquA:
14.09
5x80B-2qquA:
14.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5X80_D_SALD201_1
(UNCHARACTERIZED
HTH-TYPE
TRANSCRIPTIONAL
REGULATOR RV2887)		 2qqu BETA-FRUCTOFURANOSID
ASE
(Arabidopsis
thaliana) 		4 / 5 PRO A 395
GLY A 466
TYR A 275
VAL A 469
 None
 1.23A 5x80C-2qquA:
undetectable
5x80D-2qquA:
undetectable		 5x80C-2qquA:
14.09
5x80D-2qquA:
14.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6D8P_B_ACTB803_0
(UNCHARACTERIZED
PROTEIN)		 2qqu BETA-FRUCTOFURANOSID
ASE
(Arabidopsis
thaliana) 		4 / 4 MET A 416
TYR A 520
ARG A 453
LEU A 423
 None
 1.43A 6d8pB-2qquA:
0.2		 6d8pB-2qquA:
20.32